-
1
-
-
0037439447
-
Nonleadlikeness and leadlikeness in biochemical screening
-
G.M. Rishton Nonleadlikeness and leadlikeness in biochemical screening Drug Discov Today 8 2003 86 96
-
(2003)
Drug Discov Today
, vol.8
, pp. 86-96
-
-
Rishton, G.M.1
-
3
-
-
0037061628
-
A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening
-
S.L. McGovern, E. Caselli, N. Grigorieff, and B.K. Shoichet A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening J Med Chem 45 2002 1712 1722
-
(2002)
J Med Chem
, vol.45
, pp. 1712-1722
-
-
McGovern, S.L.1
Caselli, E.2
Grigorieff, N.3
Shoichet, B.K.4
-
4
-
-
3142781225
-
Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
-
M.R. Arkin, and J.A. Wells Small-molecule inhibitors of protein-protein interactions: progressing towards the dream Nat Rev Drug Discov 3 2004 301 317 Arkin and Wells review the allosteric inhibition of protein-protein interactions in inducible nitric oxide synthase, LFA1 I-domain and nerve growth factor.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 301-317
-
-
Arkin, M.R.1
Wells, J.A.2
-
5
-
-
0026693137
-
Crystal structure at 3.5 Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor
-
L.A. Kohlstaedt, J. Wang, J.M. Friedman, P.A. Rice, and T.A. Steitz Crystal structure at 3.5 Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor Science 256 1992 1783 1790
-
(1992)
Science
, vol.256
, pp. 1783-1790
-
-
Kohlstaedt, L.A.1
Wang, J.2
Friedman, J.M.3
Rice, P.A.4
Steitz, T.A.5
-
6
-
-
0028924567
-
Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors
-
R. Esnouf, J. Ren, C. Ross, Y. Jones, D. Stammers, and D. Stuart Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors Nat Struct Biol 2 1995 303 308
-
(1995)
Nat Struct Biol
, vol.2
, pp. 303-308
-
-
Esnouf, R.1
Ren, J.2
Ross, C.3
Jones, Y.4
Stammers, D.5
Stuart, D.6
-
7
-
-
0028842293
-
The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1
-
D.W. Rodgers, S.J. Gamblin, B.A. Harris, S. Ray, J.S. Culp, B. Hellmig, D.J. Woolf, C. Debouck, and S.C. Harrison The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1 Proc Natl Acad Sci USA 92 1995 1222 1226
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 1222-1226
-
-
Rodgers, D.W.1
Gamblin, S.J.2
Harris, B.A.3
Ray, S.4
Culp, J.S.5
Hellmig, B.6
Woolf, D.J.7
Debouck, C.8
Harrison, S.C.9
-
8
-
-
0032539696
-
Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo
-
W.H. Martin, D.J. Hoover, S.J. Armento, I.A. Stock, R.K. McPherson, D.E. Danley, R.W. Stevenson, E.J. Barrett, and J.L. Treadway Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo Proc Natl Acad Sci USA 95 1998 1776 1781
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 1776-1781
-
-
Martin, W.H.1
Hoover, D.J.2
Armento, S.J.3
Stock, I.A.4
McPherson, R.K.5
Danley, D.E.6
Stevenson, R.W.7
Barrett, E.J.8
Treadway, J.L.9
-
9
-
-
0034660681
-
A new allosteric site in glycogen phosphorylase b as a target for drug interactions
-
N.G. Oikonomakos, V.T. Skamnaki, K.E. Tsitsanou, N.G. Gavalas, and L.N. Johnson A new allosteric site in glycogen phosphorylase b as a target for drug interactions Structure Fold Des 8 2000 575 584
-
(2000)
Structure Fold des
, vol.8
, pp. 575-584
-
-
Oikonomakos, N.G.1
Skamnaki, V.T.2
Tsitsanou, K.E.3
Gavalas, N.G.4
Johnson, L.N.5
-
10
-
-
0033827122
-
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
-
V.L. Rath, M. Ammirati, D.E. Danley, J.L. Ekstrom, E.M. Gibbs, T.R. Hynes, A.M. Mathiowetz, R.K. McPherson, T.V. Olson, and J.L. Treadway Human liver glycogen phosphorylase inhibitors bind at a new allosteric site Chem Biol 7 2000 677 682
-
(2000)
Chem Biol
, vol.7
, pp. 677-682
-
-
Rath, V.L.1
Ammirati, M.2
Danley, D.E.3
Ekstrom, J.L.4
Gibbs, E.M.5
Hynes, T.R.6
Mathiowetz, A.M.7
McPherson, R.K.8
Olson, T.V.9
Treadway, J.L.10
-
11
-
-
0021102427
-
Site-site interactions in glycogen phosphorylase b probed by ligands specific for each site
-
N.B. Madsen, S. Shechosky, and R.J. Fletterick Site-site interactions in glycogen phosphorylase b probed by ligands specific for each site Biochemistry 22 1983 4460 4465
-
(1983)
Biochemistry
, vol.22
, pp. 4460-4465
-
-
Madsen, N.B.1
Shechosky, S.2
Fletterick, R.J.3
-
12
-
-
0037194657
-
Anilinoquinazoline inhibitors of fructose 1,6-bisphosphatase bind at a novel allosteric site: Synthesis, in vitro characterization, and X-ray crystallography
-
S.W. Wright, A.A. Carlo, M.D. Carty, D.E. Danley, D.L. Hageman, G.A. Karam, C.B. Levy, M.N. Mansour, A.M. Mathiowetz, and L.D. McClure Anilinoquinazoline inhibitors of fructose 1,6-bisphosphatase bind at a novel allosteric site: synthesis, in vitro characterization, and X-ray crystallography J Med Chem 45 2002 3865 3877 The novel allosteric site discovered in F16BPase is the second such site to be found at a multimer interface that exerts its inhibitory effect by stabilizing the T state conformation rather than by disrupting protein-protein interactions. The similarities with the novel allosteric site of GlyP suggest that these sites at multimer interfaces may be exploitable in other similar enzymes.
-
(2002)
J Med Chem
, vol.45
, pp. 3865-3877
-
-
Wright, S.W.1
Carlo, A.A.2
Carty, M.D.3
Danley, D.E.4
Hageman, D.L.5
Karam, G.A.6
Levy, C.B.7
Mansour, M.N.8
Mathiowetz, A.M.9
McClure, L.D.10
-
13
-
-
13044270997
-
PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d] thiophenes
-
J. Wrobel, J. Sredy, C. Moxham, A. Dietrich, Z. Li, D.R. Sawicki, L. Seestaller, L. Wu, A. Katz, and D. Sullivan PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes J Med Chem 42 1999 3199 3202
-
(1999)
J Med Chem
, vol.42
, pp. 3199-3202
-
-
Wrobel, J.1
Sredy, J.2
Moxham, C.3
Dietrich, A.4
Li, Z.5
Sawicki, D.R.6
Seestaller, L.7
Wu, L.8
Katz, A.9
Sullivan, D.10
-
14
-
-
3543017313
-
Allosteric inhibition of protein tyrosine phosphatase 1B
-
C. Wiesmann, K.J. Barr, J. Kung, J. Zhu, D.A. Erlanson, W. Shen, B.J. Fahr, M. Zhong, L. Taylor, and M. Randal Allosteric inhibition of protein tyrosine phosphatase 1B Nat Struct Mol Biol 11 2004 730 737 Wiesmann et al. report a novel allosteric site in PTP1B that functions by locking the WPD loop into the inactive conformation.
-
(2004)
Nat Struct Mol Biol
, vol.11
, pp. 730-737
-
-
Wiesmann, C.1
Barr, K.J.2
Kung, J.3
Zhu, J.4
Erlanson, D.A.5
Shen, W.6
Fahr, B.J.7
Zhong, M.8
Taylor, L.9
Randal, M.10
-
15
-
-
0034732235
-
Peptide exosite inhibitors of factor VIIa as anticoagulants
-
M.S. Dennis, C. Eigenbrot, N.J. Skelton, M.H. Ultsch, L. Santell, M.A. Dwyer, M.P. O'Connell, and R.A. Lazarus Peptide exosite inhibitors of factor VIIa as anticoagulants Nature 404 2000 465 470
-
(2000)
Nature
, vol.404
, pp. 465-470
-
-
Dennis, M.S.1
Eigenbrot, C.2
Skelton, N.J.3
Ultsch, M.H.4
Santell, L.5
Dwyer, M.A.6
O'Connell, M.P.7
Lazarus, R.A.8
-
16
-
-
0035859911
-
Selection and characterization of a new class of peptide exosite inhibitors of coagulation factor VIIa
-
M.S. Dennis, M. Roberge, C. Quan, and R.A. Lazarus Selection and characterization of a new class of peptide exosite inhibitors of coagulation factor VIIa Biochemistry 40 2001 9513 9521
-
(2001)
Biochemistry
, vol.40
, pp. 9513-9521
-
-
Dennis, M.S.1
Roberge, M.2
Quan, C.3
Lazarus, R.A.4
-
17
-
-
0035859944
-
A novel exosite on coagulation factor VIIa and its molecular interactions with a new class of peptide inhibitors
-
M. Roberge, L. Santell, M.S. Dennis, C. Eigenbrot, M.A. Dwyer, and R.A. Lazarus A novel exosite on coagulation factor VIIa and its molecular interactions with a new class of peptide inhibitors Biochemistry 40 2001 9522 9531
-
(2001)
Biochemistry
, vol.40
, pp. 9522-9531
-
-
Roberge, M.1
Santell, L.2
Dennis, M.S.3
Eigenbrot, C.4
Dwyer, M.A.5
Lazarus, R.A.6
-
18
-
-
0038498064
-
Engineering exosite peptides for complete inhibition of factor VIIa using a protease switch with substrate phage
-
H.R. Maun, C. Eigenbrot, and R.A. Lazarus Engineering exosite peptides for complete inhibition of factor VIIa using a protease switch with substrate phage J Biol Chem 278 2003 21823 21830
-
(2003)
J Biol Chem
, vol.278
, pp. 21823-21830
-
-
Maun, H.R.1
Eigenbrot, C.2
Lazarus, R.A.3
-
19
-
-
4344654060
-
Discovery of an allosteric site in the caspases
-
J.A. Hardy, J. Lam, J.T. Nguyen, T. O'Brien, and J. Wells Discovery of an allosteric site in the caspases Proc Natl Acad Sci USA 101 2004 12461 12466 A novel allosteric site was found in the caspases using Tethering. The site of inhibition was unambiguously determined before solution of the X-ray crystal structure by peptide mapping of the covalent disulfide bond that formed between the inhibitor and a naturally occurring cysteine at the allosteric site.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 12461-12466
-
-
Hardy, J.A.1
Lam, J.2
Nguyen, J.T.3
O'Brien, T.4
Wells, J.5
-
20
-
-
18344395134
-
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site
-
C. Pargellis, L. Tong, L. Churchill, P.F. Cirillo, T. Gilmore, A.G. Graham, P.M. Grob, E.R. Hickey, N. Moss, and S. Pav Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site Nat Struct Biol 9 2002 268 272 The binding site for the BIRB-796 compound on p38 kinase is notable because it does not overlap at all with the ATP-binding site. The authors report an interesting mechanism of inhibition, which they term indirect competition of binding of ATP. Conformational changes induced by BIRB-796, rather than BIRB-796 itself, prevent binding of ATP in the active site.
-
(2002)
Nat Struct Biol
, vol.9
, pp. 268-272
-
-
Pargellis, C.1
Tong, L.2
Churchill, L.3
Cirillo, P.F.4
Gilmore, T.5
Graham, A.G.6
Grob, P.M.7
Hickey, E.R.8
Moss, N.9
Pav, S.10
-
21
-
-
0034665713
-
Structural mechanism for STI-571 inhibition of abelson tyrosine kinase
-
T. Schindler, W. Bornmann, P. Pellicena, W.T. Miller, B. Clarkson, and J. Kuriyan Structural mechanism for STI-571 inhibition of abelson tyrosine kinase Science 289 2000 1938 1942
-
(2000)
Science
, vol.289
, pp. 1938-1942
-
-
Schindler, T.1
Bornmann, W.2
Pellicena, P.3
Miller, W.T.4
Clarkson, B.5
Kuriyan, J.6
-
22
-
-
12144289677
-
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
-
P.T. Wan, M.J. Garnett, S.M. Roe, S. Lee, D. Niculescu-Duvaz, V.M. Good, C.M. Jones, C.J. Marshall, C.J. Springer, and D. Barford Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF Cell 116 2004 855 867
-
(2004)
Cell
, vol.116
, pp. 855-867
-
-
Wan, P.T.1
Garnett, M.J.2
Roe, S.M.3
Lee, S.4
Niculescu-Duvaz, D.5
Good, V.M.6
Jones, C.M.7
Marshall, C.J.8
Springer, C.J.9
Barford, D.10
-
23
-
-
0037624071
-
Allosteric activators of glucokinase: Potential role in diabetes therapy
-
J. Grimsby, R. Sarabu, W.L. Corbett, N.E. Haynes, F.T. Bizzarro, J.W. Coffey, K.R. Guertin, D.W. Hilliard, R.F. Kester, and P.E. Mahaney Allosteric activators of glucokinase: potential role in diabetes therapy Science 301 2003 370 373
-
(2003)
Science
, vol.301
, pp. 370-373
-
-
Grimsby, J.1
Sarabu, R.2
Corbett, W.L.3
Haynes, N.E.4
Bizzarro, F.T.5
Coffey, J.W.6
Guertin, K.R.7
Hilliard, D.W.8
Kester, R.F.9
Mahaney, P.E.10
-
24
-
-
1542791635
-
Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase
-
K. Kamata, M. Mitsuya, T. Nishimura, J. Eiki, and Y. Nagata Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase Structure (Camb) 12 2004 429 438 This work describes an allosteric activator of glucokinase that works by promoting domain-domain interactions, in contrast to most allosteric inhibitors, which work by disrupting interactions.
-
(2004)
Structure (Camb)
, vol.12
, pp. 429-438
-
-
Kamata, K.1
Mitsuya, M.2
Nishimura, T.3
Eiki, J.4
Nagata, Y.5
-
25
-
-
10744220712
-
Inhibition of a mitotic motor protein: Where, how, and conformational consequences
-
Y. Yan, V. Sardana, B. Xu, C. Homnick, W. Halczenko, C.A. Buser, M. Schaber, G.D. Hartman, H.E. Huber, and L.C. Kuo Inhibition of a mitotic motor protein: where, how, and conformational consequences J Mol Biol 335 2004 547 554 Although the binding site for monostrol on kinesin protein KSP is close to the ATP-binding site, inhibition appears to occur predominantly via changes that are propagated the full length of the protein to the neck-linker region, which is distal from the active site and the novel allosteric site.
-
(2004)
J Mol Biol
, vol.335
, pp. 547-554
-
-
Yan, Y.1
Sardana, V.2
Xu, B.3
Homnick, C.4
Halczenko, W.5
Buser, C.A.6
Schaber, M.7
Hartman, G.D.8
Huber, H.E.9
Kuo, L.C.10
-
26
-
-
1242294467
-
Allosteric inhibition through core disruption
-
J.R. Horn, and B.K. Shoichet Allosteric inhibition through core disruption J Mol Biol 336 2004 1283 1291 Horn and Shoichet report a novel binding site in β-lactamase within a cavity that does not exist in the unliganded protein. Importantly, they provide several metrics by which this binding site might have been predicted, including identification of local strained dihedral angles, previous reports of 'crystallization artifacts' binding at the same site and the use of the COREX algorithm to predict the stability of this region.
-
(2004)
J Mol Biol
, vol.336
, pp. 1283-1291
-
-
Horn, J.R.1
Shoichet, B.K.2
-
27
-
-
3442896773
-
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
-
P.A. Williams, J. Cosme, D.M. Vinkovic, A. Ward, H.C. Angove, P.J. Day, C. Vonrhein, I.J. Tickle, and H. Jhoti Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone Science 305 2004 683 686
-
(2004)
Science
, vol.305
, pp. 683-686
-
-
Williams, P.A.1
Cosme, J.2
Vinkovic, D.M.3
Ward, A.4
Angove, H.C.5
Day, P.J.6
Vonrhein, C.7
Tickle, I.J.8
Jhoti, H.9
-
28
-
-
0346220393
-
The role of dynamics in allosteric regulation
-
D. Kern, and E.R. Zuiderweg The role of dynamics in allosteric regulation Curr Opin Struct Biol 13 2003 748 757
-
(2003)
Curr Opin Struct Biol
, vol.13
, pp. 748-757
-
-
Kern, D.1
Zuiderweg, E.R.2
-
29
-
-
0034710976
-
Can allosteric regulation be predicted from structure?
-
E. Freire Can allosteric regulation be predicted from structure? Proc Natl Acad Sci USA 97 2000 11680 11682
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 11680-11682
-
-
Freire, E.1
-
30
-
-
0037219686
-
Evolutionarily conserved networks of residues mediate allosteric communication in proteins
-
G.M. Suel, S.W. Lockless, M.A. Wall, and R. Ranganathan Evolutionarily conserved networks of residues mediate allosteric communication in proteins Nat Struct Biol 10 2003 59 69
-
(2003)
Nat Struct Biol
, vol.10
, pp. 59-69
-
-
Suel, G.M.1
Lockless, S.W.2
Wall, M.A.3
Ranganathan, R.4
-
31
-
-
0345492351
-
Allosteric determinants in guanine nucleotide-binding proteins
-
M.E. Hatley, S.W. Lockless, S.K. Gibson, A.G. Gilman, and R. Ranganathan Allosteric determinants in guanine nucleotide-binding proteins Proc Natl Acad Sci USA 100 2003 14445 14450
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 14445-14450
-
-
Hatley, M.E.1
Lockless, S.W.2
Gibson, S.K.3
Gilman, A.G.4
Ranganathan, R.5
-
32
-
-
1642304065
-
Structural determinants of allosteric ligand activation in RXR heterodimers
-
A.I. Shulman, C. Larson, D.J. Mangelsdorf, and R. Ranganathan Structural determinants of allosteric ligand activation in RXR heterodimers Cell 116 2004 417 429 Ranganathan and co-workers compare the results of a computational approach to identifying the allosteric machinery, which they term statistical coupling analysis, with mutagenesis data to validate the allosteric network of amino acids that connects the allosteric and functional surfaces of the RXR heterodimer.
-
(2004)
Cell
, vol.116
, pp. 417-429
-
-
Shulman, A.I.1
Larson, C.2
Mangelsdorf, D.J.3
Ranganathan, R.4
-
33
-
-
0029913807
-
An evolutionary trace method defines binding surfaces common to protein families
-
O. Lichtarge, H.R. Bourne, and F.E. Cohen An evolutionary trace method defines binding surfaces common to protein families J Mol Biol 257 1996 342 358
-
(1996)
J Mol Biol
, vol.257
, pp. 342-358
-
-
Lichtarge, O.1
Bourne, H.R.2
Cohen, F.E.3
-
34
-
-
0035126520
-
Prediction and confirmation of a site critical for effector regulation of RGS domain activity
-
M.E. Sowa, W. He, K.C. Slep, M.A. Kercher, O. Lichtarge, and T.G. Wensel Prediction and confirmation of a site critical for effector regulation of RGS domain activity Nat Struct Biol 8 2001 234 237
-
(2001)
Nat Struct Biol
, vol.8
, pp. 234-237
-
-
Sowa, M.E.1
He, W.2
Slep, K.C.3
Kercher, M.A.4
Lichtarge, O.5
Wensel, T.G.6
-
35
-
-
0038121108
-
JEvTrace: Refinement and variations of the evolutionary trace in JAVA
-
M.P. Joachimiak, and F.E. Cohen JEvTrace: refinement and variations of the evolutionary trace in JAVA Genome Biol 3 2002 RESEARCH0077
-
(2002)
Genome Biol
, vol.3
-
-
Joachimiak, M.P.1
Cohen, F.E.2
-
36
-
-
1042264059
-
Searching for functional sites in protein structures
-
S. Jones, and J.M. Thornton Searching for functional sites in protein structures Curr Opin Chem Biol 8 2004 3 7
-
(2004)
Curr Opin Chem Biol
, vol.8
, pp. 3-7
-
-
Jones, S.1
Thornton, J.M.2
-
37
-
-
2342569518
-
Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry
-
N. Shkriabai, S.S. Patil, S. Hess, S.R. Budihas, R. Craigie, T.R. Burke Jr., S.F. Le Grice, and M. Kvaratskhelia Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry Proc Natl Acad Sci USA 101 2004 6894 6899 Structural studies on HIV integrase have focused solely on fragments of the integrase protein because of difficulties working with the full-length protein. Affinity acetylation provides an alternative means of identifying novel allosteric sites. Working with a class of acetylated inhibitors that can acetylate local lysine, tyrosine and cysteine residues, Shkriabai and co-workers identified a new inhibitory site at the dimer interface of full-length HIV integrase.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 6894-6899
-
-
Shkriabai, N.1
Patil, S.S.2
Hess, S.3
Budihas, S.R.4
Craigie, R.5
Burke Jr., T.R.6
Le Grice, S.F.7
Kvaratskhelia, M.8
-
38
-
-
0026785750
-
Allosteric modifiers of hemoglobin: 2-[4-[[(3,5-disubstituted anilino)carbonyl]methyl]phenoxy]-2-methylpropionic acid derivatives that lower the oxygen affinity of hemoglobin in red cell suspensions, in whole blood, and in vivo in rats
-
D.J. Abraham, F.C. Wireko, R.S. Randad, C. Poyart, J. Kister, B. Bohn, J.F. Liard, and M.P. Kunert Allosteric modifiers of hemoglobin: 2-[4-[[(3,5-disubstituted anilino)carbonyl]methyl]phenoxy]-2-methylpropionic acid derivatives that lower the oxygen affinity of hemoglobin in red cell suspensions, in whole blood, and in vivo in rats Biochemistry 31 1992 9141 9149
-
(1992)
Biochemistry
, vol.31
, pp. 9141-9149
-
-
Abraham, D.J.1
Wireko, F.C.2
Randad, R.S.3
Poyart, C.4
Kister, J.5
Bohn, B.6
Liard, J.F.7
Kunert, M.P.8
-
39
-
-
0033945117
-
Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: Identification of a second allosteric site
-
S. Lazareno, A. Popham, and N.J. Birdsall Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site Mol Pharmacol 58 2000 194 207
-
(2000)
Mol Pharmacol
, vol.58
, pp. 194-207
-
-
Lazareno, S.1
Popham, A.2
Birdsall, N.J.3
-
41
-
-
0037143698
-
Transplanting allosteric control of enzyme activity by protein-protein interactions: Coupling a regulatory site to the conserved catalytic core
-
A.C. Pawlyk, and D.W. Pettigrew Transplanting allosteric control of enzyme activity by protein-protein interactions: coupling a regulatory site to the conserved catalytic core Proc Natl Acad Sci USA 99 2002 11115 11120
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11115-11120
-
-
Pawlyk, A.C.1
Pettigrew, D.W.2
-
42
-
-
0028852689
-
Transplanting a unique allosteric effect from crocodile into human haemoglobin
-
N.H. Komiyama, G. Miyazaki, J. Tame, and K. Nagai Transplanting a unique allosteric effect from crocodile into human haemoglobin Nature 373 1995 244 246
-
(1995)
Nature
, vol.373
, pp. 244-246
-
-
Komiyama, N.H.1
Miyazaki, G.2
Tame, J.3
Nagai, K.4
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