Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 46, 2011, Pages 18661-18665

  Silva, Rafael G ^a   Murkin, Andrew S ^a,b   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Enzymatic catalysis; Femtosecond motions; Kinetic isotope effect; Protein dynamics; Transition state structure

Indexed keywords

BORN OPPENHEIMER ENZYME; CARBON 13; DEUTERIUM; ENZYME; NITROGEN 15; PURINE NUCLEOSIDE PHOSPHORYLASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME BINDING; FEMTOSECOND DYNAMICS; ISOTOPE LABELING; KINETICS; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROBABILITY; PROTEIN METABOLISM; STEADY STATE; VIBRATION;

BINDING SITES; BIOCHEMISTRY; CATALYSIS; ENZYMES; HUMANS; INOSINE; KINETICS; MODELS, CHEMICAL; MOTION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEINS; PURINE-NUCLEOSIDE PHOSPHORYLASE; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY;

EID: 81755172909     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1114900108     Document Type: Article

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