New approaches for dissecting protease functions to improve probe development and drug discovery

Nature Structural and Molecular Biology

Volumn 19, Issue 1, 2012, Pages 9-16

  Deu, Edgar ^a   Verdoes, Martijn ^a   Bogyo, Matthew ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; CASPASE 8; CATHEPSIN B; CATHEPSIN H; CATHEPSIN K INHIBITOR; CATHEPSIN L; CATHEPSIN S; CYSTEINE PROTEINASE; DIPEPTIDYL PEPTIDASE I; ENZYME PRECURSOR; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEASOME; PROTEINASE; PROTEINASE INHIBITOR; RECOMBINANT ENZYME;

ACTIVITY BASED PROBE; ADAPTIVE IMMUNITY; APOPTOSIS; CLOSTRIDIUM DIFFICILE; CROSS REACTION; CYTOSOL; DRUG DEVELOPMENT; DRUG POTENCY; DRUG SCREENING; ENDOCYTOSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME LOCALIZATION; ENZYME SUBSTRATE; EXTRACELLULAR MATRIX; HEPATITIS C VIRUS; LIQUID CHROMATOGRAPHY; MOLECULAR PROBE; MULTIPLE MYELOMA; NONHUMAN; PHAGE DISPLAY; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEOMICS; REVIEW; STRUCTURE ACTIVITY RELATION; SUBSTRATE ACTIVITY SCREENING; TANDEM MASS SPECTROMETRY; TOXOPLASMA GONDII; TUMOR GROWTH; TUMOR MICROENVIRONMENT; UBIQUITINATION;

ANIMALS; BIOCATALYSIS; DRUG DISCOVERY; HUMANS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PEPTIDE HYDROLASES; PROTEASE INHIBITORS; PROTEOLYSIS; PROTEOMICS;

ANIMALIA;

EID: 84855428544     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.2203     Document Type: Review

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