Atomic detail of chemical transformation at the transition state of an enzymatic reaction

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 43, 2008, Pages 16543-16548

  Saen oon, Suwipa ^a   Quaytman Machleder, Sara ^a   Schramm, Vern L ^a   Schwartz, Steven D ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Dynamics in catalysis; Promoting vibrations; Purine nucleoside phosphorylase; Transition path sampling; Transition state lifetime

Indexed keywords

CARBON; ENZYME; ION; PHOSPHATE; PURINE NUCLEOSIDE PHOSPHORYLASE; RIBOSE 1 PHOSPHATE;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL BOND; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; ENZYME ACTIVITY; ENZYME MECHANISM; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MECHANICS; MOTION; NUCLEAR ENERGY; PRIORITY JOURNAL; REACTION ANALYSIS; VIBRATION;

CATALYSIS; HUMANS; KINETICS; MODELS, CHEMICAL; MOTION; PROBABILITY; PROTEIN CONFORMATION; PURINE-NUCLEOSIDE PHOSPHORYLASE; RIBOSEMONOPHOSPHATES; VIBRATION;

EID: 55949096608     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0808413105     Document Type: Article

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