-
1
-
-
33748308883
-
Targeting proteases: Successes, failures and future prospects
-
DOI 10.1038/nrd2092, PII NRD2092
-
Turk, B. (2006) Targeting proteases: successes, failures and future prospects Nat. Rev. Drug Discovery 5, 785-799 (Pubitemid 44323703)
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.9
, pp. 785-799
-
-
Turk, B.1
-
2
-
-
57649165535
-
Evolution of peptidase diversity
-
Page, M. J. and Di Cera, E. (2008) Evolution of peptidase diversity J. Biol. Chem. 283, 30010-30014
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 30010-30014
-
-
Page, M.J.1
Di Cera, E.2
-
3
-
-
75549091468
-
MEROPS: The peptidase database
-
Rawlings, N. D., Barrett, A. J., and Bateman, A. (2010) MEROPS: the peptidase database Nucleic Acids Res. 38, D227-233
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 227-233
-
-
Rawlings, N.D.1
Barrett, A.J.2
Bateman, A.3
-
4
-
-
0037803570
-
Human and mouse proteases: A comparative genomic approach
-
DOI 10.1038/nrg1111
-
Puente, X. S., Sanchez, L. M., Overall, C. M., and Lopez-Otin, C. (2003) Human and mouse proteases: a comparative genomic approach Nat. Rev. Genet. 4, 544-558 (Pubitemid 36781345)
-
(2003)
Nature Reviews Genetics
, vol.4
, Issue.7
, pp. 544-558
-
-
Puente, X.S.1
Sanchez, L.M.2
Overall, C.M.3
Lopez-Otin, C.4
-
5
-
-
42249109450
-
Serine peptidases: Classification, structure and function
-
Page, M. J. and Di Cera, E. (2008) Serine peptidases: classification, structure and function Cell. Mol. Life Sci. 65, 1220-1236
-
(2008)
Cell. Mol. Life Sci.
, vol.65
, pp. 1220-1236
-
-
Page, M.J.1
Di Cera, E.2
-
6
-
-
33847276695
-
In search of partners: Linking extracellular proteases to substrates
-
Overall, C. M. and Blobel, C. P. (2007) In search of partners: linking extracellular proteases to substrates Nat. Rev. Mol. Cell. Biol. 8, 245-257
-
(2007)
Nat. Rev. Mol. Cell. Biol.
, vol.8
, pp. 245-257
-
-
Overall, C.M.1
Blobel, C.P.2
-
7
-
-
59649092937
-
Allosteric regulation of proteases
-
Hauske, P., Ottmann, C., Meltzer, M., Ehrmann, M., and Kaiser, M. (2008) Allosteric regulation of proteases ChemBioChem 9, 2920-2928
-
(2008)
ChemBioChem
, vol.9
, pp. 2920-2928
-
-
Hauske, P.1
Ottmann, C.2
Meltzer, M.3
Ehrmann, M.4
Kaiser, M.5
-
8
-
-
77954600981
-
Allosteric regulation of protease activity by small molecules
-
Shen, A. (2010) Allosteric regulation of protease activity by small molecules Mol. Biosyst. 6, 1431-1443
-
(2010)
Mol. Biosyst.
, vol.6
, pp. 1431-1443
-
-
Shen, A.1
-
9
-
-
79960541421
-
Allostery in trypsin-like proteases suggests new therapeutic strategies
-
Gohara, D. W. and Di Cera, E. (2011) Allostery in trypsin-like proteases suggests new therapeutic strategies Trends Biotechnol. 29, 577-585
-
(2011)
Trends Biotechnol.
, vol.29
, pp. 577-585
-
-
Gohara, D.W.1
Di Cera, E.2
-
10
-
-
47649125643
-
Allosteric regulation and catalysis emerge via a common route
-
DOI 10.1038/nchembio.98, PII NCHEMBIO98
-
Goodey, N. M. and Benkovic, S. J. (2008) Allosteric regulation and catalysis emerge via a common route Nat. Chem. Biol. 4, 474-482 (Pubitemid 352019763)
-
(2008)
Nature Chemical Biology
, vol.4
, Issue.8
, pp. 474-482
-
-
Goodey, N.M.1
Benkovic, S.J.2
-
11
-
-
70350340728
-
The role of dynamic conformational ensembles in biomolecular recognition
-
Boehr, D. D., Nussinov, R., and Wright, P. E. (2009) The role of dynamic conformational ensembles in biomolecular recognition Nat. Chem. Biol. 5, 789-796
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 789-796
-
-
Boehr, D.D.1
Nussinov, R.2
Wright, P.E.3
-
12
-
-
37249067732
-
The origin of protein interactions and allostery in colocalization
-
DOI 10.1038/nature06524, PII NATURE06524
-
Kuriyan, J. and Eisenberg, D. (2007) The origin of protein interactions and allostery in colocalization Nature 450, 983-990 (Pubitemid 350273628)
-
(2007)
Nature
, vol.450
, Issue.7172
, pp. 983-990
-
-
Kuriyan, J.1
Eisenberg, D.2
-
13
-
-
84861219631
-
Allostery and the Monod-Wyman-Changeux model after 50 years
-
Changeux, J. P. (2012) Allostery and the Monod-Wyman-Changeux model after 50 years Annu. Rev. Biophys. 41, 103-133
-
(2012)
Annu. Rev. Biophys.
, vol.41
, pp. 103-133
-
-
Changeux, J.P.1
-
14
-
-
6344219895
-
Is allostery an intrinsic property of all dynamic proteins?
-
DOI 10.1002/prot.20232
-
Gunasekaran, K., Ma, B., and Nussinov, R. (2004) Is allostery an intrinsic property of all dynamic proteins? Proteins 57, 433-443 (Pubitemid 39390799)
-
(2004)
Proteins: Structure, Function and Genetics
, vol.57
, Issue.3
, pp. 433-443
-
-
Gunasekaran, K.1
Ma, B.2
Nussinov, R.3
-
15
-
-
41149104308
-
Allostery: Absence of a change in shape does not imply that allostery is not at play
-
Tsai, C. J., del Sol, A., and Nussinov, R. (2008) Allostery: absence of a change in shape does not imply that allostery is not at play J. Mol. Biol. 378, 1-11
-
(2008)
J. Mol. Biol.
, vol.378
, pp. 1-11
-
-
Tsai, C.J.1
Del Sol, A.2
Nussinov, R.3
-
16
-
-
0013863816
-
Comparison of experimental binding data and theoretical models in proteins containing subunits
-
Koshland, D. E., Jr., Nemethy, G., and Filmer, D. (1966) Comparison of experimental binding data and theoretical models in proteins containing subunits Biochemistry 5, 365-385
-
(1966)
Biochemistry
, vol.5
, pp. 365-385
-
-
Koshland, Jr.D.E.1
Nemethy, G.2
Filmer, D.3
-
17
-
-
70350348011
-
NMR spectroscopy brings invisible protein states into focus
-
Baldwin, A. J. and Kay, L. E. (2009) NMR spectroscopy brings invisible protein states into focus Nat. Chem. Biol. 5, 808-814
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 808-814
-
-
Baldwin, A.J.1
Kay, L.E.2
-
18
-
-
78149473070
-
Allostery and population shift in drug discovery
-
Kar, G., Keskin, O., Gursoy, A., and Nussinov, R. (2010) Allostery and population shift in drug discovery Curr. Opin. Pharmacol. 10, 715-722
-
(2010)
Curr. Opin. Pharmacol.
, vol.10
, pp. 715-722
-
-
Kar, G.1
Keskin, O.2
Gursoy, A.3
Nussinov, R.4
-
19
-
-
68149157248
-
The origin of allosteric functional modulation: Multiple pre-existing pathways
-
del Sol, A., Tsai, C. J., Ma, B., and Nussinov, R. (2009) The origin of allosteric functional modulation: multiple pre-existing pathways Structure 17, 1042-1050
-
(2009)
Structure
, vol.17
, pp. 1042-1050
-
-
Del Sol, A.1
Tsai, C.J.2
Ma, B.3
Nussinov, R.4
-
20
-
-
49649084492
-
Dynamic energy landscape view of coupled binding and protein conformational change: Induced-fit versus population-shift mechanisms
-
Okazaki, K. and Takada, S. (2008) Dynamic energy landscape view of coupled binding and protein conformational change: induced-fit versus population-shift mechanisms Proc. Natl. Acad. Sci. U.S.A. 105, 11182-11187
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 11182-11187
-
-
Okazaki, K.1
Takada, S.2
-
21
-
-
69549120472
-
Conformational selection or induced fit: A flux description of reaction mechanism
-
Hammes, G. G., Chang, Y. C., and Oas, T. G. (2009) Conformational selection or induced fit: a flux description of reaction mechanism Proc. Natl. Acad. Sci. U.S.A. 106, 13737-13741
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 13737-13741
-
-
Hammes, G.G.1
Chang, Y.C.2
Oas, T.G.3
-
22
-
-
64849113665
-
Trapping moving targets with small molecules
-
Lee, G. M. and Craik, C. S. (2009) Trapping moving targets with small molecules Science 324, 213-215
-
(2009)
Science
, vol.324
, pp. 213-215
-
-
Lee, G.M.1
Craik, C.S.2
-
23
-
-
77956310878
-
Emerging principles in protease-based drug discovery
-
Drag, M. and Salvesen, G. S. (2010) Emerging principles in protease-based drug discovery Nat. Rev. Drug Discovery 9, 690-701
-
(2010)
Nat. Rev. Drug Discovery
, vol.9
, pp. 690-701
-
-
Drag, M.1
Salvesen, G.S.2
-
24
-
-
84855428544
-
New approaches for dissecting protease functions to improve probe development and drug discovery
-
Deu, E., Verdoes, M., and Bogyo, M. (2012) New approaches for dissecting protease functions to improve probe development and drug discovery Nat. Struct. Mol. Biol. 19, 9-16
-
(2012)
Nat. Struct. Mol. Biol.
, vol.19
, pp. 9-16
-
-
Deu, E.1
Verdoes, M.2
Bogyo, M.3
-
25
-
-
9944263528
-
Searching for new allosteric sites in enzymes
-
DOI 10.1016/j.sbi.2004.10.009, PII S0959440X0400185X
-
Hardy, J. A. and Wells, J. A. (2004) Searching for new allosteric sites in enzymes Curr. Opin. Struct. Biol. 14, 706-715 (Pubitemid 39592582)
-
(2004)
Current Opinion in Structural Biology
, vol.14
, Issue.6
, pp. 706-715
-
-
Hardy, J.A.1
Wells, J.A.2
-
26
-
-
77249169281
-
Turning enzymes on with small molecules
-
Zorn, J. A. and Wells, J. A. (2010) Turning enzymes ON with small molecules Nat. Chem. Biol. 6, 179-188
-
(2010)
Nat. Chem. Biol.
, vol.6
, pp. 179-188
-
-
Zorn, J.A.1
Wells, J.A.2
-
27
-
-
0030718475
-
Molecular mechanisms of thrombin function
-
DOI 10.1007/s000180050091
-
Di Cera, E., Dang, Q. D., and Ayala, Y. M. (1997) Molecular mechanisms of thrombin function Cell. Mol. Life Sci. 53, 701-730 (Pubitemid 27477965)
-
(1997)
Cellular and Molecular Life Sciences
, vol.53
, Issue.9
, pp. 701-730
-
-
Di Cera, E.1
Dang, Q.D.2
Ayala, Y.M.3
-
28
-
-
0026476381
-
Thrombin is a Na(+)-activated enzyme
-
Wells, C. M. and Di Cera, E. (1992) Thrombin is a Na(+)-activated enzyme Biochemistry 31, 11721-11730
-
(1992)
Biochemistry
, vol.31
, pp. 11721-11730
-
-
Wells, C.M.1
Di Cera, E.2
-
29
-
-
50849101992
-
How Na+ activates thrombin - A review of the functional and structural data
-
Huntington, J. A. (2008) How Na+ activates thrombin - a review of the functional and structural data Biol. Chem. 389, 1025-1035
-
(2008)
Biol. Chem.
, vol.389
, pp. 1025-1035
-
-
Huntington, J.A.1
-
30
-
-
0029090336
-
The Na+ binding site of thrombin
-
Di Cera, E., Guinto, E. R., Vindigni, A., Dang, Q. D., Ayala, Y. M., Wuyi, M., and Tulinsky, A. (1995) The Na+ binding site of thrombin J. Biol. Chem. 270, 22089-22092
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 22089-22092
-
-
Di Cera, E.1
Guinto, E.R.2
Vindigni, A.3
Dang, Q.D.4
Ayala, Y.M.5
Wuyi, M.6
Tulinsky, A.7
-
31
-
-
0030935412
-
+ binding site of thrombin
-
DOI 10.1016/S0301-4622(96)02227-2, PII S0301462296022272
-
Zhang, E. and Tulinsky, A. (1997) The molecular environment of the Na+ binding site of thrombin Biophys. Chem. 63, 185-200 (Pubitemid 27140429)
-
(1997)
Biophysical Chemistry
, vol.63
, Issue.2-3
, pp. 185-200
-
-
Zhang, E.1
Tulinsky, A.2
-
32
-
-
53749083462
-
Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain
-
Lupardus, P. J., Shen, A., Bogyo, M., and Garcia, K. C. (2008) Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain Science 322, 265-268
-
(2008)
Science
, vol.322
, pp. 265-268
-
-
Lupardus, P.J.1
Shen, A.2
Bogyo, M.3
Garcia, K.C.4
-
33
-
-
35648975533
-
MARTX, multifunctional autoprocessing repeats-in-toxin toxins
-
DOI 10.1128/IAI.00525-07
-
Satchell, K. J. (2007) MARTX, multifunctional autoprocessing repeats-in-toxin toxins Infect. Immun. 75, 5079-5084 (Pubitemid 350033594)
-
(2007)
Infection and Immunity
, vol.75
, Issue.11
, pp. 5079-5084
-
-
Fullner Satchell, K.J.1
-
34
-
-
67650290548
-
Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin
-
Shen, A., Lupardus, P. J., Albrow, V. E., Guzzetta, A., Powers, J. C., Garcia, K. C., and Bogyo, M. (2009) Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin Nat. Chem. Biol. 5, 469-478
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 469-478
-
-
Shen, A.1
Lupardus, P.J.2
Albrow, V.E.3
Guzzetta, A.4
Powers, J.C.5
Garcia, K.C.6
Bogyo, M.7
-
35
-
-
69249090956
-
Structure-function analysis of inositol hexakisphosphate-induced autoprocessing in Clostridium difficile toxin A
-
Pruitt, R. N., Chagot, B., Cover, M., Chazin, W. J., Spiller, B., and Lacy, D. B. (2009) Structure-function analysis of inositol hexakisphosphate- induced autoprocessing in Clostridium difficile toxin A J. Biol. Chem. 284, 21934-21940
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 21934-21940
-
-
Pruitt, R.N.1
Chagot, B.2
Cover, M.3
Chazin, W.J.4
Spiller, B.5
Lacy, D.B.6
-
36
-
-
78649357145
-
Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB
-
Puri, A. W., Lupardus, P. J., Deu, E., Albrow, V. E., Garcia, K. C., Bogyo, M., and Shen, A. (2010) Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB Chem. Biol. 17, 1201-1211
-
(2010)
Chem. Biol.
, vol.17
, pp. 1201-1211
-
-
Puri, A.W.1
Lupardus, P.J.2
Deu, E.3
Albrow, V.E.4
Garcia, K.C.5
Bogyo, M.6
Shen, A.7
-
37
-
-
79952360670
-
Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins
-
Shen, A., Lupardus, P. J., Gersch, M. M., Puri, A. W., Albrow, V. E., Garcia, K. C., and Bogyo, M. (2011) Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins Nat. Struct. Mol. Biol. 18, 364-371
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 364-371
-
-
Shen, A.1
Lupardus, P.J.2
Gersch, M.M.3
Puri, A.W.4
Albrow, V.E.5
Garcia, K.C.6
Bogyo, M.7
-
38
-
-
33646727594
-
A common allosteric site and mechanism in caspases
-
Scheer, J. M., Romanowski, M. J., and Wells, J. A. (2006) A common allosteric site and mechanism in caspases Proc. Natl. Acad. Sci. U.S.A. 103, 7595-7600
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 7595-7600
-
-
Scheer, J.M.1
Romanowski, M.J.2
Wells, J.A.3
-
39
-
-
4344654060
-
Discovery of an allosteric site in the caspases
-
DOI 10.1073/pnas.0404781101
-
Hardy, J. A., Lam, J., Nguyen, J. T., O'Brien, T., and Wells, J. A. (2004) Discovery of an allosteric site in the caspases Proc. Nat. Acad. Sci. U.S.A. 101, 12461-12466 (Pubitemid 39122046)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.34
, pp. 12461-12466
-
-
Hardy, J.A.1
Lam, J.2
Nguyen, J.T.3
O'Brien, T.4
Wells, J.A.5
-
40
-
-
48749120889
-
An allosteric circuit in caspase-1
-
Datta, D., Scheer, J. M., Romanowski, M. J., and Wells, J. A. (2008) An allosteric circuit in caspase-1 J. Mol. Biol. 381, 1157-1167
-
(2008)
J. Mol. Biol.
, vol.381
, pp. 1157-1167
-
-
Datta, D.1
Scheer, J.M.2
Romanowski, M.J.3
Wells, J.A.4
-
41
-
-
70350033973
-
Dissecting an allosteric switch in caspase-7 using chemical and mutational probes
-
Hardy, J. A. and Wells, J. A. (2009) Dissecting an allosteric switch in caspase-7 using chemical and mutational probes J. Biol. Chem. 284, 26063-26069
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 26063-26069
-
-
Hardy, J.A.1
Wells, J.A.2
-
42
-
-
84865389577
-
A class of allosteric caspase inhibitors identified by high-throughput screening
-
Feldman, T., Kabaleeswaran, V., Jang, S. B., Antczak, C., Djaballah, H., Wu, H., and Jiang, X. (2012) A class of allosteric caspase inhibitors identified by high-throughput screening Mol. Cell 47, 585-595
-
(2012)
Mol. Cell
, vol.47
, pp. 585-595
-
-
Feldman, T.1
Kabaleeswaran, V.2
Jang, S.B.3
Antczak, C.4
Djaballah, H.5
Wu, H.6
Jiang, X.7
-
43
-
-
65249094873
-
Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation
-
Elliott, J. M., Rouge, L., Wiesmann, C., and Scheer, J. M. (2009) Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation J. Biol. Chem. 284, 6546-6553
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 6546-6553
-
-
Elliott, J.M.1
Rouge, L.2
Wiesmann, C.3
Scheer, J.M.4
-
44
-
-
71049189254
-
Unraveling the allosteric mechanism of serine protease inhibition by an antibody
-
Ganesan, R., Eigenbrot, C., Wu, Y., Liang, W. C., Shia, S., Lipari, M. T., and Kirchhofer, D. (2009) Unraveling the allosteric mechanism of serine protease inhibition by an antibody Structure 17, 1614-1624
-
(2009)
Structure
, vol.17
, pp. 1614-1624
-
-
Ganesan, R.1
Eigenbrot, C.2
Wu, Y.3
Liang, W.C.4
Shia, S.5
Lipari, M.T.6
Kirchhofer, D.7
-
45
-
-
84857841703
-
Allosteric antibody inhibition of human hepsin protease
-
Koschubs, T., Dengl, S., Durr, H., Kaluza, K., Georges, G., Hartl, C., Jennewein, S., Lanzendorfer, M., Auer, J., Stern, A., Huang, K. S., Packman, K., Gubler, U., Kostrewa, D., Ries, S., Hansen, S., Kohnert, U., Cramer, P., and Mundigl, O. (2012) Allosteric antibody inhibition of human hepsin protease Biochem. J. 442, 483-494
-
(2012)
Biochem. J.
, vol.442
, pp. 483-494
-
-
Koschubs, T.1
Dengl, S.2
Durr, H.3
Kaluza, K.4
Georges, G.5
Hartl, C.6
Jennewein, S.7
Lanzendorfer, M.8
Auer, J.9
Stern, A.10
Huang, K.S.11
Packman, K.12
Gubler, U.13
Kostrewa, D.14
Ries, S.15
Hansen, S.16
Kohnert, U.17
Cramer, P.18
Mundigl, O.19
-
46
-
-
38049174343
-
Structural insight into distinct mechanisms of protease inhibition by antibodies
-
Wu, Y., Eigenbrot, C., Liang, W. C., Stawicki, S., Shia, S., Fan, B., Ganesan, R., Lipari, M. T., and Kirchhofer, D. (2007) Structural insight into distinct mechanisms of protease inhibition by antibodies Proc. Natl. Acad. Sci. U.S.A. 104, 19784-19789
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 19784-19789
-
-
Wu, Y.1
Eigenbrot, C.2
Liang, W.C.3
Stawicki, S.4
Shia, S.5
Fan, B.6
Ganesan, R.7
Lipari, M.T.8
Kirchhofer, D.9
-
47
-
-
77956700490
-
Structural and mechanistic insight into how antibodies inhibit serine proteases
-
Ganesan, R., Eigenbrot, C., and Kirchhofer, D. (2010) Structural and mechanistic insight into how antibodies inhibit serine proteases Biochem. J. 430, 179-189
-
(2010)
Biochem. J.
, vol.430
, pp. 179-189
-
-
Ganesan, R.1
Eigenbrot, C.2
Kirchhofer, D.3
-
48
-
-
0020524899
-
Activation of human prothrombin by stoichiometric levels of staphylocoagulase
-
Hendrix, H., Lindhout, T., Mertens, K., Engels, W., and Hemker, H. C. (1983) Activation of human prothrombin by stoichiometric levels of staphylocoagulase J. Biol. Chem. 258, 3637-3644 (Pubitemid 13055779)
-
(1983)
Journal of Biological Chemistry
, vol.258
, Issue.6
, pp. 3637-3644
-
-
Hendrix, H.1
Lindhout, T.2
Mertens, K.3
-
49
-
-
11244267323
-
The staphylocoagulase family of zymogen activator and adhesion proteins
-
DOI 10.1007/s00018-004-4285-7
-
Panizzi, P., Friedrich, R., Fuentes-Prior, P., Bode, W., and Bock, P. E. (2004) The staphylocoagulase family of zymogen activator and adhesion proteins Cell. Mol. Life Sci. 61, 2793-2798 (Pubitemid 40064327)
-
(2004)
Cellular and Molecular Life Sciences
, vol.61
, Issue.22
, pp. 2793-2798
-
-
Panizzi, P.1
Friedrich, R.2
Fuentes-Prior, P.3
Bode, W.4
Bock, P.E.5
-
50
-
-
0141929350
-
Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation
-
DOI 10.1038/nature01962
-
Friedrich, R., Panizzi, P., Fuentes-Prior, P., Richter, K., Verhamme, I., Anderson, P. J., Kawabata, S., Huber, R., Bode, W., and Bock, P. E. (2003) Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation Nature 425, 535-539 (Pubitemid 37237051)
-
(2003)
Nature
, vol.425
, Issue.6957
, pp. 535-539
-
-
Friedrich, R.1
Panizzi, P.2
Fuentes-Prior, P.3
Richter, K.4
Verhamme, I.5
Anderson, P.J.6
Kawabata, S.-I.7
Huber, R.8
Bode, W.9
Bock, P.E.10
-
51
-
-
0031956497
-
Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes
-
Khan, A. R. and James, M. N. (1998) Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes Protein Sci. 7, 815-836 (Pubitemid 28216525)
-
(1998)
Protein Science
, vol.7
, Issue.4
, pp. 815-836
-
-
Khan, A.R.1
James, M.N.G.2
-
52
-
-
70449372265
-
Small-molecule activators of a proenzyme
-
Wolan, D. W., Zorn, J. A., Gray, D. C., and Wells, J. A. (2009) Small-molecule activators of a proenzyme Science 326, 853-858
-
(2009)
Science
, vol.326
, pp. 853-858
-
-
Wolan, D.W.1
Zorn, J.A.2
Gray, D.C.3
Wells, J.A.4
-
53
-
-
83055197029
-
Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation
-
Zorn, J. A., Wille, H., Wolan, D. W., and Wells, J. A. (2011) Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation J. Am. Chem. Soc. 133, 19630-19633
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 19630-19633
-
-
Zorn, J.A.1
Wille, H.2
Wolan, D.W.3
Wells, J.A.4
-
54
-
-
84866931834
-
Fibrils colocalize caspase-3 with procaspase-3 to foster maturation
-
Zorn, J. A., Wolan, D. W., Agard, N. J., and Wells, J. A. (2012) Fibrils colocalize caspase-3 with procaspase-3 to foster maturation J. Biol. Chem. 287, 33781-33795
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 33781-33795
-
-
Zorn, J.A.1
Wolan, D.W.2
Agard, N.J.3
Wells, J.A.4
-
55
-
-
37249004920
-
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
-
DOI 10.1038/nature06526, PII NATURE06526
-
Wells, J. A. and McClendon, C. L. (2007) Reaching for high-hanging fruit in drug discovery at protein-protein interfaces Nature 450, 1001-1009 (Pubitemid 350273630)
-
(2007)
Nature
, vol.450
, Issue.7172
, pp. 1001-1009
-
-
Wells, J.A.1
McClendon, C.L.2
-
56
-
-
69249156893
-
Inhibition of a viral enzyme by a small-molecule dimer disruptor
-
Shahian, T., Lee, G. M., Lazic, A., Arnold, L. A., Velusamy, P., Roels, C. M., Guy, R. K., and Craik, C. S. (2009) Inhibition of a viral enzyme by a small-molecule dimer disruptor Nat. Chem. Biol. 5, 640-646
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 640-646
-
-
Shahian, T.1
Lee, G.M.2
Lazic, A.3
Arnold, L.A.4
Velusamy, P.5
Roels, C.M.6
Guy, R.K.7
Craik, C.S.8
-
57
-
-
79951967246
-
HTRA proteases: Regulated proteolysis in protein quality control
-
Clausen, T., Kaiser, M., Huber, R., and Ehrmann, M. (2011) HTRA proteases: regulated proteolysis in protein quality control Nat. Rev. Mol. Cell. Biol. 12, 152-162
-
(2011)
Nat. Rev. Mol. Cell. Biol.
, vol.12
, pp. 152-162
-
-
Clausen, T.1
Kaiser, M.2
Huber, R.3
Ehrmann, M.4
-
58
-
-
80053271174
-
Protein quality control in the bacterial periplasm
-
Merdanovic, M., Clausen, T., Kaiser, M., Huber, R., and Ehrmann, M. (2011) Protein quality control in the bacterial periplasm Annu. Rev. Microbiol. 65, 149-168
-
(2011)
Annu. Rev. Microbiol.
, vol.65
, pp. 149-168
-
-
Merdanovic, M.1
Clausen, T.2
Kaiser, M.3
Huber, R.4
Ehrmann, M.5
-
59
-
-
2342659637
-
Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease
-
DOI 10.1016/S0092-8674(04)00454-4, PII S0092867404004544
-
Wilken, C., Kitzing, K., Kurzbauer, R., Ehrmann, M., and Clausen, T. (2004) Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease Cell 117, 483-494 (Pubitemid 38610233)
-
(2004)
Cell
, vol.117
, Issue.4
, pp. 483-494
-
-
Wilken, C.1
Kitzing, K.2
Kurzbauer, R.3
Ehrmann, M.4
Clausen, T.5
-
60
-
-
35348985928
-
Regulation of the σE stress response by DegS: How the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress
-
DOI 10.1101/gad.445307
-
Hasselblatt, H., Kurzbauer, R., Wilken, C., Krojer, T., Sawa, J., Kurt, J., Kirk, R., Hasenbein, S., Ehrmann, M., and Clausen, T. (2007) Regulation of the sigmaE stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress Genes Dev. 21, 2659-2670 (Pubitemid 47607674)
-
(2007)
Genes and Development
, vol.21
, Issue.20
, pp. 2659-2670
-
-
Hasselblatt, H.1
Kurzbauer, R.2
Wilken, C.3
Krojer, T.4
Sawa, J.5
Kurt, J.6
Kirk, R.7
Hasenbein, S.8
Ehrmann, M.9
Clausen, T.10
-
61
-
-
41249087703
-
Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control
-
Meltzer, M., Hasenbein, S., Hauske, P., Kucz, N., Merdanovic, M., Grau, S., Beil, A., Jones, D., Krojer, T., Clausen, T., Ehrmann, M., and Kaiser, M. (2008) Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control Angew. Chem., Int. Ed. 47, 1332-1334
-
(2008)
Angew. Chem., Int. Ed.
, vol.47
, pp. 1332-1334
-
-
Meltzer, M.1
Hasenbein, S.2
Hauske, P.3
Kucz, N.4
Merdanovic, M.5
Grau, S.6
Beil, A.7
Jones, D.8
Krojer, T.9
Clausen, T.10
Ehrmann, M.11
Kaiser, M.12
-
62
-
-
0033617146
-
A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein
-
DOI 10.1016/S0092-8674(00)80743-6
-
Spiess, C., Beil, A., and Ehrmann, M. (1999) A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein Cell 97, 339-347 (Pubitemid 29214590)
-
(1999)
Cell
, vol.97
, Issue.3
, pp. 339-347
-
-
Spiess, C.1
Beil, A.2
Ehrmann, M.3
-
63
-
-
0037187588
-
Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine
-
DOI 10.1038/416455a
-
Krojer, T., Garrido-Franco, M., Huber, R., Ehrmann, M., and Clausen, T. (2002) Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine Nature 416, 455-459 (Pubitemid 34272883)
-
(2002)
Nature
, vol.416
, Issue.6879
, pp. 455-459
-
-
Krojer, T.1
Garrido-Franco, M.2
Huber, R.3
Ehrmann, M.4
Clausen, T.5
-
64
-
-
45149106311
-
Structural basis for the regulated protease and chaperone function of DegP
-
DOI 10.1038/nature07004, PII NATURE07004
-
Krojer, T., Sawa, J., Schafer, E., Saibil, H. R., Ehrmann, M., and Clausen, T. (2008) Structural basis for the regulated protease and chaperone function of DegP Nature 453, 885-890 (Pubitemid 351832567)
-
(2008)
Nature
, vol.453
, Issue.7197
, pp. 885-890
-
-
Krojer, T.1
Sawa, J.2
Schafer, E.3
Saibil, H.R.4
Ehrmann, M.5
Clausen, T.6
-
65
-
-
77954384306
-
HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues
-
Krojer, T., Sawa, J., Huber, R., and Clausen, T. (2010) HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues Nat. Struct. Mol. Biol. 17, 844-852
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 844-852
-
-
Krojer, T.1
Sawa, J.2
Huber, R.3
Clausen, T.4
-
66
-
-
77954384789
-
Determinants of structural and functional plasticity of a widely conserved protease chaperone complex
-
Merdanovic, M., Mamant, N., Meltzer, M., Poepsel, S., Auckenthaler, A., Melgaard, R., Hauske, P., Nagel-Steger, L., Clarke, A. R., Kaiser, M., Huber, R., and Ehrmann, M. (2010) Determinants of structural and functional plasticity of a widely conserved protease chaperone complex Nat. Struct. Mol. Biol. 17, 837-843
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 837-843
-
-
Merdanovic, M.1
Mamant, N.2
Meltzer, M.3
Poepsel, S.4
Auckenthaler, A.5
Melgaard, R.6
Hauske, P.7
Nagel-Steger, L.8
Clarke, A.R.9
Kaiser, M.10
Huber, R.11
Ehrmann, M.12
-
67
-
-
80052320057
-
Allosteric modulation of caspases
-
Hacker, H. G., Sisay, M. T., and Gutschow, M. (2011) Allosteric modulation of caspases Pharmacol. Ther. 132, 180-195
-
(2011)
Pharmacol. Ther.
, vol.132
, pp. 180-195
-
-
Hacker, H.G.1
Sisay, M.T.2
Gutschow, M.3
-
68
-
-
34247853389
-
Inhibition of Caspase-2 by a Designed Ankyrin Repeat Protein: Specificity, Structure, and Inhibition Mechanism
-
DOI 10.1016/j.str.2007.03.014, PII S0969212607001426
-
Schweizer, A., Roschitzki-Voser, H., Amstutz, P., Briand, C., Gulotti-Georgieva, M., Prenosil, E., Binz, H. K., Capitani, G., Baici, A., Pluckthun, A., and Grutter, M. G. (2007) Inhibition of caspase-2 by a designed ankyrin repeat protein: specificity, structure, and inhibition mechanism Structure 15, 625-636 (Pubitemid 46702685)
-
(2007)
Structure
, vol.15
, Issue.5
, pp. 625-636
-
-
Schweizer, A.1
Roschitzki-Voser, H.2
Amstutz, P.3
Briand, C.4
Gulotti-Georgieva, M.5
Prenosil, E.6
Binz, H.K.7
Capitani, G.8
Baici, A.9
Pluckthun, A.10
Grutter, M.G.11
-
69
-
-
0034732235
-
Peptide exosite inhibitors of factor VIIa as anticoagulants
-
DOI 10.1038/35006574
-
Dennis, M. S., Eigenbrot, C., Skelton, N. J., Ultsch, M. H., Santell, L., Dwyer, M. A., O'Connell, M. P., and Lazarus, R. A. (2000) Peptide exosite inhibitors of factor VIIa as anticoagulants Nature 404, 465-470 (Pubitemid 30186881)
-
(2000)
Nature
, vol.404
, Issue.6777
, pp. 465-470
-
-
Dennis, M.S.1
Elgenbrot, C.2
Skelton, N.J.3
Ultsch, M.H.4
Santell, L.5
Dwyer, M.A.6
O'Connell, M.P.7
Lazarus, R.A.8
-
70
-
-
84858598152
-
Antibody-induced enhancement of Factor VIIa activity through distinct allosteric pathways
-
Andersen, L. M., Andreasen, P. A., Svendsen, I., Keemink, J., Ostergaard, H., and Persson, E. (2012) Antibody-induced enhancement of Factor VIIa activity through distinct allosteric pathways J. Biol. Chem. 287, 8994-9001
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 8994-9001
-
-
Andersen, L.M.1
Andreasen, P.A.2
Svendsen, I.3
Keemink, J.4
Ostergaard, H.5
Persson, E.6
-
71
-
-
67649995940
-
Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors
-
Simard, J. R., Getlik, M., Grutter, C., Pawar, V., Wulfert, S., Rabiller, M., and Rauh, D. (2009) Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors J. Am. Chem. Soc. 131, 13286-13296
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 13286-13296
-
-
Simard, J.R.1
Getlik, M.2
Grutter, C.3
Pawar, V.4
Wulfert, S.5
Rabiller, M.6
Rauh, D.7
-
72
-
-
67349094019
-
A new screening assay for allosteric inhibitors of cSrc
-
Simard, J. R., Kluter, S., Grutter, C., Getlik, M., Rabiller, M., Rode, H. B., and Rauh, D. (2009) A new screening assay for allosteric inhibitors of cSrc Nat. Chem. Biol. 5, 394-396
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 394-396
-
-
Simard, J.R.1
Kluter, S.2
Grutter, C.3
Getlik, M.4
Rabiller, M.5
Rode, H.B.6
Rauh, D.7
-
73
-
-
2542542373
-
Tethering: Fragment-based drug discovery
-
DOI 10.1146/annurev.biophys.33.110502.140409
-
Erlanson, D. A., Wells, J. A., and Braisted, A. C. (2004) Tethering: fragment-based drug discovery Annu. Rev. Biophys. Biomol. Struct. 33, 199-223 (Pubitemid 38829958)
-
(2004)
Annual Review of Biophysics and Biomolecular Structure
, vol.33
, pp. 199-223
-
-
Erlanson, D.A.1
Wells, J.A.2
Braisted, A.C.3
-
74
-
-
84862882878
-
Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization
-
Stanger, K., Steffek, M., Zhou, L., Pozniak, C. D., Quan, C., Franke, Y., Tom, J., Tam, C., Elliott, J. M., Lewcock, J. W., Zhang, Y., Murray, J., and Hannoush, R. N. (2012) Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization Nat. Chem. Biol. 8, 655-660
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 655-660
-
-
Stanger, K.1
Steffek, M.2
Zhou, L.3
Pozniak, C.D.4
Quan, C.5
Franke, Y.6
Tom, J.7
Tam, C.8
Elliott, J.M.9
Lewcock, J.W.10
Zhang, Y.11
Murray, J.12
Hannoush, R.N.13
-
75
-
-
84857509304
-
Small-molecule stabilization of protein-protein interactions: An underestimated concept in drug discovery?
-
Thiel, P., Kaiser, M., and Ottmann, C. (2012) Small-molecule stabilization of protein-protein interactions: an underestimated concept in drug discovery? Angew. Chem., Int. Ed. 51, 2012-2018
-
(2012)
Angew. Chem., Int. Ed.
, vol.51
, pp. 2012-2018
-
-
Thiel, P.1
Kaiser, M.2
Ottmann, C.3
-
76
-
-
62549093913
-
Two-state selection of conformation-specific antibodies
-
Gao, J., Sidhu, S. S., and Wells, J. A. (2009) Two-state selection of conformation-specific antibodies Proc. Natl. Acad. Sci. U.S.A. 106, 3071-3076
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 3071-3076
-
-
Gao, J.1
Sidhu, S.S.2
Wells, J.A.3
-
77
-
-
68949109960
-
Peptidic small molecule activators of the stress sensor DegS
-
Hauske, P., Mamant, N., Hasenbein, S., Nickel, S., Ottmann, C., Clausen, T., Ehrmann, M., and Kaiser, M. (2009) Peptidic small molecule activators of the stress sensor DegS Mol. Biosyst. 5, 980-985
-
(2009)
Mol. Biosyst.
, vol.5
, pp. 980-985
-
-
Hauske, P.1
Mamant, N.2
Hasenbein, S.3
Nickel, S.4
Ottmann, C.5
Clausen, T.6
Ehrmann, M.7
Kaiser, M.8
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