메뉴 건너뛰기




Volumn 1, Issue 7, 2009, Pages 1333-1349

Cannabinoids as novel anti-inflammatory drugs

Author keywords

[No Author keywords available]

Indexed keywords

1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 2 ARACHIDONOYLGLYCEROL; 2 METHYL 3 (1 NAPHTHOYL) 1 PROPYLINDOLE; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; AJULEMIC ACID; ANANDAMIDE; CANNABIDIOL; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABIS; CHEMOKINE; CYTOKINE; DEXANABINOL; GAMMA INTERFERON; NABILONE; RIMONABANT; TETRAHYDROCANNABINOL;

EID: 77953451267     PISSN: 17568919     EISSN: None     Source Type: Journal    
DOI: 10.4155/fmc.09.93     Document Type: Review
Times cited : (371)

References (130)
  • 1
    • 0142166330 scopus 로고    scopus 로고
    • Cannabinoids: Potential anticancer agents
    • Guzman M. Cannabinoids: potential anticancer agents. Nat. Rev. Cancer 3, 745-755 (2003).
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 745-755
    • Guzman, M.1
  • 2
    • 0036198117 scopus 로고    scopus 로고
    • Cancer anorexia-cachexia syndrome: Current issues in research and management
    • Inui A. Cancer anorexia-cachexia syndrome: current issues in research and management. CA Cancer J. Clin. 52, 72-91 (2002).
    • (2002) CA Cancer J. Clin. , vol.52 , pp. 72-91
    • Inui, A.1
  • 3
    • 40549117895 scopus 로고    scopus 로고
    • Current management of pain associated with multiple sclerosis
    • Pollmann W, Feneberg W. Current management of pain associated with multiple sclerosis. CNS Drugs 22, 291-324 (2008).
    • (2008) CNS Drugs , vol.22 , pp. 291-324
    • Pollmann, W.1    Feneberg, W.2
  • 4
    • 0035822323 scopus 로고    scopus 로고
    • Cannabinoids for control of chemotherapy induced nausea and vomiting: Quantitative systematic review
    • Tramer MR, Carroll D, Campbell FA, Reynolds DJ, Moore RA, McQuay HJ. Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review. BMJ 323, 16-21 (2001).
    • (2001) BMJ , vol.323 , pp. 16-21
    • Tramer, M.R.1    Carroll, D.2    Campbell, F.A.3    Reynolds, D.J.4    Moore, R.A.5    McQuay, H.J.6
  • 5
    • 23044486763 scopus 로고    scopus 로고
    • Cannabinoids and the immune system: Potential for the treatment of inflammatory diseases?
    • Croxford JL, Yamamura T. Cannabinoids and the immune system: potential for the treatment of inflammatory diseases? J. Neuroimmunol. 166, 3-18 (2005).
    • (2005) J. Neuroimmunol. , vol.166 , pp. 3-18
    • Croxford, J.L.1    Yamamura, T.2
  • 6
    • 33144480327 scopus 로고    scopus 로고
    • Cannabinoid receptors as therapeutic targets
    • Mackie K. Cannabinoid receptors as therapeutic targets. Annu. Rev. Pharmacol. Toxicol. 46, 101-122 (2006).
    • (2006) Annu. Rev. Pharmacol. Toxicol. , vol.46 , pp. 101-122
    • MacKie, K.1
  • 7
    • 0029739799 scopus 로고    scopus 로고
    • Cannabinoid receptors are coupled to nitric oxide release in invertebrate immunocytes, microglia, and human monocytes
    • Stefano GB, Liu Y, Goligorsky MS. Cannabinoid receptors are coupled to nitric oxide release in invertebrate immunocytes, microglia, and human monocytes. J. Biol. Chem. 271, 19238-19242 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 19238-19242
    • Stefano, G.B.1    Liu, Y.2    Goligorsky, M.S.3
  • 8
    • 0027078685 scopus 로고
    • Isolation and structure of a brain constituent that binds to the cannabinoid receptor
    • Devane WA, Hanus L, Breuer A et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258, 1946-1949 (1992).
    • (1992) Science , vol.258 , pp. 1946-1949
    • Devane, W.A.1    Hanus, L.2    Breuer, A.3
  • 9
    • 0029012014 scopus 로고
    • Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
    • Mechoulam R, Ben-Shabat S, Hanus L et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol. 50, 83-90 (1995).
    • (1995) Biochem. Pharmacol. , vol.50 , pp. 83-90
    • Mechoulam, R.1    Ben-Shabat, S.2    Hanus, L.3
  • 10
    • 0028970517 scopus 로고
    • 2-arachidonoylglycerol: A possible endogenous cannabinoid receptor ligand in brain
    • Sugiura T, Kondo S, Sukagawa A et al. 2-arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem. Biophys. Res. Commun. 215, 89-97 (1995).
    • (1995) Biochem. Biophys. Res. Commun. , vol.215 , pp. 89-97
    • Sugiura, T.1    Kondo, S.2    Sukagawa, A.3
  • 11
  • 12
    • 65549113847 scopus 로고    scopus 로고
    • Identification of intracellular carriers for the endocannabinoid anandamide
    • Kaczocha M, Glaser ST, Deutsch DG. Identification of intracellular carriers for the endocannabinoid anandamide. Proc. Natl Acad. Sci. USA 106, 6375-6380 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 6375-6380
    • Kaczocha, M.1    Glaser, S.T.2    Deutsch, D.G.3
  • 14
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO. The biochemistry of apoptosis. Nature 407, 770-776 (2000).
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 15
    • 0036547417 scopus 로고    scopus 로고
    • Death and anti-death: Tumour resistance to apoptosis
    • Igney FH, Krammer PH. Death and anti-death: tumour resistance to apoptosis. Nat. Rev. Cancer 2, 277-288 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 277-288
    • Igney, F.H.1    Krammer, P.H.2
  • 16
    • 0032219623 scopus 로고    scopus 로고
    • D9-tetrahydrocannabinol induces apoptosis in macrophages and lymphocytes: Involvement of Bcl-2 and caspase-1
    • Zhu W, Friedman H, Klein TW. D9-tetrahydrocannabinol induces apoptosis in macrophages and lymphocytes: involvement of Bcl-2 and caspase-1. J. Pharmacol. Exp. Ther. 286, 1103-1109 (1998).
    • (1998) J. Pharmacol. Exp. Ther. , vol.286 , pp. 1103-1109
    • Zhu, W.1    Friedman, H.2    Klein, T.W.3
  • 17
    • 0036074054 scopus 로고    scopus 로고
    • D(9)- Tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo
    • McKallip RJ, Lombard C, Martin BR, Nagarkatti M, Nagarkatti PS. D(9)- tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo. J. Pharmacol. Exp. Ther. 302, 451-465 (2002).
    • (2002) J. Pharmacol. Exp. Ther. , vol.302 , pp. 451-465
    • McKallip, R.J.1    Lombard, C.2    Martin, B.R.3    Nagarkatti, M.4    Nagarkatti, P.S.5
  • 18
    • 4043179097 scopus 로고    scopus 로고
    • Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kB-dependent apoptosis: Novel role for endogenous and exogenous cannabinoids in immunoregulation
    • Do Y, McKallip RJ, Nagarkatti M, Nagarkatti PS. Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation. J. Immunol. 173, 2373-2382 (2004).
    • (2004) J. Immunol. , vol.173 , pp. 2373-2382
    • Do, Y.1    McKallip, R.J.2    Nagarkatti, M.3    Nagarkatti, P.S.4
  • 19
    • 33749014963 scopus 로고    scopus 로고
    • Cannabinoid treatment suppresses the T-helper cell-polarizing function of mouse dendritic cells stimulated with Legionella pneumophila infection
    • Lu T, Newton C, Perkins I, Friedman H, Klein TW. Cannabinoid treatment suppresses the T-helper cell-polarizing function of mouse dendritic cells stimulated with Legionella pneumophila infection. J. Pharmacol. Exp. Ther. 319, 269-276 (2006).
    • (2006) J. Pharmacol. Exp. Ther. , vol.319 , pp. 269-276
    • Lu, T.1    Newton, C.2    Perkins, I.3    Friedman, H.4    Klein, T.W.5
  • 20
    • 41149153235 scopus 로고    scopus 로고
    • A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells
    • Lee CY, Wey SP, Liao MH et al. A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells. Int. Immunopharmacol. 8, 732-740 (2008).
    • (2008) Int. Immunopharmacol. , vol.8 , pp. 732-740
    • Lee, C.Y.1    Wey, S.P.2    Liao, M.H.3
  • 21
    • 0042061323 scopus 로고    scopus 로고
    • Ajulemic acid, a nonpsychoactive cannabinoid acid, induces apoptosis in human T lymphocytes
    • Bidinger B, Torres R, Rossetti RG et al. Ajulemic acid, a nonpsychoactive cannabinoid acid, induces apoptosis in human T lymphocytes. Clin. Immunol. 108, 95-102 (2003).
    • (2003) Clin. Immunol. , vol.108 , pp. 95-102
    • Bidinger, B.1    Torres, R.2    Rossetti, R.G.3
  • 22
    • 33846828655 scopus 로고    scopus 로고
    • CB2 cannabinoid receptor agonist, JWH-015, triggers apoptosis in immune cells: Potential role for CB2-selective ligands as immunosuppressive agents
    • Lombard C, Nagarkatti M, Nagarkatti P. CB2 cannabinoid receptor agonist, JWH-015, triggers apoptosis in immune cells: potential role for CB2-selective ligands as immunosuppressive agents. Clin. Immunol. 122, 259-270 (2007).
    • (2007) Clin. Immunol. , vol.122 , pp. 259-270
    • Lombard, C.1    Nagarkatti, M.2    Nagarkatti, P.3
  • 23
    • 0037085572 scopus 로고    scopus 로고
    • Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures
    • Molina-Holgado F, Molina-Holgado E, Guaza C, Rothwell NJ. Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide- induced nitric oxide release in astrocyte cultures. J. Neurosci. Res. 67, 829-836 (2002).
    • (2002) J. Neurosci. Res. , vol.67 , pp. 829-836
    • Molina-Holgado, F.1    Molina-Holgado, E.2    Guaza, C.3    Rothwell, N.J.4
  • 24
    • 37749034365 scopus 로고    scopus 로고
    • Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis
    • Croxford JL, Pryce G, Jackson SJ et al. Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis. J. Neuroimmunol. 193, 120-129 (2008).
    • (2008) J. Neuroimmunol. , vol.193 , pp. 120-129
    • Croxford, J.L.1    Pryce, G.2    Jackson, S.J.3
  • 25
    • 0034660138 scopus 로고    scopus 로고
    • D9-tetrahydrocannabinol treatment suppresses immunity and early IFN-g IL-12 and IL-12 receptor b 2 responses to Legionella pneumophila infection
    • Klein TW, Newton CA, Nakachi N, Friedman H. D9-tetrahydrocannabinol treatment suppresses immunity and early IFN-g, IL-12, and IL-12 receptor b 2 responses to Legionella pneumophila infection. J. Immunol. 164, 6461-6466 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 6461-6466
    • Klein, T.W.1    Newton, C.A.2    Nakachi, N.3    Friedman, H.4
  • 26
    • 0031593692 scopus 로고    scopus 로고
    • D9 tetrahydrocannabinol and cannabidiol alter cytokine production by human immune cells
    • Srivastava MD, Srivastava BI, Brouhard B. D9 tetrahydrocannabinol and cannabidiol alter cytokine production by human immune cells. Immunopharmacology 40, 179-185 (1998).
    • (1998) Immunopharmacology , vol.40 , pp. 179-185
    • Srivastava, M.D.1    Srivastava, B.I.2    Brouhard, B.3
  • 27
    • 0034717138 scopus 로고    scopus 로고
    • Genomic and functional changes induced by the activation of the peripheral cannabinoid receptor CB2 in the promyelocytic cells HL-60. Possible involvement of the CB2 receptor in cell differentiation
    • Derocq JM, Jbilo O, Bouaboula M, Segui M, Clere C, Casellas P. Genomic and functional changes induced by the activation of the peripheral cannabinoid receptor CB2 in the promyelocytic cells HL-60. Possible involvement of the CB2 receptor in cell differentiation. J. Biol. Chem. 275, 15621-15628 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 15621-15628
    • Derocq, J.M.1    Jbilo, O.2    Bouaboula, M.3    Segui, M.4    Clere, C.5    Casellas, P.6
  • 28
    • 0033986604 scopus 로고    scopus 로고
    • Cannabinoids inhibit LPS-inducible cytokine mRNA expression in rat microglial cells
    • Puffenbarger RA, Boothe AC, Cabral GA. Cannabinoids inhibit LPS-inducible cytokine mRNA expression in rat microglial cells. Glia 29, 58-69 (2000).
    • (2000) Glia , vol.29 , pp. 58-69
    • Puffenbarger, R.A.1    Boothe, A.C.2    Cabral, G.A.3
  • 29
    • 0034069673 scopus 로고    scopus 로고
    • Effects of cannabinoid receptor agonist and antagonist ligands on production of inflammatory cytokines and anti-inflammatory interleukin-10 in endotoxemic mice
    • Smith SR, Terminelli C, Denhardt G. Effects of cannabinoid receptor agonist and antagonist ligands on production of inflammatory cytokines and anti-inflammatory interleukin-10 in endotoxemic mice. J. Pharmacol. Exp. Ther. 293, 136-150 (2000).
    • (2000) J. Pharmacol. Exp. Ther. , vol.293 , pp. 136-150
    • Smith, S.R.1    Terminelli, C.2    Denhardt, G.3
  • 30
    • 33748110308 scopus 로고    scopus 로고
    • Interleukin-6: A new therapeutic target
    • Smolen JS, Maini RN. Interleukin-6: a new therapeutic target. Arthritis Res. Ther. 8(Suppl. 2), S5 (2006).
    • (2006) Arthritis Res. Ther. , vol.8 , Issue.SUPPL. 2
    • Smolen, J.S.1    Maini, R.N.2
  • 31
    • 0031962165 scopus 로고    scopus 로고
    • Dimethylheptyl-THC-11 oic acid: A nonpsychoactive antiinflammatory agent with a cannabinoid template structure
    • Zurier RB, Rossetti RG, Lane JH, Goldberg JM, Hunter SA, Burstein SH. Dimethylheptyl-THC-11 oic acid: a nonpsychoactive antiinflammatory agent with a cannabinoid template structure. Arthritis Rheum. 41, 163-170 (1998).
    • (1998) Arthritis Rheum. , vol.41 , pp. 163-170
    • Zurier, R.B.1    Rossetti, R.G.2    Lane, J.H.3    Goldberg, J.M.4    Hunter, S.A.5    Burstein, S.H.6
  • 32
    • 41849090731 scopus 로고    scopus 로고
    • Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid
    • Parker J, Atez F, Rossetti RG, Skulas A, Patel R, Zurier RB. Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid. Rheumatol. Int. 28, 631-635 (2008).
    • (2008) Rheumatol. Int. , vol.28 , pp. 631-635
    • Parker, J.1    Atez, F.2    Rossetti, R.G.3    Skulas, A.4    Patel, R.5    Zurier, R.B.6
  • 33
    • 37249091964 scopus 로고    scopus 로고
    • Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis
    • Rajesh M, Pan H, Mukhopadhyay P et al. Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis. J. Leukoc. Biol. 82, 1382-1389 (2007).
    • (2007) J. Leukoc. Biol. , vol.82 , pp. 1382-1389
    • Rajesh, M.1    Pan, H.2    Mukhopadhyay, P.3
  • 34
    • 52649089192 scopus 로고    scopus 로고
    • Inhibitory effect of synthetic cannabinoids on cytokine production in rheumatoid fibroblast-like synoviocytes
    • Selvi E, Lorenzini S, Garcia-Gonzalez E et al. Inhibitory effect of synthetic cannabinoids on cytokine production in rheumatoid fibroblast-like synoviocytes. Clin. Exp. Rheumatol. 26, 574-581 (2008).
    • (2008) Clin. Exp. Rheumatol. , vol.26 , pp. 574-581
    • Selvi, E.1    Lorenzini, S.2    Garcia-Gonzalez, E.3
  • 35
    • 0030753167 scopus 로고    scopus 로고
    • Anandamide, a natural ligand for the peripheral cannabinoid receptor is a novel synergistic growth factor for hematopoietic cells
    • Valk P, Verbakel S, Vankan Y et al. Anandamide, a natural ligand for the peripheral cannabinoid receptor is a novel synergistic growth factor for hematopoietic cells. Blood 90, 1448-1457 (1997).
    • (1997) Blood , vol.90 , pp. 1448-1457
    • Valk, P.1    Verbakel, S.2    Vankan, Y.3
  • 36
    • 33745280979 scopus 로고    scopus 로고
    • Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor g independently of cannabinoid receptors 1 and 2
    • Rockwell CE, Snider NT, Thompson JT, Vanden Heuvel JP, Kaminski NE. Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor g independently of cannabinoid receptors 1 and 2. Mol. Pharmacol. 70, 101-111 (2006).
    • (2006) Mol. Pharmacol. , vol.70 , pp. 101-111
    • Rockwell, C.E.1    Snider, N.T.2    Thompson, J.T.3    Vanden Heuvel, J.P.4    Kaminski, N.E.5
  • 37
    • 2442706289 scopus 로고    scopus 로고
    • 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells
    • Kishimoto S, Kobayashi Y, Oka S, Gokoh M, Waku K, Sugiura T. 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells. J. Biochem. 135, 517-524 (2004).
    • (2004) J. Biochem. , vol.135 , pp. 517-524
    • Kishimoto, S.1    Kobayashi, Y.2    Oka, S.3    Gokoh, M.4    Waku, K.5    Sugiura, T.6
  • 38
    • 15244359387 scopus 로고    scopus 로고
    • Pharmacological modulation of the endocannabinoid system in a viral model of multiple sclerosis
    • Mestre L, Correa F, Arevalo-Martin A et al. Pharmacological modulation of the endocannabinoid system in a viral model of multiple sclerosis. J. Neurochem. 92, 1327-1339 (2005).
    • (2005) J. Neurochem. , vol.92 , pp. 1327-1339
    • Mestre, L.1    Correa, F.2    Arevalo-Martin, A.3
  • 39
    • 0035877059 scopus 로고    scopus 로고
    • Progesterone up-regulates anandamide hydrolase in human lymphocytes: Role of cytokines and implications for fertility
    • Maccarrone M, Valensise H, Bari M, Lazzarin N, Romanini C, Finazzi-Agro A. Progesterone up-regulates anandamide hydrolase in human lymphocytes: role of cytokines and implications for fertility. J. Immunol. 166, 7183-7189 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 7183-7189
    • MacCarrone, M.1    Valensise, H.2    Bari, M.3    Lazzarin, N.4    Romanini, C.5    Finazzi-Agro, A.6
  • 40
    • 0027732254 scopus 로고
    • D9-tetrahydrocannabinol inhibition of tumor necrosis factor-a: Suppression of posttranslational events
    • Fischer-Stenger K, Dove Pettit DA, Cabral GA. D9-tetrahydrocannabinol inhibition of tumor necrosis factor-a: suppression of posttranslational events. J. Pharmacol. Exp. Ther. 267, 1558-1565 (1993).
    • (1993) J. Pharmacol. Exp. Ther. , vol.267 , pp. 1558-1565
    • Fischer-Stenger, K.1    Dove Pettit, D.A.2    Cabral, G.A.3
  • 41
    • 0028171722 scopus 로고
    • D9-tetrahydrocannabinol enhances the secretion of interleukin 1 from endotoxin-stimulated macrophages
    • Zhu W, Newton C, Dka Y, Friedman H, Klein TW. D9-tetrahydrocannabinol enhances the secretion of interleukin 1 from endotoxin-stimulated macrophages. J. Pharmacol. Exp. Ther. 270, 1334-1339 (1994).
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 1334-1339
    • Zhu, W.1    Newton, C.2    Dka, Y.3    Friedman, H.4    Klein, T.W.5
  • 42
    • 65249142200 scopus 로고    scopus 로고
    • The challenge of multiple sclerosis: How do we cure a chronic heterogeneous disease?
    • Weiner HL. The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease? Ann. Neurol. 65, 239-248 (2009).
    • (2009) Ann. Neurol. , vol.65 , pp. 239-248
    • Weiner, H.L.1
  • 43
    • 0036669791 scopus 로고    scopus 로고
    • Cannabinoids and multiple sclerosis
    • Pertwee RG. Cannabinoids and multiple sclerosis. Pharmacol. Ther. 95, 165-174 (2002).
    • (2002) Pharmacol. Ther. , vol.95 , pp. 165-174
    • Pertwee, R.G.1
  • 44
    • 38349141837 scopus 로고    scopus 로고
    • CB2 cannabinoid receptors as an emerging target for demyelinating diseases: From neuroimmune interactions to cell replacement strategies
    • Arevalo-Martin A, Garcia-Ovejero D, Gomez O et al. CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies. Br. J. Pharmacol. 153, 216-225 (2008).
    • (2008) Br. J. Pharmacol. , vol.153 , pp. 216-225
    • Arevalo-Martin, A.1    Garcia-Ovejero, D.2    Gomez, O.3
  • 45
    • 34848897836 scopus 로고    scopus 로고
    • The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis
    • Centonze D, Bari M, Rossi S et al. The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis. Brain 130, 2543-2553 (2007).
    • (2007) Brain , vol.130 , pp. 2543-2553
    • Centonze, D.1    Bari, M.2    Rossi, S.3
  • 46
    • 33744827120 scopus 로고    scopus 로고
    • Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes
    • Ghosh S, Preet A, Groopman JE, Ganju RK. Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes. Mol. Immunol. 43, 2169-2179 (2006).
    • (2006) Mol. Immunol. , vol.43 , pp. 2169-2179
    • Ghosh, S.1    Preet, A.2    Groopman, J.E.3    Ganju, R.K.4
  • 47
    • 0035149317 scopus 로고    scopus 로고
    • T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis
    • Iglesias A, Bauer J, Litzenburger T, Schubart A, Linington C. T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis. Glia 36, 220-234 (2001).
    • (2001) Glia , vol.36 , pp. 220-234
    • Iglesias, A.1    Bauer, J.2    Litzenburger, T.3    Schubart, A.4    Linington, C.5
  • 48
    • 46049093364 scopus 로고    scopus 로고
    • Th17 Cells and autoimmune encephalomyelitis (EAE/MS)
    • Aranami T, Yamamura T. Th17 Cells and autoimmune encephalomyelitis (EAE/MS). Allergol. Int. 57, 115-120 (2008).
    • (2008) Allergol. Int. , vol.57 , pp. 115-120
    • Aranami, T.1    Yamamura, T.2
  • 49
    • 52949094997 scopus 로고    scopus 로고
    • IL17 and IFNg production by peripheral blood mononuclear cells from clinically isolated syndrome to secondary progressive multiple sclerosis
    • Frisullo G, Nociti V, Iorio R et al. IL17 and IFNg production by peripheral blood mononuclear cells from clinically isolated syndrome to secondary progressive multiple sclerosis. Cytokine 44, 22-25 (2008).
    • (2008) Cytokine , vol.44 , pp. 22-25
    • Frisullo, G.1    Nociti, V.2    Iorio, R.3
  • 50
    • 33751100172 scopus 로고    scopus 로고
    • R-[2,3-dihydro-5-methyl-3-(4- morpholinylmethyl)-pyrrolo-[1,2,3-de]-1,4 -benzoxazin-6-yl]-1-naphtalenylmethanone (WIN-2) ameliorates experimental autoimmune encephalomyelitis and induces encephalitogenic T cell apoptosis: Partial involvement of the CB(2) receptor
    • Sanchez AJ, Gonzalez-Perez P, Galve-Roperh I, Garcia-Merino A. R-[2,3-dihydro-5-methyl-3-(4- morpholinylmethyl)-pyrrolo-[1,2,3-de]-1,4 -benzoxazin-6-yl]-1-naphtalenylmethanone (WIN-2) ameliorates experimental autoimmune encephalomyelitis and induces encephalitogenic T cell apoptosis: partial involvement of the CB(2) receptor. Biochem. Pharmacol. 72, 1697-1706 (2006).
    • (2006) Biochem. Pharmacol. , vol.72 , pp. 1697-1706
    • Sanchez, A.J.1    Gonzalez-Perez, P.2    Galve-Roperh, I.3    Garcia-Merino, A.4
  • 52
    • 59049099828 scopus 로고    scopus 로고
    • A cannabinoid agonist interferes with the progression of a chronic model of multiple sclerosis by downregulating adhesion molecules
    • Mestre L, Docagne F, Correa F et al. A cannabinoid agonist interferes with the progression of a chronic model of multiple sclerosis by downregulating adhesion molecules. Mol. Cell Neurosci. 40, 258-266 (2009).
    • (2009) Mol. Cell Neurosci. , vol.40 , pp. 258-266
    • Mestre, L.1    Docagne, F.2    Correa, F.3
  • 53
    • 29244478635 scopus 로고    scopus 로고
    • Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation
    • Ehrhart J, Obregon D, Mori T et al. Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation. J. Neuroinflammation 2, 29 (2005).
    • (2005) J. Neuroinflammation , vol.2 , pp. 29
    • Ehrhart, J.1    Obregon, D.2    Mori, T.3
  • 54
    • 56649092813 scopus 로고    scopus 로고
    • A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells
    • Correa F, Docagne F, Mestre L et al. A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells. Biochem. Pharmacol. 77, 86-100 (2009).
    • (2009) Biochem. Pharmacol. , vol.77 , pp. 86-100
    • Correa, F.1    Docagne, F.2    Mestre, L.3
  • 55
    • 45149123400 scopus 로고    scopus 로고
    • The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: Involvement in the pathogenesis of an animal model of multiple sclerosis
    • Palazuelos J, Davoust N, Julien B et al. The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis. J. Biol. Chem. 283, 13320-13329 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 13320-13329
    • Palazuelos, J.1    Davoust, N.2    Julien, B.3
  • 56
    • 13244283049 scopus 로고    scopus 로고
    • Synthetic cannabinoid WIN55,212-212 inhibits generation of inflammatory mediators by IL-1b-stimulated human astrocytes
    • Sheng WS, Hu S, Min X, Cabral GA, Lokensgard JR, Peterson PK. Synthetic cannabinoid WIN55,212-212 inhibits generation of inflammatory mediators by IL-1b-stimulated human astrocytes. Glia 49, 211-219 (2005).
    • (2005) Glia , vol.49 , pp. 211-219
    • Sheng, W.S.1    Hu, S.2    Min, X.3    Cabral, G.A.4    Lokensgard, J.R.5    Peterson, P.K.6
  • 57
    • 0031866598 scopus 로고    scopus 로고
    • The endogenous cannabinoid anandamide potentiates interleukin-6 production by astrocytes infected with Theiler's murine encephalomyelitis virus by a receptor-mediated pathway
    • Molina-Holgado F, Molina-Holgado E, Guaza C. The endogenous cannabinoid anandamide potentiates interleukin-6 production by astrocytes infected with Theiler's murine encephalomyelitis virus by a receptor-mediated pathway. FEBS Lett. 433, 139-142 (1998).
    • (1998) FEBS Lett. , vol.433 , pp. 139-142
    • Molina-Holgado, F.1    Molina-Holgado, E.2    Guaza, C.3
  • 58
    • 0003096661 scopus 로고    scopus 로고
    • Fundamentals of neurogastroenterology
    • Wood JD, Alpers DH, Andrews PL. Fundamentals of neurogastroenterology. Gut 45(Suppl. 2.), II6-II16 (1999).
    • (1999) Gut , vol.45 , Issue.SUPPL. 2.
    • Wood, J.D.1    Alpers, D.H.2    Andrews, P.L.3
  • 59
    • 11144355734 scopus 로고    scopus 로고
    • The endogenous cannabinoid system protects against colonic inflammation
    • Massa F, Marsicano G, Hermann H et al. The endogenous cannabinoid system protects against colonic inflammation. J. Clin. Invest. 113, 1202-1209 (2004).
    • (2004) J. Clin. Invest. , vol.113 , pp. 1202-1209
    • Massa, F.1    Marsicano, G.2    Hermann, H.3
  • 60
    • 0035010955 scopus 로고    scopus 로고
    • Cannabinoids and the gastrointestinal tract
    • Pertwee RG. Cannabinoids and the gastrointestinal tract. Gut 48, 859-867 (2001).
    • (2001) Gut , vol.48 , pp. 859-867
    • Pertwee, R.G.1
  • 61
    • 0025181580 scopus 로고
    • A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice
    • Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98, 694-702 (1990).
    • (1990) Gastroenterology , vol.98 , pp. 694-702
    • Okayasu, I.1    Hatakeyama, S.2    Yamada, M.3    Ohkusa, T.4    Inagaki, Y.5    Nakaya, R.6
  • 63
    • 0028861975 scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • Neurath MF, Fuss I, Kelsall BL, Stuber E, Strober W. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 182, 1281-1290 (1995).
    • (1995) J. Exp. Med. , vol.182 , pp. 1281-1290
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3    Stuber, E.4    Strober, W.5
  • 64
    • 33745783119 scopus 로고    scopus 로고
    • Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium
    • Kimball ES, Schneider CR, Wallace NH, Hornby PJ. Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium. Am. J. Physiol. Gastrointest. Liver Physiol. 291, G364-G371 (2006).
    • (2006) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.291
    • Kimball, E.S.1    Schneider, C.R.2    Wallace, N.H.3    Hornby, P.J.4
  • 65
    • 0034740564 scopus 로고    scopus 로고
    • Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation
    • Izzo AA, Fezza F, Capasso R et al. Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation. Br. J. Pharmacol. 134, 563-570 (2001).
    • (2001) Br. J. Pharmacol. , vol.134 , pp. 563-570
    • Izzo, A.A.1    Fezza, F.2    Capasso, R.3
  • 66
    • 0035979244 scopus 로고    scopus 로고
    • Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
    • Cravatt BF, Demarest K, Patricelli MP et al. Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proc. Natl Acad. Sci. USA 98, 9371-9376 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 9371-9376
    • Cravatt, B.F.1    Demarest, K.2    Patricelli, M.P.3
  • 68
    • 2142662143 scopus 로고    scopus 로고
    • Vasodilator mRNA levels are increased in the livers of portal hypertensive NO-synthase 3-deficient mice
    • Biecker E, Sagesser H, Reichen J. Vasodilator mRNA levels are increased in the livers of portal hypertensive NO-synthase 3-deficient mice. Eur. J. Clin. Invest. 34, 283-289 (2004).
    • (2004) Eur. J. Clin. Invest. , vol.34 , pp. 283-289
    • Biecker, E.1    Sagesser, H.2    Reichen, J.3
  • 69
    • 15744388722 scopus 로고    scopus 로고
    • Antifibrogenic role of the cannabinoid receptor CB2 in the liver
    • Julien B, Grenard P, Teixeira-Clerc F et al. Antifibrogenic role of the cannabinoid receptor CB2 in the liver. Gastroenterology 128, 742-755 (2005).
    • (2005) Gastroenterology , vol.128 , pp. 742-755
    • Julien, B.1    Grenard, P.2    Teixeira-Clerc, F.3
  • 70
    • 20944436157 scopus 로고    scopus 로고
    • Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity
    • Osei-Hyiaman D, DePetrillo M, Pacher P et al. Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J. Clin. Invest. 115, 1298-1305 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 1298-1305
    • Osei-Hyiaman, D.1    Depetrillo, M.2    Pacher, P.3
  • 71
    • 85081150436 scopus 로고    scopus 로고
    • Potential role of CB2 receptors in cannabis smokers with chronic hepatitis C
    • Schwabe RF, Siegmund SV. Potential role of CB2 receptors in cannabis smokers with chronic hepatitis C. Hepatology 42, 975-977 (2005).
    • (2005) Hepatology , vol.42 , pp. 975-977
    • Schwabe, R.F.1    Siegmund, S.V.2
  • 72
    • 33745003240 scopus 로고    scopus 로고
    • CB1 cannabinoid receptor antagonism: A new strategy for the treatment of liver fibrosis
    • Teixeira-Clerc F, Julien B, Grenard P et al. CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Nat. Med. 12, 671-676 (2006).
    • (2006) Nat. Med. , vol.12 , pp. 671-676
    • Teixeira-Clerc, F.1    Julien, B.2    Grenard, P.3
  • 73
    • 0034928628 scopus 로고    scopus 로고
    • Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis
    • Batkai S, Jarai Z, Wagner JA et al. Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis. Nat. Med. 7, 827-832 (2001).
    • (2001) Nat. Med. , vol.7 , pp. 827-832
    • Batkai, S.1    Jarai, Z.2    Wagner, J.A.3
  • 74
    • 34249788152 scopus 로고    scopus 로고
    • Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury
    • Batkai S, Osei-Hyiaman D, Pan H et al. Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury. FASEB J. 21, 1788 - 1800 (2007).
    • (2007) FASEB J. , vol.21 , pp. 1788-1800
    • Batkai, S.1    Osei-Hyiaman, D.2    Pan, H.3
  • 75
    • 34547423962 scopus 로고    scopus 로고
    • Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats
    • Gary-Bobo M, Elachouri G, Gallas JF et al. Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats. Hepatology 46, 122-129 (2007).
    • (2007) Hepatology , vol.46 , pp. 122-129
    • Gary-Bobo, M.1    Elachouri, G.2    Gallas, J.F.3
  • 76
    • 34548499520 scopus 로고    scopus 로고
    • The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species
    • Siegmund SV, Qian T, de Minicis S et al. The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species. FASEB J. 21, 2798-2806 (2007).
    • (2007) FASEB J. , vol.21 , pp. 2798-2806
    • Siegmund, S.V.1    Qian, T.2    De Minicis, S.3
  • 77
    • 21344472982 scopus 로고    scopus 로고
    • Daily cannabis smoking as a risk factor for progression of fibrosis in chronic hepatitis C
    • Hezode C, Roudot-Thoraval F, Nguyen S et al. Daily cannabis smoking as a risk factor for progression of fibrosis in chronic hepatitis C. Hepatology 42, 63-71 (2005).
    • (2005) Hepatology , vol.42 , pp. 63-71
    • Hezode, C.1    Roudot-Thoraval, F.2    Nguyen, S.3
  • 78
    • 29144480571 scopus 로고    scopus 로고
    • Endocannabinoids affect neurological and cognitive function in thioacetamide-induced hepatic encephalopathy in mice
    • Avraham Y, Israeli E, Gabbay E et al. Endocannabinoids affect neurological and cognitive function in thioacetamide-induced hepatic encephalopathy in mice. Neurobiol. Dis. 21, 237-245 (2006).
    • (2006) Neurobiol. Dis. , vol.21 , pp. 237-245
    • Avraham, Y.1    Israeli, E.2    Gabbay, E.3
  • 79
    • 45749086074 scopus 로고    scopus 로고
    • Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: Involvement of regulatory T cells
    • Hegde VL, Hegde S, Cravatt BF, Hofseth LJ, Nagarkatti M, Nagarkatti PS. Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells. Mol. Pharmacol. 74, 20-33 (2008).
    • (2008) Mol. Pharmacol. , vol.74 , pp. 20-33
    • Hegde, V.L.1    Hegde, S.2    Cravatt, B.F.3    Hofseth, L.J.4    Nagarkatti, M.5    Nagarkatti, P.S.6
  • 80
    • 12344253624 scopus 로고    scopus 로고
    • Rheumatoid arthritis, inflammation, and atherosclerosis
    • Hurlimann D, Enseleit F, Ruschitzka F. Rheumatoid arthritis, inflammation, and atherosclerosis. Herz 29, 760-768 (2004).
    • (2004) Herz , vol.29 , pp. 760-768
    • Hurlimann, D.1    Enseleit, F.2    Ruschitzka, F.3
  • 82
    • 0037441413 scopus 로고    scopus 로고
    • Suppression of human monocyte interleukin-1b production by ajulemic acid, a nonpsychoactive cannabinoid
    • Zurier RB, Rossetti RG, Burstein SH, Bidinger B. Suppression of human monocyte interleukin-1b production by ajulemic acid, a nonpsychoactive cannabinoid. Biochem. Pharmacol. 65, 649-655 (2003).
    • (2003) Biochem. Pharmacol. , vol.65 , pp. 649-655
    • Zurier, R.B.1    Rossetti, R.G.2    Burstein, S.H.3    Bidinger, B.4
  • 83
    • 38449111261 scopus 로고    scopus 로고
    • Ajulemic acid, a nonpsychoactive cannabinoid acid, suppresses osteoclastogenesis in mononuclear precursor cells and induces apoptosis in mature osteoclast-like cells
    • George KL, Saltman LH, Stein GS, Lian JB, Zurier RB. Ajulemic acid, a nonpsychoactive cannabinoid acid, suppresses osteoclastogenesis in mononuclear precursor cells and induces apoptosis in mature osteoclast-like cells. J. Cell Physiol. 214, 714-720 (2008).
    • (2008) J. Cell Physiol. , vol.214 , pp. 714-720
    • George, K.L.1    Saltman, L.H.2    Stein, G.S.3    Lian, J.B.4    Zurier, R.B.5
  • 84
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow?
    • Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet 357, 539-545 (2001).
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 85
    • 0034662868 scopus 로고    scopus 로고
    • The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
    • Malfait AM, Gallily R, Sumariwalla PF et al. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc. Natl Acad. Sci. USA 97, 9561-9566 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 9561-9566
    • Malfait, A.M.1    Gallily, R.2    Sumariwalla, P.F.3
  • 86
    • 1542283741 scopus 로고    scopus 로고
    • A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis
    • Sumariwalla PF, Gallily R, Tchilibon S, Fride E, Mechoulam R, Feldmann M. A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis. Arthritis Rheum. 50, 985-998 (2004).
    • (2004) Arthritis Rheum. , vol.50 , pp. 985-998
    • Sumariwalla, P.F.1    Gallily, R.2    Tchilibon, S.3    Fride, E.4    Mechoulam, R.5    Feldmann, M.6
  • 87
    • 0022967894 scopus 로고
    • Antimetastatic effect of flurbiprofen and other platelet aggregation inhibitors
    • Mamytbekova A, Rezabek K, Kacerovska H, Grimova J, Svobodova J. Antimetastatic effect of flurbiprofen and other platelet aggregation inhibitors. Neoplasma 33, 417-421 (1986).
    • (1986) Neoplasma , vol.33 , pp. 417-421
    • Mamytbekova, A.1    Rezabek, K.2    Kacerovska, H.3    Grimova, J.4    Svobodova, J.5
  • 89
    • 33746138649 scopus 로고    scopus 로고
    • Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
    • Carracedo A, Gironella M, Lorente M et al. Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Res. 66, 6748-6755 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 6748-6755
    • Carracedo, A.1    Gironella, M.2    Lorente, M.3
  • 90
    • 0037253496 scopus 로고    scopus 로고
    • Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
    • Casanova ML, Blazquez C, Martinez- Palacio J et al. Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J. Clin. Invest. 111, 43-50 (2003).
    • (2003) J. Clin. Invest. , vol.111 , pp. 43-50
    • Casanova, M.L.1    Blazquez, C.2    Martinez- Palacio, J.3
  • 91
    • 17344380844 scopus 로고    scopus 로고
    • Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signalregulated kinase activation
    • Galve-Roperh I, Sanchez C, Cortes ML et al. Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signalregulated kinase activation. Nat. Med. 6, 313-319 (2000).
    • (2000) Nat. Med. , vol.6 , pp. 313-319
    • Galve-Roperh, I.1    Sanchez, C.2    Cortes, M.L.3
  • 92
    • 0035422139 scopus 로고    scopus 로고
    • Inhibition of glioma growth in vivo by selective activation of the CB (2) cannabinoid receptor
    • Sanchez C, de Ceballos ML, Gomez del Pulgar T et al. Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor. Cancer Res. 61, 5784-5789 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 5784-5789
    • Sanchez, C.1    De Ceballos, M.L.2    Gomez Del Pulgar, T.3
  • 93
    • 16444375370 scopus 로고    scopus 로고
    • Cannabinoid receptor as a novel target for the treatment of prostate cancer
    • Sarfaraz S, Afaq F, Adhami VM, Mukhtar H. Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer Res. 65, 1635-1641 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 1635-1641
    • Sarfaraz, S.1    Afaq, F.2    Adhami, V.M.3    Mukhtar, H.4
  • 95
    • 20544444202 scopus 로고    scopus 로고
    • Targeting cannabinoid receptors to treat leukemia: Role of cross-talk between extrinsic and intrinsic pathways in D9- tetrahydrocannabinol (THC)-induced apoptosis of Jurkat cells
    • Lombard C, Nagarkatti M, Nagarkatti PS. Targeting cannabinoid receptors to treat leukemia: role of cross-talk between extrinsic and intrinsic pathways in D9- tetrahydrocannabinol (THC)-induced apoptosis of Jurkat cells. Leuk. Res. 29, 915-922 (2005).
    • (2005) Leuk. Res. , vol.29 , pp. 915-922
    • Lombard, C.1    Nagarkatti, M.2    Nagarkatti, P.S.3
  • 96
    • 33748417610 scopus 로고    scopus 로고
    • D9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria
    • Jia W, Hegde VL, Singh NP et al. D9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria. Mol. Cancer Res. 4, 549-562 (2006).
    • (2006) Mol. Cancer Res. , vol.4 , pp. 549-562
    • Jia, W.1    Hegde, V.L.2    Singh, N.P.3
  • 97
    • 0037100312 scopus 로고    scopus 로고
    • Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease
    • McKallip RJ, Lombard C, Fisher M et al. Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood 100, 627-634 (2002).
    • (2002) Blood , vol.100 , pp. 627-634
    • McKallip, R.J.1    Lombard, C.2    Fisher, M.3
  • 98
    • 0042972716 scopus 로고    scopus 로고
    • Possible endocannabinoid control of colorectal cancer growth
    • Ligresti A, Bisogno T, Matias I et al. Possible endocannabinoid control of colorectal cancer growth. Gastroenterology 125, 677-687 (2003).
    • (2003) Gastroenterology , vol.125 , pp. 677-687
    • Ligresti, A.1    Bisogno, T.2    Matias, I.3
  • 99
    • 59449111015 scopus 로고    scopus 로고
    • Cannabinoid receptor activation induces apoptosis through tumor necrosis factor a-mediated ceramide de novo synthesis in colon cancer cells
    • Cianchi F, Papucci L, Schiavone N et al. Cannabinoid receptor activation induces apoptosis through tumor necrosis factor a-mediated ceramide de novo synthesis in colon cancer cells. Clin. Cancer Res. 14, 7691-7700 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 7691-7700
    • Cianchi, F.1    Papucci, L.2    Schiavone, N.3
  • 100
    • 9444280832 scopus 로고    scopus 로고
    • A new strategy to block tumor growth by inhibiting endocannabinoid inactivation
    • Bifulco M, Laezza C, Valenti M et al. A new strategy to block tumor growth by inhibiting endocannabinoid inactivation. FASEB J. 18, 1606-1608 (2004).
    • (2004) FASEB J. , vol.18 , pp. 1606-1608
    • Bifulco, M.1    Laezza, C.2    Valenti, M.3
  • 101
    • 33749182829 scopus 로고    scopus 로고
    • Acyl-based anandamide uptake inhibitors cause rapid toxicity to C6 glioma cells at pharmacologically relevant concentrations
    • De Lago E, Gustafsson SB, Fernandez- Ruiz J et al. Acyl-based anandamide uptake inhibitors cause rapid toxicity to C6 glioma cells at pharmacologically relevant concentrations. J. Neurochem. 99, 677-688 (2006).
    • (2006) J. Neurochem. , vol.99 , pp. 677-688
    • De Lago, E.1    Gustafsson, S.B.2    Fernandez- Ruiz, J.3
  • 102
    • 34547112539 scopus 로고    scopus 로고
    • Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism
    • Endsley MP, Aggarwal N, Isbell MA et al. Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: location, hydrolysis and 12-lipoxygenase metabolism. Int. J. Cancer 121, 984-991 (2007).
    • (2007) Int. J. Cancer , vol.121 , pp. 984-991
    • Endsley, M.P.1    Aggarwal, N.2    Isbell, M.A.3
  • 104
    • 1842529993 scopus 로고    scopus 로고
    • Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1
    • Contassot E, Tenan M, Schnuriger V, Pelte MF, Dietrich PY. Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1. Gynecol. Oncol. 93, 182-188 (2004).
    • (2004) Gynecol. Oncol. , vol.93 , pp. 182-188
    • Contassot, E.1    Tenan, M.2    Schnuriger, V.3    Pelte, M.F.4    Dietrich, P.Y.5
  • 105
    • 4444310096 scopus 로고    scopus 로고
    • Arachidonylethanolamide induces apoptosis of human glioma cells through vanilloid receptor-1
    • Contassot E, Wilmotte R, Tenan M et al. Arachidonylethanolamide induces apoptosis of human glioma cells through vanilloid receptor-1. J. Neuropathol. Exp. Neurol. 63, 956-963 (2004).
    • (2004) J. Neuropathol. Exp. Neurol. , vol.63 , pp. 956-963
    • Contassot, E.1    Wilmotte, R.2    Tenan, M.3
  • 106
    • 34250378332 scopus 로고    scopus 로고
    • Opposing actions of endocannabinoids on cholangiocarcinoma growth: Recruitment of Fas and Fas ligand to lipid rafts
    • DeMorrow S, Glaser S, Francis H et al. Opposing actions of endocannabinoids on cholangiocarcinoma growth: recruitment of Fas and Fas ligand to lipid rafts. J. Biol. Chem. 282, 13098-13113 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 13098-13113
    • Demorrow, S.1    Glaser, S.2    Francis, H.3
  • 107
    • 0035651034 scopus 로고    scopus 로고
    • Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth
    • Bifulco M, Laezza C, Portella G et al. Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth. FASEB J. 15, 2745-2747 (2001).
    • (2001) FASEB J. , vol.15 , pp. 2745-2747
    • Bifulco, M.1    Laezza, C.2    Portella, G.3
  • 108
    • 33746125474 scopus 로고    scopus 로고
    • D9- tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation
    • Caffarel MM, Sarrio D, Palacios J, Guzman M, Sanchez C. D9- tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation. Cancer Res. 66, 6615-6621 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 6615-6621
    • Caffarel, M.M.1    Sarrio, D.2    Palacios, J.3    Guzman, M.4    Sanchez, C.5
  • 109
    • 0036682308 scopus 로고    scopus 로고
    • Mantle cell lymphomas express a distinct genetic signature affecting lymphocyte trafficking and growth regulation as compared with subpopulations of normal human B cells
    • Ek S, Hogerkorp CM, Dictor M, Ehinger M, Borrebaeck CA. Mantle cell lymphomas express a distinct genetic signature affecting lymphocyte trafficking and growth regulation as compared with subpopulations of normal human B cells. Cancer Res. 62, 4398-4405 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 4398-4405
    • Ek, S.1    Hogerkorp, C.M.2    Dictor, M.3    Ehinger, M.4    Borrebaeck, C.A.5
  • 110
    • 0141613823 scopus 로고    scopus 로고
    • High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of cyclin D1 in mantle cell lymphoma
    • Islam TC, Asplund AC, Lindvall JM et al. High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of cyclin D1 in mantle cell lymphoma. Leukemia 17, 1880-1890 (2003).
    • (2003) Leukemia , vol.17 , pp. 1880-1890
    • Islam, T.C.1    Asplund, A.C.2    Lindvall, J.M.3
  • 111
    • 0032968706 scopus 로고    scopus 로고
    • Immunologic basis of antigen-induced airway hyperresponsiveness
    • Wills-Karp M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu. Rev. Immunol. 17, 255-281 (1999).
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 255-281
    • Wills-Karp, M.1
  • 112
    • 0028170510 scopus 로고
    • TH2 and 'TH2-like' cells in allergy and asthma: Pharmacological perspectives
    • Anderson GP, Coyle AJ. TH2 and 'TH2-like' cells in allergy and asthma: pharmacological perspectives. Trends Pharmacol. Sci. 15, 324-332 (1994).
    • (1994) Trends Pharmacol. Sci. , vol.15 , pp. 324-332
    • Anderson, G.P.1    Coyle, A.J.2
  • 113
    • 0037379995 scopus 로고    scopus 로고
    • Attenuation of the ovalbumin-induced allergic airway response by cannabinoid treatment in A/J mice
    • Jan TR, Farraj AK, Harkema JR, Kaminski NE. Attenuation of the ovalbumin-induced allergic airway response by cannabinoid treatment in A/J mice. Toxicol. Appl. Pharmacol. 188, 24-35 (2003).
    • (2003) Toxicol. Appl. Pharmacol. , vol.188 , pp. 24-35
    • Jan, T.R.1    Farraj, A.K.2    Harkema, J.R.3    Kaminski, N.E.4
  • 115
    • 0017138806 scopus 로고
    • Effect of oral administration of D-tetrahydrocannabinol on airway mechanics in normal and asthmatic subjects
    • Abboud RT, Sanders HD. Effect of oral administration of D-tetrahydrocannabinol on airway mechanics in normal and asthmatic subjects. Chest 70, 480-485 (1976).
    • (1976) Chest , vol.70 , pp. 480-485
    • Abboud, R.T.1    Sanders, H.D.2
  • 117
    • 0034597761 scopus 로고    scopus 로고
    • Bidirectional control of airway responsiveness by endogenous cannabinoids
    • Calignano A, Katona I, Desarnaud F et al. Bidirectional control of airway responsiveness by endogenous cannabinoids. Nature 408, 96-101 (2000).
    • (2000) Nature , vol.408 , pp. 96-101
    • Calignano, A.1    Katona, I.2    Desarnaud, F.3
  • 118
    • 34547100965 scopus 로고    scopus 로고
    • Cannabidiol attenuates high glucoseinduced endothelial cell inflammatory response and barrier disruption
    • Rajesh M, Mukhopadhyay P, Batkai S et al. Cannabidiol attenuates high glucoseinduced endothelial cell inflammatory response and barrier disruption. Am. J. Physiol. Heart Circ. Physiol. 293, H610-H619 (2007).
    • (2007) Am. J. Physiol. Heart Circ. Physiol. , vol.293
    • Rajesh, M.1    Mukhopadhyay, P.2    Batkai, S.3
  • 119
    • 38349113185 scopus 로고    scopus 로고
    • CB2 cannabinoid receptor agonists attenuate TNF-a-induced human vascular smooth muscle cell proliferation and migration
    • Rajesh M, Mukhopadhyay P, Hasko G, Huffman JW, Mackie K, Pacher P. CB2 cannabinoid receptor agonists attenuate TNF-a-induced human vascular smooth muscle cell proliferation and migration. Br. J. Pharmacol. 153, 347-357 (2008).
    • (2008) Br. J. Pharmacol. , vol.153 , pp. 347-357
    • Rajesh, M.1    Mukhopadhyay, P.2    Hasko, G.3    Huffman, J.W.4    MacKie, K.5    Pacher, P.6
  • 120
    • 0019805095 scopus 로고
    • S antigen-induced experimental autoimmune uveo-retinitis in rats
    • de Kozak Y, Sakai J, Thillaye B, Faure JP. S antigen-induced experimental autoimmune uveo-retinitis in rats. Curr. Eye Res. 1, 327-337 (1981).
    • (1981) Curr. Eye Res. , vol.1 , pp. 327-337
    • De Kozak, Y.1    Sakai, J.2    Thillaye, B.3    Faure, J.P.4
  • 121
    • 34548446421 scopus 로고    scopus 로고
    • Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH- in a rodent model of autoimmune uveoretinitis
    • Xu H, Cheng CL, Chen M et al. Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH- in a rodent model of autoimmune uveoretinitis. J. Leukoc. Biol. 82, 532-541 (2007).
    • (2007) J. Leukoc. Biol. , vol.82 , pp. 532-541
    • Xu, H.1    Cheng, C.L.2    Chen, M.3
  • 122
    • 22044449933 scopus 로고    scopus 로고
    • Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 production in murine macrophages: Role of IL-10 and ERK1/2 kinase signaling
    • Correa F, Mestre L, Docagne F, Guaza C. Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 production in murine macrophages: role of IL-10 and ERK1/2 kinase signaling. Br. J. Pharmacol. 145, 441-448 (2005).
    • (2005) Br. J. Pharmacol. , vol.145 , pp. 441-448
    • Correa, F.1    Mestre, L.2    Docagne, F.3    Guaza, C.4
  • 123
    • 22644445751 scopus 로고    scopus 로고
    • Local administration of an adeno-associated viral vector expressing IL-10 reduces monocyte infiltration and subsequent photoreceptor damage during experimental autoimmune uveitis
    • Broderick CA, Smith AJ, Balaggan KS et al. Local administration of an adeno-associated viral vector expressing IL-10 reduces monocyte infiltration and subsequent photoreceptor damage during experimental autoimmune uveitis. Mol. Ther. 12, 369-373 (2005).
    • (2005) Mol. Ther. , vol.12 , pp. 369-373
    • Broderick, C.A.1    Smith, A.J.2    Balaggan, K.S.3
  • 124
    • 0036406868 scopus 로고    scopus 로고
    • Inhibition of experimental autoimmune uveoretinitis by systemic and subconjunctival adenovirus-mediated transfer of the viral IL-10 gene
    • De Kozak Y, Thillaye-Goldenberg B, Naud MC, Da Costa AV, Auriault C, Verwaerde C. Inhibition of experimental autoimmune uveoretinitis by systemic and subconjunctival adenovirus-mediated transfer of the viral IL-10 gene. Clin. Exp. Immunol. 130, 212-223 (2002).
    • (2002) Clin. Exp. Immunol. , vol.130 , pp. 212-223
    • De Kozak, Y.1    Thillaye-Goldenberg, B.2    Naud, M.C.3    Da Costa, A.V.4    Auriault, C.5    Verwaerde, C.6
  • 125
    • 1842470094 scopus 로고    scopus 로고
    • B cell death and protection
    • Mandrup-Poulsen T. b cell death and protection. Ann. NY Acad. Sci. 1005, 32-42 (2003).
    • (2003) Ann. NY Acad. Sci. , vol.1005 , pp. 32-42
    • Mandrup-Poulsen, T.1
  • 126
    • 0035102203 scopus 로고    scopus 로고
    • Examination of the immunosuppressive effect of D9-tetrahydrocannabinol in streptozotocin-induced autoimmune diabetes
    • Li X, Kaminski NE, Fischer LJ. Examination of the immunosuppressive effect of D9-tetrahydrocannabinol in streptozotocin-induced autoimmune diabetes. Int. Immunopharmacol. 1, 699-712 (2001).
    • (2001) Int. Immunopharmacol. , vol.1 , pp. 699-712
    • Li, X.1    Kaminski, N.E.2    Fischer, L.J.3
  • 127
    • 33646404921 scopus 로고    scopus 로고
    • Cannabidiol lowers incidence of diabetes in non-obese diabetic mice
    • Weiss L, Zeira M, Reich S et al. Cannabidiol lowers incidence of diabetes in non-obese diabetic mice. Autoimmunity 39, 143-151 (2006).
    • (2006) Autoimmunity , vol.39 , pp. 143-151
    • Weiss, L.1    Zeira, M.2    Reich, S.3
  • 128
    • 37349096614 scopus 로고    scopus 로고
    • Cannabidiol arrests onset of autoimmune diabetes in NOD mice
    • Weiss L, Zeira M, Reich S et al. Cannabidiol arrests onset of autoimmune diabetes in NOD mice. Neuropharmacology 54, 244-249 (2008).
    • (2008) Neuropharmacology , vol.54 , pp. 244-249
    • Weiss, L.1    Zeira, M.2    Reich, S.3
  • 129
  • 130
    • 4444365789 scopus 로고    scopus 로고
    • Cannabinoids blocks tactile allodynia in diabetic mice without attenuation of its antinociceptive effect
    • Dogrul A, Gul H, Yildiz O, Bilgin F, Guzeldemir ME. Cannabinoids blocks tactile allodynia in diabetic mice without attenuation of its antinociceptive effect. Neurosci. Lett. 368, 82-86 (2004).
    • (2004) Neurosci. Lett. , vol.368 , pp. 82-86
    • Dogrul, A.1    Gul, H.2    Yildiz, O.3    Bilgin, F.4    Guzeldemir, M.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.