Structure-function analysis of inositol hexakisphosphate-induced autoprocessing in Clostridium difficile toxin A

Journal of Biological Chemistry

Volumn 284, Issue 33, 2009, Pages 21934-21940

  Pruitt, Rory N ^a   Chagot, Benjamin ^a   Cover, Michael ^a   Chazin, Walter J ^a   Spiller, Ben ^a   Lacy, D Borden ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AUTOCATALYTIC; AUTOPROCESSING; C-TERMINAL EXTENSIONS; CATION INTERACTIONS; CLOSTRIDIUM DIFFICILE; CYSTEINE PROTEASE; CYTOSOLS; CYTOTOXINS; FUNCTIONAL DATAS; G PROTEIN; GLUCOSYLATION; GLUCOSYLTRANSFERASES; HOST CELLS; INOSITOL HEXAKISPHOSPHATE; INTRAMOLECULAR MECHANISM; N-TERMINALS; STRUCTURE-FUNCTION ANALYSIS; X RAY CRYSTAL STRUCTURES;

ALCOHOLS; ANTIGENS; CELL MEMBRANES; METABOLITES; SUGARS; TOXIC MATERIALS;

CRYSTAL STRUCTURE;

CLOSTRIDIUM DIFFICILE TOXIN A; CYSTEINE PROTEINASE; PHYTIC ACID;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CLOSTRIDIUM DIFFICILE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROCESSING; STRUCTURE ACTIVITY RELATION;

BACTERIAL TOXINS; CATALYTIC DOMAIN; CATIONS; CLOSTRIDIUM DIFFICILE; CRYSTALLOGRAPHY, X-RAY; ENTEROTOXINS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHYTIC ACID; POINT MUTATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SPECTROPHOTOMETRY; TIME FACTORS;

CLOSTRIDIUM DIFFICILE;

EID: 69249090956     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.018929     Document Type: Article

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