Conformational aspects of inhibitor design: Enzyme-substrate interactions in the transition state

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 5, 1999, Pages 647-652

  Wolfenden, Richard ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ENZYME; ENZYME INHIBITOR; INOSINE; PENTOSTATIN;

BINDING AFFINITY; CONFORMATIONAL TRANSITION; DISSOCIATION CONSTANT; DRUG DESIGN; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; REVIEW;

DRUG DESIGN; ENZYME INHIBITORS; KINETICS; MODELS, CHEMICAL; PROTEIN CONFORMATION;

EID: 0033136041     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00247-8     Document Type: Review

References (40)

1. Segal, H. I. In The Enzymes, 2nd edition; Boyer, P. D.; Lardy, H.; Myrbäck, K., Eds.; Academic: New York, 1959; Vol. 1, pp 1-48.
2. Polanyi, M. Zeitschrift für Elektrochemie 1921, 27, 143.
3. Schwab, G.-M. Catalysis (Transl. from the German by Taylor, H. S. and Spence, R.); van Nostrand: New York, 1937; pp 241-243.
4. Pauling, L. Chem. Eng. News. 1946, 24, 1375.
5. Jencks, W. P. In Current Aspects of Biochemical Energetics; Kaplan, N. O.; Kennedy, E. P., Eds.; Academic: New York, 1966; pp 273-298.
6. Wolfenden, R. Nature 1969, 223, 704.
7. Campbell, I. D.; Jones, R. B.; Kiener, P. A.; Richards, E.; Waley, S. G.; Wolfenden, R. Biochem. Biophys. Res. Comm. 1978, 83, 347.
8. (a) Wolfenden, R. Accts. Chem. Res. 1972, 5, 10.
9. (b) Lienhard, G. E. Science 1973, 180, 149.
10. (c) Wolfenden, R. Ann. Rev. Biophys. Bioeng. 1976, 5, 271.
11. Radzicka, A.; Wolfenden, R. In Contemporary Enzyme Kinetics and Mechanism, 2nd edition; Purich, D. L., Ed.; Academic: New York, 1996: pp 273-298.
12. Huff, J. R. J. Med. Chem. 1991, 34, 2305.
13. Maurizi, M. R.; Ginsberg, A. J. Biol. Chem. 1982, 257, 4271.
14. Schramm, V. L.; Baker, D. C. Biochemistry 1985, 24, 641.
15. Kati, W. M.; Wolfenden, R. Biochemistry 1989, 28, 7919.
16. Wilson, D. K.; Rudolph, F. B.; Quiocho, F. A. Science 1991, 252, 1278.
17. Shih, P.; Wolfenden, R. Biochemistry 1996, 35, 4697.
18. Webb, J. L. Enzyme and Metabolic Inhibitors; Academic: New York, 1966; Vol. 2, pp 245-616.
19. Johnson, L.; Wolfenden, R. J. Mol. Biol. 1970, 47, 93.
20. Lolis, E.; Petsko, G. A. Biochemistry 1990, 29, 6619.
21. Betts, L.; Xiang, S.; Short, S. A.; Wolfenden, R.; Carter, C. W., Jr. J. Mol. Biol. 1994, 235, 635.
22. Wolfenden, R. Mol. Cell. Biochem. 1974, 3, 207.
23. Kati, W. M.; Acheson, S. A.; Wolfenden, R. Biochemistry 1992, 31, 7356.
24. Carlow, D. C.; Wolfenden, R. Biochemistry 1998, 37, 11873.
25. Page, M. I.; Jencks, W. P. Proc. Natl. Acad. Sci., USA 1971, 68, 1678.
26. Westerik, J. O.; Wolfenden, R. J. Biol. Chem. 1972, 247, 8195.
27. Thompson, R. C. J. Biol. Chem. 1973, 12, 47.
28. (a) Bartlett, P. A.; Marlowe, C. K. Biochemistry 1983, 22, 4618.
29. (b) Mader, M. M.; Bartlett, P. A. 1997, 97, 1281.
30. Andersson, L.; Wolfenden, R. J. Biol. Chem. 1980, 255, 11106.
31. Harcourt, A. V. J. Chem. Soc. 1867, 20, 460.
32. Radzicka, A.; Wolfenden, R. Science 1995, 267, 90.
33. Radzicka, A.; Wolfenden, R. J. Am. Chem. Soc. 1996, 118, 6105.
34. Wolfenden, R.; Ridgway, C.; Young, G. J. Amer. Chem. Soc. 1998, 120, 833.
35. Wolfenden, R.; Lu, X.; Young, G. J. Amer. Chem. Soc. 1998, 120, 6814.
36. Bearne, S. L.; Wolfenden, R. J. Amer. Chem. Soc. 1995, 117, 9588.
37. Bearne, S. L.; Wolfenden, R., Biochemistry 1997, 36, 1646.
38. Andrews, P. R.; Smith, G. D.; Young, I. G. Biochemistry 1973, 12, 3492.
39. Ghanem, A.; Tsen, W.; Rowlett, R. S. J. Biol. Chem. 1986, 261, 1164.
40. Cleland, W. W. In Contemporary Enzyme Kinetics and Mechanism, 2nd edition; Purich, D. L., Ed.; Academic: New York, 1996; pp 407-440.