Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5′-methylthioadenosine phosphorylase

Journal of Biological Chemistry

Volumn 286, Issue 6, 2011, Pages 4902-4911

  Basu, Indranil ^a   Locker, Joseph ^a   Cassera, Maria B ^a   Belbin, Thomas J ^a   Merino, Emilio F ^a   Dong, Xinyuan ^a   Hemeon, Ivan ^a   Evans, Gary B ^b   Guha, Chandan ^a   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b CALLAGHAN INNOVATION   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-TUMOR ACTIVITIES; GENE EXPRESSION PROFILES; HUMAN LUNG; IN-VIVO; LUNG CANCER THERAPY; METHYLTHIOADENOSINE PHOSPHORYLASE; NON-SMALL CELL LUNG CARCINOMATA; POLYAMINES; S-ADENOSYLMETHIONINE; SALVAGE ENZYMES; TRANSITION-STATE ANALOGUES; TUMOR GROWTH; TUMOR SUPPRESSORS;

AMINO ACIDS; BIOLOGICAL ORGANS; DISEASES; GENE EXPRESSION; PHOSPHORYLATION;

TUMORS;

1 [(9 DEAZAADENIN 9 YL)METHYL] 3 HYDROXY 4 (METHYLTHIOMETHYL)PYRROLIDINE; 5' METHYLTHIOADENOSINE; 5' METHYLTHIOADENOSINE PHOSPHORYLASE; ADENINE; ANTIMETASTATIC AGENT; MESSENGER RNA; METHIONINE; POLYAMINE DERIVATIVE; RAG2 PROTEIN; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG; 5'-METHYLTHIOADENOSINE; 5'-METHYLTHIOADENOSINE PHOSPHORYLASE; ANTINEOPLASTIC AGENT; DEOXYADENOSINE DERIVATIVE; DRUG DERIVATIVE; IMMUCILLIN A; METHYLTHIO DADME IMMUCILLIN A; METHYLTHIO-DADME-IMMUCILLIN-A; NUCLEOSIDE; PURINE NUCLEOSIDE PHOSPHORYLASE; PYRROLIDINE DERIVATIVE; TUMOR SUPPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CONTROLLED STUDY; DOWN REGULATION; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG METABOLISM; DRUG STRUCTURE; DRUG TUMOR LEVEL; DRUG URINE LEVEL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG ALVEOLUS CELL CARCINOMA; LUNG NON SMALL CELL CANCER; MALE; METASTASIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT; UPREGULATION; ANIMAL; CANCER TRANSPLANTATION; DRUG ANTAGONISM; DRUG SCREENING; ENZYMOLOGY; GENETICS; LUNG TUMOR; METABOLISM; METASTASIS; METHODOLOGY; NUDE MOUSE; TUMOR CELL LINE; XENOGRAFT;

MUS;

ADENINE; ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; DEOXYADENOSINES; HUMANS; LUNG NEOPLASMS; MICE; MICE, NUDE; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; PURINE-NUCLEOSIDE PHOSPHORYLASE; PYRROLIDINES; S-ADENOSYLMETHIONINE; THIONUCLEOSIDES; TRANSPLANTATION, HETEROLOGOUS; TUMOR SUPPRESSOR PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79953000186     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.198374     Document Type: Article

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