Molecular mechanisms of thrombin function

Cellular and Molecular Life Sciences

Volumn 53, Issue 9, 1997, Pages 701-730

  Di Cera, E ^a   Dang, Q D ^a   Ayala, Y M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Allosteric enzymes; Blood coagulation; Complement; Molecular evolution; Monovalent cations; Protein engineering; Serine proteases; Thrombin

Indexed keywords

CHROMOGENIC SUBSTRATE; COMPLEMENT; FIBRINOGEN; HIRUDIN; MUTANT PROTEIN; PROTEIN C; SERINE PROTEINASE; SODIUM ION; THROMBIN; THROMBIN INHIBITOR; THROMBOMODULIN; VITAMIN K GROUP;

ALLOSTERISM; BINDING AFFINITY; BINDING KINETICS; BLOOD CLOTTING; DRUG DESIGN; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITOR INTERACTION; ENZYME MECHANISM; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HUMAN; MOLECULAR MODEL; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; ANIMALS; ANTITHROMBINS; BLOOD COAGULATION; FIBRINOGEN; HIRUDINS; HUMANS; MODELS, MOLECULAR; PROTEIN C; PROTEIN CONFORMATION; SODIUM; SUBSTRATE SPECIFICITY; THERMODYNAMICS; THROMBIN; THROMBOMODULIN;

EID: 0030718475     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000180050091     Document Type: Review

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