An alternative menaquinone biosynthetic pathway operating in microorganisms

Science

Volumn 321, Issue 5896, 2008, Pages 1670-1673

  Hiratsuka, Tomoshige ^a   Furihata, Kazuo ^b   Ishikawa, Jun ^c   Yamashita, Haruyuki ^d   Itoh, Nobuya ^a   Seto, Haruo ^e   Dairi, Tohru ^a  

^a TOYAMA PREFECTURAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^d ADEKA CORPORATION   (Japan)

^e TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHORISMIC ACID; MENAQUINONE; RECOMBINANT ENZYME;

BIOINFORMATICS; CHEMOTHERAPY; ELECTRON; ENZYME ACTIVITY; GENETIC ANALYSIS; GENOMICS; MICROBIAL ACTIVITY; PATHOGEN; VITAMIN;

ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BIOINFORMATICS; BIOSYNTHESIS; CAMPYLOBACTER JEJUNI; COMMENSAL; ELECTRON TRANSPORT; ESCHERICHIA COLI; FUNGAL STRAIN; GENE SEQUENCE; HELICOBACTER PYLORI; INTESTINE FLORA; LACTOBACILLUS; MEN GENE; MOLECULAR CLONING; MUTANT; NONHUMAN; PRIORITY JOURNAL; STREPTOMYCES;

ARCHAEA; BACTERIA; BIOSYNTHETIC PATHWAYS; CAMPYLOBACTER JEJUNI; CHORISMIC ACID; CLONING, MOLECULAR; COMPUTATIONAL BIOLOGY; ENZYMES; GENES, BACTERIAL; HELICOBACTER PYLORI; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NUCLEOSIDES; RECOMBINANT PROTEINS; STREPTOMYCES COELICOLOR; THERMUS THERMOPHILUS; VITAMIN K 2;

BACTERIA (MICROORGANISMS); CAMPYLOBACTER JEJUNI; ESCHERICHIA COLI; HELICOBACTER PYLORI; STREPTOMYCES;

EID: 52249100797     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1160446     Document Type: Article

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24. This work was supported in part by a Grant-in-Aid for Scientific Research (B) to S.H. and by a Grant-in-Aid for Scientific Research on Priority Areas "Applied Genomics" from the Ministry of Education, Culture, Sports, Science and Technology of Japan, the Urakami Foundation, and the Skylark Food Science Institute to T.D. Author contributions: T.H., H.S., and T.D. conceived and designed the experiments; T.H., K.F., J.I., H.S., and T.D. performed the experiments; T.H., K.F., H.Y., N.I., H.S., and T.D. analyzed the data; and H.S. and T.D. wrote the paper. The DNA sequences determined and characterized in this study have been deposited in the DDBJ, EMBL, and GenBank data banks as follows: SCO4506, AB447888; SCO4327, AB447889; SCO4550, AB447890; SCO4326, AB447891; TTHA0556, AB447892; TTHA1568, AB447893.