Cannabinoid receptors CB1 and CB2: A characterization of expression and adenylate cyclase modulation within the immune system

Toxicology and Applied Pharmacology

Volumn 142, Issue 2, 1997, Pages 278-287

  Schatz, Anthony R ^a,b   Lee, Michael ^a,c   Condie, Robin B ^a   Pulaski, James T ^a   Kaminski, Norbert E ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b ABBOTT LABORATORIES   (United States)

^c Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; ADENYLATE CYCLASE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR; RECEPTOR SUBTYPE; TETRAHYDROCANNABINOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BINDING SITE; DRUG MECHANISM; DRUG RECEPTOR BINDING; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREGULATION; INHIBITION KINETICS; MOUSE; NONHUMAN; QUANTITATIVE DIAGNOSIS; RAT;

ANIMALIA; CANNABIS;

EID: 0031062297     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.8034     Document Type: Article

References (27)

1. Aviv, H., and Leder, P. (1972). Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc. Natl. Acad. Sci. USA 69, 1408-1412.
2. Bartlett, M. S. (1937). Sub-sampling for attributes. J. R. Stat. Soc. Suppl. 4, 131.
3. Bouaboula, M., Rinaldi, M., Carayon, P., Carillon, C., Delpech, B., Shire, D., Le Fur, G., and Casellas, P. (1993). Cannabinoid-receptor expression in human leukocytes. Eur. J. Biochem. 214, 173-180.
4. Chomczynski, P., and Mackey, K. (1995). Substitution of chloroform by bromochloropropane in the single-slip method of RNA isolation. Anal. Biochem. 225, 163-164.
5. Chomczynski, P., and Sacchi, N. (1987). Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
6. Condie, R., Herring, A., Koh, W. S., Lee, M., and Kaminski, N. E. (1996). Cannabinoid inhibition of adenylate cyclase-mediated signal transduction and IL-2 expression in the murine T-cell line, EL4.IL-2. J. Biol. Chem. 271, 13175-13183.
7. Dunnett, C. W. (1955). A multiple comparison procedure for comparing several treatments with a control. J. Am. Stat. Assoc. 50, 1096-1121.
8. Feinberg, A. P., and Vogelstein, B. (1984). Addendum: "A Technique for Radiolabeling DNA Restriction Endonuclease Fragments to High Specific Activity." Anal. Biochem. 137, 266-267.
9. Gerard, C. M., Mollereau, C., Vassart, G., and Parmentier, M. (1991). Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochem. J. 279, 129-134.
10. Gilliland, G., Perrin, K., Blanchard, K., and Bunn, H. (1990a). Analysis of cytokine mRNA and DNA: Detection and quantitation by competitive polymerase chain reaction. Proc. Natl. Acad. Sci. USA 87, 2725-2729.
11. Gilliland, G., Perrin, S., and Bunn, H. (1990b). Competitive PCR for quantitation of mRNA. In PCR Protocols: A Guide to Methods and Applications (M. A. Innis, D. H. Gelfand, J. J. Sninsky, and T. J. White, Eds.), pp. 60-66. Academic Press, San Diego, CA.
12. Heidel, J. J., and Keith, W. B. (1989). Specific inhibition of FSH-stimulated cAMP accumulation by Δ9-tetrahydrocannabinol in cultures of rat Sertoli cells. Toxicol. Appl. Pharmacol. 101, 124-134.
13. Hewlett, A. C. (1985). Cannabinoid inhibition of adenylate cyclase. Biochemistry of the response in neuroblastoma cell membranes. Mol. Pharmacol. 27, 429-436.
14. Kaminski, N. E., Abood, M. E., Kessler, F. K., Martin, B. R., and Schatz, A. R. (1992). Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation. Mol. Pharmacol. 42, 736-742.
15. Kaminski, N. E., Koh, W. S., Lee, M., Yang, K. H., and Kessler, F. K. (1994). Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein coupled mechanism. Biochem. Pharmacol. 48, 1899-1908.
16. Koh, W. S., Lee, M., Yang, K. H., and Kaminski, N. E. (1996). Expression of functional glucagon receptors on mouse spleenocytes. Life Sci. 58, 741-751.
17. 9-tetrahydrocannabinol and other cannabinoids on cAMP accumulation in synaptosomes. Life Sci. 48, 1133-1141.
18. Lynn, A. B., and Herkenham, M. (1994). Localization of cannabinoid receptors and nonsaturable high-density cannabinoid binding sites in peripheral tissues of the rat: Implications for receptor-mediated immune modulation by cannabinoids. J. Pharmacol. Exp. Ther. 268, 1612-1623.
19. Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., and Bonner, T. I. (1990). Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature (London) 346, 561-564.
20. Munro, S., Thomas, K. L., and Abu-Shaar, M. (1993). Molecular characterization of a peripheral receptor for cannabinoids. Nature (London) 365, 61-65.
21. Rowley, J. T., and Rowley, P. T. (1989). Tetrahydrocannabinol inhibits adenylate cyclase in human leukemia cells. Life Sci. 46, 217-222.
22. 9-tetrahydrocannabinol in mouse spleen cells: A potential mechanism for cannabinoid-mediated immunosuppression. Life Sci. 51, 25-30.
23. 9-Tetrahydrocanabinol selectively inhibits T-cell dependent humoral immune responses through direct inhibition of accessory T-cell function. Immunopharmacology 26, 129-137.
24. Shire, D., Carillon, C., Kaghad, M., Calandra, B., Rinaldi-Carmona, M., Le Fur, G., Caput, D., and Ferrara, P. (1995). An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. J. Biol. Chem. 270, 3726-3731.
25. Thomas, B. F., Compton, D. R., and Martin, B. R. (1990). Characterization of the lipophilicity of natural and synthetic analogs of Δ9-tetrahydrocannabinol and its relationship to pharmacological potency. J. Pharmacol. Exp. Ther. 255, 624-630.
26. Vanden Heuvel, J., Clark, G., Kohn, M., Tritscher, A., Greenlee, W., Lucier, G., and Bell, D. (1994). Dioxin-responsive genes: Examination of dose-response relationships using quantitative reverse transcriptase-polymerase chain reaction. Cancer Res. 54, 62-68.
27. Vanden Heuvel, J., Tyson, F., and Bell, D. (1993). Construction of recombinant RNA templates for use as internal standards in quantitative RTPCR. BioTechniques 14, 395-398.