Peptide exosite inhibitors of factor VIIa as anticoagulants

Nature

Volumn 404, Issue 6777, 2000, Pages 465-470

  Dennis, Mark S ^a   Elgenbrot, Charles ^a   Skelton, Nicholas J ^a   Ultsch, Mark H ^a   Santell, Lydia ^a   Dwyer, Mary A ^a,b   O'Connell, Mark P ^a   Lazarus, Robert A ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 7A; THROMBOPLASTIN;

ANTICOAGULATION; ARTICLE; COMPETITIVE INHIBITION; CRYSTAL STRUCTURE; DRUG EFFECT; ENZYME INHIBITOR COMPLEX; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; ANTICOAGULANTS; BINDING SITES; CONSENSUS SEQUENCE; CRYSTALLOGRAPHY, X-RAY; ENZYME PRECURSORS; FACTOR VIIA; FACTOR X; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEPTIDE LIBRARY; PEPTIDES; PROTEIN CONFORMATION; RABBITS; SERINE PROTEINASE INHIBITORS; THROMBOPLASTIN;

EID: 0034732235     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35006574     Document Type: Article

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