Inhibitors of cathepsin B improve memory and reduce β-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, β-secretase site of the amyloid precursor protein

Journal of Biological Chemistry

Volumn 283, Issue 12, 2008, Pages 7745-7753

  Hook, Vivian Y H ^a   Kindy, Mark ^b   Hook, Gregory ^c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b Applied Neurotechnology Inc   (United States)

^c American Life Science Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; GLYCOPROTEINS; PUMPING PLANTS; WATER TREATMENT;

ALZHEIMER DISEASES; AMYLOID PLAQUES; AMYLOID PRECURSOR PROTEINS; ANIMAL MODELS; CATHEPSIN B; CYSTEINE PROTEASES; IN-VIVO; LOGICAL APPROACHES; MEMORY FUNCTIONS; MORRIS WATER MAZES; SECRETASE; SECRETORY VESICLES; SUBSTANTIAL IMPROVEMENTS; TRANSGENIC;

DATA STORAGE EQUIPMENT;

ALOXISTATIN; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CA 074ME; CATHEPSIN B; N (3 PROPYLCARBAMOYLOXIRANE 2 CARBONYL)ISOLEUCYLPROLINE; UNCLASSIFIED DRUG; CA 074 METHYL ESTER; CYSTEINE PROTEINASE INHIBITOR; DIPEPTIDE; DRUG DERIVATIVE; LEUCINE; SECRETASE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; MAZE TEST; MEMORY; MEMORY DISORDER; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SECRETORY VESICLE; SENILE PLAQUE; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; CATTLE; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; ENZYMOLOGY; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM; PATHOLOGY;

ANIMALIA; MUS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CATHEPSIN B; CATTLE; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION; HUMANS; LEUCINE; MAZE LEARNING; MEMORY; MICE; MICE, TRANSGENIC;

EID: 43149100823     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708362200     Document Type: Article

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