Picomolar inhibitors as transition-state probes of 5′-methylthioadenosine nucleosidases

ACS Chemical Biology

Volumn 2, Issue 11, 2007, Pages 725-734

  Gutierrez, Jemy A ^a   Luo, Minkui ^a   Singh, Vipender ^a   Li, Lei ^a   Brown, Rosemary L ^b   Norris, Gillain E ^b   Evans, Gary B ^c   Furneaux, Richard H ^c   Tyler, Peter C ^c   Painter, Gavin F ^c   Lenz, Dirk H ^c   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b MASSEY UNIVERSITY   (New Zealand)

^c CALLAGHAN INNOVATION   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

5' METHYLTHIOADENOSINE NUCLEOSIDASE INHIBITOR; ANTIINFECTIVE AGENT; CARBON 14; DADME IMMUCILLIN A; ENZYME INHIBITOR; IMMUCILLIN A; METHYLTHIOADENOSINE NUCLEOSIDASE; NUCLEOSIDASE; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG DESIGN; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ESCHERICHIA COLI; HELICOBACTER PYLORI; HUMAN; KLEBSIELLA PNEUMONIAE; NEISSERIA MENINGITIDIS; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTEIN TARGETING; QUORUM SENSING; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; ENZYME INHIBITORS; ISOTOPES; MOLECULAR MIMICRY; MOLECULAR PROBES; PROTEIN BINDING; PROTEIN CONFORMATION; PURINE-NUCLEOSIDE PHOSPHORYLASE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; HELICOBACTER PYLORI; KLEBSIELLA PNEUMONIAE; NEISSERIA MENINGITIDIS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

EID: 37349047044     PISSN: 15548929     EISSN: None     Source Type: Journal    
DOI: 10.1021/cb700166z     Document Type: Article

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