Antibody-induced enhancement of factor VIIa activity through distinct allosteric pathways

Journal of Biological Chemistry

Volumn 287, Issue 12, 2012, Pages 8994-9001

  Andersen, Lisbeth M ^a,b   Andreasen, Peter A ^b   Svendsen, Ivan ^a   Keemink, Janneke ^b   Østergaard, Henrik ^a   Persson, Egon ^a  

^a NOVO NORDISK A S   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVITY ENHANCEMENT; ALLOSTERIC ACTIVATION; ANTITHROMBIN; CATALYTIC DOMAINS; CATALYTIC EFFICIENCIES; COAGULATION FACTOR; COFACTORS; DIISOPROPYLFLUOROPHOSPHATE; MOLECULAR UNDERSTANDING; MONOCLONAL ANTIBODIES (MABS); OXYANION HOLE; REGULATORY MECHANISM; SITE DIRECTED MUTAGENESIS; STRUCTURAL FEATURE; SUBSTRATE BINDING; TISSUE FACTORS;

CHEMICAL ACTIVATION; COAGULATION; MONOCLONAL ANTIBODIES; POSITIVE IONS; TISSUE;

CONFORMATIONS;

4 AMINOBENZAMIDINE; BLOOD CLOTTING FACTOR 7A; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; THROMBOPLASTIN;

ANIMAL EXPERIMENT; ANTIBODY ISOLATION; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CARBAMOYLATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SITE DIRECTED MUTAGENESIS;

ALLOSTERIC REGULATION; ANIMALS; ANTIBODIES, MONOCLONAL; BINDING SITES; FACTOR VIIA; HUMANS; KINETICS; MICE; PROTEIN BINDING; THROMBOPLASTIN;

EID: 84858598152     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.312330     Document Type: Article

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