Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation

Journal of Biological Chemistry

Volumn 284, Issue 10, 2009, Pages 6546-6553

  Elliott, J Michael ^a   Rouge, Lionel ^a   Wiesmann, Christian ^a   Scheer, Justin M ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACIDS; AUTOACTIVATION; CASPASE; CASPASES; CLEAVAGE SITES; CRITICAL ELEMENTS; DIMERIC PROTEINS; INFLAMMATORY SIGNALING; KINETIC FACTORS; PROCASPASE; SECONDARY STRUCTURES;

OLIGOMERIZATION; ORGANIC ACIDS;

CRYSTAL STRUCTURE;

ASPARTIC ACID; DIMER; ENZYME PRECURSOR; INTERLEUKIN 1BETA CONVERTING ENZYME; PROCASPASE 1; UNCLASSIFIED DRUG; AUTACOID;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INFLAMMATION; MOLECULAR MECHANICS; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; SIGNAL TRANSDUCTION; CHEMISTRY; DIMERIZATION; ENZYME STABILITY; ENZYMOLOGY; KINETICS; METABOLISM; PHYSIOLOGY; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

CASPASE 1; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ENZYME ACTIVATION; ENZYME PRECURSORS; ENZYME STABILITY; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; KINETICS; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 65249094873     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806121200     Document Type: Article

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