메뉴 건너뛰기




Volumn 70, Issue 1, 2013, Pages 89-103

Tightrope act: Autophagy in stem cell renewal, differentiation, proliferation, and aging

Author keywords

Aging; Autophagy; ESC; HSC; Lysosomes; MSC; NSC; Senescence; Stem cells

Indexed keywords

ATORVASTATIN; AUTOPHAGY PROTEIN 5; BECLIN 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RAPAMYCIN; SMALL INTERFERING RNA; STEM CELL FACTOR;

EID: 84872340936     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1032-3     Document Type: Review
Times cited : (108)

References (129)
  • 1
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulated pathway of cellular degradation
    • 11099404 1:CAS:528:DC%2BD3cXovVOitbw%3D 10.1126/science.290.5497.1717
    • Klionsky DJ, Emr SD (2000) Autophagy as a regulated pathway of cellular degradation. Science 290:1717-1721
    • (2000) Science , vol.290 , pp. 1717-1721
    • Klionsky, D.J.1    Emr, S.D.2
  • 2
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • 16469695 1:CAS:528:DC%2BD28Xhslaqs74%3D 10.1016/j.cell.2006.01.016
    • Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124:471-484
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 3
    • 20344406240 scopus 로고    scopus 로고
    • Autophagy in metazoans: Cell survival in the land of plenty
    • 15928708 1:CAS:528:DC%2BD2MXks1Gmtb0%3D 10.1038/nrm1660
    • Lum JJ, DeBerardinis RJ, Thompson CB (2005) Autophagy in metazoans: cell survival in the land of plenty. Nat Rev Mol Cell Biol 6:439-448
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 439-448
    • Lum, J.J.1    Deberardinis, R.J.2    Thompson, C.B.3
  • 4
    • 0032512636 scopus 로고    scopus 로고
    • Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
    • 9461583 1:CAS:528:DyaK1cXht1ahsr8%3D 10.1074/jbc.273.7.3963
    • Noda T, Ohsumi Y (1998) Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem 273:3963-3966
    • (1998) J Biol Chem , vol.273 , pp. 3963-3966
    • Noda, T.1    Ohsumi, Y.2
  • 5
    • 4344563878 scopus 로고    scopus 로고
    • Role and regulation of starvation-induced autophagy in the Drosophila fat body
    • 15296714 1:CAS:528:DC%2BD2cXnsVKntr0%3D 10.1016/j.devcel.2004.07.009
    • Scott RC, Schuldiner O, Neufeld TP (2004) Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell 7:167-178
    • (2004) Dev Cell , vol.7 , pp. 167-178
    • Scott, R.C.1    Schuldiner, O.2    Neufeld, T.P.3
  • 6
    • 51049118332 scopus 로고    scopus 로고
    • The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: Beyond the usual suspects' review series
    • 18704115 1:CAS:528:DC%2BD1cXhtVGgt7jL 10.1038/embor.2008.163
    • Geng J, Klionsky DJ (2008) The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep 9:859-864
    • (2008) EMBO Rep , vol.9 , pp. 859-864
    • Geng, J.1    Klionsky, D.J.2
  • 8
    • 67650517556 scopus 로고    scopus 로고
    • NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets
    • 19502794 1:CAS:528:DC%2BC3cXovFykuw%3D%3D 10.4161/cc.8.13.8892
    • Lamark T, Kirkin V, Dikic I, Johansen T (2009) NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets. Cell Cycle 8:1986-1990
    • (2009) Cell Cycle , vol.8 , pp. 1986-1990
    • Lamark, T.1    Kirkin, V.2    Dikic, I.3    Johansen, T.4
  • 10
    • 8344242220 scopus 로고    scopus 로고
    • Autophagy in health and disease: A double-edged sword
    • 15528435 1:CAS:528:DC%2BD2cXptFyju78%3D 10.1126/science.1099993
    • Shintani T, Klionsky DJ (2004) Autophagy in health and disease: a double-edged sword. Science 306:990-995
    • (2004) Science , vol.306 , pp. 990-995
    • Shintani, T.1    Klionsky, D.J.2
  • 11
    • 80053391464 scopus 로고    scopus 로고
    • CAMP induces autophagy via a novel pathway involving ERK, cyclin e and Beclin 1
    • 21750416 1:CAS:528:DC%2BC38XisFSnt7c%3D 10.4161/auto.7.10.16649
    • Ugland H, Naderi S, Brech A, Collas P, Blomhoff HK (2011) cAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1. Autophagy 7:1199-1211
    • (2011) Autophagy , vol.7 , pp. 1199-1211
    • Ugland, H.1    Naderi, S.2    Brech, A.3    Collas, P.4    Blomhoff, H.K.5
  • 12
    • 77953744638 scopus 로고    scopus 로고
    • Nonredundant role of Atg7 in mitochondrial clearance during erythroid development
    • 20215867 10.4161/auto.6.3.11528
    • Mortensen M, Simon AK (2010) Nonredundant role of Atg7 in mitochondrial clearance during erythroid development. Autophagy 6:423-425
    • (2010) Autophagy , vol.6 , pp. 423-425
    • Mortensen, M.1    Simon, A.K.2
  • 13
    • 39149111914 scopus 로고    scopus 로고
    • Roles of autophagy and mTOR signaling in neuronal differentiation of mouse neuroblastoma cells
    • 18207367 1:CAS:528:DC%2BD1cXitVejsro%3D 10.1016/j.cellsig.2007.11.015
    • Zeng M, Zhou JN (2008) Roles of autophagy and mTOR signaling in neuronal differentiation of mouse neuroblastoma cells. Cell Signal 20:659-665
    • (2008) Cell Signal , vol.20 , pp. 659-665
    • Zeng, M.1    Zhou, J.N.2
  • 14
    • 33644984490 scopus 로고    scopus 로고
    • A new description of cellular quiescence
    • 16509772 10.1371/journal.pbio.0040083 1:CAS:528:DC%2BD28Xislyjsro%3D
    • Coller HA, Sang L, Roberts JM (2006) A new description of cellular quiescence. PLoS Biol 4:e83
    • (2006) PLoS Biol , vol.4 , pp. 83
    • Coller, H.A.1    Sang, L.2    Roberts, J.M.3
  • 16
    • 77955908881 scopus 로고    scopus 로고
    • A novel Gfer-Drp1 link in preserving mitochondrial dynamics and function in pluripotent stem cells
    • 20581476 10.4161/auto.6.6.12625
    • Todd LR, Gomathinayagam R, Sankar U (2010) A novel Gfer-Drp1 link in preserving mitochondrial dynamics and function in pluripotent stem cells. Autophagy 6:821-822
    • (2010) Autophagy , vol.6 , pp. 821-822
    • Todd, L.R.1    Gomathinayagam, R.2    Sankar, U.3
  • 17
    • 20544441737 scopus 로고    scopus 로고
    • A Pax3/Pax7-dependent population of skeletal muscle progenitor cells
    • 15843801 1:CAS:528:DC%2BD2MXltFeltLs%3D 10.1038/nature03594
    • Relaix F, Rocancourt D, Mansouri A, Buckingham M (2005) A Pax3/Pax7-dependent population of skeletal muscle progenitor cells. Nature 435:948-953
    • (2005) Nature , vol.435 , pp. 948-953
    • Relaix, F.1    Rocancourt, D.2    Mansouri, A.3    Buckingham, M.4
  • 19
    • 50849107643 scopus 로고    scopus 로고
    • The skin: A home to multiple classes of epithelial progenitor cells
    • 18491239 10.1007/s12015-008-9022-4
    • Yan X, Owens DM (2008) The skin: a home to multiple classes of epithelial progenitor cells. Stem Cell Rev 4:113-118
    • (2008) Stem Cell Rev , vol.4 , pp. 113-118
    • Yan, X.1    Owens, D.M.2
  • 20
    • 31544481865 scopus 로고    scopus 로고
    • SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity
    • 16219798 1:CAS:528:DC%2BD28Xht1Onsbs%3D 10.1182/blood-2005-05-2140
    • Yilmaz OH, Kiel MJ, Morrison SJ (2006) SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood 107:924-930
    • (2006) Blood , vol.107 , pp. 924-930
    • Yilmaz, O.H.1    Kiel, M.J.2    Morrison, S.J.3
  • 21
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • 20144757 1:CAS:528:DC%2BC3cXlt1KlsLc%3D 10.1016/j.cell.2010.01.028
    • Mizushima N, Yoshimori T, Levine B (2010) Methods in mammalian autophagy research. Cell 140:313-326
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 22
    • 77955344712 scopus 로고    scopus 로고
    • A novel quantitative flow cytometry-based assay for autophagy
    • Eng KE, Panas MD, Hedestam GB, McInerney GM (2010) A novel quantitative flow cytometry-based assay for autophagy. Autophagy 6:634-641
    • (2010) Autophagy , vol.6 , pp. 634-641
    • Eng, K.E.1    Panas, M.D.2    Hedestam, G.B.3    McInerney, G.M.4
  • 23
    • 46849121421 scopus 로고    scopus 로고
    • Utilizing flow cytometry to monitor autophagy in living mammalian cells
    • 18376137 1:CAS:528:DC%2BD1cXpsVCkt7o%3D
    • Shvets E, Fass E, Elazar Z (2008) Utilizing flow cytometry to monitor autophagy in living mammalian cells. Autophagy 4:621-628
    • (2008) Autophagy , vol.4 , pp. 621-628
    • Shvets, E.1    Fass, E.2    Elazar, Z.3
  • 27
    • 38049098543 scopus 로고    scopus 로고
    • The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy
    • 17986448 1:CAS:528:DC%2BD2sXhsVGjtr7F 10.1074/jbc.C700195200
    • Hanada T, Noda NN, Satomi Y, Ichimura Y, Fujioka Y, Takao T, Inagaki F, Ohsumi Y (2007) The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem 282:37298-37302
    • (2007) J Biol Chem , vol.282 , pp. 37298-37302
    • Hanada, T.1    Noda, N.N.2    Satomi, Y.3    Ichimura, Y.4    Fujioka, Y.5    Takao, T.6    Inagaki, F.7    Ohsumi, Y.8
  • 28
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • 14657337 1:CAS:528:DC%2BD3sXpvFaqtbg%3D 10.1073/pnas.2436255100
    • Yue Z, Jin S, Yang C, Levine AJ, Heintz N (2003) Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 100:15077-15082
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3    Levine, A.J.4    Heintz, N.5
  • 29
    • 0036683054 scopus 로고    scopus 로고
    • Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells
    • 12145208 1:CAS:528:DC%2BD38XnvVGnur8%3D 10.1093/emboj/cdf413
    • Xu D, Wilson TJ, Chan D, De Luca E, Zhou J, Hertzog PJ, Kola I (2002) Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells. EMBO J 21:4081-4093
    • (2002) EMBO J , vol.21 , pp. 4081-4093
    • Xu, D.1    Wilson, T.J.2    Chan, D.3    De Luca, E.4    Zhou, J.5    Hertzog, P.J.6    Kola, I.7
  • 30
    • 0034665461 scopus 로고    scopus 로고
    • P53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage
    • 10990460 1:CAS:528:DC%2BD3cXntVartLw%3D 10.1093/emboj/19.18.4967
    • Chao C, Saito S, Kang J, Anderson CW, Appella E, Xu Y (2000) p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO J 19:4967-4975
    • (2000) EMBO J , vol.19 , pp. 4967-4975
    • Chao, C.1    Saito, S.2    Kang, J.3    Anderson, C.W.4    Appella, E.5    Xu, Y.6
  • 31
    • 0035206383 scopus 로고    scopus 로고
    • Mechanisms of p53-dependent apoptosis
    • 11709054 1:CAS:528:DC%2BD3MXpt1Crs7w%3D 10.1042/BST0290684
    • Schuler M, Green DR (2001) Mechanisms of p53-dependent apoptosis. Biochem Soc Trans 29:684-688
    • (2001) Biochem Soc Trans , vol.29 , pp. 684-688
    • Schuler, M.1    Green, D.R.2
  • 33
    • 33847404337 scopus 로고    scopus 로고
    • Autophagy gene-dependent clearance of apoptotic cells during embryonic development
    • 17350577 1:CAS:528:DC%2BD2sXjvVSgu7c%3D 10.1016/j.cell.2006.12.044
    • Qu X, Zou Z, Sun Q, Luby-Phelps K, Cheng P, Hogan RN, Gilpin C, Levine B (2007) Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell 128:931-946
    • (2007) Cell , vol.128 , pp. 931-946
    • Qu, X.1    Zou, Z.2    Sun, Q.3    Luby-Phelps, K.4    Cheng, P.5    Hogan, R.N.6    Gilpin, C.7    Levine, B.8
  • 34
    • 77955908881 scopus 로고    scopus 로고
    • A novel Gfer-Drp1 link in preserving mitochondrial dynamics and function in pluripotent stem cells
    • 20581476 10.4161/auto.6.6.12625
    • Todd LR, Gomathinayagam R, Sankar U (2010) A novel Gfer-Drp1 link in preserving mitochondrial dynamics and function in pluripotent stem cells. Autophagy 6:821-822
    • (2010) Autophagy , vol.6 , pp. 821-822
    • Todd, L.R.1    Gomathinayagam, R.2    Sankar, U.3
  • 38
    • 0033760607 scopus 로고    scopus 로고
    • Autophagy in embryonic erythroid cells: Its role in maturation
    • 11089924 1:STN:280:DC%2BD3M7ptlyqsA%3D%3D 10.1078/0171-9335-00096
    • Takano-Ohmuro H, Mukaida M, Kominami E, Morioka K (2000) Autophagy in embryonic erythroid cells: its role in maturation. Eur J Cell Biol 79:759-764
    • (2000) Eur J Cell Biol , vol.79 , pp. 759-764
    • Takano-Ohmuro, H.1    Mukaida, M.2    Kominami, E.3    Morioka, K.4
  • 39
    • 77955448361 scopus 로고    scopus 로고
    • ATM engages the TSC2/mTORC1 signaling node to regulate autophagy
    • Alexander A, Kim J, Walker CL (2010) ATM engages the TSC2/mTORC1 signaling node to regulate autophagy. Autophagy 6:672-673
    • (2010) Autophagy , vol.6 , pp. 672-673
    • Alexander, A.1    Kim, J.2    Walker, C.L.3
  • 42
    • 33751171109 scopus 로고    scopus 로고
    • ATM is activated by mitotic stress and suppresses centrosome amplification in primary but not in tumor cells
    • 16775842 1:CAS:528:DC%2BD28Xht1ahsLbK 10.1002/jcb.20848
    • Shen K, Wang Y, Brooks SC, Raz A, Wang YA (2006) ATM is activated by mitotic stress and suppresses centrosome amplification in primary but not in tumor cells. J Cell Biochem 99:1267-1274
    • (2006) J Cell Biochem , vol.99 , pp. 1267-1274
    • Shen, K.1    Wang, Y.2    Brooks, S.C.3    Raz, A.4    Wang, Y.A.5
  • 43
    • 33846461678 scopus 로고    scopus 로고
    • A critical role for the autophagy gene Atg5 in T cell survival and proliferation
    • 17190837 1:CAS:528:DC%2BD2sXhtFGjsbs%3D 10.1084/jem.20061303
    • Pua HH, Dzhagalov I, Chuck M, Mizushima N, He YW (2007) A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med 204:25-31
    • (2007) J Exp Med , vol.204 , pp. 25-31
    • Pua, H.H.1    Dzhagalov, I.2    Chuck, M.3    Mizushima, N.4    He, Y.W.5
  • 44
    • 80052382925 scopus 로고    scopus 로고
    • Lack of autophagy in the hematopoietic system leads to loss of hematopoietic stem cell function and dysregulated myeloid proliferation
    • 21552009 1:CAS:528:DC%2BC38Xhs1Oqtrs%3D 10.4161/auto.7.9.15886
    • Mortensen M, Watson AS, Simon AK (2011) Lack of autophagy in the hematopoietic system leads to loss of hematopoietic stem cell function and dysregulated myeloid proliferation. Autophagy 7:1069-1070
    • (2011) Autophagy , vol.7 , pp. 1069-1070
    • Mortensen, M.1    Watson, A.S.2    Simon, A.K.3
  • 45
    • 78649689953 scopus 로고    scopus 로고
    • FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells
    • 20716775 1:CAS:528:DC%2BC3cXhs1SlsrrI 10.1182/blood-2010-06-288589
    • Liu F, Lee JY, Wei H, Tanabe O, Engel JD, Morrison SJ, Guan JL (2010) FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood 116:4806-4814
    • (2010) Blood , vol.116 , pp. 4806-4814
    • Liu, F.1    Lee, J.Y.2    Wei, H.3    Tanabe, O.4    Engel, J.D.5    Morrison, S.J.6    Guan, J.L.7
  • 46
    • 65249176304 scopus 로고    scopus 로고
    • ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
    • 19225151 1:CAS:528:DC%2BD1MXotVyqsL8%3D 10.1091/mbc.E08-12-1249
    • Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M, Kim DH (2009) ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 20:1992-2003
    • (2009) Mol Biol Cell , vol.20 , pp. 1992-2003
    • Jung, C.H.1    Jun, C.B.2    Ro, S.H.3    Kim, Y.M.4    Otto, N.M.5    Cao, J.6    Kundu, M.7    Kim, D.H.8
  • 47
    • 1542618348 scopus 로고    scopus 로고
    • The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
    • 14985505 1:CAS:528:DC%2BD2cXisFWmsrg%3D 10.1073/pnas.0308061100
    • Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC (2004) The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 101:3329-3335
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3329-3335
    • Shaw, R.J.1    Kosmatka, M.2    Bardeesy, N.3    Hurley, R.L.4    Witters, L.A.5    Depinho, R.A.6    Cantley, L.C.7
  • 48
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
    • 14511394 10.1186/1475-4924-2-28
    • Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Makela TP, Alessi DR, Hardie DG (2003) Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2:28
    • (2003) J Biol , vol.2 , pp. 28
    • Hawley, S.A.1    Boudeau, J.2    Reid, J.L.3    Mustard, K.J.4    Udd, L.5    Makela, T.P.6    Alessi, D.R.7    Hardie, D.G.8
  • 50
    • 47849125676 scopus 로고    scopus 로고
    • MicroRNAs: New regulators of immune cell development and function
    • 18645592 1:CAS:528:DC%2BD1cXoslCmu78%3D 10.1038/ni.f.209
    • Baltimore D, Boldin MP, O'Connell RM, Rao DS, Taganov KD (2008) MicroRNAs: new regulators of immune cell development and function. Nat Immunol 9:839-845
    • (2008) Nat Immunol , vol.9 , pp. 839-845
    • Baltimore, D.1    Boldin, M.P.2    O'Connell, R.M.3    Rao, D.S.4    Taganov, K.D.5
  • 54
    • 66449114033 scopus 로고    scopus 로고
    • P62 at the crossroads of autophagy, apoptosis, and cancer
    • 19524504 1:CAS:528:DC%2BD1MXps1eiurs%3D 10.1016/j.cell.2009.05.023
    • Moscat J, Diaz-Meco MT (2009) p62 at the crossroads of autophagy, apoptosis, and cancer. Cell 137:1001-1004
    • (2009) Cell , vol.137 , pp. 1001-1004
    • Moscat, J.1    Diaz-Meco, M.T.2
  • 56
    • 26944484011 scopus 로고    scopus 로고
    • Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling
    • 16246731 1:CAS:528:DC%2BD2MXht1SntrfJ 10.1016/j.molcel.2005.09.014
    • Geetha T, Jiang J, Wooten MW (2005) Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling. Mol Cell 20:301-312
    • (2005) Mol Cell , vol.20 , pp. 301-312
    • Geetha, T.1    Jiang, J.2    Wooten, M.W.3
  • 57
    • 0031946369 scopus 로고    scopus 로고
    • Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62
    • 9566925 1:CAS:528:DyaK1cXis1GmsL4%3D
    • Sanchez P, De Carcer G, Sandoval IV, Moscat J, Diaz-Meco MT (1998) Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. Mol Cell Biol 18:3069-3080
    • (1998) Mol Cell Biol , vol.18 , pp. 3069-3080
    • Sanchez, P.1    De Carcer, G.2    Sandoval, I.V.3    Moscat, J.4    Diaz-Meco, M.T.5
  • 58
    • 59449106021 scopus 로고    scopus 로고
    • CAMP-mediated induction of cyclin e sensitizes growth-arrested adipose stem cells to DNA damage-induced apoptosis
    • 18799628 1:CAS:528:DC%2BD1cXhsVynurnK 10.1091/mbc.E08-01-0094
    • Ugland H, Boquest AC, Naderi S, Collas P, Blomhoff HK (2008) cAMP-mediated induction of cyclin E sensitizes growth-arrested adipose stem cells to DNA damage-induced apoptosis. Mol Biol Cell 19:5082-5092
    • (2008) Mol Biol Cell , vol.19 , pp. 5082-5092
    • Ugland, H.1    Boquest, A.C.2    Naderi, S.3    Collas, P.4    Blomhoff, H.K.5
  • 59
    • 70349234637 scopus 로고    scopus 로고
    • Autophagy: Regulation and role in disease
    • 19552522 1:CAS:528:DC%2BD1MXptlKnsbk%3D 10.1080/10408360903044068
    • Meijer AJ, Codogno P (2009) Autophagy: regulation and role in disease. Crit Rev Clin Lab Sci 46:210-240
    • (2009) Crit Rev Clin Lab Sci , vol.46 , pp. 210-240
    • Meijer, A.J.1    Codogno, P.2
  • 60
    • 0038269032 scopus 로고    scopus 로고
    • Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells
    • 12609989 1:CAS:528:DC%2BD3sXjsVKnsbk%3D 10.1074/jbc.M210998200
    • Pattingre S, Bauvy C, Codogno P (2003) Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells. J Biol Chem 278:16667-16674
    • (2003) J Biol Chem , vol.278 , pp. 16667-16674
    • Pattingre, S.1    Bauvy, C.2    Codogno, P.3
  • 61
    • 35848938724 scopus 로고    scopus 로고
    • Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy
    • 17786026 1:CAS:528:DC%2BD2sXhtlOhsL7P
    • Shinojima N, Yokoyama T, Kondo Y, Kondo S (2007) Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy. Autophagy 3:635-637
    • (2007) Autophagy , vol.3 , pp. 635-637
    • Shinojima, N.1    Yokoyama, T.2    Kondo, Y.3    Kondo, S.4
  • 62
    • 27644466759 scopus 로고    scopus 로고
    • Autophagy and signaling: Their role in cell survival and cell death
    • 16247498 1:CAS:528:DC%2BD2MXhtFCjt7%2FI 10.1038/sj.cdd.4401751
    • Codogno P, Meijer AJ (2005) Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ 12(Suppl 2):1509-1518
    • (2005) Cell Death Differ , vol.12 , Issue.SUPPL. 2 , pp. 1509-1518
    • Codogno, P.1    Meijer, A.J.2
  • 64
    • 58849163098 scopus 로고    scopus 로고
    • Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death
    • 18764739 1:CAS:528:DC%2BD1MXhtFOrtrc%3D 10.1089/ars.2008.2263
    • Pivtoraiko VN, Stone SL, Roth KA, Shacka JJ (2009) Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death. Antioxid Redox Signal 11:481-496
    • (2009) Antioxid Redox Signal , vol.11 , pp. 481-496
    • Pivtoraiko, V.N.1    Stone, S.L.2    Roth, K.A.3    Shacka, J.J.4
  • 67
    • 84856618999 scopus 로고    scopus 로고
    • Autophagy is required for self-renewal and differentiation of adult human stem cells
    • 22184008 1:CAS:528:DC%2BC38Xhsl2gurs%3D 10.1038/cr.2011.200
    • Salemi S, Yousefi S, Constantinescu MA, Fey MF, Simon HU (2012) Autophagy is required for self-renewal and differentiation of adult human stem cells. Cell Res 22:432-435
    • (2012) Cell Res , vol.22 , pp. 432-435
    • Salemi, S.1    Yousefi, S.2    Constantinescu, M.A.3    Fey, M.F.4    Simon, H.U.5
  • 68
    • 84863430453 scopus 로고    scopus 로고
    • Mitophagy: A Complex Mechanism of Mitochondrial Removal
    • [Epub ahead of print]
    • Novak I (2012) Mitophagy: A Complex Mechanism of Mitochondrial Removal. Antioxid Redox Signal [Epub ahead of print]
    • (2012) Antioxid Redox Signal
    • Novak, I.1
  • 70
    • 22144474039 scopus 로고    scopus 로고
    • P62 modulates Akt activity via association with PKCzeta in neuronal survival and differentiation
    • 16011831 1:CAS:528:DC%2BD2MXmsVOgu7k%3D 10.1016/j.bbrc.2005.06.138
    • Joung I, Kim HJ, Kwon YK (2005) p62 modulates Akt activity via association with PKCzeta in neuronal survival and differentiation. Biochem Biophys Res Commun 334:654-660
    • (2005) Biochem Biophys Res Commun , vol.334 , pp. 654-660
    • Joung, I.1    Kim, H.J.2    Kwon, Y.K.3
  • 71
    • 79953666792 scopus 로고    scopus 로고
    • Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARalpha oncoprotein
    • 21187718 1:CAS:528:DC%2BC3MXlvVWnur4%3D 10.4161/auto.7.4.14397
    • Wang Z, Cao L, Kang R, Yang M, Liu L, Zhao Y, Yu Y, Xie M, Yin X, Livesey KM, Tang D (2011) Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARalpha oncoprotein. Autophagy 7:401-411
    • (2011) Autophagy , vol.7 , pp. 401-411
    • Wang, Z.1    Cao, L.2    Kang, R.3    Yang, M.4    Liu, L.5    Zhao, Y.6    Yu, Y.7    Xie, M.8    Yin, X.9    Livesey, K.M.10    Tang, D.11
  • 72
    • 0033536637 scopus 로고    scopus 로고
    • The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
    • 10514377 1:CAS:528:DyaK1MXmvVCgu70%3D 10.1126/science.286.5438.309
    • Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC (1999) The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286:309-312
    • (1999) Science , vol.286 , pp. 309-312
    • Joazeiro, C.A.1    Wing, S.S.2    Huang, H.3    Leverson, J.D.4    Hunter, T.5    Liu, Y.C.6
  • 73
  • 74
    • 11144244315 scopus 로고    scopus 로고
    • Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl)
    • 15315962 1:CAS:528:DC%2BD2MXis1GqtA%3D%3D 10.1182/blood-2004-05-1768
    • Zeng S, Xu Z, Lipkowitz S, Longley JB (2005) Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl). Blood 105:226-232
    • (2005) Blood , vol.105 , pp. 226-232
    • Zeng, S.1    Xu, Z.2    Lipkowitz, S.3    Longley, J.B.4
  • 75
    • 50549087736 scopus 로고    scopus 로고
    • Growth stimulation leads to cellular senescence when the cell cycle is blocked
    • 18948731 1:CAS:528:DC%2BD1cXhsFWgtL3K 10.4161/cc.7.21.6919
    • Demidenko ZN, Blagosklonny MV (2008) Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle 7:3355-3361
    • (2008) Cell Cycle , vol.7 , pp. 3355-3361
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 76
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • 15734677 1:CAS:528:DC%2BD2MXitVWntbk%3D 10.1016/j.cell.2005.01.027
    • Kirkwood TB (2005) Understanding the odd science of aging. Cell 120:437-447
    • (2005) Cell , vol.120 , pp. 437-447
    • Kirkwood, T.B.1
  • 77
    • 33745614062 scopus 로고    scopus 로고
    • Stem cells, ageing and the quest for immortality
    • 16810243 1:CAS:528:DC%2BD28Xmtlahsrc%3D 10.1038/nature04958
    • Rando TA (2006) Stem cells, ageing and the quest for immortality. Nature 441:1080-1086
    • (2006) Nature , vol.441 , pp. 1080-1086
    • Rando, T.A.1
  • 79
    • 0344961120 scopus 로고    scopus 로고
    • Murine marrow-derived mesenchymal stem cell: Isolation, in vitro expansion, and characterization
    • 14616976 10.1046/j.1365-2141.2003.04669.x
    • Meirelles Lda S, Nardi NB (2003) Murine marrow-derived mesenchymal stem cell: isolation, in vitro expansion, and characterization. Br J Haematol 123:702-711
    • (2003) Br J Haematol , vol.123 , pp. 702-711
    • Meirelles Lda, S.1    Nardi, N.B.2
  • 80
    • 31344473379 scopus 로고    scopus 로고
    • Aging of mesenchymal stem cells
    • 16310414 1:CAS:528:DC%2BD28Xis1yisLw%3D 10.1016/j.arr.2005.10.001
    • Sethe S, Scutt A, Stolzing A (2006) Aging of mesenchymal stem cells. Ageing Res Rev 5:91-116
    • (2006) Ageing Res Rev , vol.5 , pp. 91-116
    • Sethe, S.1    Scutt, A.2    Stolzing, A.3
  • 81
    • 36448968532 scopus 로고    scopus 로고
    • FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells
    • 18054316 1:CAS:528:DC%2BD2sXhsVektb%2FI 10.1016/j.cmet.2007.11.004
    • Zhao J, Brault JJ, Schild A, Cao P, Sandri M, Schiaffino S, Lecker SH, Goldberg AL (2007) FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab 6:472-483
    • (2007) Cell Metab , vol.6 , pp. 472-483
    • Zhao, J.1    Brault, J.J.2    Schild, A.3    Cao, P.4    Sandri, M.5    Schiaffino, S.6    Lecker, S.H.7    Goldberg, A.L.8
  • 82
    • 34249978518 scopus 로고    scopus 로고
    • Autophagy and NF-kappaB: Fight for fate
    • 17485237 1:CAS:528:DC%2BD2sXmsFCmsrs%3D 10.1016/j.cytogfr.2007.04.006
    • Xiao G (2007) Autophagy and NF-kappaB: fight for fate. Cytokine Growth Factor Rev 18:233-243
    • (2007) Cytokine Growth Factor Rev , vol.18 , pp. 233-243
    • Xiao, G.1
  • 85
    • 3242721268 scopus 로고    scopus 로고
    • MTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells
    • 15254238 1:CAS:528:DC%2BD2cXmtlKltbY%3D 10.1128/MCB.24.15.6710-6718.2004
    • Murakami M, Ichisaka T, Maeda M, Oshiro N, Hara K, Edenhofer F, Kiyama H, Yonezawa K, Yamanaka S (2004) mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol Cell Biol 24:6710-6718
    • (2004) Mol Cell Biol , vol.24 , pp. 6710-6718
    • Murakami, M.1    Ichisaka, T.2    Maeda, M.3    Oshiro, N.4    Hara, K.5    Edenhofer, F.6    Kiyama, H.7    Yonezawa, K.8    Yamanaka, S.9
  • 86
    • 53349091768 scopus 로고    scopus 로고
    • TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
    • 18809716 1:CAS:528:DC%2BD1cXht1SrtLnM 10.1084/jem.20081297
    • Chen C, Liu Y, Liu R, Ikenoue T, Guan KL, Zheng P (2008) TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med 205:2397-2408
    • (2008) J Exp Med , vol.205 , pp. 2397-2408
    • Chen, C.1    Liu, Y.2    Liu, R.3    Ikenoue, T.4    Guan, K.L.5    Zheng, P.6
  • 87
    • 77955861146 scopus 로고    scopus 로고
    • Autophagy in health and disease. 5. Mitophagy as a way of life
    • 20357180 1:CAS:528:DC%2BC3cXhtVOht7jK 10.1152/ajpcell.00097.2010
    • Gottlieb RA, Carreira RS (2010) Autophagy in health and disease. 5. Mitophagy as a way of life. Am J Physiol Cell Physiol 299:C203-C210
    • (2010) Am J Physiol Cell Physiol , vol.299
    • Gottlieb, R.A.1    Carreira, R.S.2
  • 88
    • 75549090275 scopus 로고    scopus 로고
    • MTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
    • Chen C, Liu Y, Zheng P (2009) mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal (98):ra75
    • (2009) Sci Signal , Issue.98
    • Chen, C.1    Liu, Y.2    Zheng, P.3
  • 89
    • 1142275269 scopus 로고    scopus 로고
    • Age-related changes in lymphocyte development and function
    • 14749784 1:CAS:528:DC%2BD2cXntFWmsQ%3D%3D 10.1038/ni1033
    • Linton PJ, Dorshkind K (2004) Age-related changes in lymphocyte development and function. Nat Immunol 5:133-139
    • (2004) Nat Immunol , vol.5 , pp. 133-139
    • Linton, P.J.1    Dorshkind, K.2
  • 90
    • 2942700206 scopus 로고    scopus 로고
    • Reduction in the developmental potential of intrathymic T cell progenitors with age
    • 15210781 1:CAS:528:DC%2BD2cXltVajtbY%3D
    • Min H, Montecino-Rodriguez E, Dorshkind K (2004) Reduction in the developmental potential of intrathymic T cell progenitors with age. J Immunol 173:245-250
    • (2004) J Immunol , vol.173 , pp. 245-250
    • Min, H.1    Montecino-Rodriguez, E.2    Dorshkind, K.3
  • 92
    • 0035929650 scopus 로고    scopus 로고
    • The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway
    • 11477064 1:CAS:528:DC%2BD3MXntFaitbo%3D 10.1074/jbc.C100319200
    • Arico S, Petiot A, Bauvy C, Dubbelhuis PF, Meijer AJ, Codogno P, Ogier-Denis E (2001) The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 276:35243-35246
    • (2001) J Biol Chem , vol.276 , pp. 35243-35246
    • Arico, S.1    Petiot, A.2    Bauvy, C.3    Dubbelhuis, P.F.4    Meijer, A.J.5    Codogno, P.6    Ogier-Denis, E.7
  • 94
    • 2342646219 scopus 로고    scopus 로고
    • Acute regulation of the tumour suppressor phosphatase, PTEN, by anionic lipids and reactive oxygen species
    • 15046604 1:CAS:528:DC%2BD2cXjtVSgu7s%3D 10.1042/BST0320338
    • Downes CP, Walker S, McConnachie G, Lindsay Y, Batty IH, Leslie NR (2004) Acute regulation of the tumour suppressor phosphatase, PTEN, by anionic lipids and reactive oxygen species. Biochem Soc Trans 32:338-342
    • (2004) Biochem Soc Trans , vol.32 , pp. 338-342
    • Downes, C.P.1    Walker, S.2    McConnachie, G.3    Lindsay, Y.4    Batty, I.H.5    Leslie, N.R.6
  • 96
    • 33749167092 scopus 로고    scopus 로고
    • Ageing: Balancing regeneration and cancer
    • 16957734 1:CAS:528:DC%2BD28XhtVSns7fF 10.1038/nature05221
    • Beausejour CM, Campisi J (2006) Ageing: balancing regeneration and cancer. Nature 443:404-405
    • (2006) Nature , vol.443 , pp. 404-405
    • Beausejour, C.M.1    Campisi, J.2
  • 99
    • 22344449361 scopus 로고    scopus 로고
    • Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways
    • 15964994 1:CAS:528:DC%2BD2MXlslChurc%3D 10.1101/gad.1299505
    • Molofsky AV, He S, Bydon M, Morrison SJ, Pardal R (2005) Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev 19:1432-1437
    • (2005) Genes Dev , vol.19 , pp. 1432-1437
    • Molofsky, A.V.1    He, S.2    Bydon, M.3    Morrison, S.J.4    Pardal, R.5
  • 101
    • 35848937781 scopus 로고    scopus 로고
    • Autophagy is required for dietary restriction-mediated life span extension in C. elegans
    • 17912023
    • Jia K, Levine B (2007) Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy 3:597-599
    • (2007) Autophagy , vol.3 , pp. 597-599
    • Jia, K.1    Levine, B.2
  • 102
    • 38949159709 scopus 로고    scopus 로고
    • Effects of dietary restriction on hematopoietic stem-cell aging are genetically regulated
    • 17947508 1:CAS:528:DC%2BD1cXhvFeis78%3D 10.1182/blood-2007-01-069807
    • Ertl RP, Chen J, Astle CM, Duffy TM, Harrison DE (2008) Effects of dietary restriction on hematopoietic stem-cell aging are genetically regulated. Blood 111:1709-1716
    • (2008) Blood , vol.111 , pp. 1709-1716
    • Ertl, R.P.1    Chen, J.2    Astle, C.M.3    Duffy, T.M.4    Harrison, D.E.5
  • 103
    • 0034113064 scopus 로고    scopus 로고
    • When lysosomes get old
    • 10767573 1:CAS:528:DC%2BD3cXitlOku70%3D 10.1016/S0531-5565(00)00075-9
    • Cuervo AM, Dice JF (2000) When lysosomes get old. Exp Gerontol 35:119-131
    • (2000) Exp Gerontol , vol.35 , pp. 119-131
    • Cuervo, A.M.1    Dice, J.F.2
  • 104
    • 0031889998 scopus 로고    scopus 로고
    • Lipofuscin: Mechanisms of formation and increase with age
    • 9531959 1:CAS:528:DyaK1cXhvFynsb8%3D 10.1111/j.1699-0463.1998.tb01346.x
    • Terman A, Brunk UT (1998) Lipofuscin: mechanisms of formation and increase with age. APMIS 106:265-276
    • (1998) APMIS , vol.106 , pp. 265-276
    • Terman, A.1    Brunk, U.T.2
  • 105
    • 33744513898 scopus 로고    scopus 로고
    • Age-related impairment of mesenchymal progenitor cell function
    • 16842494 1:CAS:528:DC%2BD28XmsVSqt7Y%3D 10.1111/j.1474-9726.2006.00213.x
    • Stolzing A, Scutt A (2006) Age-related impairment of mesenchymal progenitor cell function. Aging Cell 5:213-224
    • (2006) Aging Cell , vol.5 , pp. 213-224
    • Stolzing, A.1    Scutt, A.2
  • 106
    • 39149093357 scopus 로고    scopus 로고
    • Age-related changes in human bone marrow-derived mesenchymal stem cells: Consequences for cell therapies
    • 18241911 1:CAS:528:DC%2BD1cXhsl2htLY%3D 10.1016/j.mad.2007.12.002
    • Stolzing A, Jones E, McGonagle D, Scutt A (2008) Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies. Mech Ageing Dev 129:163-173
    • (2008) Mech Ageing Dev , vol.129 , pp. 163-173
    • Stolzing, A.1    Jones, E.2    McGonagle, D.3    Scutt, A.4
  • 107
    • 79953326332 scopus 로고    scopus 로고
    • Lysosome positioning coordinates mTORC1 activity and autophagy
    • 21460804 10.1038/ncb0411-342 1:CAS:528:DC%2BC3MXktFWjtrs%3D
    • Pous C, Codogno P (2011) Lysosome positioning coordinates mTORC1 activity and autophagy. Nat Cell Biol 13:342-344
    • (2011) Nat Cell Biol , vol.13 , pp. 342-344
    • Pous, C.1    Codogno, P.2
  • 110
    • 84861983563 scopus 로고    scopus 로고
    • Autophagy activation. A novel mechanism of atorvastatin to protect mesenchymal stem cells from hypoxia and serum deprivation via AMP-activated protein kinase/mammalian target of rapamycin pathway
    • Zhang Q, Yang YJ, Wang H, Dong QT, Wang TJ, Qian HY, Xu H (2012) Autophagy activation. A novel mechanism of atorvastatin to protect mesenchymal stem cells from hypoxia and serum deprivation via AMP-activated protein kinase/mammalian target of rapamycin pathway. Stem Cells Dev
    • (2012) Stem Cells Dev
    • Zhang, Q.1    Yang, Y.J.2    Wang, H.3    Dong, Q.T.4    Wang, T.J.5    Qian, H.Y.6    Xu, H.7
  • 112
    • 0035182533 scopus 로고    scopus 로고
    • Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations
    • 11687494 1:CAS:528:DC%2BD3MXos1Omsbw%3D 10.1146/annurev.cellbio.17.1.387
    • Weissman IL, Anderson DJ, Gage F (2001) Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu Rev Cell Dev Biol 17:387-403
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 387-403
    • Weissman, I.L.1    Anderson, D.J.2    Gage, F.3
  • 113
    • 61649122814 scopus 로고    scopus 로고
    • Insulin withdrawal-induced cell death in adult hippocampal neural stem cells as a model of autophagic cell death
    • 19158478 1:CAS:528:DC%2BD1MXovFeiu70%3D 10.4161/auto.5.2.7641
    • Baek SH, Kim EK, Goudreau JL, Lookingland KJ, Kim SW, Yu SW (2009) Insulin withdrawal-induced cell death in adult hippocampal neural stem cells as a model of autophagic cell death. Autophagy 5:277-279
    • (2009) Autophagy , vol.5 , pp. 277-279
    • Baek, S.H.1    Kim, E.K.2    Goudreau, J.L.3    Lookingland, K.J.4    Kim, S.W.5    Yu, S.W.6
  • 114
    • 84856431622 scopus 로고    scopus 로고
    • The end of autophagic cell death?
    • Shen S, Kepp O, Kroemer G (2012) The end of autophagic cell death? Autophagy 8:1-3
    • (2012) Autophagy , vol.8 , pp. 1-3
    • Shen, S.1    Kepp, O.2    Kroemer, G.3
  • 115
    • 80053302394 scopus 로고    scopus 로고
    • Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity
    • 21384342 1:CAS:528:DC%2BC3MXht1eqsLrJ 10.1002/ijc.25975
    • Zhuang W, Li B, Long L, Chen L, Huang Q, Liang Z (2011) Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity. Int J Cancer 129:2720-2731
    • (2011) Int J Cancer , vol.129 , pp. 2720-2731
    • Zhuang, W.1    Li, B.2    Long, L.3    Chen, L.4    Huang, Q.5    Liang, Z.6
  • 116
    • 74149087187 scopus 로고    scopus 로고
    • Autophagy impairment inhibits differentiation of glioma stem/progenitor cells
    • 20004652 1:CAS:528:DC%2BC3cXnvFKrsg%3D%3D 10.1016/j.brainres.2009.12.004
    • Zhao Y, Huang Q, Yang J, Lou M, Wang A, Dong J, Qin Z, Zhang T (2010) Autophagy impairment inhibits differentiation of glioma stem/progenitor cells. Brain Res 1313:250-258
    • (2010) Brain Res , vol.1313 , pp. 250-258
    • Zhao, Y.1    Huang, Q.2    Yang, J.3    Lou, M.4    Wang, A.5    Dong, J.6    Qin, Z.7    Zhang, T.8
  • 118
  • 119
    • 31944448885 scopus 로고    scopus 로고
    • Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation
    • 16432235 1:CAS:528:DC%2BD28Xhs1Gns7k%3D 10.1073/pnas.0510652103
    • Wang S, Garcia AJ, Wu M, Lawson DA, Witte ON, Wu H (2006) Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. Proc Natl Acad Sci USA 103:1480-1485
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1480-1485
    • Wang, S.1    Garcia, A.J.2    Wu, M.3    Lawson, D.A.4    Witte, O.N.5    Wu, H.6
  • 120
    • 33646376411 scopus 로고    scopus 로고
    • Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    • 16598206 1:CAS:528:DC%2BD28XkvVykurY%3D 10.1038/nature04703
    • Yilmaz OH, Valdez R, Theisen BK, Guo W, Ferguson DO, Wu H, Morrison SJ (2006) Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441:475-482
    • (2006) Nature , vol.441 , pp. 475-482
    • Yilmaz, O.H.1    Valdez, R.2    Theisen, B.K.3    Guo, W.4    Ferguson, D.O.5    Wu, H.6    Morrison, S.J.7
  • 121
    • 40949143108 scopus 로고    scopus 로고
    • Gemcitabine resistance in pancreatic cancer: Picking the key players
    • 18316544 1:CAS:528:DC%2BD1cXislSku7k%3D 10.1158/1078-0432.CCR-07-2247
    • Kim MP, Gallick GE (2008) Gemcitabine resistance in pancreatic cancer: picking the key players. Clin Cancer Res 14:1284-1285
    • (2008) Clin Cancer Res , vol.14 , pp. 1284-1285
    • Kim, M.P.1    Gallick, G.E.2
  • 122
    • 0037451783 scopus 로고    scopus 로고
    • Autophagy: A barrier or an adaptive response to cancer
    • 12618311 1:CAS:528:DC%2BD3sXhs1eiu7g%3D
    • Ogier-Denis E, Codogno P (2003) Autophagy: a barrier or an adaptive response to cancer. Biochim Biophys Acta 1603:113-128
    • (2003) Biochim Biophys Acta , vol.1603 , pp. 113-128
    • Ogier-Denis, E.1    Codogno, P.2
  • 124
    • 0036285034 scopus 로고    scopus 로고
    • C-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability
    • 12049739 1:CAS:528:DC%2BD38XksFKjtLc%3D 10.1016/S1097-2765(02)00520-8
    • Vafa O, Wade M, Kern S, Beeche M, Pandita TK, Hampton GM, Wahl GM (2002) c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell 9:1031-1044
    • (2002) Mol Cell , vol.9 , pp. 1031-1044
    • Vafa, O.1    Wade, M.2    Kern, S.3    Beeche, M.4    Pandita, T.K.5    Hampton, G.M.6    Wahl, G.M.7
  • 125
    • 80052819789 scopus 로고    scopus 로고
    • Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells
    • 21615676 1:CAS:528:DC%2BC3MXhtlShtLvM 10.1111/j.1474-9726.2011.00722.x
    • Chen T, Shen L, Yu J, Wan H, Guo A, Chen J, Long Y, Zhao J, Pei G (2011) Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells. Aging Cell 10:908-911
    • (2011) Aging Cell , vol.10 , pp. 908-911
    • Chen, T.1    Shen, L.2    Yu, J.3    Wan, H.4    Guo, A.5    Chen, J.6    Long, Y.7    Zhao, J.8    Pei, G.9
  • 126
    • 77950603770 scopus 로고    scopus 로고
    • Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway
    • 19642865 1:CAS:528:DC%2BC3cXktlygsbg%3D 10.1089/scd.2009.0147
    • Lee KW, Yook JY, Son MY, Kim MJ, Koo DB, Han YM, Cho YS (2010) Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway. Stem Cells Dev 19:557-568
    • (2010) Stem Cells Dev , vol.19 , pp. 557-568
    • Lee, K.W.1    Yook, J.Y.2    Son, M.Y.3    Kim, M.J.4    Koo, D.B.5    Han, Y.M.6    Cho, Y.S.7
  • 127
    • 80655140600 scopus 로고    scopus 로고
    • MTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: A roadmap from energy metabolism to stem cell renewal and aging
    • Menendez JA, Vellon L, Oliveras-Ferraros C, Cufi S, Vazquez-Martin A (2011) mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: A roadmap from energy metabolism to stem cell renewal and aging. Cell Cycle 10:3658-3677
    • (2011) Cell Cycle , vol.10 , pp. 3658-3677
    • Menendez, J.A.1    Vellon, L.2    Oliveras-Ferraros, C.3    Cufi, S.4    Vazquez-Martin, A.5
  • 129
    • 59049094829 scopus 로고    scopus 로고
    • Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation
    • 19017649 1:CAS:528:DC%2BD1MXlvFeisA%3D%3D 10.1074/jbc.M806088200
    • Young JE, Martinez RA, La Spada AR (2009) Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation. J Biol Chem 284:2363-2373
    • (2009) J Biol Chem , vol.284 , pp. 2363-2373
    • Young, J.E.1    Martinez, R.A.2    La Spada, A.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.