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Volumn 27, Issue 1, 2013, Pages 64-80

The role of endocannabinoids in pain modulation

Author keywords

2 arachidonoylglycerol; Analgesia; Anandamide, N arachidonoylethanolamine; Antinociception; CB receptors; Endocannabinoids

Indexed keywords

7 PHENYL 1 [5 (2 PYRIDINYL) 2 OXAZOLYL] 1 HEPTANONE; ARVANIL; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; ENDOCANNABINOID; GAMMA INTERFERON; INTERLEUKIN 6; N (4 HYDROXYPHENYL)ARACHIDONAMIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84872425727     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/fcp.12008     Document Type: Review
Times cited : (74)

References (196)
  • 1
    • 33644804271 scopus 로고    scopus 로고
    • The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids
    • Pertwee R.G. The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids. AAPS J. (2005) 7 625-654.
    • (2005) AAPS J. , vol.7 , pp. 625-654
    • Pertwee, R.G.1
  • 3
    • 0034666557 scopus 로고    scopus 로고
    • SR141716A enhances spatial memory as assessed in a radial-arm maze task in rats
    • Lichtman A.H. SR141716A enhances spatial memory as assessed in a radial-arm maze task in rats. Eur. J. Pharmacol. (2000) 404 175-179.
    • (2000) Eur. J. Pharmacol. , vol.404 , pp. 175-179
    • Lichtman, A.H.1
  • 5
    • 77649275461 scopus 로고    scopus 로고
    • Cannabinoids and the gut: new developments and emerging concepts
    • Izzo A.A., Sharkey K.A. Cannabinoids and the gut: new developments and emerging concepts. Pharmacol. Ther. (2010) 126 21-38.
    • (2010) Pharmacol. Ther. , vol.126 , pp. 21-38
    • Izzo, A.A.1    Sharkey, K.A.2
  • 6
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda L.A., Lolait S.J., Brownstein M.J., Young A.C., Bonner T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature (1990) 346 561-564.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 7
    • 0034467577 scopus 로고    scopus 로고
    • Control of the cell survival/death decision by cannabinoids
    • Guzman M., Sanchez C., Galve-Roperh I. Control of the cell survival/death decision by cannabinoids. J. Mol. Med. (2001) 78 613-625.
    • (2001) J. Mol. Med. , vol.78 , pp. 613-625
    • Guzman, M.1    Sanchez, C.2    Galve-Roperh, I.3
  • 8
    • 0027078685 scopus 로고
    • Isolation and structure of a brain constituent that binds to the cannabinoid receptor
    • Devane W.A., Hanus L., Breuer A. et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science (1992) 258 1946-1949.
    • (1992) Science , vol.258 , pp. 1946-1949
    • Devane, W.A.1    Hanus, L.2    Breuer, A.3
  • 9
    • 36849007485 scopus 로고    scopus 로고
    • Symptom-related changes of endocannabinoid and palmitoylethanolamide levels in brain areas of R6/2 mice, a transgenic model of Huntington's disease
    • Bisogno T., Martire A., Petrosino S., Popoli P., Di Marzo V. Symptom-related changes of endocannabinoid and palmitoylethanolamide levels in brain areas of R6/2 mice, a transgenic model of Huntington's disease. Neurochem. Int. (2008) 52 307-313.
    • (2008) Neurochem. Int. , vol.52 , pp. 307-313
    • Bisogno, T.1    Martire, A.2    Petrosino, S.3    Popoli, P.4    Di Marzo, V.5
  • 11
    • 34547100965 scopus 로고    scopus 로고
    • Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption
    • Rajesh M., Mukhopadhyay P., Batkai S. et al. Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption. Am. J. Physiol. Heart Circ. Physiol. (2007) 293 610-619.
    • (2007) Am. J. Physiol. Heart Circ. Physiol. , vol.293 , pp. 610-619
    • Rajesh, M.1    Mukhopadhyay, P.2    Batkai, S.3
  • 12
    • 38349113185 scopus 로고    scopus 로고
    • CB2 cannabinoid receptor agonists attenuate TNF-α-induced human vascular smooth muscle cell proliferation and migration
    • Rajesh M., Mukhopadhyay P., Hasko G., Huffman J.W., Mackie K., Pacher P. CB2 cannabinoid receptor agonists attenuate TNF-α-induced human vascular smooth muscle cell proliferation and migration. Br. J. Pharmacol. (2008) 153 347-357.
    • (2008) Br. J. Pharmacol. , vol.153 , pp. 347-357
    • Rajesh, M.1    Mukhopadhyay, P.2    Hasko, G.3    Huffman, J.W.4    Mackie, K.5    Pacher, P.6
  • 13
    • 0242268553 scopus 로고    scopus 로고
    • The molecular logic of endocannabinoid signalling
    • Piomelli D. The molecular logic of endocannabinoid signalling. Nat. Rev. Neurosci. (2003) 4 873-884.
    • (2003) Nat. Rev. Neurosci. , vol.4 , pp. 873-884
    • Piomelli, D.1
  • 14
    • 0026357750 scopus 로고
    • Characterization and localization of cannabinoid receptors in brain: an in vitro technique using slide-mounted tissue sections
    • Herkenham M. Characterization and localization of cannabinoid receptors in brain: an in vitro technique using slide-mounted tissue sections. NIDA Res. Monogr. (1991) 112 129-145.
    • (1991) NIDA Res. Monogr. , vol.112 , pp. 129-145
    • Herkenham, M.1
  • 15
    • 0025954862 scopus 로고
    • Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
    • Herkenham M., Lynn A.B., Johnson M.R., Melvin L.S., de Costa B.R., Rice K.C. Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J. Neurosci. (1991) 11 563-583.
    • (1991) J. Neurosci. , vol.11 , pp. 563-583
    • Herkenham, M.1    Lynn, A.B.2    Johnson, M.R.3    Melvin, L.S.4    de Costa, B.R.5    Rice, K.C.6
  • 17
    • 0038692066 scopus 로고    scopus 로고
    • Cannabis and the brain
    • Iversen L. Cannabis and the brain. Brain (2003) 126 1252-1270.
    • (2003) Brain , vol.126 , pp. 1252-1270
    • Iversen, L.1
  • 18
    • 29744460503 scopus 로고    scopus 로고
    • Subcellular localization of type 1 cannabinoid receptors in the rat basal ganglia
    • Matyas F., Yanovsky Y., Mackie K., Kelsch W., Misgeld U., Freund T.F. Subcellular localization of type 1 cannabinoid receptors in the rat basal ganglia. Neuroscience (2006) 137 337-361.
    • (2006) Neuroscience , vol.137 , pp. 337-361
    • Matyas, F.1    Yanovsky, Y.2    Mackie, K.3    Kelsch, W.4    Misgeld, U.5    Freund, T.F.6
  • 19
    • 1842428537 scopus 로고    scopus 로고
    • Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism
    • Carrier E.J., Kearn C.S., Barkmeier A.J. et al. Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism. Mol. Pharmacol. (2004) 65 999-1007.
    • (2004) Mol. Pharmacol. , vol.65 , pp. 999-1007
    • Carrier, E.J.1    Kearn, C.S.2    Barkmeier, A.J.3
  • 20
    • 32844465920 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors: immunohistochemical localization in rat brain
    • Gong J.P., Onaivi E.S., Ishiguro H. et al. Cannabinoid CB2 receptors: immunohistochemical localization in rat brain. Brain Res. (2006) 1071 10-23.
    • (2006) Brain Res. , vol.1071 , pp. 10-23
    • Gong, J.P.1    Onaivi, E.S.2    Ishiguro, H.3
  • 21
    • 13244283049 scopus 로고    scopus 로고
    • Synthetic cannabinoid WIN55, 212-2 inhibits generation of inflammatory mediators by IL-1beta-stimulated human astrocytes
    • Sheng W.S., Hu S., Min X., Cabral G.A., Lokensgard J.R., Peterson P.K. Synthetic cannabinoid WIN55, 212-2 inhibits generation of inflammatory mediators by IL-1beta-stimulated human astrocytes. Glia (2005) 49 211-219.
    • (2005) Glia , vol.49 , pp. 211-219
    • Sheng, W.S.1    Hu, S.2    Min, X.3    Cabral, G.A.4    Lokensgard, J.R.5    Peterson, P.K.6
  • 22
    • 33749544716 scopus 로고    scopus 로고
    • Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain
    • Onaivi E.S., Ishiguro H., Gong J.P. et al. Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain. Ann. N. Y. Acad. Sci. (2006) 1074 514-536.
    • (2006) Ann. N. Y. Acad. Sci. , vol.1074 , pp. 514-536
    • Onaivi, E.S.1    Ishiguro, H.2    Gong, J.P.3
  • 25
    • 69649091696 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptor agonists protect the striatum against malonate toxicity: relevance for Huntington's disease
    • Sagredo O., Gonzalez S., Aroyo I. et al. Cannabinoid CB2 receptor agonists protect the striatum against malonate toxicity: relevance for Huntington's disease. Glia (2009) 57 1154-1167.
    • (2009) Glia , vol.57 , pp. 1154-1167
    • Sagredo, O.1    Gonzalez, S.2    Aroyo, I.3
  • 26
    • 8844260491 scopus 로고    scopus 로고
    • Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors
    • Golech S.A., McCarron R.M., Chen Y. et al. Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors. Brain Res. Mol. Brain Res. (2004) 132 87-92.
    • (2004) Brain Res. Mol. Brain Res. , vol.132 , pp. 87-92
    • Golech, S.A.1    McCarron, R.M.2    Chen, Y.3
  • 27
    • 26844504226 scopus 로고    scopus 로고
    • Identification and functional characterization of brainstem cannabinoid CB2 receptors
    • Van Sickle M.D., Duncan M., Kingsley P.J. et al. Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science (2005) 310 329-332.
    • (2005) Science , vol.310 , pp. 329-332
    • Van Sickle, M.D.1    Duncan, M.2    Kingsley, P.J.3
  • 28
    • 24044458606 scopus 로고    scopus 로고
    • Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons
    • Wotherspoon G., Fox A., McIntyre P., Colley S., Bevan S., Winter J. Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons. Neuroscience (2005) 135 235-245.
    • (2005) Neuroscience , vol.135 , pp. 235-245
    • Wotherspoon, G.1    Fox, A.2    McIntyre, P.3    Colley, S.4    Bevan, S.5    Winter, J.6
  • 29
    • 33244493807 scopus 로고    scopus 로고
    • Expression of the cannabinoid CB2 receptor in the rat cerebellum: an immunohistochemical study
    • Ashton J.C., Friberg D., Darlington C.L., Smith P.F. Expression of the cannabinoid CB2 receptor in the rat cerebellum: an immunohistochemical study. Neurosci. Lett. (2006) 396 113-116.
    • (2006) Neurosci. Lett. , vol.396 , pp. 113-116
    • Ashton, J.C.1    Friberg, D.2    Darlington, C.L.3    Smith, P.F.4
  • 30
    • 0029094470 scopus 로고
    • Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
    • Galiegue S., Mary S., Marchand J. et al. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur. J. Biochem. (1995) 232 54-61.
    • (1995) Eur. J. Biochem. , vol.232 , pp. 54-61
    • Galiegue, S.1    Mary, S.2    Marchand, J.3
  • 31
    • 0031062297 scopus 로고    scopus 로고
    • Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune system
    • Schatz A.R., Lee M., Condie R.B., Pulaski J.T., Kaminski N.E. Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune system. Toxicol. Appl. Pharmacol. (1997) 142 278-287.
    • (1997) Toxicol. Appl. Pharmacol. , vol.142 , pp. 278-287
    • Schatz, A.R.1    Lee, M.2    Condie, R.B.3    Pulaski, J.T.4    Kaminski, N.E.5
  • 32
    • 37249091964 scopus 로고    scopus 로고
    • Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis
    • Rajesh M., Pan H., Mukhopadhyay P. et al. Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis. J. Leukoc. Biol. (2007) 82 1382-1389.
    • (2007) J. Leukoc. Biol. , vol.82 , pp. 1382-1389
    • Rajesh, M.1    Pan, H.2    Mukhopadhyay, P.3
  • 33
    • 0036019385 scopus 로고    scopus 로고
    • CB(1) and CB(2) receptor-mediated signalling: a focus on endocannabinoids
    • McAllister S.D., Glass M. CB(1) and CB(2) receptor-mediated signalling: a focus on endocannabinoids. Prostaglandins Leukot. Essent. Fatty Acids (2002) 66 161-171.
    • (2002) Prostaglandins Leukot. Essent. Fatty Acids , vol.66 , pp. 161-171
    • McAllister, S.D.1    Glass, M.2
  • 34
    • 33144480327 scopus 로고    scopus 로고
    • Cannabinoid receptors as therapeutic targets
    • Mackie K. Cannabinoid receptors as therapeutic targets. Annu. Rev. Pharmacol. Toxicol. (2006) 46 101-122.
    • (2006) Annu. Rev. Pharmacol. Toxicol. , vol.46 , pp. 101-122
    • Mackie, K.1
  • 35
    • 0037062411 scopus 로고    scopus 로고
    • An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors
    • Huang S.M., Bisogno T., Trevisani M. et al. An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc. Natl Acad. Sci. USA (2002) 99 8400-8405.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 8400-8405
    • Huang, S.M.1    Bisogno, T.2    Trevisani, M.3
  • 36
    • 0036260823 scopus 로고    scopus 로고
    • Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor
    • Porter A.C., Sauer J.M., Knierman M.D. et al. Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor. J. Pharmacol. Exp. Ther. (2002) 301 1020-1024.
    • (2002) J. Pharmacol. Exp. Ther. , vol.301 , pp. 1020-1024
    • Porter, A.C.1    Sauer, J.M.2    Knierman, M.D.3
  • 38
    • 0034614374 scopus 로고    scopus 로고
    • Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor-comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells
    • Sugiura T., Kondo S., Kishimoto S. et al. Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor-comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells. J. Biol. Chem. (2000) 275 605-612.
    • (2000) J. Biol. Chem. , vol.275 , pp. 605-612
    • Sugiura, T.1    Kondo, S.2    Kishimoto, S.3
  • 39
    • 0029154145 scopus 로고
    • Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes
    • Venance L., Piomelli D., Glowinski J., Giaume C. Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes. Nature (1995) 376 590-594.
    • (1995) Nature , vol.376 , pp. 590-594
    • Venance, L.1    Piomelli, D.2    Glowinski, J.3    Giaume, C.4
  • 40
    • 0033047698 scopus 로고    scopus 로고
    • Anandamide and WIN 55212-2 inhibit cyclic AMP formation through G-protein-coupled receptors distinct from CB1 cannabinoid receptors in cultured astrocytes
    • Sagan S., Venance L., Torrens Y., Cordier J., Glowinski J., Giaume C. Anandamide and WIN 55212-2 inhibit cyclic AMP formation through G-protein-coupled receptors distinct from CB1 cannabinoid receptors in cultured astrocytes. Eur. J. Neurosci. (1999) 11 691-699.
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 691-699
    • Sagan, S.1    Venance, L.2    Torrens, Y.3    Cordier, J.4    Glowinski, J.5    Giaume, C.6
  • 42
    • 0034717813 scopus 로고    scopus 로고
    • Interacting effects of capsaicin and anandamide on intracellular calcium in sensory neurones
    • Szoke E., Balla Z., Csernoch L., Czeh G., Szolcsanyi J. Interacting effects of capsaicin and anandamide on intracellular calcium in sensory neurones. NeuroReport (2000) 11 1949-1952.
    • (2000) NeuroReport , vol.11 , pp. 1949-1952
    • Szoke, E.1    Balla, Z.2    Csernoch, L.3    Czeh, G.4    Szolcsanyi, J.5
  • 43
    • 0029012014 scopus 로고
    • Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
    • Mechoulam R., Ben-Shabat S., Hanus L. et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol. (1995) 50 83-90.
    • (1995) Biochem. Pharmacol. , vol.50 , pp. 83-90
    • Mechoulam, R.1    Ben-Shabat, S.2    Hanus, L.3
  • 44
    • 0028970517 scopus 로고
    • 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain
    • Sugiura T., Kondo S., Sukagawa A. et al. 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem. Biophys. Res. Commun. (1995) 215 89-97.
    • (1995) Biochem. Biophys. Res. Commun. , vol.215 , pp. 89-97
    • Sugiura, T.1    Kondo, S.2    Sukagawa, A.3
  • 45
    • 33947128224 scopus 로고    scopus 로고
    • Endocannabinoids and the regulation of their levels in health and disease
    • Di Marzo V., Petrosino S. Endocannabinoids and the regulation of their levels in health and disease. Curr. Opin. Lipidol. (2007) 18 129-140.
    • (2007) Curr. Opin. Lipidol. , vol.18 , pp. 129-140
    • Di Marzo, V.1    Petrosino, S.2
  • 46
    • 40949112752 scopus 로고    scopus 로고
    • Pharmacotherapeutic targeting of the endocannabinoid signaling system: drugs for obesity and the metabolic syndrome
    • Vemuri V.K., Janero D.R., Makriyannis A. Pharmacotherapeutic targeting of the endocannabinoid signaling system: drugs for obesity and the metabolic syndrome. Physiol. Behav. (2008) 93 671-686.
    • (2008) Physiol. Behav. , vol.93 , pp. 671-686
    • Vemuri, V.K.1    Janero, D.R.2    Makriyannis, A.3
  • 47
    • 65549150497 scopus 로고    scopus 로고
    • Pharmacotherapeutic modulation of the endocannabinoid signalling system in psychiatric disorders: drug-discovery strategies
    • Janero D.R., Vadivel S.K., Makriyannis A. Pharmacotherapeutic modulation of the endocannabinoid signalling system in psychiatric disorders: drug-discovery strategies. Int. Rev. Psychiatry (2009) 21 122-133.
    • (2009) Int. Rev. Psychiatry , vol.21 , pp. 122-133
    • Janero, D.R.1    Vadivel, S.K.2    Makriyannis, A.3
  • 48
    • 0034332637 scopus 로고    scopus 로고
    • N-acyl-dopamines: novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo
    • Bisogno T., Melck D., Bobrov M. et al. N-acyl-dopamines: novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo. Biochem. J. (2000) 1 817-824.
    • (2000) Biochem. J. , vol.1 , pp. 817-824
    • Bisogno, T.1    Melck, D.2    Bobrov, M.3
  • 49
    • 0037207087 scopus 로고    scopus 로고
    • Endocannabinoids and related fatty acid derivatives in pain modulation
    • Walker M.J., Krey F.J., Chu C.J., Huang S.M. Endocannabinoids and related fatty acid derivatives in pain modulation. Chem. Phys. Lipids (2002) 121 159-172.
    • (2002) Chem. Phys. Lipids , vol.121 , pp. 159-172
    • Walker, M.J.1    Krey, F.J.2    Chu, C.J.3    Huang, S.M.4
  • 50
    • 0035957425 scopus 로고    scopus 로고
    • 2-Arachidonoyl glycerol ether, endogenous agonist of the cannabinoid CB1 receptor
    • Hanus L. et al. 2-Arachidonoyl glycerol ether, endogenous agonist of the cannabinoid CB1 receptor. Proc. Natl Acad. Sci. U S A (2001) 98 3662-3665.
    • (2001) Proc. Natl Acad. Sci. U S A , vol.98 , pp. 3662-3665
    • Hanus, L.1
  • 51
    • 0033567190 scopus 로고    scopus 로고
    • Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages
    • Di Marzo V., Bisogno T., De Petrocellis L. et al. Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages. Eur. J. Biochem. (1999) 264 258-267.
    • (1999) Eur. J. Biochem. , vol.264 , pp. 258-267
    • Di Marzo, V.1    Bisogno, T.2    De Petrocellis, L.3
  • 52
    • 79551562874 scopus 로고    scopus 로고
    • Endocannabinoids Generated by Ca2 + or by Metabotropic Glutamate Receptors Appear to Arise from Different Pools of Diacylglycerol Lipase
    • Longhua Z., Meina W., Bisogno Tiziana B., Di Marzo V., Alger B.E. Endocannabinoids Generated by Ca2 + or by Metabotropic Glutamate Receptors Appear to Arise from Different Pools of Diacylglycerol Lipase. PLoS One (2011) 6 16305.
    • (2011) PLoS One , vol.6 , pp. 16305
    • Longhua, Z.1    Meina, W.2    Bisogno Tiziana, B.3    Di Marzo, V.4    Alger, B.E.5
  • 53
    • 0035890082 scopus 로고    scopus 로고
    • Exogenous anandamide protects rat brain against acute neuronal injury in vivo
    • van Der Stelt M., Veldhuis W.B., van Haaften G.W. et al. Exogenous anandamide protects rat brain against acute neuronal injury in vivo. J. Neurosci. (2001) 21 8765-8771.
    • (2001) J. Neurosci. , vol.21 , pp. 8765-8771
    • van Der Stelt, M.1    Veldhuis, W.B.2    van Haaften, G.W.3
  • 54
    • 57449098411 scopus 로고    scopus 로고
    • The endocannabinoid system is modulated in response to spinal cord injury in rats
    • Garcia-Ovejero D., Arevalo-Martin A., Petrosino S. et al. The endocannabinoid system is modulated in response to spinal cord injury in rats. Neurobiol. Dis. (2009) 33 57-71.
    • (2009) Neurobiol. Dis. , vol.33 , pp. 57-71
    • Garcia-Ovejero, D.1    Arevalo-Martin, A.2    Petrosino, S.3
  • 55
    • 44849141696 scopus 로고    scopus 로고
    • Enzymatic pathways that regulate endocannabinoid signaling in the nervous system
    • Ahn K., McKinney M.K., Cravatt B.F. Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. Chem. Rev. (2008) 108 1687-1707.
    • (2008) Chem. Rev. , vol.108 , pp. 1687-1707
    • Ahn, K.1    McKinney, M.K.2    Cravatt, B.F.3
  • 56
    • 39349101977 scopus 로고    scopus 로고
    • Presynaptic modulation by endocannabinoids
    • Lovinger D.M. Presynaptic modulation by endocannabinoids. Handb. Exp. Pharmacol. (2008) 184 435-477.
    • (2008) Handb. Exp. Pharmacol. , vol.184 , pp. 435-477
    • Lovinger, D.M.1
  • 57
    • 80051743256 scopus 로고    scopus 로고
    • Estradiol decreases cortical reactive astrogliosis after brain injury by a mechanism involving cannabinoid receptors
    • Lopez R., Mateos Vicente B., Romero-Zerbo S.Y. et al. Estradiol decreases cortical reactive astrogliosis after brain injury by a mechanism involving cannabinoid receptors. Cereb. Cortex (2011) 21 2046-2055.
    • (2011) Cereb. Cortex , vol.21 , pp. 2046-2055
    • Lopez, R.1    Mateos Vicente, B.2    Romero-Zerbo, S.Y.3
  • 58
    • 0028837562 scopus 로고
    • Occurrence and postmortem generation of anandamide and other long-chain N-acylethanolamines in mammalian brain
    • Schmid P.C., Krebsbach R.J., Perry S.R., Dettmer T.M., Maasson J.L., Schmid H.H. Occurrence and postmortem generation of anandamide and other long-chain N-acylethanolamines in mammalian brain. FEBS Lett. (1995) 375 143-147.
    • (1995) FEBS Lett. , vol.375 , pp. 143-147
    • Schmid, P.C.1    Krebsbach, R.J.2    Perry, S.R.3    Dettmer, T.M.4    Maasson, J.L.5    Schmid, H.H.6
  • 59
    • 0034801539 scopus 로고    scopus 로고
    • Anandamide, but not 2-arachidonoylglycerol, accumulates during in vivo neurodegeneration
    • Hansen H.H., Schmid P.C., Bittigau P. et al. Anandamide, but not 2-arachidonoylglycerol, accumulates during in vivo neurodegeneration. J. Neurochem. (2001) 78 1415-1427.
    • (2001) J. Neurochem. , vol.78 , pp. 1415-1427
    • Hansen, H.H.1    Schmid, P.C.2    Bittigau, P.3
  • 61
    • 0021032702 scopus 로고
    • Catabolism of N-acylethanolamine phospholipids by dog brain preparations
    • Natarajan V., Schmid P.C., Reddy P.V., Schmid H.H. Catabolism of N-acylethanolamine phospholipids by dog brain preparations. J. Neurochem. (1984) 41 1303-1312.
    • (1984) J. Neurochem. , vol.41 , pp. 1303-1312
    • Natarajan, V.1    Schmid, P.C.2    Reddy, P.V.3    Schmid, H.H.4
  • 62
    • 0031033841 scopus 로고    scopus 로고
    • Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain
    • Cadas H., di Tomaso E., Piomelli D. Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain. J. Neurosci. (1997) 17 1226-1242.
    • (1997) J. Neurosci. , vol.17 , pp. 1226-1242
    • Cadas, H.1    di Tomaso, E.2    Piomelli, D.3
  • 64
    • 0038684167 scopus 로고    scopus 로고
    • Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models
    • Zhang J., Hoffert C., Vu H.K., Groblewski T., Ahmad S., O'Donnell D. Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models. Eur. J. Neurosci. (2003) 17 2750-2754.
    • (2003) Eur. J. Neurosci. , vol.17 , pp. 2750-2754
    • Zhang, J.1    Hoffert, C.2    Vu, H.K.3    Groblewski, T.4    Ahmad, S.5    O'Donnell, D.6
  • 65
    • 2442683462 scopus 로고    scopus 로고
    • Metabolism and physiological significance of anadamide and 2-arachidonoylglycerol, endogenous cannabinoid receptor ligands
    • Fonteh A.N., Wykle R.L. (Eds), Birkhδuser Verlag, Basel, Switzerland
    • Sugiura T., Kishimoto S., Oka S., Gokoh M., Wake K. Metabolism and physiological significance of anadamide and 2-arachidonoylglycerol, endogenous cannabinoid receptor ligands, in: Fonteh A.N., Wykle R.L. (Eds), Arachidonate remodeling and inflammation, Birkhδuser Verlag, Basel, Switzerland, 2004, pp. 211-237.
    • (2004) Arachidonate remodeling and inflammation , pp. 211-237
    • Sugiura, T.1    Kishimoto, S.2    Oka, S.3    Gokoh, M.4    Wake, K.5
  • 66
    • 38449086056 scopus 로고    scopus 로고
    • Endocannabinoids and traumatic brain injury
    • Mechoulam R., Shohami E. Endocannabinoids and traumatic brain injury. Mol. Neurobiol. (2007) 36 68-74.
    • (2007) Mol. Neurobiol. , vol.36 , pp. 68-74
    • Mechoulam, R.1    Shohami, E.2
  • 67
    • 0029027117 scopus 로고
    • Effects of a cannabinoid on spontaneous and evoked neuronal activity in the substantia nigra pars reticulata
    • Miller A.S., Walker J.M. Effects of a cannabinoid on spontaneous and evoked neuronal activity in the substantia nigra pars reticulata. Eur. J. Pharmacol. (1995) 279 179-185.
    • (1995) Eur. J. Pharmacol. , vol.279 , pp. 179-185
    • Miller, A.S.1    Walker, J.M.2
  • 68
    • 23044486763 scopus 로고    scopus 로고
    • Cannabinoids and the immune system: potential for the treatment of inflammatory diseases
    • Croxford J.L., Yamamura T. Cannabinoids and the immune system: potential for the treatment of inflammatory diseases. J. Neuroimmunol. (2005) 166 3-18.
    • (2005) J. Neuroimmunol. , vol.166 , pp. 3-18
    • Croxford, J.L.1    Yamamura, T.2
  • 69
    • 0029904838 scopus 로고    scopus 로고
    • Molecular characterization of an enzyme that degrades neuromodulatory fatty acid amides
    • Cravatt B.F., Giang D.K., Mayfield S.P., Boger D.L., Lerner R.A., Gilula N.B. Molecular characterization of an enzyme that degrades neuromodulatory fatty acid amides. Nature (1996) 384 83-87.
    • (1996) Nature , vol.384 , pp. 83-87
    • Cravatt, B.F.1    Giang, D.K.2    Mayfield, S.P.3    Boger, D.L.4    Lerner, R.A.5    Gilula, N.B.6
  • 70
    • 2942525207 scopus 로고    scopus 로고
    • Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172
    • Fegley D., Kathuria S., Mercier R. et al. Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proc. Natl Acad. Sci. USA (2004) 101 8756-8761.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 8756-8761
    • Fegley, D.1    Kathuria, S.2    Mercier, R.3
  • 71
    • 37149013708 scopus 로고    scopus 로고
    • A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol
    • Blankman J.L., Simon G.M., Cravatt B.F. A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem. Biol. (2007) 14 1347-1356.
    • (2007) Chem. Biol. , vol.14 , pp. 1347-1356
    • Blankman, J.L.1    Simon, G.M.2    Cravatt, B.F.3
  • 72
    • 48249097797 scopus 로고    scopus 로고
    • Endocannabinoids: synthesis and degradation
    • Di Marzo V. Endocannabinoids: synthesis and degradation. Rev. Physiol. Biochem. Pharmacol. (2008) 160 1-24.
    • (2008) Rev. Physiol. Biochem. Pharmacol. , vol.160 , pp. 1-24
    • Di Marzo, V.1
  • 73
    • 84555198880 scopus 로고    scopus 로고
    • A catalytically silent FAAH-1 variant drives anandamide transport in neurons
    • Fu J., Bottegoni G., Sasso O. et al. A catalytically silent FAAH-1 variant drives anandamide transport in neurons. Nat. Neurosci. (2011) 15 64-69.
    • (2011) Nat. Neurosci. , vol.15 , pp. 64-69
    • Fu, J.1    Bottegoni, G.2    Sasso, O.3
  • 74
    • 0032494704 scopus 로고    scopus 로고
    • A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain
    • Egertova M., Giang D.K., Cravatt B.F., Elphick M.R. A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain. Proc. Biol. Sci. (1998) 265 2081-2085.
    • (1998) Proc. Biol. Sci. , vol.265 , pp. 2081-2085
    • Egertova, M.1    Giang, D.K.2    Cravatt, B.F.3    Elphick, M.R.4
  • 75
    • 58749088402 scopus 로고    scopus 로고
    • Biochemical and Biological Properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a Mechanism-Based Inhibitor of Fatty Acid Amide Hydrolase
    • Karbarz M.J., Luo L., Chang L. et al. Biochemical and Biological Properties of 4-(3-phenyl-[1, 2, 4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a Mechanism-Based Inhibitor of Fatty Acid Amide Hydrolase. Anesth. Analg. (2009) 108 316-329.
    • (2009) Anesth. Analg. , vol.108 , pp. 316-329
    • Karbarz, M.J.1    Luo, L.2    Chang, L.3
  • 76
    • 0035979244 scopus 로고    scopus 로고
    • Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
    • Cravatt B.F., Demarest K., Patricelli M.P. et al. Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proc. Natl Acad. Sci. USA (2001) 98 9371-9376.
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 9371-9376
    • Cravatt, B.F.1    Demarest, K.2    Patricelli, M.P.3
  • 77
    • 0032829859 scopus 로고    scopus 로고
    • Equilibrium in the hydrolysis and synthesis of cannabimimetic anandamide demonstrated by a purified enzyme
    • Katayama K., Ueda N., Katoh I., Yamamoto S. Equilibrium in the hydrolysis and synthesis of cannabimimetic anandamide demonstrated by a purified enzyme. Biochim. Biophys. Acta (1999) 1440 205-214.
    • (1999) Biochim. Biophys. Acta , vol.1440 , pp. 205-214
    • Katayama, K.1    Ueda, N.2    Katoh, I.3    Yamamoto, S.4
  • 78
    • 0031589532 scopus 로고    scopus 로고
    • Reversible hydrolysis and synthesis of anandamide demonstrated by recombinant rat fatty-acid amide hydrolase
    • Kurahashi Y., Ueda N., Suzuki H., Suzuki M., Yamamoto S. Reversible hydrolysis and synthesis of anandamide demonstrated by recombinant rat fatty-acid amide hydrolase. Biochem. Biophys. Res. Commun. (1997) 237 512-515.
    • (1997) Biochem. Biophys. Res. Commun. , vol.237 , pp. 512-515
    • Kurahashi, Y.1    Ueda, N.2    Suzuki, H.3    Suzuki, M.4    Yamamoto, S.5
  • 79
    • 0030866539 scopus 로고    scopus 로고
    • The cloned rat hydrolytic enzyme responsible for the breakdown of anandamide also catalyzes its formation via the condensation of arachidonic acid and ethanolamine
    • Arreaza G., Devane W., Omeir R.L. et al. The cloned rat hydrolytic enzyme responsible for the breakdown of anandamide also catalyzes its formation via the condensation of arachidonic acid and ethanolamine. Neurosci. Lett. (1997) 234 59-62.
    • (1997) Neurosci. Lett. , vol.234 , pp. 59-62
    • Arreaza, G.1    Devane, W.2    Omeir, R.L.3
  • 80
    • 4644310682 scopus 로고    scopus 로고
    • ATP induces a rapid and pronounced increase in 2-arachidonoylglycerol production by astrocytes, a response limited by monoacylglycerol lipase
    • Walter L., Dinh T., Stella N. ATP induces a rapid and pronounced increase in 2-arachidonoylglycerol production by astrocytes, a response limited by monoacylglycerol lipase. J. Neurosci. (2004) 24 8068-8074.
    • (2004) J. Neurosci. , vol.24 , pp. 8068-8074
    • Walter, L.1    Dinh, T.2    Stella, N.3
  • 81
    • 0032559369 scopus 로고    scopus 로고
    • Anandamide aminohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand
    • Goparaju S.K., Udea N., Yamaguchi H., Yamamoto S. Anandamide aminohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand. FEBS Lett. (1998) 422 69-73.
    • (1998) FEBS Lett. , vol.422 , pp. 69-73
    • Goparaju, S.K.1    Udea, N.2    Yamaguchi, H.3    Yamamoto, S.4
  • 82
    • 33947319316 scopus 로고    scopus 로고
    • Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors
    • Maione S., De Petrocellis L., de Novellis V. et al. Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors. Br. J. Pharmacol. (2007) 150 766-781.
    • (2007) Br. J. Pharmacol. , vol.150 , pp. 766-781
    • Maione, S.1    De Petrocellis, L.2    de Novellis, V.3
  • 83
    • 0030611859 scopus 로고    scopus 로고
    • Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2
    • Yu M., Ives D., Ramesha C.S. Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2. J. Biol. Chem. (1997) 272 21181-21186.
    • (1997) J. Biol. Chem. , vol.272 , pp. 21181-21186
    • Yu, M.1    Ives, D.2    Ramesha, C.S.3
  • 84
    • 33748138697 scopus 로고    scopus 로고
    • Lipid signaling and synaptic plasticity
    • Sang N., Chen C. Lipid signaling and synaptic plasticity. Neuroscientist (2006) 2 425-434.
    • (2006) Neuroscientist , vol.2 , pp. 425-434
    • Sang, N.1    Chen, C.2
  • 85
    • 34548284823 scopus 로고    scopus 로고
    • COX-2 oxidative metabolite of endocannabinoid 2-AG enhances excitatory glutamatergic synaptic transmission and induces neurotoxicity
    • Sang N., Zhang J., Chen C. COX-2 oxidative metabolite of endocannabinoid 2-AG enhances excitatory glutamatergic synaptic transmission and induces neurotoxicity. J. Neurochem. (2007) 102 1966-1977.
    • (2007) J. Neurochem. , vol.102 , pp. 1966-1977
    • Sang, N.1    Zhang, J.2    Chen, C.3
  • 86
    • 0036267160 scopus 로고    scopus 로고
    • Pharmacological characterization of the anandamide cyclooxygenase metabolite:prostaglandin E2 ethanolamide
    • Ross R.A., Craib S.J., Stevenson L.A. et al. Pharmacological characterization of the anandamide cyclooxygenase metabolite:prostaglandin E2 ethanolamide. J. Pharmacol. Exp. Ther. (2002) 301 900-907.
    • (2002) J. Pharmacol. Exp. Ther. , vol.301 , pp. 900-907
    • Ross, R.A.1    Craib, S.J.2    Stevenson, L.A.3
  • 87
    • 1242342013 scopus 로고    scopus 로고
    • The glyceryl ester of prostaglandin E2 mobilize calcium and activates signal transduction in RAW 264.7 cells
    • Nirodi C.S., Crew B.C., Kozak K.R., Rorrow J.D., Marnett L.J. The glyceryl ester of prostaglandin E2 mobilize calcium and activates signal transduction in RAW 264.7 cells. Proc. Natl Acad. Sci. USA (2004) 101 1840-1845.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 1840-1845
    • Nirodi, C.S.1    Crew, B.C.2    Kozak, K.R.3    Rorrow, J.D.4    Marnett, L.J.5
  • 90
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner M.O. The biochemistry of apoptosis. Nature (2000) 407 770-776.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 91
    • 0030770947 scopus 로고    scopus 로고
    • Oxidative stress in closed-head injury: brain antioxidant capacity as an indicator of functional outcome
    • Shohami E., Beit-Yannai E., Horowitz M., Kohen R. Oxidative stress in closed-head injury: brain antioxidant capacity as an indicator of functional outcome. J. Cereb. Blood Flow Metab. (1997) 17 1007-1019.
    • (1997) J. Cereb. Blood Flow Metab. , vol.17 , pp. 1007-1019
    • Shohami, E.1    Beit-Yannai, E.2    Horowitz, M.3    Kohen, R.4
  • 92
    • 0031047431 scopus 로고    scopus 로고
    • Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant
    • Shohami E., Gallily R., Mechoulam R., Bass R., Ben Hur T. Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant. J. Neuroimmunol. (1997) 72 169-177.
    • (1997) J. Neuroimmunol. , vol.72 , pp. 169-177
    • Shohami, E.1    Gallily, R.2    Mechoulam, R.3    Bass, R.4    Ben Hur, T.5
  • 93
    • 0035676046 scopus 로고    scopus 로고
    • Cannabinoid-mediated inhibition of inducible nitric oxide production by rat microglial cells: evidence for CB1 receptor participation
    • Cabral G.A., Harmon K.N., Carlisle S.J. Cannabinoid-mediated inhibition of inducible nitric oxide production by rat microglial cells: evidence for CB1 receptor participation. Adv. Exp. Med. Biol. (2001) 493 207-214.
    • (2001) Adv. Exp. Med. Biol. , vol.493 , pp. 207-214
    • Cabral, G.A.1    Harmon, K.N.2    Carlisle, S.J.3
  • 94
    • 0031866598 scopus 로고    scopus 로고
    • The endogenous cannabinoid anandamide potentiates IL-6 production by astrocytes infected with Theiler's murine encephalomyelitis virus by a receptor- mediated pathway
    • Molina-Holgado F., Molina-Holgado E., Guaza C. The endogenous cannabinoid anandamide potentiates IL-6 production by astrocytes infected with Theiler's murine encephalomyelitis virus by a receptor- mediated pathway. FEBS Lett. (1998) 433 139-142.
    • (1998) FEBS Lett. , vol.433 , pp. 139-142
    • Molina-Holgado, F.1    Molina-Holgado, E.2    Guaza, C.3
  • 95
    • 0030071636 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor modulation of voltage-gated Ca2 + channels involves multiple receptor subtypes in cortical neurons
    • Choi S., Lovinger D.M. Metabotropic glutamate receptor modulation of voltage-gated Ca2 + channels involves multiple receptor subtypes in cortical neurons. J. Neurosci. (1996) 16 36-45.
    • (1996) J. Neurosci. , vol.16 , pp. 36-45
    • Choi, S.1    Lovinger, D.M.2
  • 96
    • 0030746408 scopus 로고    scopus 로고
    • Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons
    • Twitchell W., Brown S., Mackie K. Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons. J. Neurophysiol. (1997) 78 43-50.
    • (1997) J. Neurophysiol. , vol.78 , pp. 43-50
    • Twitchell, W.1    Brown, S.2    Mackie, K.3
  • 97
    • 0029937282 scopus 로고    scopus 로고
    • Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission in rat hippocampal cultures
    • Shen M., Piser T.M., Seybold V.S., Thayer S.A. Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission in rat hippocampal cultures. J. Neurosci. (1996) 16 4322-4334.
    • (1996) J. Neurosci. , vol.16 , pp. 4322-4334
    • Shen, M.1    Piser, T.M.2    Seybold, V.S.3    Thayer, S.A.4
  • 98
    • 0036773310 scopus 로고    scopus 로고
    • Acute neuronal injury, excitotoxicity, and the endocannabinoid system
    • van der Stelt M., Veldhuis W.B., Maccarrone M. et al. Acute neuronal injury, excitotoxicity, and the endocannabinoid system. Mol. Neurobiol. (2002) 26 317-346.
    • (2002) Mol. Neurobiol. , vol.26 , pp. 317-346
    • van der Stelt, M.1    Veldhuis, W.B.2    Maccarrone, M.3
  • 99
    • 33947628060 scopus 로고    scopus 로고
    • Molecular targets in cerebral ischemia for developing novel therapeutics
    • Mehta S.L., Manhas N., Raghubir R. Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res. Rev. (2007) 54 34-66.
    • (2007) Brain Res. Rev. , vol.54 , pp. 34-66
    • Mehta, S.L.1    Manhas, N.2    Raghubir, R.3
  • 100
    • 0021722983 scopus 로고
    • Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cell membranes
    • Howlett A.C., Fleming R.M. Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cell membranes. Mol. Pharmacol. (1984) 26 532-538.
    • (1984) Mol. Pharmacol. , vol.26 , pp. 532-538
    • Howlett, A.C.1    Fleming, R.M.2
  • 102
    • 0029842102 scopus 로고    scopus 로고
    • Regulation of a neuronal form of focal adhesion kinase by anandamide
    • Derkinderen P., Toutant M., Burgaya F. et al. Regulation of a neuronal form of focal adhesion kinase by anandamide. Science (1996) 273 1719-1722.
    • (1996) Science , vol.273 , pp. 1719-1722
    • Derkinderen, P.1    Toutant, M.2    Burgaya, F.3
  • 103
    • 0037444557 scopus 로고    scopus 로고
    • Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus
    • Derkinderen P., Valjent E., Toutant M. et al. Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus. J. Neurosci. (2003) 23 2371-2382.
    • (2003) J. Neurosci. , vol.23 , pp. 2371-2382
    • Derkinderen, P.1    Valjent, E.2    Toutant, M.3
  • 104
    • 0142166330 scopus 로고    scopus 로고
    • Cannabinoids: potential anticancer agents
    • Guzman M. Cannabinoids: potential anticancer agents. Nat. Rev. Cancer (2003) 3 745-755.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 745-755
    • Guzman, M.1
  • 105
    • 33646872652 scopus 로고    scopus 로고
    • Receptor-independent actions of cannabinoids on cell membranes: focus on endocannabinoids
    • Oz M. Receptor-independent actions of cannabinoids on cell membranes: focus on endocannabinoids. Pharmacol. Ther. (2006) 111 114-144.
    • (2006) Pharmacol. Ther. , vol.111 , pp. 114-144
    • Oz, M.1
  • 106
    • 0033614984 scopus 로고    scopus 로고
    • Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
    • Zygmunt P.M., Peterson J., Andersson D.A. et al. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature (1999) 400 452-457.
    • (1999) Nature , vol.400 , pp. 452-457
    • Zygmunt, P.M.1    Peterson, J.2    Andersson, D.A.3
  • 107
    • 23044515008 scopus 로고    scopus 로고
    • Lipids as regulators of the activity of transient receptor potential type V1 (TRPV1) channels
    • De Petrocellis L., Di Marzo V. Lipids as regulators of the activity of transient receptor potential type V1 (TRPV1) channels. Life Sci. (2005) 77 1651-1666.
    • (2005) Life Sci. , vol.77 , pp. 1651-1666
    • De Petrocellis, L.1    Di Marzo, V.2
  • 108
    • 0034644769 scopus 로고    scopus 로고
    • Anandamide induces apoptosis in human cells via vanilloid receptors - evidence for a protective role of cannabinoid receptors
    • Maccarrone M., Lorenzon T., Bari M., Melino G., Finazzi-Agro A. Anandamide induces apoptosis in human cells via vanilloid receptors - evidence for a protective role of cannabinoid receptors. J. Biol. Chem. (2000) 275 31938-31945.
    • (2000) J. Biol. Chem. , vol.275 , pp. 31938-31945
    • Maccarrone, M.1    Lorenzon, T.2    Bari, M.3    Melino, G.4    Finazzi-Agro, A.5
  • 109
    • 2342584603 scopus 로고    scopus 로고
    • The "dark side" of endocannabinoids: a neurotoxic role for anandamide
    • Cernak I., Vink R., Natale J. et al. The "dark side" of endocannabinoids: a neurotoxic role for anandamide. J. Cereb. Blood Flow Metab. (2004) 24 564-578.
    • (2004) J. Cereb. Blood Flow Metab. , vol.24 , pp. 564-578
    • Cernak, I.1    Vink, R.2    Natale, J.3
  • 110
    • 0032970173 scopus 로고    scopus 로고
    • Vanilloid (Capsaicin) receptors and mechanisms
    • Szallasi A., Blumberg P.M. Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol. Rev. (1999) 51 159-212.
    • (1999) Pharmacol. Rev. , vol.51 , pp. 159-212
    • Szallasi, A.1    Blumberg, P.M.2
  • 111
    • 0036713282 scopus 로고    scopus 로고
    • Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus in vitro
    • Marinelli S., Vaughan C.W., Christie M.J., Connor M. Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus in vitro. J. Physiol. (2002) 543 531-540.
    • (2002) J. Physiol. , vol.543 , pp. 531-540
    • Marinelli, S.1    Vaughan, C.W.2    Christie, M.J.3    Connor, M.4
  • 112
    • 3343005418 scopus 로고    scopus 로고
    • AM404 enhances the spontaneous release of L-glutamate in a manner sensitive to capsazepine in adult rat substantia gelatinosa neurones
    • Yue H.Y., Fujita T., Kawasaki Y., Kumamoto E. AM404 enhances the spontaneous release of L-glutamate in a manner sensitive to capsazepine in adult rat substantia gelatinosa neurones. Brain Res. (2004) 1018 283-287.
    • (2004) Brain Res. , vol.1018 , pp. 283-287
    • Yue, H.Y.1    Fujita, T.2    Kawasaki, Y.3    Kumamoto, E.4
  • 113
    • 0033661798 scopus 로고    scopus 로고
    • Cannabinoid receptors and the regulation of immune response
    • Berdyshev E.V. Cannabinoid receptors and the regulation of immune response. Chem. Phys. Lipids (2000) 108 169-190.
    • (2000) Chem. Phys. Lipids , vol.108 , pp. 169-190
    • Berdyshev, E.V.1
  • 114
    • 33846828655 scopus 로고    scopus 로고
    • CB2 cannabinoid receptor agonist, JWH-015, triggers apoptosis in immune cells: potential role for CB2-selective ligands as immunosuppressive agents
    • Lombard C., Nagarkatti M., Nagarkatti P. CB2 cannabinoid receptor agonist, JWH-015, triggers apoptosis in immune cells: potential role for CB2-selective ligands as immunosuppressive agents. Clin. Immunol. (2007) 122 259-270.
    • (2007) Clin. Immunol. , vol.122 , pp. 259-270
    • Lombard, C.1    Nagarkatti, M.2    Nagarkatti, P.3
  • 115
    • 0034672605 scopus 로고    scopus 로고
    • Serum-dependent effects of tamoxifen and cannabinoids upon C6 glioma cell viability
    • Jacobsson S.O., Rongard E., Stridh M., Tiger G., Fowler C.J. Serum-dependent effects of tamoxifen and cannabinoids upon C6 glioma cell viability. Biochem. Pharmacol. (2000) 60 1807-1813.
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 1807-1813
    • Jacobsson, S.O.1    Rongard, E.2    Stridh, M.3    Tiger, G.4    Fowler, C.J.5
  • 117
    • 0034696960 scopus 로고    scopus 로고
    • Anandamide induces apoptosis of PC-12 cells: involvement of superoxide and caspase-3
    • Sarker K.P., Obara S., Nakata M., Kitajima I., Maruyama I. Anandamide induces apoptosis of PC-12 cells: involvement of superoxide and caspase-3. FEBS Lett. (2000) 472 39-44.
    • (2000) FEBS Lett. , vol.472 , pp. 39-44
    • Sarker, K.P.1    Obara, S.2    Nakata, M.3    Kitajima, I.4    Maruyama, I.5
  • 118
    • 29544446576 scopus 로고    scopus 로고
    • The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells
    • Eljaschewitsch E., Witting A., Mawrin C. et al. The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells. Neuron (2006) 49 67-79.
    • (2006) Neuron , vol.49 , pp. 67-79
    • Eljaschewitsch, E.1    Witting, A.2    Mawrin, C.3
  • 119
    • 0028580259 scopus 로고
    • Depolarization-induced suppression of GABAergic inhibition in rat hippocampal pyramidal cells: G protein involvement in a presynaptic mechanism
    • Pitler T.A., Alger B.E. Depolarization-induced suppression of GABAergic inhibition in rat hippocampal pyramidal cells: G protein involvement in a presynaptic mechanism. Neuron (1994) 13 1447-1455.
    • (1994) Neuron , vol.13 , pp. 1447-1455
    • Pitler, T.A.1    Alger, B.E.2
  • 120
    • 0035967145 scopus 로고    scopus 로고
    • Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
    • Wilson R.I., Nicoll R.A. Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. Nature (2001) 410 588-592.
    • (2001) Nature , vol.410 , pp. 588-592
    • Wilson, R.I.1    Nicoll, R.A.2
  • 121
    • 0035899302 scopus 로고    scopus 로고
    • Presynaptic specificity of endocannabinoid signaling in the hippocampus
    • Wilson R.I., Kunos G., Nicoll R.A. Presynaptic specificity of endocannabinoid signaling in the hippocampus. Neuron (2001) 31 453-462.
    • (2001) Neuron , vol.31 , pp. 453-462
    • Wilson, R.I.1    Kunos, G.2    Nicoll, R.A.3
  • 122
    • 34948904224 scopus 로고    scopus 로고
    • Implication of cannabinoids in neurological diseases
    • Alsasua del Valle A. Implication of cannabinoids in neurological diseases. Cell. Mol. Neurobiol. (2006) 26 579-591.
    • (2006) Cell. Mol. Neurobiol. , vol.26 , pp. 579-591
    • Alsasua del Valle, A.1
  • 123
    • 0037390731 scopus 로고    scopus 로고
    • Endocannabinoids mediate rapid retrograde signaling at interneuron right-arrow pyramidal neuron synapses of the neocortex
    • Trettel J., Levine E.S. Endocannabinoids mediate rapid retrograde signaling at interneuron right-arrow pyramidal neuron synapses of the neocortex. J. Neurophysiol. (2003) 89 2334-2338.
    • (2003) J. Neurophysiol. , vol.89 , pp. 2334-2338
    • Trettel, J.1    Levine, E.S.2
  • 124
    • 0035053627 scopus 로고    scopus 로고
    • Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells
    • Kreitzer A.C., Regehr W.G. Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells. Neuron (2001) 29 717-727.
    • (2001) Neuron , vol.29 , pp. 717-727
    • Kreitzer, A.C.1    Regehr, W.G.2
  • 125
    • 0037661996 scopus 로고    scopus 로고
    • Role of endogenous cannabinoids in synaptic signaling
    • Freund T.F., Katona I., Piomelli D. Role of endogenous cannabinoids in synaptic signaling. Physiol. Rev. (2003) 83 1017-1066.
    • (2003) Physiol. Rev. , vol.83 , pp. 1017-1066
    • Freund, T.F.1    Katona, I.2    Piomelli, D.3
  • 126
    • 0026603679 scopus 로고
    • Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells
    • Mackie K., Hille B. Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells. Proc. Natl Acad. Sci. USA (1992) 89 3825-3829.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 3825-3829
    • Mackie, K.1    Hille, B.2
  • 127
    • 3042785976 scopus 로고    scopus 로고
    • Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus
    • Kim J., Alger B.E. Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus. Nat. Neurosci. (2004) 7 697-698.
    • (2004) Nat. Neurosci. , vol.7 , pp. 697-698
    • Kim, J.1    Alger, B.E.2
  • 128
    • 33744974528 scopus 로고    scopus 로고
    • Molecular composition of the endocannabinoid system at glutamatergic synapses
    • Katona I., Urban G.M., Wallace M. et al. Molecular composition of the endocannabinoid system at glutamatergic synapses. J. Neurosci. (2006) 26 5628-5637.
    • (2006) J. Neurosci. , vol.26 , pp. 5628-5637
    • Katona, I.1    Urban, G.M.2    Wallace, M.3
  • 129
    • 33646932964 scopus 로고    scopus 로고
    • Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor
    • Yoshida T., Fukaya M., Uchigashima M. et al. Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor. J. Neurosci. (2006) 26 4740-4751.
    • (2006) J. Neurosci. , vol.26 , pp. 4740-4751
    • Yoshida, T.1    Fukaya, M.2    Uchigashima, M.3
  • 130
    • 0037177601 scopus 로고    scopus 로고
    • Endocannabinoid signaling in the brain
    • Wilson R.I., Nicoll R.A. Endocannabinoid signaling in the brain. Science (2002) 296 678-682.
    • (2002) Science , vol.296 , pp. 678-682
    • Wilson, R.I.1    Nicoll, R.A.2
  • 131
    • 0036867665 scopus 로고    scopus 로고
    • Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids
    • Alger B.E. Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids. Prog. Neurobiol. (2002) 68 247-286.
    • (2002) Prog. Neurobiol. , vol.68 , pp. 247-286
    • Alger, B.E.1
  • 132
    • 0030044427 scopus 로고
    • Suppression of noxious stimulus evoked expression of fos-like immunoreactivity in rat spinal cord by a selective cannabinoid agonist
    • Tsou K., Lowitz K.A., Hohmann A.G. et al. Suppression of noxious stimulus evoked expression of fos-like immunoreactivity in rat spinal cord by a selective cannabinoid agonist. Neuroscience (1995) 70 791-798.
    • (1995) Neuroscience , vol.70 , pp. 791-798
    • Tsou, K.1    Lowitz, K.A.2    Hohmann, A.G.3
  • 133
    • 0342762087 scopus 로고    scopus 로고
    • The analgesic effects of R(+)-WIN55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain
    • Herzberg U., Eliav E., Bennett G.J., Kopin I.J. The analgesic effects of R(+)-WIN55, 212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain. Neurosci. Lett. (1997) 221 157-160.
    • (1997) Neurosci. Lett. , vol.221 , pp. 157-160
    • Herzberg, U.1    Eliav, E.2    Bennett, G.J.3    Kopin, I.J.4
  • 134
    • 0142043867 scopus 로고    scopus 로고
    • Animal and cellular models of chronic pain
    • Wang L.X., Wang Z.J. Animal and cellular models of chronic pain. Adv. Drug Deliv. Rev. (2003) 55 949-965.
    • (2003) Adv. Drug Deliv. Rev. , vol.55 , pp. 949-965
    • Wang, L.X.1    Wang, Z.J.2
  • 137
    • 0029036140 scopus 로고
    • An examination of the central sites of action of cannabinoid-induced antinociception in the rat
    • Martin W.J., Patrick S.L., Coffin P.O., Tsou K., Walker J.M. An examination of the central sites of action of cannabinoid-induced antinociception in the rat. Life Sci. (1995) 56 2103-2109.
    • (1995) Life Sci. , vol.56 , pp. 2103-2109
    • Martin, W.J.1    Patrick, S.L.2    Coffin, P.O.3    Tsou, K.4    Walker, J.M.5
  • 138
    • 0032125488 scopus 로고    scopus 로고
    • Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: a perspective on the contributions of apoptosis and necrosis
    • Martin L.J., Al-Abdulla N.A., Brambrink A.M., Kirsch J.R., Sieber F.E., Portera-Cailliau C. Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: a perspective on the contributions of apoptosis and necrosis. Brain Res. Bull. (1998) 46 281-309.
    • (1998) Brain Res. Bull. , vol.46 , pp. 281-309
    • Martin, L.J.1    Al-Abdulla, N.A.2    Brambrink, A.M.3    Kirsch, J.R.4    Sieber, F.E.5    Portera-Cailliau, C.6
  • 139
    • 0033027735 scopus 로고    scopus 로고
    • Spinal cannabinoids are anti-allodynic in rats with persistent inflammation
    • Martin W.J., Loo C.M., Basbaum A.I. Spinal cannabinoids are anti-allodynic in rats with persistent inflammation. Pain (1999) 82 199-205.
    • (1999) Pain , vol.82 , pp. 199-205
    • Martin, W.J.1    Loo, C.M.2    Basbaum, A.I.3
  • 140
    • 0033586315 scopus 로고    scopus 로고
    • Anatomical basis for cannabinoid-induced antinociception as revealed by intracerebral microinjections
    • Martin W.J., Coffin P.O., Attias E., Balinsky M., Tsou K., Walker J.M. Anatomical basis for cannabinoid-induced antinociception as revealed by intracerebral microinjections. Brain Res. (1999) 822 237-242.
    • (1999) Brain Res. , vol.822 , pp. 237-242
    • Martin, W.J.1    Coffin, P.O.2    Attias, E.3    Balinsky, M.4    Tsou, K.5    Walker, J.M.6
  • 142
    • 77952743001 scopus 로고    scopus 로고
    • Abdullah, Krista L. Scoggins, Dana E. Selley, William L. Dewey. Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice
    • Hoot M.R., Sim-Selley L.J., Poklis J.L., Rehab A. Abdullah, Krista L. Scoggins, Dana E. Selley, William L. Dewey. Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice. Brain Res. (2010) 1339 18-25.
    • (2010) Brain Res. , vol.1339 , pp. 18-25
    • Hoot, M.R.1    Sim-Selley, L.J.2    Poklis, J.L.3    Rehab, A.4
  • 143
    • 0032459476 scopus 로고    scopus 로고
    • Cannabinoid transmission and pain perception
    • Martin B.R., Lichtman A.H. Cannabinoid transmission and pain perception. Neurobiol. Dis. (1998) 5 447-461.
    • (1998) Neurobiol. Dis. , vol.5 , pp. 447-461
    • Martin, B.R.1    Lichtman, A.H.2
  • 144
    • 0032489002 scopus 로고    scopus 로고
    • Cannabinoid receptor-mediated inhibition of the rat tail-flick reflex after microinjection into the rostral ventromedial medulla
    • Martin W.J., Tsou K., Walker J.M. Cannabinoid receptor-mediated inhibition of the rat tail-flick reflex after microinjection into the rostral ventromedial medulla. Neurosci. Lett. (1998) 242 33-36.
    • (1998) Neurosci. Lett. , vol.242 , pp. 33-36
    • Martin, W.J.1    Tsou, K.2    Walker, J.M.3
  • 145
    • 0002866945 scopus 로고
    • Structural requirements for cannabinoid receptor probes
    • Pertwee R.G. (Ed.), Academic Press, London
    • Martin B.R., Thomas B.F., Razdan R.K. Structural requirements for cannabinoid receptor probes, in: Pertwee R.G. (Ed.), Cannabinoid receptors, Academic Press, London, 1995b, pp. 35-85.
    • (1995) Cannabinoid receptors , pp. 35-85
    • Martin, B.R.1    Thomas, B.F.2    Razdan, R.K.3
  • 146
    • 0037475146 scopus 로고    scopus 로고
    • A peripheral cannabinoid mechanism suppresses spinal fos protein expression and pain behavior in a rat model of inflammation
    • Nackley A.G., Suplita R.L., Hohmann A.G. A peripheral cannabinoid mechanism suppresses spinal fos protein expression and pain behavior in a rat model of inflammation. Neuroscience (2003) 117 659-670.
    • (2003) Neuroscience , vol.117 , pp. 659-670
    • Nackley, A.G.1    Suplita, R.L.2    Hohmann, A.G.3
  • 147
    • 23244444097 scopus 로고    scopus 로고
    • Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats
    • Sagar D.R., Kelly S., Millns P.J., O'Shaughnessey C.T., Kendall D.A., Chapman V. Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats. Eur. J. Neurosci. (2005) 22 371-379.
    • (2005) Eur. J. Neurosci. , vol.22 , pp. 371-379
    • Sagar, D.R.1    Kelly, S.2    Millns, P.J.3    O'Shaughnessey, C.T.4    Kendall, D.A.5    Chapman, V.6
  • 149
    • 0017367697 scopus 로고    scopus 로고
    • 9-nor-9bhydroxyhexahydrocannabinol a cannabinoid with potent antinociceptive activity: comparisons with morphine
    • Bloom A.S., Dewey W.L., Harris L.S., Brosius K.K. 9-nor-9bhydroxyhexahydrocannabinol a cannabinoid with potent antinociceptive activity: comparisons with morphine. J. Pharmacol. Exp. Ther. (1997) 200 263-270.
    • (1997) J. Pharmacol. Exp. Ther. , vol.200 , pp. 263-270
    • Bloom, A.S.1    Dewey, W.L.2    Harris, L.S.3    Brosius, K.K.4
  • 151
    • 0023740791 scopus 로고
    • Analgesic and antiinflammatory activity of constituents of Cannabis sativa L
    • Formukong E.A., Evans A.T., Evans F.J. Analgesic and antiinflammatory activity of constituents of Cannabis sativa L. Inflammation (1988) 12 361-371.
    • (1988) Inflammation , vol.12 , pp. 361-371
    • Formukong, E.A.1    Evans, A.T.2    Evans, F.J.3
  • 152
    • 33646365073 scopus 로고    scopus 로고
    • Characterization of chronic constriction of the saphenous nerve, a model of neuropathic pain in mice showing rapid molecular and electrophysiological changes
    • Walczak J.S., Pichette V., Leblond F., Desbiens K., Beaulieu P. Characterization of chronic constriction of the saphenous nerve, a model of neuropathic pain in mice showing rapid molecular and electrophysiological changes. J. Neurosci. Res. (2006) 83 1310-1322.
    • (2006) J. Neurosci. Res. , vol.83 , pp. 1310-1322
    • Walczak, J.S.1    Pichette, V.2    Leblond, F.3    Desbiens, K.4    Beaulieu, P.5
  • 153
    • 84872393893 scopus 로고    scopus 로고
    • Anandamide uptake and hydrolysis as targets for the treatment of neuropathic pain: effect of AM404 and URB597 in rats with chronic constriction injury of the sciatic nerve. XV Symposium on the Cannabinoids, Clearwater Beach, FL, 24-29 June 2005, p.
    • Costa B., Colleoni M., Trovato A.E., Conti S., Pomelli F., Franke C. Anandamide uptake and hydrolysis as targets for the treatment of neuropathic pain: effect of AM404 and URB597 in rats with chronic constriction injury of the sciatic nerve. XV Symposium on the Cannabinoids, Clearwater Beach, FL, 24-29 June 2005, p. 33.
    • Costa, B.1    Colleoni, M.2    Trovato, A.E.3    Conti, S.4    Pomelli, F.5    Franke, C.6
  • 154
    • 33749341230 scopus 로고    scopus 로고
    • AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain
    • Costa B., Siniscalco D., Trovato A.E. et al. AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain. Br. J. Pharmacol. (2006) 148 1022-1032.
    • (2006) Br. J. Pharmacol. , vol.148 , pp. 1022-1032
    • Costa, B.1    Siniscalco, D.2    Trovato, A.E.3
  • 155
    • 0033555839 scopus 로고    scopus 로고
    • Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice
    • Ledent C., Valverde O., Cossu G. et al. Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science (1999) 283 401-404.
    • (1999) Science , vol.283 , pp. 401-404
    • Ledent, C.1    Valverde, O.2    Cossu, G.3
  • 156
    • 34347342722 scopus 로고    scopus 로고
    • Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
    • Agarwal N., Pacher P., Tegeder I. et al. Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat. Neurosci. (2007) 10 870-879.
    • (2007) Nat. Neurosci. , vol.10 , pp. 870-879
    • Agarwal, N.1    Pacher, P.2    Tegeder, I.3
  • 157
    • 33846389346 scopus 로고    scopus 로고
    • Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats
    • Petrosino S., Palazzo E., de Novellis V. et al. Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats. Neuropharmacology (2007) 52 415-422.
    • (2007) Neuropharmacology , vol.52 , pp. 415-422
    • Petrosino, S.1    Palazzo, E.2    de Novellis, V.3
  • 158
    • 27144440511 scopus 로고    scopus 로고
    • Involvement of an increased spinal TRPV1 sensitization through its up-regulation in mechanical allodynia of CCI rats
    • Kanai Y., Nakazato E., Fujiuchi A., Hara T., Imai A. Involvement of an increased spinal TRPV1 sensitization through its up-regulation in mechanical allodynia of CCI rats. Neuropharmacology (2005) 49 977-984.
    • (2005) Neuropharmacology , vol.49 , pp. 977-984
    • Kanai, Y.1    Nakazato, E.2    Fujiuchi, A.3    Hara, T.4    Imai, A.5
  • 159
    • 70349110145 scopus 로고    scopus 로고
    • Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain
    • Kinsey S.G., Long J.Z., O'Neal S.T. et al. Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain. J. Pharmacol. Exp. Ther. (2009) 330 902-910.
    • (2009) J. Pharmacol. Exp. Ther. , vol.330 , pp. 902-910
    • Kinsey, S.G.1    Long, J.Z.2    O'Neal, S.T.3
  • 160
    • 0031779305 scopus 로고    scopus 로고
    • Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors
    • Richardson J.D., Kilo S., Hargreaves K.M. Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors. Pain (1998) 75 111-119.
    • (1998) Pain , vol.75 , pp. 111-119
    • Richardson, J.D.1    Kilo, S.2    Hargreaves, K.M.3
  • 161
  • 162
    • 0026639295 scopus 로고
    • Antinociceptive activity of intrathecally administered cannabinoids alone, and in combination with morphine, in mice
    • Welch S.P., Stevens D.L. Antinociceptive activity of intrathecally administered cannabinoids alone, and in combination with morphine, in mice. J. Pharmacol. Exp. Ther. (1992) 262 10-18.
    • (1992) J. Pharmacol. Exp. Ther. , vol.262 , pp. 10-18
    • Welch, S.P.1    Stevens, D.L.2
  • 163
    • 0032925678 scopus 로고    scopus 로고
    • Enhancement of m opioid antinociception by oral D9-tetrahydrocannabinol: dose-response analysis and receptor identification
    • Cichewicz D.L., Martin Z.L., Smith F.L., Welch S.P. Enhancement of m opioid antinociception by oral D9-tetrahydrocannabinol: dose-response analysis and receptor identification. J. Pharmacol. Exp. Ther. (1999) 289 859-867.
    • (1999) J. Pharmacol. Exp. Ther. , vol.289 , pp. 859-867
    • Cichewicz, D.L.1    Martin, Z.L.2    Smith, F.L.3    Welch, S.P.4
  • 164
  • 166
    • 4644372326 scopus 로고    scopus 로고
    • The endogenous cannabinoid system and its role in nociceptive behavior
    • Cravatt B.F., Lichtman A.H. The endogenous cannabinoid system and its role in nociceptive behavior. J. Neurobiol. (2004) 61 149-160.
    • (2004) J. Neurobiol. , vol.61 , pp. 149-160
    • Cravatt, B.F.1    Lichtman, A.H.2
  • 167
    • 0001033268 scopus 로고    scopus 로고
    • The cannabinoid CB l receptor is localised predominantly on N52 within the rat dorsal root ganglion
    • Bridges D., Rice A.S.C., Egertova M., Elphick M.R., Winter J. The cannabinoid CB l receptor is localised predominantly on N52 within the rat dorsal root ganglion. Soc. Neurosci. Abstr. (2001) 27 716.3.
    • (2001) Soc. Neurosci. Abstr. , vol.27 , pp. 7163
    • Bridges, D.1    Rice, A.S.C.2    Egertova, M.3    Elphick, M.R.4    Winter, J.5
  • 168
    • 0142038950 scopus 로고    scopus 로고
    • Neuroprotective and brain edema-reducing efficacy of the novel cannabinoid receptor agonist BAY 38-7271
    • Mauler F., Hinz V., Augstein K.H., Fassbender M., Horvath E. Neuroprotective and brain edema-reducing efficacy of the novel cannabinoid receptor agonist BAY 38-7271. Brain Res. (2003) 989 99-111.
    • (2003) Brain Res. , vol.989 , pp. 99-111
    • Mauler, F.1    Hinz, V.2    Augstein, K.H.3    Fassbender, M.4    Horvath, E.5
  • 169
    • 0032802188 scopus 로고    scopus 로고
    • Pharmacology of cannabinoid receptor ligands
    • Pertwee R.G. Pharmacology of cannabinoid receptor ligands. Curr. Med. Chem. (1999) 6 635-664.
    • (1999) Curr. Med. Chem. , vol.6 , pp. 635-664
    • Pertwee, R.G.1
  • 170
    • 0026795683 scopus 로고
    • Regulation of opioid binding sites in the superficial dorsal horn of the rat spinal cord following loose ligation of the sciatic nerve: comparison with sciatic nerve section and lumbar dorsal rhizotomy
    • Besse D., Lombard M.C., Perrot S., Besson J.M. Regulation of opioid binding sites in the superficial dorsal horn of the rat spinal cord following loose ligation of the sciatic nerve: comparison with sciatic nerve section and lumbar dorsal rhizotomy. Neuroscience (1992) 50 921-933.
    • (1992) Neuroscience , vol.50 , pp. 921-933
    • Besse, D.1    Lombard, M.C.2    Perrot, S.3    Besson, J.M.4
  • 171
    • 0032484245 scopus 로고    scopus 로고
    • Cannabinoid modulation of wide dynamic range neurons in the lumbar dorsal horn of the rat by spinally administered WIN55,212-2
    • Hohmann A.G., Tsou K., Walker J.M. Cannabinoid modulation of wide dynamic range neurons in the lumbar dorsal horn of the rat by spinally administered WIN55, 212-2. Neurosci. Lett. (1998) 257 119-122.
    • (1998) Neurosci. Lett. , vol.257 , pp. 119-122
    • Hohmann, A.G.1    Tsou, K.2    Walker, J.M.3
  • 172
    • 4043055159 scopus 로고    scopus 로고
    • The good and the bad effects of (-)trans-delta-9-tetrahydrocannabinol (Delta 9 THC) on humans
    • Carlini E.A. The good and the bad effects of (-)trans-delta-9-tetrahydrocannabinol (Delta 9 THC) on humans. Toxicon (2004) 44 461-467.
    • (2004) Toxicon , vol.44 , pp. 461-467
    • Carlini, E.A.1
  • 173
    • 77958035149 scopus 로고    scopus 로고
    • Smoked cannabis for chronic neuropathic pain: a randomized controlled trial
    • Ware M., Wang T., Shapiro S., Robinson A. et al. Smoked cannabis for chronic neuropathic pain: a randomized controlled trial. CMAJ (2010) 182 694-701.
    • (2010) CMAJ , vol.182 , pp. 694-701
    • Ware, M.1    Wang, T.2    Shapiro, S.3    Robinson, A.4
  • 174
    • 0034617372 scopus 로고    scopus 로고
    • Pharmacological evaluation of aerosolized cannabinoids in mice
    • Lichtman A.H., Peart J., Poklis J.L. et al. Pharmacological evaluation of aerosolized cannabinoids in mice. Eur. J. Pharmacol. (2000) 399 141-149.
    • (2000) Eur. J. Pharmacol. , vol.399 , pp. 141-149
    • Lichtman, A.H.1    Peart, J.2    Poklis, J.L.3
  • 175
    • 0023833764 scopus 로고
    • Quantitative changes in hippocampal structure following long-term exposure to delta 9-tetrahydrocannabinol: possible mediation by glucocorticoid systems
    • Landfield P.W., Cadwallader L.B., Vinsant S. Quantitative changes in hippocampal structure following long-term exposure to delta 9-tetrahydrocannabinol: possible mediation by glucocorticoid systems. Brain Res. (1988) 443 47-62.
    • (1988) Brain Res. , vol.443 , pp. 47-62
    • Landfield, P.W.1    Cadwallader, L.B.2    Vinsant, S.3
  • 176
    • 20444398090 scopus 로고    scopus 로고
    • Endocannabinoids ignaling system andb rain reward: emphasis on dopamine
    • Gardner E.L. Endocannabinoids ignaling system andb rain reward: emphasis on dopamine. Pharmacol. Biochem. Behav. (2005) 81 263-284.
    • (2005) Pharmacol. Biochem. Behav. , vol.81 , pp. 263-284
    • Gardner, E.L.1
  • 177
    • 62149143788 scopus 로고    scopus 로고
    • 2-Arachidonoylglycerol elicits neuroprotective effects on excitotoxically lesioned dentate gyrus granule cells via abnormal- cannabidiol sensitive receptors on microglial cells
    • Kreutz S., Koch M., Bottger C., Ghadban C., Korf H.W., Dehghani F. 2-Arachidonoylglycerol elicits neuroprotective effects on excitotoxically lesioned dentate gyrus granule cells via abnormal- cannabidiol sensitive receptors on microglial cells. Glia (2009) 57 286-294.
    • (2009) Glia , vol.57 , pp. 286-294
    • Kreutz, S.1    Koch, M.2    Bottger, C.3    Ghadban, C.4    Korf, H.W.5    Dehghani, F.6
  • 178
    • 0033561159 scopus 로고    scopus 로고
    • Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures
    • Nagayama T., Sinor A.D., Simon R.P. et al. Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures. J. Neurosci. (1999) 19 2987-2995.
    • (1999) J. Neurosci. , vol.19 , pp. 2987-2995
    • Nagayama, T.1    Sinor, A.D.2    Simon, R.P.3
  • 179
    • 0141865717 scopus 로고    scopus 로고
    • CB1 cannabinoid receptors and on-demand defense against excitotoxicity
    • Marsicano G., Goodenough S., Monory K. et al. CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science (2003) 302 84-88.
    • (2003) Science , vol.302 , pp. 84-88
    • Marsicano, G.1    Goodenough, S.2    Monory, K.3
  • 180
    • 9644268887 scopus 로고    scopus 로고
    • Cannabinoid signaling in glial cells
    • Stella N. Cannabinoid signaling in glial cells. Glia (2004) 48 267-277.
    • (2004) Glia , vol.48 , pp. 267-277
    • Stella, N.1
  • 181
    • 0036019404 scopus 로고    scopus 로고
    • Endocannabinoids and pain: spinal and peripheral analgesia in inflammation and neuropathy
    • Rice A.S.C., Farquhar-Smith W.P., Nagy I. Endocannabinoids and pain: spinal and peripheral analgesia in inflammation and neuropathy. Prostaglandins Leukot. Essent. FattyAcids (2002) 66 243-256.
    • (2002) Prostaglandins Leukot. Essent. FattyAcids , vol.66 , pp. 243-256
    • Rice, A.S.C.1    Farquhar-Smith, W.P.2    Nagy, I.3
  • 182
    • 29844435136 scopus 로고    scopus 로고
    • Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis
    • Blake D.R., Robson P., Ho M., Jubb R.W., McCabe C.S. Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis. Rheumatology (Oxford) (2006) 45 50-52.
    • (2006) Rheumatology (Oxford) , vol.45 , pp. 50-52
    • Blake, D.R.1    Robson, P.2    Ho, M.3    Jubb, R.W.4    McCabe, C.S.5
  • 183
    • 38049028807 scopus 로고    scopus 로고
    • Cannabinoids for the treatment of neuropathic pain: clinical evidence
    • Ashton J.C., Milligan E.D. Cannabinoids for the treatment of neuropathic pain: clinical evidence. Curr. Opin. Investig. Drugs (2008) 9 65-75.
    • (2008) Curr. Opin. Investig. Drugs , vol.9 , pp. 65-75
    • Ashton, J.C.1    Milligan, E.D.2
  • 184
    • 38449103007 scopus 로고    scopus 로고
    • Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers
    • Wallace M., Schulteis G., Atkinson J.H. et al. Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers. Anesthesiology (2007) 107 785-796.
    • (2007) Anesthesiology , vol.107 , pp. 785-796
    • Wallace, M.1    Schulteis, G.2    Atkinson, J.H.3
  • 185
    • 75949093107 scopus 로고    scopus 로고
    • Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain
    • Johnson J.R., Burnell-Nugent M., Lossignol D., Ganae-Motan E.D., Potts R., Fallon M.T. Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain. J. Pain. Symptom. Manag. (2010) 39 167-179.
    • (2010) J. Pain. Symptom. Manag. , vol.39 , pp. 167-179
    • Johnson, J.R.1    Burnell-Nugent, M.2    Lossignol, D.3    Ganae-Motan, E.D.4    Potts, R.5    Fallon, M.T.6
  • 186
    • 33847013770 scopus 로고    scopus 로고
    • Cannabis in painful HIV-associated sensory neuropathy
    • Abrams D.I., Jay C.A., Shade S.B. et al. Cannabis in painful HIV-associated sensory neuropathy. Neurology (2007) 68 515-521.
    • (2007) Neurology , vol.68 , pp. 515-521
    • Abrams, D.I.1    Jay, C.A.2    Shade, S.B.3
  • 188
    • 40549117895 scopus 로고    scopus 로고
    • Current management of pain associated with multiple sclerosis
    • Pollmann W., Feneberg W. Current management of pain associated with multiple sclerosis. CNS Drugs (2008) 22 291-324.
    • (2008) CNS Drugs , vol.22 , pp. 291-324
    • Pollmann, W.1    Feneberg, W.2
  • 189
    • 0348010292 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains
    • Benito C., Nunez E., Tolon R.M. et al. Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. J. Neurosci. (2003) 23 11136-11141.
    • (2003) J. Neurosci. , vol.23 , pp. 11136-11141
    • Benito, C.1    Nunez, E.2    Tolon, R.M.3
  • 190
    • 0038249025 scopus 로고    scopus 로고
    • Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism
    • Maccarrone M., Gubellini P., Bari M. et al. Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism. J. Neurochem. (2003) 85 1018-1025.
    • (2003) J. Neurochem. , vol.85 , pp. 1018-1025
    • Maccarrone, M.1    Gubellini, P.2    Bari, M.3
  • 191
    • 14244264502 scopus 로고    scopus 로고
    • Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation
    • Ramirez B.G., Blazquez C., Gomez del Pulgar T., Guzman M., de Ceballos M.L. Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation. J. Neurosci. (2005) 25 1904-1913.
    • (2005) J. Neurosci. , vol.25 , pp. 1904-1913
    • Ramirez, B.G.1    Blazquez, C.2    Gomez del Pulgar, T.3    Guzman, M.4    de Ceballos, M.L.5
  • 192
    • 35648993493 scopus 로고    scopus 로고
    • Endocannabinoids and neurodegenerative diseases
    • Micale V., Mazzola C., Drago F. Endocannabinoids and neurodegenerative diseases. Pharmacol. Res. (2007) 56 382-392.
    • (2007) Pharmacol. Res. , vol.56 , pp. 382-392
    • Micale, V.1    Mazzola, C.2    Drago, F.3
  • 193
    • 77949887689 scopus 로고    scopus 로고
    • Unravelling the complex dissociation of [3H]-rimonabant from plated CB1 cannabinoid receptor-expressing cells
    • Wennerberg M., Balendran A., Clapham J.C., Vauquelin G. Unravelling the complex dissociation of [3H]-rimonabant from plated CB1 cannabinoid receptor-expressing cells. Fundam. Clin. Pharmacol. (2010) 24 181-187.
    • (2010) Fundam. Clin. Pharmacol. , vol.24 , pp. 181-187
    • Wennerberg, M.1    Balendran, A.2    Clapham, J.C.3    Vauquelin, G.4
  • 195
    • 45849112147 scopus 로고    scopus 로고
    • Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse
    • Palmer J.A., Higuera E.S., Chang L., Chaplan S.R. Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse. Neuroscience (2008) 154 1554-1561.
    • (2008) Neuroscience , vol.154 , pp. 1554-1561
    • Palmer, J.A.1    Higuera, E.S.2    Chang, L.3    Chaplan, S.R.4
  • 196
    • 33646142292 scopus 로고    scopus 로고
    • The endocannabinoid 2-AG protects the blood-brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines
    • Panikashvili D., Shein N.A., Mechoulam R. et al. The endocannabinoid 2-AG protects the blood-brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines. Neurobiol. Dis. (2006) 22 257-264.
    • (2006) Neurobiol. Dis. , vol.22 , pp. 257-264
    • Panikashvili, D.1    Shein, N.A.2    Mechoulam, R.3


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