Cannabinoid analgesia

Pharmacology and Therapeutics

Volumn 95, Issue 2, 2002, Pages 127-135

  Walker, J Michael ^a   Huang, Susan M ^b  

^a BROWN UNIVERSITY   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

Analgesia; Anandamide; Cannabinoid; Endocannabinoid; Pain; Receptor

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; AJULEMIC ACID; CANNABINOID; CANNABINOID RECEPTOR; CANNABIS; CODEINE; DRONABINOL; MORPHINE; NABILONE; RIMONABANT; UNCLASSIFIED DRUG;

ANALGESIA; ARTICLE; CLINICAL TRIAL; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; HUMAN; MOTOR ACTIVITY; MOTOR SYSTEM; NERVE TRACT; NEUROTRANSMISSION; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; SENSORY NERVE CELL; SENSORY SYSTEM; SIDE EFFECT; SPINAL CORD NERVE CELL; THALAMUS;

EID: 0036669790     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(02)00252-8     Document Type: Review

References (70)

1. Ameri A. The effects of cannabinoids on the brain. Prog Neurobiol. 58:1999;315-348.
2. Bicher H.I., Mechoulam R. Pharmacological effects of two active constituents of marihuana. Arch Int Pharmacodyn Ther. 172:1968;24-31.
3. Bloom A.S., Dewey W.L., Harris L.S., Brosius K.K. 9-Nor-9β-hydroxyhexahydrocannabinol a cannabinoid with potent antinociceptive activity: comparisons with morphine. J Pharmacol Exp Ther. 200:1977;263-270.
4. 8-THC-11-oic acid (CT3) in mice. Life Sci. 63:1998;161-168.
5. 9-tetrahydrocannabinol in the rat and mouse. Psychopharmacology. 25:1972;275-280.
6. Calignano A., La Rana G., Giuffrida A., Piomelli D. Control of pain initiation by endogenous cannabinoids. Nature. 394:1998;277-281.
7. 1 receptor antagonist, SR141716A, selectively facilitates nociceptive responses of dorsal horn neurones in the rat. Br J Pharmacol. 127:1999;1765-1767.
8. Childers S.R., Breivogel C.S. Cannabis and endogenous cannabinoid systems. Drug Alcohol Depend. 51:1998;173-187.
9. Clark W.C., Janal M.N., Zeidenberg P., Nahas G.G. Effects of moderate and high doses of marihuana on thermal pain: a sensory decision theory analysis. J Clin Pharmacol. 21:1981;299S-310S.
10. Devane W.A., Dysarz F.A. 3rd, Johnson M.R., Melvin L.S., Howlett A.C. Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol. 34:1988;605-613.
11. Devane W.A., Hanus L., Breuer A., Pertwee R.G., Stevenson L.S., Griffin G., Gibson D., Mandelbaum A., Etinger A., Mechoulam R. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science. 258:1992;1946-1949.
12. Dixon W.E. The pharmacology of cannabis. Indica Br Med J. 2:1899;1354-1357.
13. 35S]GTPγS binding in the dorsal horn of the spinal cord of noninflamed and inflamed rats. Eur J Neurosci. 12:2000;2079-2086.
14. Formukong E.A., Evans A.T., Evans F.J. Analgesic and antiinflammatory activity of constituents of Cannabis sativa L. Inflammation. 12:1988;361-371.
15. Galiegue S., Mary S., Marchand J., Dussossoy D., Carriere D., Carayon P., Bouaboula M., Shire D., LeFur G., Casellas P. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem. 232:1995;54-61.
16. Herkenham M., Lynn A.B., Johnson M.R., Melvin L.S., De Costa B.R., Rice K.C. Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J Neurosci. 11:1991;563-583.
17. Herzberg U., Eliav E., Bennett G.J., Kopin I.J. The analgesic effects of R(+)-WIN 55,212-2 mesylate a high affinity cannabinoid agonist, in a rat model of neuropathic pain. Neurosci Lett. 221:1997;157-160.
18. Hill S.Y., Schwin R., Goodwin D.W., Powell B.J. Marihuana and pain. J Pharmacol Exp Ther. 188:1974;415-418.
19. Hohmann A.G., Herkenham M. Regulation of cannabinoid and mu opioid receptors in rat lumbar spinal cord following neonatal capsaicin treatment. Neurosci Lett. 252:1998;13-16.
20. Hohmann A.G., Herkenham M. Cannabinoid receptors undergo axonal flow in sensory nerves. Neuroscience. 92:1999;1171-1175.
21. Hohmann A.G., Walker J.M. Cannabinoid suppression of noxious heat-evoked activity in wide dynamic range neurons in the lumbar dorsal horn of the rat. J Neurophysiol. 81:1999;575-583.
22. Hohmann A.G., Martin W.J., Tsou K., Walker J.M. Inhibition of noxious stimulus-evoked activity of spinal cord dorsal horn neurons by the cannabinoid WIN 55,212-2. Life Sci. 56:1995;2111-2119.
23. Hohmann A.G., Tsou K., Walker J.M. Cannabinoid modulation of wide dynamic range neurons in the lumbar dorsal horn of the rat by spinally administered WIN55,212-2. Neurosci Let. 257:1998;1-4.
24. Hohmann A.G., Briley E.M., Herkenham M. Pre- and postsynaptic distribution of cannabinoid and mu opioid receptors in rat spinal cord. Brain Res. 822:1999;17-25.
25. Howlett A.C., Johnson M.R., Melvin L.S., Milne G.M. Nonclassical cannabinoid analgetics inhibit adenylate cyclase: development of a cannabinoid receptor model. Mol Pharmacol. 33:1988;297-302.
26. 2 receptor. Bioorg Med Chem. 7:1999;2905-2914.
27. Iversen L.L. The Science of Marijuana. 2000;Oxford University Press, Oxford.
28. Jacob J., Ramabadran K., Campos-Medeiros M.A. Pharmacological analysis of levonantradol antinociception in mice. J Clin Pharmacol. 21:1981;327S-333S.
29. Joy J.E., Watson S.J., Benson J.A. Jr. Marijuana and Medicine: Assessing the Science Base. 1999;National Academy Press, Washington, D.C.
30. Kosersky D.S., Dewey W.L., Harris L.S. Antipyretic analgesic and anti-inflammatory effects of delta 9-tetrahydrocannabinol in the rat. Eur J Pharmacol. 24:1973;1-7.
31. Lichtman A.H., Martin B.R. Spinal and supraspinal components of cannabinoid-induced antinociception. J Pharmacol Exp Ther. 258:1991;517-523.
32. 2-noradrenergic mechanism. Brain Res. 559:1991;309-314.
33. Mackie K., Devane W.A., Hille B. Anandamide an endogenous cannabinoid inhibits calcium currents as a partial agonist in N18 neuroblastoma cells. Mol Pharmacol. 44:1993;498-503.
34. Mackie K., Lai Y., Wextenbroek R., Mitchell R. Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor. J Neurosci. 15:1995;6552-6561.
35. Mailleux P., Vanderhaeghen J.J. Distribution of neuronal cannabinoid receptor in the adult rat brain: a comparative receptor binding radioautography and in situ hybridization histochemistry. Neuroscience. 48:1992;655-668.
36. Martin W.J., Lai N.K., Patrick S.L., Tsou K., Walker J.M. Antinociceptive actions of WIN 55,212-2 following intraventricular administration in rats. Brain Res. 629:1993;300-304.
37. Martin W.J., Patrick S.L., Coffin P.O., Tsou K., Walker J.M. An examination of the central sites of action of cannabinoid-induced antinociception in the rat. Life Sci. 56:1995;2103-2110.
38. Martin W.J., Hohmann A.G., Walker J.M. Suppression of noxious stimulus-evoked activity in the ventral posterolateral nucleus of the thalamus by the cannabinoid WIN 55,212-2:correlation between electrophysiological and antinociceptive effects. J Neurosci. 16:1996;6601-6611.
39. Martin W.J., Tsou K., Walker J.M. Cannabinoid receptor-mediated inhibition of the rat tail-flick reflex after microinjection into the rostral ventromedial medulla. Neurosci Let. 232:1998;33-36.
40. Martin W.J., Coffin P.O., Attias E., Balinsky M., Tsou K., Walker J.M. Anatomical basis for cannabinoid-induced antinociception as revealed by intracerebral microinjections. Brain Res. 822:1999;237-242.
41. Matsuda L.A., Lolait S.J., Brownstein M.J., Young A.C., Bonner T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. 346:1990;561-564.
42. Mechoulam R., Ben-Shabat S., Hanuš L., Ligumsky M., Kaminski N.E., Schatz A.R., Gopher A., Almog S., Martin B.R., Compton D.R., Pertweek R.G., Griffin G., Bayewitch M., Barg J., Vogel Z. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol. 50:1995;83-90.
43. Meng I.D., Manning B.H., Martin W.J., Fields H.L. An analgesia circuit activated by cannabinoids. Nature. 395:1998;381-383.
44. Munro S., Thomas K.L., Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature. 365:1993;61-65.
45. Noyes R. Jr., Brunk S.F., Avery D.H., Canter A. The analgesic properties of delta-9-tetrahydrocannabinol and codeine. Clin Pharmacol Ther. 18:1975;84-89.
46. Noyes R. Jr., Brunk S.F., Baram D.A., Canter A. Analgesic effect of delta-9-tetrahydrocannabinol. J Clin Pharmacol. 1:1975;139-143.
47. Proudfit H.K. Pharmacologic evidence for the modulation of nociception by noradrenergic neurons. Fields H.L., Besson J.M. Pain Modulation. 1988;357-370 Elsevier Science Publishers B.V. Amsterdam, New York.
48. Raft D., Gregg J., Ghia J., Harris L. Effects of intravenous tetrahydrocannabinol on experimental and surgical pain. Psychological correlates of the analgesic response. Clin Pharmacol Ther. 21:1977;26-33.
49. Rhee M.H., Vogel Z., Barg J., Bayewitch M., Levy R., Hanus L., Breuer A., Mechoulam R. Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylyl cyclase. J Med Chem. 40:1997;3228-3233.
50. Richardson J.D., Aanonsen L., Hargreaves K.M. SR141716A, a cannabinoid receptor antagonist, produces hyperalgesia in untreated mice. Eur J Pharmacol. 319:1997;R3-R4.
51. Richardson J.D., Aanonsen L., Hargreaves K.M. Antihyperalgesic effects of spinal cannabinoids. Eur J Pharmacol. 345:1998;145-153.
52. Richardson J.D., Aanonsen L., Hargreaves K.M. Hypoactivity of the spinal cannabinoid system results in NMDA-dependent hyperalgesia. J Neurosci. 18:1998;451-457.
53. 1 receptors. Pain. 75:1998;111-119.
54. Sañudo-Peña M.C., Walker J.M. A novel neurotransmitter system involved in the control of motor behavior by the basal ganglia. Ann N Y Acad Sci. 860:1998;475-479.
55. 1 receptor localization in spinal cord and roots, dorsal root ganglion, and peripheral nerve. Acta Pharmacol Sin. 12:1999;1115-1120.
56. 2: a characterization of expression and adenylate cyclase modulation within the immune system. Toxicol Appl Pharmacol. 142:1997;278-287.
57. 9-tetrahydrocannabinol THC. J Pharmacol Exp Ther. 186:1973;646-655.
58. Strangman N.M., Walker J.M. The cannabinoid WIN 55, 212-2 inhibits the activity-dependent facilitation of spinal nociceptive responses. J Neurophysiol. 82:1999;472-477.
59. Strangman N.M., Patrick S.L., Hohmann A.G., Tsou K., Walker J.M. Evidence for a role of endogenous cannabinoids in the modulation of acute and tonic pain sensitivity. Brain Res. 813:1998;323-328.
60. Sugiura T., Kondo S., Sukagawa A., Nakane S., Shinoda A., Itoh K., Yamashita A., Waku K. 2-Arachidonylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem Biophys Res Commun. 215:1995;89-97.
61. Tsou K., Lowitz K.A., Hohmann A.G., Martin W.J., Hathaway C.B., Bereiter D.A., Walker J.M. Suppression of noxious stimulus-evoked expression of fos-like immunoreactivity in rat spinal cord by a selective cannabinoid agonist. Neuroscience. 70:1995;791-798.
62. 1 receptors in rat central nervous system. Neuroscience. 83:1998;393-411.
63. Ueda N., Yamamoto S. Anandamide amidohydrolase (fatty acid amide hydrolase). Prostaglandins Other Lipid Mediat. 61:2000;19-28.
64. Vaughan V.W., McGregor I.S., Christie M.J. Cannabinoid receptor activation inhibits GABAergic neurotransmission in rostral ventromedial medulla neurons in vitro. Br J Pharmacol. 127:1999;935-940.
65. Vaughan V.W., Connor M., Bagley E.E., Christie M.J. Actions of cannabinoids on membrane properties and synaptic transmission in rat periaqueductal gray neurons in vitro. Mol Pharmacol. 57:2000;288-295.
66. Walker J.M., Huang S.M., Strangman N.M., Tsou K., Sañudo-Peña M.C. Pain modulation by release of the endogenous cannabinoid anandamide. Proc Natl Acad Sci USA. 96:1999;12198-12203.
67. Walker J.M., Huang S.M., Strangman N.M., Sañudo-Peña M.C. Identification of the role of endogenous cannabinoids in pain modulation: strategies and pitfalls. J Pain. 1:2000;20-32.
68. Welch S.P., Stevens D.L. Antinociceptive activity of intrathecally administered cannabinoids alone and in combination with morphine in mice. J Pharmacol Exp Ther. 262:1992;10-18.
69. Yaksh T.L. The antinociceptive effects of intrathecally administered levonantradol and desacetyllevonantradol in the rat. J Clin Pharmacol. 21:1981;334S-340S.
70. Zeidenberg P., Clark W.C., Jaffe J., Anderson S.W., Chin S., Malitz S. Effect of oral administration of delta9-tetrahydrocannabinol on memory, speech, and perception of thermal stimulation: results with four normal human volunteer subjects. Comp Psychiatry. 14:1973;549-556.