Benchmark reaction rates, the stability of biological molecules in water, and the evolution of catalytic power in enzymes

Annual Review of Biochemistry

Volumn 80, Issue , 2011, Pages 645-667

  Wolfenden, Richard ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

catalytic proficiency; enzyme evolution; rate enhancement; transition state analog

Indexed keywords

ADENOSINE; ADENOSINE TRIPHOSPHATE; AMINO ACID; BENZOIC ACID DERIVATIVE; CARBON; CARBOXYLIC ACID DERIVATIVE; CYTIDINE; DIHYDROOROTIC ACID DERIVATIVE; FUMARIC ACID; GUANOSINE; HYDROGEN; MANDELIC ACID; NITROGEN; OROTIDINE 5' PHOSPHATE DECARBOXYLASE; OXYGEN; PEPTIDYLTRANSFERASE; PHOSPHORAMIDIC ACID; PHOSPHORUS; PHOSPHORUS PENTOXIDE; POLYMER; POLYSACCHARIDE; RNA; SULFUR; UREA; UROPORPHYRINOGEN; WATER;

ARTICLE; CATALYST; CHEMICAL BOND; CHEMICAL REACTION KINETICS; DECARBOXYLATION; ENZYME ACTIVITY; HALF LIFE TIME; HYDROLYSIS; MOLECULAR EVOLUTION; MOLECULAR STABILITY; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; RACEMIZATION; RIBOSOME; RING OPENING; TEMPERATURE SENSITIVITY; THERMODYNAMICS; WARMING;

EID: 79959431109     PISSN: 00664154     EISSN: 00664154     Source Type: Book Series    
DOI: 10.1146/annurev-biochem-060409-093051     Document Type: Article

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