Role of the proteolytic hierarchy between cathepsin L, cathepsin D and caspase-3 in regulation of cellular susceptibility to apoptosis and autophagy

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1783, Issue 12, 2008, Pages 2294-2300

  Zheng, Xin ^a   Chu, Fei ^a   Mirkin, Bernard L ^a,b   Sudha, Thangirala ^c   Mousa, Shaker A ^c   Rebbaa, Abdelhadi ^c  

^a CHILDREN'S MEMORIAL HOSPITAL   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c ALBANY COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

Author keywords

Apoptosis; Autophagy; Cathepsin D; Cathepsin L; LC3

Indexed keywords

CASPASE 3; CATHEPSIN D; CATHEPSIN L; DNA; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL; CONTROLLED STUDY; DNA DAMAGE; ELECTRON MICROSCOPY; ENZYME ACTIVITY; ENZYME SUBSTRATE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION;

APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; CASPASE 3; CATHEPSIN D; CATHEPSINS; CELL SURVIVAL; CYSTEINE ENDOPEPTIDASES; HUMANS; MICROSCOPY, FLUORESCENCE; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED;

EID: 56649123313     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2008.07.027     Document Type: Article

References (24)

1. Green D.R., and Reed J.C. Mitochondria and apoptosis. Science 281 (1998) 1309-1312
2. Ciechanover A. Intracellular protein degradation: from a vague idea, through the lysosome and the ubiquitin-proteasome system, and onto human diseases and drug targeting (Nobel lecture). Angew Chem. Int. Ed. Engl. 44 (2005) 5944-5967
3. Duffy M.J. Proteases as prognostic markers in cancer. Clin. Cancer Res. 2 (1996) 613-618
4. Heinrich M., Neumeyer J., Jakob M., Hallas C., Tchikov V., Winoto-Morbach S., Wickel M., Schneider-Brachert W., Trauzold A., Hethke A., and Schutze S. Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation. Cell Death Differ. 11 (2004) 550-563
5. Broker L.E., Kruyt F.A., and Giaccone G. Cell death independent of caspases: a review. Clin. Cancer Res. 11 (2005) 3155-3162
6. Wright W.W., Smith L., Kerr C., and Charron M. Mice that express enzymatically inactive cathepsin L exhibit abnormal spermatogenesis. Biol. Reprod. 68 (2003) 680-687
7. Wille A., Gerber A., Heimburg A., Reisenauer A., Peters C., Saftig P., Reinheckel T., Welte T., and Buhling F. Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells. Biol. Chem. 385 (2004) 665-670
8. Hashmi S., Britton C., Liu J., Guiliano D.B., Oksov Y., and Lustigman S. Cathepsin L is essential for embryogenesis and development of Caenorhabditis elegans. J. Biol. Chem. 277 (2002) 3477-3486
9. Stypmann J., Glaser K., Roth W., Tobin D.J., Petermann I., Matthias R., Monnig G., Haverkamp W., Breithardt G., Schmahl W., Peters C., and Reinheckel T. Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 6234-6239
10. Felbor U., Kessler B., Mothes W., Goebel H.H., Ploegh H.L., Bronson R.T., and Olsen B.R. Neuronal loss and brain atrophy in mice lacking cathepsins B and L. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 7883-7888
11. Benavides F., Starost M.F., Flores M., Gimenez-Conti I.B., Guenet J.L., and Conti C.J. Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation. Am. J. Pathol. 161 (2002) 693-703
12. Tobin D.J., Foitzik K., Reinheckel T., Mecklenburg L., Botchkarev V.A., Peters C., and Paus R. The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling. Am. J. Pathol. 160 (2002) 1807-1821
13. Zheng X., Chou P.M., Mirkin B.L., and Rebbaa A. Senescence-initiated reversal of drug resistance: specific role of cathepsin L. Cancer Res. 64 (2004) 1773-1780
14. Cohen H.Y., Miller C., Bitterman K.J., Wall N.R., Hekking B., Kessler B., Howitz K.T., Gorospe M., de Cabo R., and Sinclair D.A. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305 (2004) 390-392
15. Asanuma K., Tanida I., Shirato I., Ueno T., Takahara H., Nishitani T., Kominami E., and Tomino Y. MAP-LC3, a promising autophagosomal marker, is processed during the differentiation and recovery of podocytes from PAN nephrosis. FASEB J. 17 (2003) 1165-1167
16. Novikoff P.M., Touster O., Novikoff A.B., and Tulsiani D.P. Effects of swainsonine on rat liver and kidney: biochemical and morphological studies. J. Cell Biol. 101 (1985) 339-349
17. Gonzalez-Polo R.A., Boya P., Pauleau A.L., Jalil A., Larochette N., Souquere S., Eskelinen E.L., Pierron G., Saftig P., and Kroemer G. The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death. J. Cell Sci. 118 (2005) 3091-3102
18. Lawrence B.P., and Brown W.J. Autophagic vacuoles rapidly fuse with pre-existing lysosomes in cultured hepatocytes. J. Cell Sci. 102 Pt 3 (1992) 515-526
19. Chang B.D., Swift M.E., Shen M., Fang J., Broude E.V., and Roninson I.B. Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 389-394
20. Nelson D.A., and White E. Exploiting different ways to die. Genes Dev. 18 (2004) 1223-1226
21. Lockshin R.A., and Zakeri Z. Caspase-independent cell deaths. Curr. Opin. Cell Biol. 14 (2002) 727-733
22. Rebbaa A., Zheng X., Chou P.M., and Mirkin B.L. Caspase inhibition switches doxorubicin-induced apoptosis to senescence. Oncogene 22 (2003) 2805-2811
23. Roninson I.B., Broude E.V., and Chang B.D. If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist Updat. 4 (2001) 303-313
24. Shay J.W., and Roninson I.B. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 23 (2004) 2919-2933