-
1
-
-
0033136041
-
Conformational aspects of inhibitor design: Enzyme-substrate interactions in the transition state
-
DOI 10.1016/S0968-0896(98)00247-8, PII S0968089698002478
-
Wolfenden, R. (1999) Conformational aspects of inhibitor design: enzyme-substrate interactions in the transition state Bioorg. Med. Chem. 7, 647-652 (Pubitemid 29238061)
-
(1999)
Bioorganic and Medicinal Chemistry
, vol.7
, Issue.5
, pp. 647-652
-
-
Wolfenden, R.1
-
2
-
-
79959420922
-
Enzymatic transition states, transition-state analogs, dynamics, thermodynamics, and lifetimes
-
Schramm, V. L. (2011) Enzymatic transition states, transition-state analogs, dynamics, thermodynamics, and lifetimes Annu. Rev. Biochem. 80, 703-732
-
(2011)
Annu. Rev. Biochem.
, vol.80
, pp. 703-732
-
-
Schramm, V.L.1
-
3
-
-
55949096608
-
Atomic detail of chemical transformation at the transition state of an enzymatic reaction
-
Saen-Oon, S., Quaytman-Machleder, S., Schramm, V. L., and Schwartz, S. D. (2008) Atomic detail of chemical transformation at the transition state of an enzymatic reaction Proc. Natl. Acad. Sci. U.S.A. 105, 16543-16548
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 16543-16548
-
-
Saen-Oon, S.1
Quaytman-Machleder, S.2
Schramm, V.L.3
Schwartz, S.D.4
-
4
-
-
68049093016
-
Enzymatic transition states and dynamic motion in barrier crossing
-
Schwartz, S. D. and Schramm, V. L. (2009) Enzymatic transition states and dynamic motion in barrier crossing Nat. Chem. Biol. 5, 551-558
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 551-558
-
-
Schwartz, S.D.1
Schramm, V.L.2
-
5
-
-
78650157687
-
Conformational dynamics in human purine nucleoside phosphorylase with reactants and transition-state analogues
-
Hirschi, J. S., Arora, K., Brooks, C. L., 3rd, and Schramm, V. L. (2010) Conformational dynamics in human purine nucleoside phosphorylase with reactants and transition-state analogues J. Phys. Chem. B 114, 16263-16272
-
(2010)
J. Phys. Chem. B
, vol.114
, pp. 16263-16272
-
-
Hirschi, J.S.1
Arora, K.2
Brooks III, C.L.3
Schramm, V.L.4
-
6
-
-
0034604660
-
Femtochemistry: Atomic-scale dynamics of the chemical bond using ultrafast lasers (Nobel lecture)
-
DOI 10.1002/1521-3773(20000804)39:15<2586::AID-ANIE2586>3.0.CO;2-O
-
Zewail, A. H. (2000) Femtochemistry: Atomic-scale dynamics of the chemical bond using ultrafast lasers (Nobel Lecture) Angew. Chem., Int. Ed. 39, 2586-2631 (Pubitemid 30629182)
-
(2000)
Angewandte Chemie - International Edition
, vol.39
, Issue.15
, pp. 2586-2631
-
-
Zewail, A.H.1
-
7
-
-
0000116875
-
Femtosecond real-time alignment in chemical reactions
-
Dantus, M., Bowman, R. M., Baskin, J. S., and Zewail, A. H. (1989) Femtosecond real-time alignment in chemical reactions Chem. Phys. Lett. 159, 406-412
-
(1989)
Chem. Phys. Lett.
, vol.159
, pp. 406-412
-
-
Dantus, M.1
Bowman, R.M.2
Baskin, J.S.3
Zewail, A.H.4
-
8
-
-
0000925575
-
Femtosecond vibrational transition-state dynamics in a chemical reaction
-
Pedersen, S., Bañares, L., and Zewail, A. H. (1992) Femtosecond vibrational transition-state dynamics in a chemical reaction J. Chem. Phys. 97, 8801-8804
-
(1992)
J. Chem. Phys.
, vol.97
, pp. 8801-8804
-
-
Pedersen, S.1
Bañares, L.2
Zewail, A.H.3
-
9
-
-
0345082644
-
Direct observation of the transition state
-
Polanyi, J. C. and Zewail, A. H. (1995) Direct observation of the transition state Acc. Chem. Res. 28, 119-132
-
(1995)
Acc. Chem. Res.
, vol.28
, pp. 119-132
-
-
Polanyi, J.C.1
Zewail, A.H.2
-
10
-
-
0036424048
-
Transition path sampling: Throwing ropes over rough mountain passes in the dark
-
Bolhuis, P. G., Chandler, D., Dellago, C., and Geissler, P. L. (2002) Transition path sampling: throwing ropes over rough mountain passes in the dark Annu. Rev. Phys. Chem. 53, 291-318
-
(2002)
Annu. Rev. Phys. Chem.
, vol.53
, pp. 291-318
-
-
Bolhuis, P.G.1
Chandler, D.2
Dellago, C.3
Geissler, P.L.4
-
11
-
-
0000801009
-
Efficient transition path sampling: Application to Lennard-Jones cluster rearrangements
-
Dellago, C., Bolhuis, P. G., and Chandler, D. (1998) Efficient transition path sampling: application to Lennard-Jones cluster rearrangements J. Chem. Phys. 108, 9236-9245 (Pubitemid 128571335)
-
(1998)
Journal of Chemical Physics
, vol.108
, Issue.22
, pp. 9236-9245
-
-
Dellago, C.1
Bolhuis, P.G.2
Chandler, D.3
-
12
-
-
26444486352
-
How enzyme dynamics helps catalyze a reaction in atomic detail: A transition path sampling study
-
DOI 10.1021/ja043320h
-
Basner, J. E. and Schwartz, S. D. (2005) How enzyme dynamics helps catalyze a chemical reaction in atomic detail: a transition path sampling study J. Am. Chem. Soc. 127, 13822-13831 (Pubitemid 41437032)
-
(2005)
Journal of the American Chemical Society
, vol.127
, Issue.40
, pp. 13822-13831
-
-
Basner, J.E.1
Schwartz, S.D.2
-
13
-
-
84255214322
-
Protein dynamics and enzymatic chemical barrier passage
-
Antoniou, D. and Schwartz, S. D. (2011) Protein dynamics and enzymatic chemical barrier passage J. Phys. Chem. B 115, 15147-15158
-
(2011)
J. Phys. Chem. B
, vol.115
, pp. 15147-15158
-
-
Antoniou, D.1
Schwartz, S.D.2
-
14
-
-
68049085675
-
A 21st century revisionist's view at a turning point in enzymology
-
Nagel, Z. D. and Klinman, J. P. (2009) A 21st century revisionist's view at a turning point in enzymology Nat. Chem. Biol. 5, 543-550
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 543-550
-
-
Nagel, Z.D.1
Klinman, J.P.2
-
15
-
-
0042355696
-
Just a near attack conformer for catalysis (chorismate to prephenate rearrangements in water, antibody, enzymes, and their mutants)
-
DOI 10.1021/ja0357846
-
Hur, S. and Bruice, T. C. (2003) Just a near attack conformer for catalysis (chorismate to prephenate rearrangements in water, antibody, enzymes, and their mutants) J. Am. Chem. Soc. 125, 10540-10542 (Pubitemid 37055905)
-
(2003)
Journal of the American Chemical Society
, vol.125
, Issue.35
, pp. 10540-10542
-
-
Hur, S.1
Bruice, T.C.2
-
16
-
-
79959431109
-
Benchmark reaction rates, the stability of biological molecules in water, and the evolution of catalytic power in enzymes
-
Wolfenden, R. (2011) Benchmark reaction rates, the stability of biological molecules in water, and the evolution of catalytic power in enzymes Annu. Rev. Biochem. 80, 645-667
-
(2011)
Annu. Rev. Biochem.
, vol.80
, pp. 645-667
-
-
Wolfenden, R.1
-
17
-
-
81755172909
-
Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme
-
Silva, R. G., Murkin, A. S., and Schramm, V. L. (2011) Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme Proc. Natl. Acad. Sci. U.S.A. 108, 18661-18665
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 18661-18665
-
-
Silva, R.G.1
Murkin, A.S.2
Schramm, V.L.3
-
18
-
-
82555185640
-
Mass-dependent bond vibrational dynamics influence catalysis by HIV-1 protease
-
Kipp, D. R., Silva, R. G., and Schramm, V. L. (2011) Mass-dependent bond vibrational dynamics influence catalysis by HIV-1 protease J. Am. Chem. Soc. 133, 19358-19361
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 19358-19361
-
-
Kipp, D.R.1
Silva, R.G.2
Schramm, V.L.3
-
19
-
-
84867065402
-
Capturing the reaction pathway in near-atomic-resolution crystal structures of HIV-1 protease
-
Shen, C. H., Tie, Y., Yu, X., Wang, Y. F., Kovalevsky, A. Y., Harrison, R. W., and Weber, I. T. (2012) Capturing the reaction pathway in near-atomic-resolution crystal structures of HIV-1 protease Biochemistry 51, 7726-7732
-
(2012)
Biochemistry
, vol.51
, pp. 7726-7732
-
-
Shen, C.H.1
Tie, Y.2
Yu, X.3
Wang, Y.F.4
Kovalevsky, A.Y.5
Harrison, R.W.6
Weber, I.T.7
-
20
-
-
84860175384
-
Transition states of native and drug-resistant HIV-1 protease are the same
-
Kipp, D. R., Hirschi, J. S., Wakata, A., Goldstein, H., and Schramm, V. L. (2012) Transition states of native and drug-resistant HIV-1 protease are the same Proc. Natl. Acad. Sci. U.S.A. 109, 6543-6548
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 6543-6548
-
-
Kipp, D.R.1
Hirschi, J.S.2
Wakata, A.3
Goldstein, H.4
Schramm, V.L.5
-
21
-
-
0028920872
-
Isotope effects: Determination of enzyme transition state structure
-
Cleland, W. W. (1995) Isotope effects: determination of enzyme transition state structure Methods Enzymol. 249, 341-373
-
(1995)
Methods Enzymol.
, vol.249
, pp. 341-373
-
-
Cleland, W.W.1
-
22
-
-
0016904563
-
Transition state analog inhibitors and enzyme catalysis
-
Wolfenden, R. (1976) Transition state analog inhibitors and enzyme catalysis Annu. Rev. Biophys. Bioeng. 5, 271-306
-
(1976)
Annu. Rev. Biophys. Bioeng.
, vol.5
, pp. 271-306
-
-
Wolfenden, R.1
-
23
-
-
0014681301
-
Transition state analogues for enzyme catalysis
-
Wolfenden, R. (1969) Transition state analogues for enzyme catalysis Nature 223, 704-705
-
(1969)
Nature
, vol.223
, pp. 704-705
-
-
Wolfenden, R.1
-
25
-
-
0009942589
-
Isotope effects on enzyme-catalyzed reactions
-
University Park Press, Baltimore
-
Cleland, W. W., O'Leary, M. H., and Northrop, D. B. (1977) Isotope effects on enzyme-catalyzed reactions, In Proceedings of the Sixth Annual Harry Steenbock Symposium, University Park Press, Baltimore.
-
(1977)
Proceedings of the Sixth Annual Harry Steenbock Symposium
-
-
Cleland, W.W.1
O'Leary, M.H.2
Northrop, D.B.3
-
26
-
-
0032860328
-
Enzymatic transition-state analysis and transition-state analogs
-
DOI 10.1016/S0076-6879(99)08015-5
-
Schramm, V. L. (1999) Enzymatic transition-sate analysis and transition-state analogs Methods Enzymol. 308, 301-355 (Pubitemid 29418909)
-
(1999)
Methods in Enzymology
, vol.308
, pp. 301-355
-
-
Schramm, V.L.1
-
27
-
-
77249160713
-
HIV-1 protease inhibitors with a transition-state mimic comprising a tertiary alcohol: Improved antiviral activity in cells
-
Mahalingam, A. K., Axelsson, L., Ekegren, J. K., Wannberg, J., Kihlström, J., Unge, T., Wallberg, H., Samuelsson, B., Larhed, M., and Hallberg, A. (2010) HIV-1 protease inhibitors with a transition-state mimic comprising a tertiary alcohol: improved antiviral activity in cells J. Med. Chem. 53, 607-615
-
(2010)
J. Med. Chem.
, vol.53
, pp. 607-615
-
-
Mahalingam, A.K.1
Axelsson, L.2
Ekegren, J.K.3
Wannberg, J.4
Kihlström, J.5
Unge, T.6
Wallberg, H.7
Samuelsson, B.8
Larhed, M.9
Hallberg, A.10
-
28
-
-
84912208190
-
Chemical achievement and hope for the future
-
Pauling, L. (1948) Chemical achievement and hope for the future Am. Sci. 36, 51-58
-
(1948)
Am. Sci.
, vol.36
, pp. 51-58
-
-
Pauling, L.1
-
29
-
-
0035969964
-
Transition state structure of purine nucleoside phosphorylase and principles of atomic motion in enzymatic catalysis
-
DOI 10.1021/bi002499f
-
Fedorov, A., Shi, W., Kicska, G., Fedorov, E., Tyler, P. C., Furneaux, R. H., Hanson, J. C., Gainsford, G. J., Larese, J. Z., Schramm, V. L., and Almo, S. C. (2001) Transition state structure of purine nucleoside phosphorylase and principles of atomic motion in enzymatic catalysis Biochemistry 40, 853-860 (Pubitemid 32108576)
-
(2001)
Biochemistry
, vol.40
, Issue.4
, pp. 853-860
-
-
Fedorov, A.1
Shi, W.2
Kicska, G.3
Fedorov, E.4
Tyler, P.C.5
Furneaux, R.H.6
Hanson, J.C.7
Gainsford, G.J.8
Larese, J.Z.9
Schramm, V.L.10
Almo, S.C.11
-
30
-
-
0035695812
-
Atomic motion in enzymatic reaction coordinates
-
DOI 10.1016/S0959-440X(01)00269-X
-
Schramm, V. L. and Shi, W. (2001) Atomic motion in enzymatic reaction coordinates Curr. Opin. Struct. Biol. 11, 657-665 (Pubitemid 34076625)
-
(2001)
Current Opinion in Structural Biology
, vol.11
, Issue.6
, pp. 657-665
-
-
Schramm, V.L.1
Shi, W.2
-
31
-
-
80052797384
-
Hybrid schemes based on quantum mechanics/molecular mechanics simulations goals to success, problems, and perspectives
-
Ferrer, S., Ruiz-Pernía, J., Martí, S., Moliner, V., Tuñón, I., Bertrán, J., and Andrés., J. (2011) Hybrid schemes based on quantum mechanics/molecular mechanics simulations goals to success, problems, and perspectives Adv. Protein Chem. Struct. Biol. 85, 81-142
-
(2011)
Adv. Protein Chem. Struct. Biol.
, vol.85
, pp. 81-142
-
-
Ferrer, S.1
Ruiz-Pernía, J.2
Martí, S.3
Moliner, V.4
Tuñón, I.5
Bertrán, J.6
Andrés, J.7
-
32
-
-
78650152378
-
Slow conformational motions that favor sub-picosecond motions important for catalysis
-
Exequiel, J. R., Pineda, T., Antoniou, D., and Schwartz, S. D. (2010) Slow conformational motions that favor sub-picosecond motions important for catalysis J. Phys. Chem. B 114, 15985-15990
-
(2010)
J. Phys. Chem. B
, vol.114
, pp. 15985-15990
-
-
Exequiel, J.R.1
Pineda, T.2
Antoniou, D.3
Schwartz, S.D.4
-
33
-
-
0346726109
-
How Enzymes Work: Analysis by Modern Rate Theory and Computer Simulations
-
DOI 10.1126/science.1088172
-
Garcia-Viloca, M., Gao, J., Karplus, M., and Truhlar, D. G. (2004) How enzymes work: analysis by modern rate theory and computer simulations Science 303, 186-195 (Pubitemid 38057561)
-
(2004)
Science
, vol.303
, Issue.5655
, pp. 186-195
-
-
Garcia-Viloca, M.1
Gao, J.2
Karplus, M.3
Truhlar, D.G.4
-
34
-
-
0014113017
-
Mode of inhibition of coformycin on adenosine deaminase
-
Sawa, T., Fukagawa, Y., Homma, I., Takeuchi, T., and Umezawa, H. (1967) Mode of inhibition of coformycin on adenosine deaminase J. Antibiot. (Tokyo) 20, 227-231
-
(1967)
J. Antibiot. (Tokyo)
, vol.20
, pp. 227-231
-
-
Sawa, T.1
Fukagawa, Y.2
Homma, I.3
Takeuchi, T.4
Umezawa, H.5
-
35
-
-
0016765942
-
Tight-binding inhibitors-II. Non-steady state nature of inhibition of milk xanthine oxidase by allopurinol and alloxanthine and of human erythrocytic adenosine deaminase by coformycin
-
Cha, S., Agarwal, R. P., and Parks, R. E., Jr. (1975) Tight-binding inhibitors-II. Non-steady state nature of inhibition of milk xanthine oxidase by allopurinol and alloxanthine and of human erythrocytic adenosine deaminase by coformycin Biochem. Pharmacol. 24, 2187-2197
-
(1975)
Biochem. Pharmacol.
, vol.24
, pp. 2187-2197
-
-
Cha, S.1
Agarwal, R.P.2
Parks, Jr.R.E.3
-
36
-
-
84869067961
-
Methylthioadenosine deaminase in an alternative quorum sensing pathway in Pseudomonas aeruginosa
-
Guan, R., Ho, M. C., Fröhlich, R. F., Tyler, P. C., Almo, S. C., and Schramm, V. L. (2012) Methylthioadenosine deaminase in an alternative quorum sensing pathway in Pseudomonas aeruginosa Biochemistry 51, 9094-9103
-
(2012)
Biochemistry
, vol.51
, pp. 9094-9103
-
-
Guan, R.1
Ho, M.C.2
Fröhlich, R.F.3
Tyler, P.C.4
Almo, S.C.5
Schramm, V.L.6
-
37
-
-
84866695338
-
Femtomolar inhibitors bind to 5′-methylthioadenosine nucleosidases with favorable enthalpy and entropy
-
Thomas, K., Haapalainen, A. M., Burgos, E. S., Evans, G. B., Tyler, P. C., Gulab, S., Guan, R., and Schramm, V. L. (2012) Femtomolar inhibitors bind to 5′-methylthioadenosine nucleosidases with favorable enthalpy and entropy Biochemistry 51, 7541-7550
-
(2012)
Biochemistry
, vol.51
, pp. 7541-7550
-
-
Thomas, K.1
Haapalainen, A.M.2
Burgos, E.S.3
Evans, G.B.4
Tyler, P.C.5
Gulab, S.6
Guan, R.7
Schramm, V.L.8
-
38
-
-
84865709239
-
A picomolar transition state analogue inhibitor of MTAN as a specific antibiotic for Helicobacter pylori
-
Wang, S., Haapalainen, A. M., Yan, F., Du, Q., Tyler, P. C., Evans, G. B., Rinaldo-Matthis, A., Brown, R. L., Norris, G. E., Almo, S. C., and Schramm, V. L. (2012) A picomolar transition state analogue inhibitor of MTAN as a specific antibiotic for Helicobacter pylori Biochemistry 51, 6892-6894
-
(2012)
Biochemistry
, vol.51
, pp. 6892-6894
-
-
Wang, S.1
Haapalainen, A.M.2
Yan, F.3
Du, Q.4
Tyler, P.C.5
Evans, G.B.6
Rinaldo-Matthis, A.7
Brown, R.L.8
Norris, G.E.9
Almo, S.C.10
Schramm, V.L.11
-
39
-
-
84864964706
-
Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics
-
Clinch, K., Evans, G. B., Fröhlich, R. F., Gulab, S. A., Gutierrez, J. A., Mason, J. M., Schramm, V. L., Tyler, P. C., and Woolhouse, A. D. (2012) Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics Bioorg. Med. Chem. 20, 5181-5187
-
(2012)
Bioorg. Med. Chem.
, vol.20
, pp. 5181-5187
-
-
Clinch, K.1
Evans, G.B.2
Fröhlich, R.F.3
Gulab, S.A.4
Gutierrez, J.A.5
Mason, J.M.6
Schramm, V.L.7
Tyler, P.C.8
Woolhouse, A.D.9
-
40
-
-
0021152172
-
Effects of allosteric activation on the primary and secondary kinetic isotope effects for three AMP nucleosidases
-
Parkin, D. W. and Schramm, V. L. (1984) Effects of allosteric activation on the primary and secondary kinetic isotope effects for three AMP nucleosidases J. Biol. Chem. 259, 9418-25 (Pubitemid 14060500)
-
(1984)
Journal of Biological Chemistry
, vol.259
, Issue.15
, pp. 9418-9425
-
-
Parkin, D.W.1
Schramm, V.L.2
-
41
-
-
0023129244
-
Transition-state structures for N-glycoside hydrolysis of AMP by acid and by AMP nucleosidase in the presence and absence of allosteric activator
-
DOI 10.1021/bi00377a037
-
Mentch, F., Parkin, D. W., and Schramm, V. L. (1987) Transition-state structures for N-glycoside hydrolysis of AMP by acid and by AMP nucleosidase in the presence and absence of allosteric activator Biochemistry 26, 921-930 (Pubitemid 17021074)
-
(1987)
Biochemistry
, vol.26
, Issue.3
, pp. 921-930
-
-
Mentch, F.1
Parkin, D.W.2
Schramm, V.L.3
-
42
-
-
0023127914
-
Catalytic and allosteric mechanism of AMP nucleosidase from primary, β-secondary, and multiple heavy atom kinetic isotope effects
-
DOI 10.1021/bi00377a036
-
Parkin, D. W. and Schramm, V. L. (1987) Catalytic and allosteric mechanism of AMP nucleosidase from primary, beta-secondary, and multiple heavy atom kinetic isotope effects Biochemistry 26, 913-920 (Pubitemid 17021073)
-
(1987)
Biochemistry
, vol.26
, Issue.3
, pp. 913-920
-
-
Parkin, D.W.1
Schramm, V.L.2
-
44
-
-
0028074975
-
Electrostatic potential surface analysis of the transition state for AMP nucleosidase and for formycin 5'-phosphate, a transition-state inhibitor
-
DOI 10.1021/bi00196a005
-
Ehrlich, J. I. and Schramm, V. L. (1994) Electrostatic potential surface analysis of the transition state for AMP nucleosidase and for formycin 5′-phosphate, a transition-state inhibitor Biochemistry 33, 8890-8896 (Pubitemid 24257996)
-
(1994)
Biochemistry
, vol.33
, Issue.30
, pp. 8890-8896
-
-
Ehrlich, J.I.1
Schramm, V.L.2
-
45
-
-
0008501948
-
The enzymatic cleavage of adenylic acid to adenine and ribose 5-phosphate
-
Hurwitz, J., Heppel, L. A., and Horecker, B. L. (1957) The enzymatic cleavage of adenylic acid to adenine and ribose 5-phosphate J. Biol. Chem. 226, 525-540
-
(1957)
J. Biol. Chem.
, vol.226
, pp. 525-540
-
-
Hurwitz, J.1
Heppel, L.A.2
Horecker, B.L.3
-
46
-
-
34250201455
-
Transition state analysis of acid-catalyzed dAMP hydrolysis
-
DOI 10.1021/ja067371l
-
McCann, J. A. and Berti, P. J. (2007) Transition state analysis of acid-catalyzed dAMP hydrolysis J. Am. Chem. Soc. 129, 7055-7064 (Pubitemid 46903270)
-
(2007)
Journal of the American Chemical Society
, vol.129
, Issue.22
, pp. 7055-7064
-
-
McCann, J.A.B.1
Berti, P.J.2
-
47
-
-
0017140479
-
Comparison of initial velocity and binding data for allosteric adenosine monophosphate nucleosidase
-
Schramm, V. L. (1976) Comparison of initial velocity and binding data for allosteric adenosine monophosphate nucleosidase J. Biol. Chem. 251, 3417-3424
-
(1976)
J. Biol. Chem.
, vol.251
, pp. 3417-3424
-
-
Schramm, V.L.1
-
48
-
-
0018610885
-
4
-
DeWolf, W. E., Jr., Fullin, F. A., and Schramm, V. L. (1979) The catalytic site of AMP nucleosidase. Substrate specificity and pH effects with AMP and formycin 5′-PO4 J. Biol. Chem. 254, 10868-10875 (Pubitemid 10159382)
-
(1979)
Journal of Biological Chemistry
, vol.254
, Issue.21
, pp. 10868-10875
-
-
De Wolf Jr., W.E.1
Fullin, F.A.2
Schramm, V.L.3
-
49
-
-
4143089174
-
Structure of Escherichia coli AMP nucleosidase reveals similarity to nucleoside phosphorylases
-
DOI 10.1016/j.str.2004.05.015, PII S0969212604002175
-
Zhang, Y., Cottet, S. E., and Ealick, S. E. (2004) Structure of Escherichia coli AMP nucleosidase reveals similarity to nucleoside phosphorylases Structure 12, 1383-1394 (Pubitemid 39092083)
-
(2004)
Structure
, vol.12
, Issue.8
, pp. 1383-1394
-
-
Zhang, Y.1
Cottet, S.E.2
Ealick, S.E.3
-
50
-
-
0019132908
-
Adenylate degradation in Escherichia coli. The role of AMP nucleosidase and properties of the purified enzyme
-
Leung, H,B. and Schramm, V. L. (1980) Adenylate degradation in Escherichia coli. The role of AMP nucleosidase and properties of the purified enzyme J. Biol. Chem. 255, 10867-10874 (Pubitemid 11171742)
-
(1980)
Journal of Biological Chemistry
, vol.255
, Issue.22
, pp. 10867-10874
-
-
Leung, H.B.1
Schramm, V.L.2
-
51
-
-
40949094869
-
An AMP nucleosidase gene knockout in Escherichia coli elevates intracellular ATP levels and increases cold tolerance
-
DOI 10.1098/rsbl.2007.0432, PII 1125660826183P39
-
Morrison, B. A. and Shain, D. H. (2008) An AMP nucleosidase gene knockout in Escherichia coli elevates intracellular ATP levels and increases cold tolerance Biol. Lett. 4, 53-56 (Pubitemid 351598296)
-
(2008)
Biology Letters
, vol.4
, Issue.1
, pp. 53-56
-
-
Morrison, B.A.1
Shain, D.H.2
-
52
-
-
79959486576
-
Manipulations of AMP metabolic genes increase growth rate and cold tolerance in Escherichia coli: Implications for psychrophilic evolution
-
Parry, B. R. and Shain, D. H. (2011) Manipulations of AMP metabolic genes increase growth rate and cold tolerance in Escherichia coli: implications for psychrophilic evolution Mol. Biol. Evol. 28, 2139-2145
-
(2011)
Mol. Biol. Evol.
, vol.28
, pp. 2139-2145
-
-
Parry, B.R.1
Shain, D.H.2
-
53
-
-
84919573117
-
Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity
-
Giblett, E. R., Ammann, A. J., Wara, D. W., Sandman, R., and Diamond, L. K. (1975) Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity Lancet 1, 1010-1013
-
(1975)
Lancet
, vol.1
, pp. 1010-1013
-
-
Giblett, E.R.1
Ammann, A.J.2
Wara, D.W.3
Sandman, R.4
Diamond, L.K.5
-
54
-
-
0017054309
-
Abnormal purine metabolism and purine overproduction in a patient deficient in purine nucleoside phosphorylase
-
Cohen, A., Doyle, D., Martin, D. W., Jr., and Ammann, A. J. (1976) Abnormal purine metabolism and purine overproduction in a patient deficient in purine nucleoside phosphorylase New Engl. J. Med. 295, 1449-1454 (Pubitemid 8003705)
-
(1976)
New England Journal of Medicine
, vol.295
, Issue.26
, pp. 1449-1454
-
-
Cohen, A.1
Doyle, D.2
Martin Jr., D.W.3
Ammann, A.J.4
-
55
-
-
0017807276
-
Deoxyguanosine triphosphate as a possible toxic metabolite in the immunodeficiency associated with purine nucleoside phosphorylase deficiency
-
Cohen, A., Gudas, L. J., Ammann, A. J., Staal, G. E., and Martin, D. W., Jr. (1978) Deoxyguanosine triphosphate as a possible toxic metabolite in the immunodeficiency associated with purine nucleoside phosphorylase deficiency J. Clin. Invest. 61, 1405-1409
-
(1978)
J. Clin. Invest.
, vol.61
, pp. 1405-1409
-
-
Cohen, A.1
Gudas, L.J.2
Ammann, A.J.3
Staal, G.E.4
Martin, Jr.D.W.5
-
56
-
-
0343517471
-
Inhibitors of the enzyme purine nucleoside phosphorylase as potential therapy for psoriasis
-
Morris, P. E., and Omura, G. A. (2000) Inhibitors of the enzyme purine nucleoside phosphorylase as potential therapy for psoriasis Curr. Pharm. Des. 6, 943-959 (Pubitemid 30409391)
-
(2000)
Current Pharmaceutical Design
, vol.6
, Issue.9
, pp. 943-959
-
-
Morris Jr., P.E.1
Omura, G.A.2
-
57
-
-
0027729453
-
Purine nucleoside phosphorylase. Catalytic mechanism and transition-state analysis of the arsenolysis reaction
-
DOI 10.1021/bi00211a033
-
Kline, P. C. and Schramm, V. L. (1993) Purine nucleoside phosphorylase. Catalytic mechanism and transition-state analysis of the arsenolysis reaction Biochemistry 32, 13212-13219 (Pubitemid 24005930)
-
(1993)
Biochemistry
, vol.32
, Issue.48
, pp. 13212-13219
-
-
Kline, P.C.1
Schramm, V.L.2
-
58
-
-
0032537481
-
One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase
-
DOI 10.1021/bi980658d
-
Miles, R. W., Tyler, P. C., Furneaux, R. H., Bagdassarian, C. K., and Schramm, V. L. (1998) One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase Biochemistry 37, 8615-8621 (Pubitemid 28299598)
-
(1998)
Biochemistry
, vol.37
, Issue.24
, pp. 8615-8621
-
-
Miles, R.W.1
Tyler, P.C.2
Furneaux, R.H.3
Bagdassarian, C.K.4
Schramm, V.L.5
-
59
-
-
77956299127
-
Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia
-
Balakrishnan, K., Verma, D., O'Brien, S., Kilpatrick, J. M., Chen, Y., Tyler, B. F., Bickel, S., Bantia, S., Keating, M. J., Kantarjian, H., Gandhi, V., and Ravandi, F. (2010) Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia Blood 116, 886-892
-
(2010)
Blood
, vol.116
, pp. 886-892
-
-
Balakrishnan, K.1
Verma, D.2
O'Brien, S.3
Kilpatrick, J.M.4
Chen, Y.5
Tyler, B.F.6
Bickel, S.7
Bantia, S.8
Keating, M.J.9
Kantarjian, H.10
Gandhi, V.11
Ravandi, F.12
-
60
-
-
80052158260
-
In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia
-
Homminga, I., Zwaan, C. M., Manz, C. Y., Parker, C., Bantia, S., Smits, W. K., Higginbotham, F., Pieters, R., and Meijerink, J. P. (2011) In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia Blood 118, 2184-2190
-
(2011)
Blood
, vol.118
, pp. 2184-2190
-
-
Homminga, I.1
Zwaan, C.M.2
Manz, C.Y.3
Parker, C.4
Bantia, S.5
Smits, W.K.6
Higginbotham, F.7
Pieters, R.8
Meijerink, J.P.9
-
61
-
-
1042299983
-
Transition State Analysis for Human and Plasmodium falciparum Purine Nucleoside Phosphorylases
-
DOI 10.1021/bi0359123
-
Lewandowicz, A. and Schramm, V. L. (2004) Transition state analysis for human and Plasmodium falciparum purine nucleoside phosphorylases Biochemistry 43, 1458-1468 (Pubitemid 38200551)
-
(2004)
Biochemistry
, vol.43
, Issue.6
, pp. 1458-1468
-
-
Lewandowicz, A.1
Schramm, V.L.2
-
62
-
-
0242691662
-
Synthesis of Second-Generation Transition State Analogues of Human Purine Nucleoside Phosphorylase
-
DOI 10.1021/jm030305z
-
Evans, G. B., Furneaux, R. H., Lewandowicz, A., Schramm, V. L., and Tyler, P. C. (2003) Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase J. Med. Chem. 46, 5271-5276 (Pubitemid 37414195)
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, Issue.24
, pp. 5271-5276
-
-
Evans, G.B.1
Furneaux, R.H.2
Lewandowicz, A.3
Schramm, V.L.4
Tyler, P.C.5
-
63
-
-
84872583419
-
-
Presented at the Annual European Congress of Rheumatology (EULAR); 2012 June 6-9; Berlin, Germany. Abstract
-
Bantia, S., Harman, L., Hollister, A., and Pearson, P. (2012) BCX4208, a novel enzyme inhibitor for chronic management of gout shows a low risk of potential drug-drug interactions. Presented at the Annual European Congress of Rheumatology (EULAR); 2012 June 6-9; Berlin, Germany. Abstract.
-
(2012)
BCX4208, A Novel Enzyme Inhibitor for Chronic Management of Gout Shows A Low Risk of Potential Drug-drug Interactions
-
-
Bantia, S.1
Harman, L.2
Hollister, A.3
Pearson, P.4
-
64
-
-
0036479245
-
Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase
-
DOI 10.1074/jbc.M105906200
-
Kicska, G. A., Tyler, P. C., Evans, G. B., Furneaux, R. H., Schramm, V. L., and Kim, K. (2002) Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase J. Biol. Chem. 277, 3226-3231 (Pubitemid 34953185)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.5
, pp. 3226-3231
-
-
Kicska, G.A.1
Tyler, P.C.2
Evans, G.B.3
Furneaux, R.H.4
Schramm, V.L.5
Kim, K.6
-
65
-
-
34347227434
-
Transition-state variation in human, bovine, and Plasmodium falciparum adenosine deaminases
-
DOI 10.1021/ja072122y
-
Luo, M., Singh, V., Taylor, E. A., and Schramm, V. L. (2007) Transition-state variation in human, bovine, and Plasmodium falciparum adenosine deaminases J. Am. Chem. Soc. 129, 8008-8017 (Pubitemid 46998200)
-
(2007)
Journal of the American Chemical Society
, vol.129
, Issue.25
, pp. 8008-8017
-
-
Luo, M.1
Singh, V.2
Taylor, E.A.3
Schramm, V.L.4
-
66
-
-
80855133585
-
Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model
-
Cassera, M. B., Hazleton, K. Z., Merino, E. F., Obaldia, N., 3rd, Ho, M. C., Murkin, A. S., DePinto, R., Gutierrez, J. A., Almo, S. C., Evans, G. B., Babu, Y. S., and Schramm, V. L. (2011) Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model PLoS One 6, e26916
-
(2011)
PLoS One
, vol.6
, pp. 26916
-
-
Cassera, M.B.1
Hazleton, K.Z.2
Merino, E.F.3
Obaldia III, N.4
Ho, M.C.5
Murkin, A.S.6
Depinto, R.7
Gutierrez, J.A.8
Almo, S.C.9
Evans, G.B.10
Babu, Y.S.11
Schramm, V.L.12
-
67
-
-
33750979005
-
Transition-state structure of human 5′-methylthioadenosine phosphorylase
-
DOI 10.1021/ja065419p
-
Singh, V. and Schramm, V. L. (2006) Transition-state structure of human 5′-methylthioadenosine phosphorylase J. Am. Chem. Soc. 128, 14691-14696 (Pubitemid 44749872)
-
(2006)
Journal of the American Chemical Society
, vol.128
, Issue.45
, pp. 14691-14696
-
-
Singh, V.1
Schramm, V.L.2
-
68
-
-
2542531592
-
Targeting the polyamine pathway with transition-state analogue inhibitors of 5′-methylthioadenosine phosphorylase
-
DOI 10.1021/jm0306475
-
Evans, G. B., Furneaux, R. H., Schramm, V. L., Singh, V., and Tyler, P. C. (2004) Targeting the polyamine pathway with transition-state analogue inhibitors of 5′-methylthioadenosine phosphorylase J. Med. Chem. 47, 3275-3281 (Pubitemid 38702720)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.12
, pp. 3275-3281
-
-
Evans, G.B.1
Furneaux, R.H.2
Schramm, V.L.3
Singh, V.4
Tyler, P.C.5
-
69
-
-
34547102012
-
A transition state analogue of 5′-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers
-
DOI 10.1074/jbc.M702287200
-
Basu, I., Cordovano, G., Das, I., Belbin, T. J., Guha, C., and Schramm, V. L. (2007) A transition state analogue of 5′-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers J. Biol. Chem. 282, 21477-21486 (Pubitemid 47099931)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.29
, pp. 21477-21486
-
-
Basu, I.1
Cordovano, G.2
Das, I.3
Belbin, T.J.4
Guha, C.5
Schramm, V.L.6
-
70
-
-
79953000186
-
Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5′-methylthioadenosine phosphorylase
-
Basu, I., Locker, J., Cassera, M. B., Belbin, T. J., Merino, E. F., Dong, X., Hemeon, I., Evans, G. B., Guha, C., and Schramm, V. L. (2011) Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5′-methylthioadenosine phosphorylase J. Biol. Chem. 286, 4902-4911
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 4902-4911
-
-
Basu, I.1
Locker, J.2
Cassera, M.B.3
Belbin, T.J.4
Merino, E.F.5
Dong, X.6
Hemeon, I.7
Evans, G.B.8
Guha, C.9
Schramm, V.L.10
-
71
-
-
84857822674
-
Small-molecule inhibitors of ricin and Shiga toxins
-
Wahome, P. G., Robertus, J. D., and Mantis, N. J. (2012) Small-molecule inhibitors of ricin and Shiga toxins Curr. Top. Microbiol. Immunol. 357, 179-207
-
(2012)
Curr. Top. Microbiol. Immunol.
, vol.357
, pp. 179-207
-
-
Wahome, P.G.1
Robertus, J.D.2
Mantis, N.J.3
-
72
-
-
0034686760
-
Transition-state analysis for depurination of DNA by ricin A-chain
-
DOI 10.1021/ja992751a
-
Chen, X.-Y., Berti, P. J., and Schramm, V. L. (2000) Transition state analysis for depurination of DNA by Ricin A-chain J. Am. Chem. Soc. 122, 6527-6534 (Pubitemid 30489970)
-
(2000)
Journal of the American Chemical Society
, vol.122
, Issue.28
, pp. 6527-6534
-
-
Chen, X.-Y.1
Berti, P.J.2
Schramm, V.L.3
-
73
-
-
34247857453
-
Circular DNA and DNA/RNA hybrid molecules as scaffolds for Ricin inhibitor design
-
DOI 10.1021/ja068054h
-
Sturm, M. B., Roday, S., and Schramm, V. L. (2007) Circular DNA and DNA/RNA hybrid molecules as scaffolds for ricin inhibitor design J. Am. Chem. Soc. 129, 5544-5550 (Pubitemid 46697642)
-
(2007)
Journal of the American Chemical Society
, vol.129
, Issue.17
, pp. 5544-5550
-
-
Sturm, M.B.1
Roday, S.2
Schramm, V.L.3
-
74
-
-
70350072944
-
Transition state analogues rescue ribosomes from saporin-L1 ribosome inactivating protein
-
Sturm, M. B., Tyler, P. C., Evans, G. B., and Schramm, V. L. (2009) Transition state analogues rescue ribosomes from saporin-L1 ribosome inactivating protein Biochemistry 48, 9941-9948
-
(2009)
Biochemistry
, vol.48
, pp. 9941-9948
-
-
Sturm, M.B.1
Tyler, P.C.2
Evans, G.B.3
Schramm, V.L.4
-
75
-
-
73949090667
-
Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins
-
Ho, M. C., Sturm, M. B., Almo, S. C., and Schramm, V. L. (2009) Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins Proc. Natl. Acad. Sci. U.S.A. 106, 20276-20281
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 20276-20281
-
-
Ho, M.C.1
Sturm, M.B.2
Almo, S.C.3
Schramm, V.L.4
-
76
-
-
0014868746
-
The cellular control of the synthesis and activity of the bacterial luminescent system
-
Nealson, K., Platt, T., and Hastings, J. W. (1970) The cellular control of the synthesis and activity of the bacterial luminescent system J. Bacteriol. 104, 313-322
-
(1970)
J. Bacteriol.
, vol.104
, pp. 313-322
-
-
Nealson, K.1
Platt, T.2
Hastings, J.W.3
-
77
-
-
84855865173
-
Modelling the onset of virulence in pathogenic bacteria
-
Kepseu, W. D., Van Gijsegem, F., and Sepulchre, J. A. (2012) Modelling the onset of virulence in pathogenic bacteria Methods Mol. Biol. 804, 501-517
-
(2012)
Methods Mol. Biol.
, vol.804
, pp. 501-517
-
-
Kepseu, W.D.1
Van Gijsegem, F.2
Sepulchre, J.A.3
-
78
-
-
84862091097
-
LsrR-mediated quorum sensing controls invasiveness of Salmonella typhimurium by regulating SPI-1 and flagella genes
-
Choi, J., Shin, D., Kim, M., Park, J., Lim, S., and Ryu, S. (2012) LsrR-mediated quorum sensing controls invasiveness of Salmonella typhimurium by regulating SPI-1 and flagella genes PLoS One 7, e37059
-
(2012)
PLoS One
, vol.7
, pp. 37059
-
-
Choi, J.1
Shin, D.2
Kim, M.3
Park, J.4
Lim, S.5
Ryu, S.6
-
79
-
-
84864006267
-
The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression
-
Liang, H., Deng, X., Ji, Q., Sun, F., Shen, T., and He, C. (2012) The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression J. Bacteriol. 194, 3098-3108
-
(2012)
J. Bacteriol.
, vol.194
, pp. 3098-3108
-
-
Liang, H.1
Deng, X.2
Ji, Q.3
Sun, F.4
Shen, T.5
He, C.6
-
80
-
-
11144220048
-
Role of quorum sensing in the pathogenicity of Burkholderia pseudomallei
-
DOI 10.1099/jmm.0.45661-0
-
Ulrich, R. L., Deshazer, D., Brueggemann, E. E., Hines, H. B., Oyston, P. C., and Jeddeloh, J. A. (2004) Role of quorum sensing in the pathogenicity of Burkholderia pseudomallei J. Med. Microbiol. 53, 1053-1064 (Pubitemid 40052485)
-
(2004)
Journal of Medical Microbiology
, vol.53
, Issue.11
, pp. 1053-1064
-
-
Ulrich, R.L.1
DeShazer, D.2
Brueggemann, E.E.3
Hines, H.B.4
Oyston, P.C.5
Jeddeloh, J.A.6
-
81
-
-
62649162275
-
Transition state analogs of 5′-methylthioadenosine nucleosidase disrupt quorum sensing
-
Gutierrez, J. A., Crowder, T., Rinaldo-Matthis, A., Ho, M. C., Almo, S. C., and Schramm, V. L. (2009) Transition state analogs of 5′- methylthioadenosine nucleosidase disrupt quorum sensing Nat. Chem. Biol. 5, 251-257
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 251-257
-
-
Gutierrez, J.A.1
Crowder, T.2
Rinaldo-Matthis, A.3
Ho, M.C.4
Almo, S.C.5
Schramm, V.L.6
-
82
-
-
23944446462
-
Transition state structure of 5′-methylthioadenosine/S- adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues
-
DOI 10.1021/bi050863a
-
Singh, V., Lee, J. E., Núñez, S., Howell, P. L., and Schramm, V. L. (2005) Transition state structure of 5′- methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues Biochemistry 44, 11647-11659 (Pubitemid 41262698)
-
(2005)
Biochemistry
, vol.44
, Issue.35
, pp. 11647-11659
-
-
Singh, V.1
Lee, J.E.2
Nunez, S.3
Howell, P.L.4
Schramm, V.L.5
-
83
-
-
33947201538
-
Transition-state analysis of S. pneumoniae 5′-methylthioadenosine nucleosidase
-
DOI 10.1021/ja065082r
-
Singh, V. and Schramm, V. L. (2007) Transition-state analysis of S. pneumoniae 5′-methylthioadenosine nucleosidase J. Am. Chem. Soc. 129, 2783-2795 (Pubitemid 46417953)
-
(2007)
Journal of the American Chemical Society
, vol.129
, Issue.10
, pp. 2783-2795
-
-
Singh, V.1
Schramm, V.L.2
-
84
-
-
36148932926
-
Transition-state structure of Neisseria meningitides 5′- methylthioadenosine/S-adenosylhomocysteine nucleosidase
-
DOI 10.1021/ja0754204
-
Singh, V., Luo, M., Brown, R. L., Norris, G. E., and Schramm, V. L. (2007) Transition-state structure of Neisseria meningitides 5′- methylthioadenosine/S-adenosylhomocysteine nucleosidase J. Am. Chem. Soc. 129, 13831-13833 (Pubitemid 350106071)
-
(2007)
Journal of the American Chemical Society
, vol.129
, Issue.45
, pp. 13831-13833
-
-
Singh, V.1
Luo, M.2
Brown, R.L.3
Norris, G.E.4
Schramm, V.L.5
-
85
-
-
37349047044
-
Picomolar inhibitors as transition-state probes of 5′- methylthioadenosine nucleosidases
-
DOI 10.1021/cb700166z
-
Gutierrez, J. A., Luo, M., Singh, V., Li, L., Brown, R. L., Norris, G. E., Evans, G. B., Furneaux, R. H., Tyler, P. C., Painter, G. F., Lenz, D. H., and Schramm, V. L. (2007) Picomolar inhibitors as transition-state probes of 5′-methylthioadenosine nucleosidases ACS Chem. Biol. 2, 725-734 (Pubitemid 350285908)
-
(2007)
ACS Chemical Biology
, vol.2
, Issue.11
, pp. 725-734
-
-
Gutierrez, J.A.1
Luo, M.2
Singh, V.3
Li, L.4
Brown, R.L.5
Norris, G.E.6
Evans, G.B.7
Furneaux, R.H.8
Tyler, P.C.9
Painter, G.F.10
Lenz, D.H.11
Schramm, V.L.12
-
86
-
-
20244369305
-
Femtomolar transition state analogue inhibitors of 5′- methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli
-
DOI 10.1074/jbc.M414472200
-
Singh, V., Evans, G. B., Lenz, D. H., Mason, J. M., Clinch, K., Mee, S., Painter, G. F., Tyler, P. C., Furneaux, R. H., Lee, J. E., Howell, P. L., and Schramm, V. L. (2005) Femtomolar transition state analogue inhibitors of 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli J. Biol. Chem. 280, 18265-18273 (Pubitemid 41389072)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.18
, pp. 18265-18273
-
-
Singh, V.1
Evans, G.B.2
Lenz, D.H.3
Mason, J.M.4
Clinch, K.5
Mee, S.6
Painter, G.F.7
Tyler, P.C.8
Furneaux, R.H.9
Lee, J.E.10
Howell, P.L.11
Schramm, V.L.12
-
87
-
-
79957616242
-
5′-methylthioadenosine nucleosidase is implicated in playing a key role in a modified futalosine pathway for menaquinone biosynthesis in Campylobacter jejuni
-
Li, X., Apel, D., Gaynor, E. C., and Tanner, M. E. (2011) 5′-methylthioadenosine nucleosidase is implicated in playing a key role in a modified futalosine pathway for menaquinone biosynthesis in Campylobacter jejuni J. Biol. Chem. 286, 19392-19398
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 19392-19398
-
-
Li, X.1
Apel, D.2
Gaynor, E.C.3
Tanner, M.E.4
-
88
-
-
52249100797
-
An alternative menaquinone biosynthetic pathway operating in microorganisms
-
Hiratsuka, T., Furihata, K., Ishikawa, J., Yamashita, H., Itoh, N., Seto, H., and Dairi, T. (2008) An alternative menaquinone biosynthetic pathway operating in microorganisms Science 321, 1670-1673
-
(2008)
Science
, vol.321
, pp. 1670-1673
-
-
Hiratsuka, T.1
Furihata, K.2
Ishikawa, J.3
Yamashita, H.4
Itoh, N.5
Seto, H.6
Dairi, T.7
-
89
-
-
84866483156
-
Menaquinone biosyntheses in microorganisms
-
Dairi, T. (2012) Menaquinone biosyntheses in microorganisms Methods Enzymol. 515, 107-22
-
(2012)
Methods Enzymol.
, vol.515
, pp. 107-122
-
-
Dairi, T.1
-
90
-
-
84865709239
-
A picomolar transition state analogue inhibitor of MTAN as a specific antibiotic for Helicobacter pylori
-
Wang, S., Haapalainen, A. M., Yan, F., Du, Q., Tyler, P. C., Evans, G. B., Rinaldo-Matthis, A., Brown, R. L., Norris, G. E., Almo, S. C., and Schramm, V. L. (2012) A picomolar transition state analogue inhibitor of MTAN as a specific antibiotic for Helicobacter pylori Biochemistry 51, 6892-6894
-
(2012)
Biochemistry
, vol.51
, pp. 6892-6894
-
-
Wang, S.1
Haapalainen, A.M.2
Yan, F.3
Du, Q.4
Tyler, P.C.5
Evans, G.B.6
Rinaldo-Matthis, A.7
Brown, R.L.8
Norris, G.E.9
Almo, S.C.10
Schramm, V.L.11
-
91
-
-
79951876264
-
Transition state analysis of the arsenolytic depyrimidination of thymidine by human thymidine phosphorylase
-
Schwartz, P. A., Vetticatt, M. J., and Schramm, V. L. (2011) Transition state analysis of the arsenolytic depyrimidination of thymidine by human thymidine phosphorylase Biochemistry 50, 1412-1420
-
(2011)
Biochemistry
, vol.50
, pp. 1412-1420
-
-
Schwartz, P.A.1
Vetticatt, M.J.2
Schramm, V.L.3
-
92
-
-
77957167437
-
Transition state analysis of thymidine hydrolysis by human thymidine phosphorylase
-
Schwartz, P. A., Vetticatt, M. J., and Schramm, V. L. (2010) Transition state analysis of thymidine hydrolysis by human thymidine phosphorylase J. Am. Chem. Soc. 132, 13425-13433
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 13425-13433
-
-
Schwartz, P.A.1
Vetticatt, M.J.2
Schramm, V.L.3
-
93
-
-
1642559369
-
Crystal Structure of Human Thymidine Phosphorylase in Complex with a Small Molecule Inhibitor
-
DOI 10.1016/j.str.2003.11.018
-
Norman, R. A., Barry, S. T., Bate, M., Breed, J., Colls, J. G., Ernill, R. J., Luke, R. W., Minshull, C. A., McAlister, M. S., McCall, E. J., McMiken, H. H., Paterson, D. S., Timms, D., Tucker, J. A., and Pauptit, R. A. (2004) Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor Science 12, 75-84 (Pubitemid 38120276)
-
(2004)
Structure
, vol.12
, Issue.1
, pp. 75-84
-
-
Norman, R.A.1
Barry, S.T.2
Bate, M.3
Breed, J.4
Colls, J.G.5
Ernill, R.J.6
Luke, R.W.A.7
Minshull, C.A.8
McAlister, M.S.B.9
McCall, E.J.10
McMiken, H.H.J.11
Paterson, D.S.12
Timms, D.13
Tucker, J.A.14
Pauptit, R.A.15
-
94
-
-
2442467753
-
Inhibitors of ADP-Ribosylating Bacterial Toxins Based on Oxacarbenium Ion Character at Their Transition States
-
DOI 10.1021/ja038159+
-
Zhou, G. C., Parikh, S. L., Tyler, P. C., Evans, G. B., Furneaux, R. H., Zubkova, O. V., Benjes, P. A., and Schramm, V. L. (2004) Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states J. Am. Chem. Soc. 126, 5690-5698 (Pubitemid 38621407)
-
(2004)
Journal of the American Chemical Society
, vol.126
, Issue.18
, pp. 5690-5698
-
-
Zhou, G.-C.1
Parikh, S.L.2
Tyler, P.C.3
Evans, G.B.4
Furneaux, R.H.5
Zubkova, O.V.6
Benjes, P.A.7
Schramm, V.L.8
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