AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain

British Journal of Pharmacology

Volumn 148, Issue 7, 2006, Pages 1022-1032

  Costa, Barbara ^a   Siniscalco, Dario ^b   Trovato, Anna Elisa ^c   Comelli, Francesca ^a   Sotgiu, Maria Luisa ^d   Colleoni, Mariapia ^c   Maione, Sabatino ^b   Rossi, Francesco ^b   Giagnoni, Gabriella ^a  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d CNR   (Italy)

Author keywords

AM404; Apoptosis; Cannabinoid; Cytokines; Endocannabinoid; IL 10; Neuropathic pain; Nitric oxide; TNF ; VDM11

Indexed keywords

5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; ANALGESIC AGENT; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CAPSAZEPINE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; N (4 HYDROXY 2 METHYLPHENYL)ARACHIDONAMIDE; N (4 HYDROXYPHENYL)ARACHIDONAMIDE; NEURONAL NITRIC OXIDE SYNTHASE; PROTEIN BAX; PROTEIN BCL 2; RIMONABANT; RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; AMIDE; ARACHIDONIC ACID DERIVATIVE; CALCIUM CHANNEL BLOCKING AGENT; CANNABINOID RECEPTOR; N (4 HYDROXYPHENYL)ARACHIDONYLAMIDE; N-(4-HYDROXYPHENYL)ARACHIDONYLAMIDE; NITRATE; NITRITE;

ALLODYNIA; ANALGESIA; ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG ANTAGONISM; HYPERALGESIA; IMMUNOMODULATION; LOCOMOTION; MALE; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE; WESTERN BLOTTING; ANIMAL; DRUG EFFECT; GENETICS; HEAT; METABOLISM; MOTOR ACTIVITY; PAIN; PERIPHERAL NEUROPATHY; PROTO ONCOGENE; PSYCHOLOGICAL ASPECT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STIMULATION; WISTAR RAT;

ANALGESICS; ANIMALS; APOPTOSIS; ARACHIDONIC ACIDS; BCL-2-ASSOCIATED X PROTEIN; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; CALCIUM CHANNEL BLOCKERS; CYTOKINES; GENES, BCL-2; HEAT; HYPERALGESIA; MALE; MOTOR ACTIVITY; NF-KAPPA B; NITRATES; NITRITES; PAIN; PERIPHERAL NERVOUS SYSTEM DISEASES; PHYSICAL STIMULATION; POLYUNSATURATED ALKAMIDES; RATS; RATS, WISTAR; RECEPTORS, CANNABINOID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 33749341230     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706798     Document Type: Article

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