-
1
-
-
0034537290
-
Autophagy as a regulated pathway of cellular degradation
-
11099404 1:CAS:528:DC%2BD3cXovVOitbw%3D 10.1126/science.290.5497.1717
-
Klionsky DJ, Emr SD (2000) Autophagy as a regulated pathway of cellular degradation. Science 290:1717-1721
-
(2000)
Science
, vol.290
, pp. 1717-1721
-
-
Klionsky, D.J.1
Emr, S.D.2
-
2
-
-
32044465506
-
TOR signaling in growth and metabolism
-
16469695 1:CAS:528:DC%2BD28Xhslaqs74%3D 10.1016/j.cell.2006.01.016
-
Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124:471-484
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
3
-
-
20344406240
-
Autophagy in metazoans: Cell survival in the land of plenty
-
15928708 1:CAS:528:DC%2BD2MXks1Gmtb0%3D 10.1038/nrm1660
-
Lum JJ, DeBerardinis RJ, Thompson CB (2005) Autophagy in metazoans: cell survival in the land of plenty. Nat Rev Mol Cell Biol 6:439-448
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 439-448
-
-
Lum, J.J.1
Deberardinis, R.J.2
Thompson, C.B.3
-
4
-
-
0032512636
-
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
-
9461583 1:CAS:528:DyaK1cXht1ahsr8%3D 10.1074/jbc.273.7.3963
-
Noda T, Ohsumi Y (1998) Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem 273:3963-3966
-
(1998)
J Biol Chem
, vol.273
, pp. 3963-3966
-
-
Noda, T.1
Ohsumi, Y.2
-
5
-
-
4344563878
-
Role and regulation of starvation-induced autophagy in the Drosophila fat body
-
15296714 1:CAS:528:DC%2BD2cXnsVKntr0%3D 10.1016/j.devcel.2004.07.009
-
Scott RC, Schuldiner O, Neufeld TP (2004) Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell 7:167-178
-
(2004)
Dev Cell
, vol.7
, pp. 167-178
-
-
Scott, R.C.1
Schuldiner, O.2
Neufeld, T.P.3
-
6
-
-
51049118332
-
The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: Beyond the usual suspects' review series
-
18704115 1:CAS:528:DC%2BD1cXhtVGgt7jL 10.1038/embor.2008.163
-
Geng J, Klionsky DJ (2008) The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep 9:859-864
-
(2008)
EMBO Rep
, vol.9
, pp. 859-864
-
-
Geng, J.1
Klionsky, D.J.2
-
7
-
-
77951249136
-
Lysosome dysfunction triggers Atg7-dependent neural apoptosis
-
20123985 1:CAS:528:DC%2BC3cXjvFajtbc%3D 10.1074/jbc.M110.103747
-
Walls KC, Ghosh AP, Franklin AV, Klocke BJ, Ballestas M, Shacka JJ, Zhang J, Roth KA (2010) Lysosome dysfunction triggers Atg7-dependent neural apoptosis. J Biol Chem 285:10497-10507
-
(2010)
J Biol Chem
, vol.285
, pp. 10497-10507
-
-
Walls, K.C.1
Ghosh, A.P.2
Franklin, A.V.3
Klocke, B.J.4
Ballestas, M.5
Shacka, J.J.6
Zhang, J.7
Roth, K.A.8
-
8
-
-
67650517556
-
NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets
-
19502794 1:CAS:528:DC%2BC3cXovFykuw%3D%3D 10.4161/cc.8.13.8892
-
Lamark T, Kirkin V, Dikic I, Johansen T (2009) NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets. Cell Cycle 8:1986-1990
-
(2009)
Cell Cycle
, vol.8
, pp. 1986-1990
-
-
Lamark, T.1
Kirkin, V.2
Dikic, I.3
Johansen, T.4
-
9
-
-
74049153002
-
Nix is a selective autophagy receptor for mitochondrial clearance
-
20010802 1:CAS:528:DC%2BD1MXhsFChtbbP 10.1038/embor.2009.256
-
Novak I, Kirkin V, McEwan DG, Zhang J, Wild P, Rozenknop A, Rogov V, Lohr F, Popovic D, Occhipinti A, Reichert AS, Terzic J, Dotsch V, Ney PA, Dikic I (2010) Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Rep 11:45-51
-
(2010)
EMBO Rep
, vol.11
, pp. 45-51
-
-
Novak, I.1
Kirkin, V.2
McEwan, D.G.3
Zhang, J.4
Wild, P.5
Rozenknop, A.6
Rogov, V.7
Lohr, F.8
Popovic, D.9
Occhipinti, A.10
Reichert, A.S.11
Terzic, J.12
Dotsch, V.13
Ney, P.A.14
Dikic, I.15
-
10
-
-
8344242220
-
Autophagy in health and disease: A double-edged sword
-
15528435 1:CAS:528:DC%2BD2cXptFyju78%3D 10.1126/science.1099993
-
Shintani T, Klionsky DJ (2004) Autophagy in health and disease: a double-edged sword. Science 306:990-995
-
(2004)
Science
, vol.306
, pp. 990-995
-
-
Shintani, T.1
Klionsky, D.J.2
-
11
-
-
80053391464
-
CAMP induces autophagy via a novel pathway involving ERK, cyclin e and Beclin 1
-
21750416 1:CAS:528:DC%2BC38XisFSnt7c%3D 10.4161/auto.7.10.16649
-
Ugland H, Naderi S, Brech A, Collas P, Blomhoff HK (2011) cAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1. Autophagy 7:1199-1211
-
(2011)
Autophagy
, vol.7
, pp. 1199-1211
-
-
Ugland, H.1
Naderi, S.2
Brech, A.3
Collas, P.4
Blomhoff, H.K.5
-
12
-
-
77953744638
-
Nonredundant role of Atg7 in mitochondrial clearance during erythroid development
-
20215867 10.4161/auto.6.3.11528
-
Mortensen M, Simon AK (2010) Nonredundant role of Atg7 in mitochondrial clearance during erythroid development. Autophagy 6:423-425
-
(2010)
Autophagy
, vol.6
, pp. 423-425
-
-
Mortensen, M.1
Simon, A.K.2
-
13
-
-
39149111914
-
Roles of autophagy and mTOR signaling in neuronal differentiation of mouse neuroblastoma cells
-
18207367 1:CAS:528:DC%2BD1cXitVejsro%3D 10.1016/j.cellsig.2007.11.015
-
Zeng M, Zhou JN (2008) Roles of autophagy and mTOR signaling in neuronal differentiation of mouse neuroblastoma cells. Cell Signal 20:659-665
-
(2008)
Cell Signal
, vol.20
, pp. 659-665
-
-
Zeng, M.1
Zhou, J.N.2
-
14
-
-
33644984490
-
A new description of cellular quiescence
-
16509772 10.1371/journal.pbio.0040083 1:CAS:528:DC%2BD28Xislyjsro%3D
-
Coller HA, Sang L, Roberts JM (2006) A new description of cellular quiescence. PLoS Biol 4:e83
-
(2006)
PLoS Biol
, vol.4
, pp. 83
-
-
Coller, H.A.1
Sang, L.2
Roberts, J.M.3
-
15
-
-
81255143302
-
MicroRNA-101 is a potent inhibitor of autophagy
-
Frankel LB, Wen J, Lees M, Hoyer-Hansen M, Farkas T, Krogh A, Jaattela M, Lund AH (2011) microRNA-101 is a potent inhibitor of autophagy. EMBO J 30:4628-4641
-
(2011)
EMBO J
, vol.30
, pp. 4628-4641
-
-
Frankel, L.B.1
Wen, J.2
Lees, M.3
Hoyer-Hansen, M.4
Farkas, T.5
Krogh, A.6
Jaattela, M.7
Lund, A.H.8
-
16
-
-
77955908881
-
A novel Gfer-Drp1 link in preserving mitochondrial dynamics and function in pluripotent stem cells
-
20581476 10.4161/auto.6.6.12625
-
Todd LR, Gomathinayagam R, Sankar U (2010) A novel Gfer-Drp1 link in preserving mitochondrial dynamics and function in pluripotent stem cells. Autophagy 6:821-822
-
(2010)
Autophagy
, vol.6
, pp. 821-822
-
-
Todd, L.R.1
Gomathinayagam, R.2
Sankar, U.3
-
17
-
-
20544441737
-
A Pax3/Pax7-dependent population of skeletal muscle progenitor cells
-
15843801 1:CAS:528:DC%2BD2MXltFeltLs%3D 10.1038/nature03594
-
Relaix F, Rocancourt D, Mansouri A, Buckingham M (2005) A Pax3/Pax7-dependent population of skeletal muscle progenitor cells. Nature 435:948-953
-
(2005)
Nature
, vol.435
, pp. 948-953
-
-
Relaix, F.1
Rocancourt, D.2
Mansouri, A.3
Buckingham, M.4
-
18
-
-
35548974423
-
Identification of stem cells in small intestine and colon by marker gene Lgr5
-
17934449 1:CAS:528:DC%2BD2sXht1Wgtr3E 10.1038/nature06196
-
Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449:1003-1007
-
(2007)
Nature
, vol.449
, pp. 1003-1007
-
-
Barker, N.1
Van Es, J.H.2
Kuipers, J.3
Kujala, P.4
Van Den Born, M.5
Cozijnsen, M.6
Haegebarth, A.7
Korving, J.8
Begthel, H.9
Peters, P.J.10
Clevers, H.11
-
19
-
-
50849107643
-
The skin: A home to multiple classes of epithelial progenitor cells
-
18491239 10.1007/s12015-008-9022-4
-
Yan X, Owens DM (2008) The skin: a home to multiple classes of epithelial progenitor cells. Stem Cell Rev 4:113-118
-
(2008)
Stem Cell Rev
, vol.4
, pp. 113-118
-
-
Yan, X.1
Owens, D.M.2
-
20
-
-
31544481865
-
SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity
-
16219798 1:CAS:528:DC%2BD28Xht1Onsbs%3D 10.1182/blood-2005-05-2140
-
Yilmaz OH, Kiel MJ, Morrison SJ (2006) SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood 107:924-930
-
(2006)
Blood
, vol.107
, pp. 924-930
-
-
Yilmaz, O.H.1
Kiel, M.J.2
Morrison, S.J.3
-
21
-
-
75749122303
-
Methods in mammalian autophagy research
-
20144757 1:CAS:528:DC%2BC3cXlt1KlsLc%3D 10.1016/j.cell.2010.01.028
-
Mizushima N, Yoshimori T, Levine B (2010) Methods in mammalian autophagy research. Cell 140:313-326
-
(2010)
Cell
, vol.140
, pp. 313-326
-
-
Mizushima, N.1
Yoshimori, T.2
Levine, B.3
-
23
-
-
46849121421
-
Utilizing flow cytometry to monitor autophagy in living mammalian cells
-
18376137 1:CAS:528:DC%2BD1cXpsVCkt7o%3D
-
Shvets E, Fass E, Elazar Z (2008) Utilizing flow cytometry to monitor autophagy in living mammalian cells. Autophagy 4:621-628
-
(2008)
Autophagy
, vol.4
, pp. 621-628
-
-
Shvets, E.1
Fass, E.2
Elazar, Z.3
-
24
-
-
81055126626
-
Autophagy in human embryonic stem cells
-
22110659 1:CAS:528:DC%2BC3MXhsFynurfE 10.1371/journal.pone.0027485
-
Tra T, Gong L, Kao LP, Li XL, Grandela C, Devenish RJ, Wolvetang E, Prescott M (2011) Autophagy in human embryonic stem cells. PLoS ONE 6:e27485
-
(2011)
PLoS ONE
, vol.6
, pp. 27485
-
-
Tra, T.1
Gong, L.2
Kao, L.P.3
Li, X.L.4
Grandela, C.5
Devenish, R.J.6
Wolvetang, E.7
Prescott, M.8
-
25
-
-
84862151014
-
A novel method for autophagy detection in primary cells: Impaired levels of macroautophagy in immunosenescent T cells
-
[Epub ahead of print]
-
Phadwal K, Alegre-Abarrategui J, Watson AS, Pike L, Anbalagan S, Hammond EM, Wade-Martins R, McMichael A, Klenerman P, Simon AK (2012) A novel method for autophagy detection in primary cells: Impaired levels of macroautophagy in immunosenescent T cells. Autophagy 8 [Epub ahead of print]
-
(2012)
Autophagy
, vol.8
-
-
Phadwal, K.1
Alegre-Abarrategui, J.2
Watson, A.S.3
Pike, L.4
Anbalagan, S.5
Hammond, E.M.6
Wade-Martins, R.7
McMichael, A.8
Klenerman, P.9
Simon, A.K.10
-
26
-
-
0035911162
-
Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells
-
11266458 1:CAS:528:DC%2BD3MXhtlGmtrY%3D 10.1083/jcb.152.4.657
-
Mizushima N, Yamamoto A, Hatano M, Kobayashi Y, Kabeya Y, Suzuki K, Tokuhisa T, Ohsumi Y, Yoshimori T (2001) Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol 152:657-668
-
(2001)
J Cell Biol
, vol.152
, pp. 657-668
-
-
Mizushima, N.1
Yamamoto, A.2
Hatano, M.3
Kobayashi, Y.4
Kabeya, Y.5
Suzuki, K.6
Tokuhisa, T.7
Ohsumi, Y.8
Yoshimori, T.9
-
27
-
-
38049098543
-
The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy
-
17986448 1:CAS:528:DC%2BD2sXhsVGjtr7F 10.1074/jbc.C700195200
-
Hanada T, Noda NN, Satomi Y, Ichimura Y, Fujioka Y, Takao T, Inagaki F, Ohsumi Y (2007) The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem 282:37298-37302
-
(2007)
J Biol Chem
, vol.282
, pp. 37298-37302
-
-
Hanada, T.1
Noda, N.N.2
Satomi, Y.3
Ichimura, Y.4
Fujioka, Y.5
Takao, T.6
Inagaki, F.7
Ohsumi, Y.8
-
28
-
-
0345166111
-
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
-
14657337 1:CAS:528:DC%2BD3sXpvFaqtbg%3D 10.1073/pnas.2436255100
-
Yue Z, Jin S, Yang C, Levine AJ, Heintz N (2003) Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 100:15077-15082
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 15077-15082
-
-
Yue, Z.1
Jin, S.2
Yang, C.3
Levine, A.J.4
Heintz, N.5
-
29
-
-
0036683054
-
Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells
-
12145208 1:CAS:528:DC%2BD38XnvVGnur8%3D 10.1093/emboj/cdf413
-
Xu D, Wilson TJ, Chan D, De Luca E, Zhou J, Hertzog PJ, Kola I (2002) Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells. EMBO J 21:4081-4093
-
(2002)
EMBO J
, vol.21
, pp. 4081-4093
-
-
Xu, D.1
Wilson, T.J.2
Chan, D.3
De Luca, E.4
Zhou, J.5
Hertzog, P.J.6
Kola, I.7
-
30
-
-
0034665461
-
P53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage
-
10990460 1:CAS:528:DC%2BD3cXntVartLw%3D 10.1093/emboj/19.18.4967
-
Chao C, Saito S, Kang J, Anderson CW, Appella E, Xu Y (2000) p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO J 19:4967-4975
-
(2000)
EMBO J
, vol.19
, pp. 4967-4975
-
-
Chao, C.1
Saito, S.2
Kang, J.3
Anderson, C.W.4
Appella, E.5
Xu, Y.6
-
31
-
-
0035206383
-
Mechanisms of p53-dependent apoptosis
-
11709054 1:CAS:528:DC%2BD3MXpt1Crs7w%3D 10.1042/BST0290684
-
Schuler M, Green DR (2001) Mechanisms of p53-dependent apoptosis. Biochem Soc Trans 29:684-688
-
(2001)
Biochem Soc Trans
, vol.29
, pp. 684-688
-
-
Schuler, M.1
Green, D.R.2
-
32
-
-
0035967169
-
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
-
11279485 1:CAS:528:DC%2BD3MXis1Grur4%3D 10.1038/35069004
-
Joza N, Susin SA, Daugas E, Stanford WL, Cho SK, Li CY, Sasaki T, Elia AJ, Cheng HY, Ravagnan L, Ferri KF, Zamzami N, Wakeham A, Hakem R, Yoshida H, Kong YY, Mak TW, Zuniga-Pflucker JC, Kroemer G, Penninger JM (2001) Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature 410:549-554
-
(2001)
Nature
, vol.410
, pp. 549-554
-
-
Joza, N.1
Susin, S.A.2
Daugas, E.3
Stanford, W.L.4
Cho, S.K.5
Li, C.Y.6
Sasaki, T.7
Elia, A.J.8
Cheng, H.Y.9
Ravagnan, L.10
Ferri, K.F.11
Zamzami, N.12
Wakeham, A.13
Hakem, R.14
Yoshida, H.15
Kong, Y.Y.16
Mak, T.W.17
Zuniga-Pflucker, J.C.18
Kroemer, G.19
Penninger, J.M.20
more..
-
33
-
-
33847404337
-
Autophagy gene-dependent clearance of apoptotic cells during embryonic development
-
17350577 1:CAS:528:DC%2BD2sXjvVSgu7c%3D 10.1016/j.cell.2006.12.044
-
Qu X, Zou Z, Sun Q, Luby-Phelps K, Cheng P, Hogan RN, Gilpin C, Levine B (2007) Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell 128:931-946
-
(2007)
Cell
, vol.128
, pp. 931-946
-
-
Qu, X.1
Zou, Z.2
Sun, Q.3
Luby-Phelps, K.4
Cheng, P.5
Hogan, R.N.6
Gilpin, C.7
Levine, B.8
-
34
-
-
77955908881
-
A novel Gfer-Drp1 link in preserving mitochondrial dynamics and function in pluripotent stem cells
-
20581476 10.4161/auto.6.6.12625
-
Todd LR, Gomathinayagam R, Sankar U (2010) A novel Gfer-Drp1 link in preserving mitochondrial dynamics and function in pluripotent stem cells. Autophagy 6:821-822
-
(2010)
Autophagy
, vol.6
, pp. 821-822
-
-
Todd, L.R.1
Gomathinayagam, R.2
Sankar, U.3
-
35
-
-
34347344990
-
Ambra1 regulates autophagy and development of the nervous system
-
17589504 1:CAS:528:DC%2BD2sXntlOlu7s%3D
-
Fimia GM, Stoykova A, Romagnoli A, Giunta L, Di Bartolomeo S, Nardacci R, Corazzari M, Fuoco C, Ucar A, Schwartz P, Gruss P, Piacentini M, Chowdhury K, Cecconi F (2007) Ambra1 regulates autophagy and development of the nervous system. Nature 447:1121-1125
-
(2007)
Nature
, vol.447
, pp. 1121-1125
-
-
Fimia, G.M.1
Stoykova, A.2
Romagnoli, A.3
Giunta, L.4
Di Bartolomeo, S.5
Nardacci, R.6
Corazzari, M.7
Fuoco, C.8
Ucar, A.9
Schwartz, P.10
Gruss, P.11
Piacentini, M.12
Chowdhury, K.13
Cecconi, F.14
-
36
-
-
80053564250
-
Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity
-
21909099 1:CAS:528:DC%2BC3MXhtFyls7%2FF 10.1038/ncb2332
-
Kuo TC, Chen CT, Baron D, Onder TT, Loewer S, Almeida S, Weismann CM, Xu P, Houghton JM, Gao FB, Daley GQ, Doxsey S (2011) Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity. Nat Cell Biol 13:1214-1223
-
(2011)
Nat Cell Biol
, vol.13
, pp. 1214-1223
-
-
Kuo, T.C.1
Chen, C.T.2
Baron, D.3
Onder, T.T.4
Loewer, S.5
Almeida, S.6
Weismann, C.M.7
Xu, P.8
Houghton, J.M.9
Gao, F.B.10
Daley, G.Q.11
Doxsey, S.12
-
37
-
-
70449448312
-
Autophagy regulates adipose mass and differentiation in mice
-
19855132 1:CAS:528:DC%2BD1MXivF2kt7c%3D 10.1172/JCI35541
-
Singh R, Xiang Y, Wang Y, Baikati K, Cuervo AM, Luu YK, Tang Y, Pessin JE, Schwartz GJ, Czaja MJ (2009) Autophagy regulates adipose mass and differentiation in mice. J Clin Invest 119:3329-3339
-
(2009)
J Clin Invest
, vol.119
, pp. 3329-3339
-
-
Singh, R.1
Xiang, Y.2
Wang, Y.3
Baikati, K.4
Cuervo, A.M.5
Luu, Y.K.6
Tang, Y.7
Pessin, J.E.8
Schwartz, G.J.9
Czaja, M.J.10
-
38
-
-
0033760607
-
Autophagy in embryonic erythroid cells: Its role in maturation
-
11089924 1:STN:280:DC%2BD3M7ptlyqsA%3D%3D 10.1078/0171-9335-00096
-
Takano-Ohmuro H, Mukaida M, Kominami E, Morioka K (2000) Autophagy in embryonic erythroid cells: its role in maturation. Eur J Cell Biol 79:759-764
-
(2000)
Eur J Cell Biol
, vol.79
, pp. 759-764
-
-
Takano-Ohmuro, H.1
Mukaida, M.2
Kominami, E.3
Morioka, K.4
-
39
-
-
77955448361
-
ATM engages the TSC2/mTORC1 signaling node to regulate autophagy
-
Alexander A, Kim J, Walker CL (2010) ATM engages the TSC2/mTORC1 signaling node to regulate autophagy. Autophagy 6:672-673
-
(2010)
Autophagy
, vol.6
, pp. 672-673
-
-
Alexander, A.1
Kim, J.2
Walker, C.L.3
-
40
-
-
79952728102
-
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance
-
21339326 1:CAS:528:DC%2BC3MXjslCmsbk%3D 10.1084/jem.20101145
-
Mortensen M, Soilleux EJ, Djordjevic G, Tripp R, Lutteropp M, Sadighi-Akha E, Stranks AJ, Glanville J, Knight S, Jacobsen SE, Kranc KR, Simon AK (2011) The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. J Exp Med 208:455-467
-
(2011)
J Exp Med
, vol.208
, pp. 455-467
-
-
Mortensen, M.1
Soilleux, E.J.2
Djordjevic, G.3
Tripp, R.4
Lutteropp, M.5
Sadighi-Akha, E.6
Stranks, A.J.7
Glanville, J.8
Knight, S.9
Jacobsen, S.E.10
Kranc, K.R.11
Simon, A.K.12
-
41
-
-
7244250309
-
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
-
15496926 1:CAS:528:DC%2BD2cXoslSlt78%3D 10.1038/nature02989
-
Ito K, Hirao A, Arai F, Matsuoka S, Takubo K, Hamaguchi I, Nomiyama K, Hosokawa K, Sakurada K, Nakagata N, Ikeda Y, Mak TW, Suda T (2004) Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 431:997-1002
-
(2004)
Nature
, vol.431
, pp. 997-1002
-
-
Ito, K.1
Hirao, A.2
Arai, F.3
Matsuoka, S.4
Takubo, K.5
Hamaguchi, I.6
Nomiyama, K.7
Hosokawa, K.8
Sakurada, K.9
Nakagata, N.10
Ikeda, Y.11
Mak, T.W.12
Suda, T.13
-
42
-
-
33751171109
-
ATM is activated by mitotic stress and suppresses centrosome amplification in primary but not in tumor cells
-
16775842 1:CAS:528:DC%2BD28Xht1ahsLbK 10.1002/jcb.20848
-
Shen K, Wang Y, Brooks SC, Raz A, Wang YA (2006) ATM is activated by mitotic stress and suppresses centrosome amplification in primary but not in tumor cells. J Cell Biochem 99:1267-1274
-
(2006)
J Cell Biochem
, vol.99
, pp. 1267-1274
-
-
Shen, K.1
Wang, Y.2
Brooks, S.C.3
Raz, A.4
Wang, Y.A.5
-
43
-
-
33846461678
-
A critical role for the autophagy gene Atg5 in T cell survival and proliferation
-
17190837 1:CAS:528:DC%2BD2sXhtFGjsbs%3D 10.1084/jem.20061303
-
Pua HH, Dzhagalov I, Chuck M, Mizushima N, He YW (2007) A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med 204:25-31
-
(2007)
J Exp Med
, vol.204
, pp. 25-31
-
-
Pua, H.H.1
Dzhagalov, I.2
Chuck, M.3
Mizushima, N.4
He, Y.W.5
-
44
-
-
80052382925
-
Lack of autophagy in the hematopoietic system leads to loss of hematopoietic stem cell function and dysregulated myeloid proliferation
-
21552009 1:CAS:528:DC%2BC38Xhs1Oqtrs%3D 10.4161/auto.7.9.15886
-
Mortensen M, Watson AS, Simon AK (2011) Lack of autophagy in the hematopoietic system leads to loss of hematopoietic stem cell function and dysregulated myeloid proliferation. Autophagy 7:1069-1070
-
(2011)
Autophagy
, vol.7
, pp. 1069-1070
-
-
Mortensen, M.1
Watson, A.S.2
Simon, A.K.3
-
45
-
-
78649689953
-
FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells
-
20716775 1:CAS:528:DC%2BC3cXhs1SlsrrI 10.1182/blood-2010-06-288589
-
Liu F, Lee JY, Wei H, Tanabe O, Engel JD, Morrison SJ, Guan JL (2010) FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood 116:4806-4814
-
(2010)
Blood
, vol.116
, pp. 4806-4814
-
-
Liu, F.1
Lee, J.Y.2
Wei, H.3
Tanabe, O.4
Engel, J.D.5
Morrison, S.J.6
Guan, J.L.7
-
46
-
-
65249176304
-
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
-
19225151 1:CAS:528:DC%2BD1MXotVyqsL8%3D 10.1091/mbc.E08-12-1249
-
Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M, Kim DH (2009) ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 20:1992-2003
-
(2009)
Mol Biol Cell
, vol.20
, pp. 1992-2003
-
-
Jung, C.H.1
Jun, C.B.2
Ro, S.H.3
Kim, Y.M.4
Otto, N.M.5
Cao, J.6
Kundu, M.7
Kim, D.H.8
-
47
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
14985505 1:CAS:528:DC%2BD2cXisFWmsrg%3D 10.1073/pnas.0308061100
-
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC (2004) The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 101:3329-3335
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
Depinho, R.A.6
Cantley, L.C.7
-
48
-
-
0345107247
-
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
-
14511394 10.1186/1475-4924-2-28
-
Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Makela TP, Alessi DR, Hardie DG (2003) Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2:28
-
(2003)
J Biol
, vol.2
, pp. 28
-
-
Hawley, S.A.1
Boudeau, J.2
Reid, J.L.3
Mustard, K.J.4
Udd, L.5
Makela, T.P.6
Alessi, D.R.7
Hardie, D.G.8
-
49
-
-
78649851511
-
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
-
21124451 1:CAS:528:DC%2BC3cXhsFSrsrzE 10.1038/nature09572
-
Gurumurthy S, Xie SZ, Alagesan B, Kim J, Yusuf RZ, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, Park PJ, Shirihai OS, Scadden DT, Bardeesy N (2010) The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature 468:659-663
-
(2010)
Nature
, vol.468
, pp. 659-663
-
-
Gurumurthy, S.1
Xie, S.Z.2
Alagesan, B.3
Kim, J.4
Yusuf, R.Z.5
Saez, B.6
Tzatsos, A.7
Ozsolak, F.8
Milos, P.9
Ferrari, F.10
Park, P.J.11
Shirihai, O.S.12
Scadden, D.T.13
Bardeesy, N.14
-
50
-
-
47849125676
-
MicroRNAs: New regulators of immune cell development and function
-
18645592 1:CAS:528:DC%2BD1cXoslCmu78%3D 10.1038/ni.f.209
-
Baltimore D, Boldin MP, O'Connell RM, Rao DS, Taganov KD (2008) MicroRNAs: new regulators of immune cell development and function. Nat Immunol 9:839-845
-
(2008)
Nat Immunol
, vol.9
, pp. 839-845
-
-
Baltimore, D.1
Boldin, M.P.2
O'Connell, R.M.3
Rao, D.S.4
Taganov, K.D.5
-
51
-
-
33645525964
-
MicroRNA fingerprints during human megakaryocytopoiesis
-
16549775 1:CAS:528:DC%2BD28XjsVGlsbY%3D 10.1073/pnas.0600587103
-
Garzon R, Pichiorri F, Palumbo T, Iuliano R, Cimmino A, Aqeilan R, Volinia S, Bhatt D, Alder H, Marcucci G, Calin GA, Liu CG, Bloomfield CD, Andreeff M, Croce CM (2006) MicroRNA fingerprints during human megakaryocytopoiesis. Proc Natl Acad Sci USA 103:5078-5083
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 5078-5083
-
-
Garzon, R.1
Pichiorri, F.2
Palumbo, T.3
Iuliano, R.4
Cimmino, A.5
Aqeilan, R.6
Volinia, S.7
Bhatt, D.8
Alder, H.9
Marcucci, G.10
Calin, G.A.11
Liu, C.G.12
Bloomfield, C.D.13
Andreeff, M.14
Croce, C.M.15
-
52
-
-
79960996763
-
MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1-regulated pathways in mice
-
21628417 1:CAS:528:DC%2BC3MXhtVWlsbfP 10.1182/blood-2011-02-336487
-
Meenhuis A, van Veelen PA, de Looper H, van Boxtel N, van den Berge IJ, Sun SM, Taskesen E, Stern P, de Ru AH, van Adrichem AJ, Demmers J, Jongen-Lavrencic M, Lowenberg B, Touw IP, Sharp PA, Erkeland SJ (2011) MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1-regulated pathways in mice. Blood 118:916-925
-
(2011)
Blood
, vol.118
, pp. 916-925
-
-
Meenhuis, A.1
Van Veelen, P.A.2
De Looper, H.3
Van Boxtel, N.4
Van Den Berge, I.J.5
Sun, S.M.6
Taskesen, E.7
Stern, P.8
De Ru, A.H.9
Van Adrichem, A.J.10
Demmers, J.11
Jongen-Lavrencic, M.12
Lowenberg, B.13
Touw, I.P.14
Sharp, P.A.15
Erkeland, S.J.16
-
53
-
-
34347383305
-
MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation
-
17589498 1:CAS:528:DC%2BD2sXntFemtb4%3D 10.1038/ncb1613
-
Fontana L, Pelosi E, Greco P, Racanicchi S, Testa U, Liuzzi F, Croce CM, Brunetti E, Grignani F, Peschle C (2007) MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation. Nat Cell Biol 9:775-787
-
(2007)
Nat Cell Biol
, vol.9
, pp. 775-787
-
-
Fontana, L.1
Pelosi, E.2
Greco, P.3
Racanicchi, S.4
Testa, U.5
Liuzzi, F.6
Croce, C.M.7
Brunetti, E.8
Grignani, F.9
Peschle, C.10
-
54
-
-
66449114033
-
P62 at the crossroads of autophagy, apoptosis, and cancer
-
19524504 1:CAS:528:DC%2BD1MXps1eiurs%3D 10.1016/j.cell.2009.05.023
-
Moscat J, Diaz-Meco MT (2009) p62 at the crossroads of autophagy, apoptosis, and cancer. Cell 137:1001-1004
-
(2009)
Cell
, vol.137
, pp. 1001-1004
-
-
Moscat, J.1
Diaz-Meco, M.T.2
-
55
-
-
33644629034
-
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62
-
16517408 1:CAS:528:DC%2BD28Xislyhtrs%3D 10.1016/j.cmet.2006.01.011
-
Rodriguez A, Duran A, Selloum M, Champy MF, Diez-Guerra FJ, Flores JM, Serrano M, Auwerx J, Diaz-Meco MT, Moscat J (2006) Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. Cell Metab 3:211-222
-
(2006)
Cell Metab
, vol.3
, pp. 211-222
-
-
Rodriguez, A.1
Duran, A.2
Selloum, M.3
Champy, M.F.4
Diez-Guerra, F.J.5
Flores, J.M.6
Serrano, M.7
Auwerx, J.8
Diaz-Meco, M.T.9
Moscat, J.10
-
56
-
-
26944484011
-
Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling
-
16246731 1:CAS:528:DC%2BD2MXht1SntrfJ 10.1016/j.molcel.2005.09.014
-
Geetha T, Jiang J, Wooten MW (2005) Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling. Mol Cell 20:301-312
-
(2005)
Mol Cell
, vol.20
, pp. 301-312
-
-
Geetha, T.1
Jiang, J.2
Wooten, M.W.3
-
57
-
-
0031946369
-
Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62
-
9566925 1:CAS:528:DyaK1cXis1GmsL4%3D
-
Sanchez P, De Carcer G, Sandoval IV, Moscat J, Diaz-Meco MT (1998) Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. Mol Cell Biol 18:3069-3080
-
(1998)
Mol Cell Biol
, vol.18
, pp. 3069-3080
-
-
Sanchez, P.1
De Carcer, G.2
Sandoval, I.V.3
Moscat, J.4
Diaz-Meco, M.T.5
-
58
-
-
59449106021
-
CAMP-mediated induction of cyclin e sensitizes growth-arrested adipose stem cells to DNA damage-induced apoptosis
-
18799628 1:CAS:528:DC%2BD1cXhsVynurnK 10.1091/mbc.E08-01-0094
-
Ugland H, Boquest AC, Naderi S, Collas P, Blomhoff HK (2008) cAMP-mediated induction of cyclin E sensitizes growth-arrested adipose stem cells to DNA damage-induced apoptosis. Mol Biol Cell 19:5082-5092
-
(2008)
Mol Biol Cell
, vol.19
, pp. 5082-5092
-
-
Ugland, H.1
Boquest, A.C.2
Naderi, S.3
Collas, P.4
Blomhoff, H.K.5
-
59
-
-
70349234637
-
Autophagy: Regulation and role in disease
-
19552522 1:CAS:528:DC%2BD1MXptlKnsbk%3D 10.1080/10408360903044068
-
Meijer AJ, Codogno P (2009) Autophagy: regulation and role in disease. Crit Rev Clin Lab Sci 46:210-240
-
(2009)
Crit Rev Clin Lab Sci
, vol.46
, pp. 210-240
-
-
Meijer, A.J.1
Codogno, P.2
-
60
-
-
0038269032
-
Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells
-
12609989 1:CAS:528:DC%2BD3sXjsVKnsbk%3D 10.1074/jbc.M210998200
-
Pattingre S, Bauvy C, Codogno P (2003) Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells. J Biol Chem 278:16667-16674
-
(2003)
J Biol Chem
, vol.278
, pp. 16667-16674
-
-
Pattingre, S.1
Bauvy, C.2
Codogno, P.3
-
61
-
-
35848938724
-
Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy
-
17786026 1:CAS:528:DC%2BD2sXhtlOhsL7P
-
Shinojima N, Yokoyama T, Kondo Y, Kondo S (2007) Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy. Autophagy 3:635-637
-
(2007)
Autophagy
, vol.3
, pp. 635-637
-
-
Shinojima, N.1
Yokoyama, T.2
Kondo, Y.3
Kondo, S.4
-
62
-
-
27644466759
-
Autophagy and signaling: Their role in cell survival and cell death
-
16247498 1:CAS:528:DC%2BD2MXhtFCjt7%2FI 10.1038/sj.cdd.4401751
-
Codogno P, Meijer AJ (2005) Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ 12(Suppl 2):1509-1518
-
(2005)
Cell Death Differ
, vol.12
, Issue.SUPPL. 2
, pp. 1509-1518
-
-
Codogno, P.1
Meijer, A.J.2
-
63
-
-
79960046702
-
Activation of autophagy in mesenchymal stem cells provides tumor stromal support
-
21317300 1:CAS:528:DC%2BC3MXosVOlsL0%3D 10.1093/carcin/bgr029
-
Sanchez CG, Penfornis P, Oskowitz AZ, Boonjindasup AG, Cai DZ, Dhule SS, Rowan BG, Kelekar A, Krause DS, Pochampally RR (2011) Activation of autophagy in mesenchymal stem cells provides tumor stromal support. Carcinogenesis 32:964-972
-
(2011)
Carcinogenesis
, vol.32
, pp. 964-972
-
-
Sanchez, C.G.1
Penfornis, P.2
Oskowitz, A.Z.3
Boonjindasup, A.G.4
Cai, D.Z.5
Dhule, S.S.6
Rowan, B.G.7
Kelekar, A.8
Krause, D.S.9
Pochampally, R.R.10
-
64
-
-
58849163098
-
Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death
-
18764739 1:CAS:528:DC%2BD1MXhtFOrtrc%3D 10.1089/ars.2008.2263
-
Pivtoraiko VN, Stone SL, Roth KA, Shacka JJ (2009) Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death. Antioxid Redox Signal 11:481-496
-
(2009)
Antioxid Redox Signal
, vol.11
, pp. 481-496
-
-
Pivtoraiko, V.N.1
Stone, S.L.2
Roth, K.A.3
Shacka, J.J.4
-
65
-
-
33745885329
-
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
-
16839881 1:CAS:528:DC%2BD28Xns1Cgt7w%3D 10.1016/j.cell.2006.05.034
-
Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, Harrison PR, Gasco M, Garrone O, Crook T, Ryan KM (2006) DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 126:121-134
-
(2006)
Cell
, vol.126
, pp. 121-134
-
-
Crighton, D.1
Wilkinson, S.2
O'Prey, J.3
Syed, N.4
Smith, P.5
Harrison, P.R.6
Gasco, M.7
Garrone, O.8
Crook, T.9
Ryan, K.M.10
-
66
-
-
84857345898
-
Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells
-
Vazquez P, Arroba AI, Cecconi F, de la Rosa EJ, Boya P, De Pablo F (2012) Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells. Autophagy 8:187-199
-
(2012)
Autophagy
, vol.8
, pp. 187-199
-
-
Vazquez, P.1
Arroba, A.I.2
Cecconi, F.3
De La Rosa, E.J.4
Boya, P.5
De Pablo, F.6
-
67
-
-
84856618999
-
Autophagy is required for self-renewal and differentiation of adult human stem cells
-
22184008 1:CAS:528:DC%2BC38Xhsl2gurs%3D 10.1038/cr.2011.200
-
Salemi S, Yousefi S, Constantinescu MA, Fey MF, Simon HU (2012) Autophagy is required for self-renewal and differentiation of adult human stem cells. Cell Res 22:432-435
-
(2012)
Cell Res
, vol.22
, pp. 432-435
-
-
Salemi, S.1
Yousefi, S.2
Constantinescu, M.A.3
Fey, M.F.4
Simon, H.U.5
-
68
-
-
84863430453
-
Mitophagy: A Complex Mechanism of Mitochondrial Removal
-
[Epub ahead of print]
-
Novak I (2012) Mitophagy: A Complex Mechanism of Mitochondrial Removal. Antioxid Redox Signal [Epub ahead of print]
-
(2012)
Antioxid Redox Signal
-
-
Novak, I.1
-
69
-
-
47049100413
-
Essential role for Nix in autophagic maturation of erythroid cells
-
18454133 1:CAS:528:DC%2BD1cXot1ygsrg%3D 10.1038/nature07006
-
Sandoval H, Thiagarajan P, Dasgupta SK, Schumacher A, Prchal JT, Chen M, Wang J (2008) Essential role for Nix in autophagic maturation of erythroid cells. Nature 454:232-235
-
(2008)
Nature
, vol.454
, pp. 232-235
-
-
Sandoval, H.1
Thiagarajan, P.2
Dasgupta, S.K.3
Schumacher, A.4
Prchal, J.T.5
Chen, M.6
Wang, J.7
-
70
-
-
22144474039
-
P62 modulates Akt activity via association with PKCzeta in neuronal survival and differentiation
-
16011831 1:CAS:528:DC%2BD2MXmsVOgu7k%3D 10.1016/j.bbrc.2005.06.138
-
Joung I, Kim HJ, Kwon YK (2005) p62 modulates Akt activity via association with PKCzeta in neuronal survival and differentiation. Biochem Biophys Res Commun 334:654-660
-
(2005)
Biochem Biophys Res Commun
, vol.334
, pp. 654-660
-
-
Joung, I.1
Kim, H.J.2
Kwon, Y.K.3
-
71
-
-
79953666792
-
Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARalpha oncoprotein
-
21187718 1:CAS:528:DC%2BC3MXlvVWnur4%3D 10.4161/auto.7.4.14397
-
Wang Z, Cao L, Kang R, Yang M, Liu L, Zhao Y, Yu Y, Xie M, Yin X, Livesey KM, Tang D (2011) Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARalpha oncoprotein. Autophagy 7:401-411
-
(2011)
Autophagy
, vol.7
, pp. 401-411
-
-
Wang, Z.1
Cao, L.2
Kang, R.3
Yang, M.4
Liu, L.5
Zhao, Y.6
Yu, Y.7
Xie, M.8
Yin, X.9
Livesey, K.M.10
Tang, D.11
-
72
-
-
0033536637
-
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
-
10514377 1:CAS:528:DyaK1MXmvVCgu70%3D 10.1126/science.286.5438.309
-
Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC (1999) The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286:309-312
-
(1999)
Science
, vol.286
, pp. 309-312
-
-
Joazeiro, C.A.1
Wing, S.S.2
Huang, H.3
Leverson, J.D.4
Hunter, T.5
Liu, Y.C.6
-
73
-
-
0027812323
-
The kit-ligand (steel factor) and its receptor c-kit/W: Pleiotropic roles in gametogenesis and melanogenesis
-
Besmer P, Manova K, Duttlinger R, Huang EJ, Packer A, Gyssler C, Bachvarova RF (1993) The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis. Dev Suppl: 125-137
-
(1993)
Dev Suppl
, pp. 125-137
-
-
Besmer, P.1
Manova, K.2
Duttlinger, R.3
Huang, E.J.4
Packer, A.5
Gyssler, C.6
Bachvarova, R.F.7
-
74
-
-
11144244315
-
Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl)
-
15315962 1:CAS:528:DC%2BD2MXis1GqtA%3D%3D 10.1182/blood-2004-05-1768
-
Zeng S, Xu Z, Lipkowitz S, Longley JB (2005) Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl). Blood 105:226-232
-
(2005)
Blood
, vol.105
, pp. 226-232
-
-
Zeng, S.1
Xu, Z.2
Lipkowitz, S.3
Longley, J.B.4
-
75
-
-
50549087736
-
Growth stimulation leads to cellular senescence when the cell cycle is blocked
-
18948731 1:CAS:528:DC%2BD1cXhsFWgtL3K 10.4161/cc.7.21.6919
-
Demidenko ZN, Blagosklonny MV (2008) Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle 7:3355-3361
-
(2008)
Cell Cycle
, vol.7
, pp. 3355-3361
-
-
Demidenko, Z.N.1
Blagosklonny, M.V.2
-
76
-
-
13944262937
-
Understanding the odd science of aging
-
15734677 1:CAS:528:DC%2BD2MXitVWntbk%3D 10.1016/j.cell.2005.01.027
-
Kirkwood TB (2005) Understanding the odd science of aging. Cell 120:437-447
-
(2005)
Cell
, vol.120
, pp. 437-447
-
-
Kirkwood, T.B.1
-
77
-
-
33745614062
-
Stem cells, ageing and the quest for immortality
-
16810243 1:CAS:528:DC%2BD28Xmtlahsrc%3D 10.1038/nature04958
-
Rando TA (2006) Stem cells, ageing and the quest for immortality. Nature 441:1080-1086
-
(2006)
Nature
, vol.441
, pp. 1080-1086
-
-
Rando, T.A.1
-
78
-
-
0027486732
-
Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
-
8460632 1:CAS:528:DyaK2cXhs1Sks7c%3D
-
Vaziri H, Schachter F, Uchida I, Wei L, Zhu X, Effros R, Cohen D, Harley CB (1993) Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet 52:661-667
-
(1993)
Am J Hum Genet
, vol.52
, pp. 661-667
-
-
Vaziri, H.1
Schachter, F.2
Uchida, I.3
Wei, L.4
Zhu, X.5
Effros, R.6
Cohen, D.7
Harley, C.B.8
-
79
-
-
0344961120
-
Murine marrow-derived mesenchymal stem cell: Isolation, in vitro expansion, and characterization
-
14616976 10.1046/j.1365-2141.2003.04669.x
-
Meirelles Lda S, Nardi NB (2003) Murine marrow-derived mesenchymal stem cell: isolation, in vitro expansion, and characterization. Br J Haematol 123:702-711
-
(2003)
Br J Haematol
, vol.123
, pp. 702-711
-
-
Meirelles Lda, S.1
Nardi, N.B.2
-
80
-
-
31344473379
-
Aging of mesenchymal stem cells
-
16310414 1:CAS:528:DC%2BD28Xis1yisLw%3D 10.1016/j.arr.2005.10.001
-
Sethe S, Scutt A, Stolzing A (2006) Aging of mesenchymal stem cells. Ageing Res Rev 5:91-116
-
(2006)
Ageing Res Rev
, vol.5
, pp. 91-116
-
-
Sethe, S.1
Scutt, A.2
Stolzing, A.3
-
81
-
-
36448968532
-
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells
-
18054316 1:CAS:528:DC%2BD2sXhsVektb%2FI 10.1016/j.cmet.2007.11.004
-
Zhao J, Brault JJ, Schild A, Cao P, Sandri M, Schiaffino S, Lecker SH, Goldberg AL (2007) FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab 6:472-483
-
(2007)
Cell Metab
, vol.6
, pp. 472-483
-
-
Zhao, J.1
Brault, J.J.2
Schild, A.3
Cao, P.4
Sandri, M.5
Schiaffino, S.6
Lecker, S.H.7
Goldberg, A.L.8
-
82
-
-
34249978518
-
Autophagy and NF-kappaB: Fight for fate
-
17485237 1:CAS:528:DC%2BD2sXmsFCmsrs%3D 10.1016/j.cytogfr.2007.04.006
-
Xiao G (2007) Autophagy and NF-kappaB: fight for fate. Cytokine Growth Factor Rev 18:233-243
-
(2007)
Cytokine Growth Factor Rev
, vol.18
, pp. 233-243
-
-
Xiao, G.1
-
83
-
-
44649141966
-
Regulation of autophagy by cytoplasmic p53
-
18454141 1:CAS:528:DC%2BD1cXmsFyksbw%3D 10.1038/ncb1730
-
Tasdemir E, Maiuri MC, Galluzzi L, Vitale I, Djavaheri-Mergny M, D'Amelio M, Criollo A, Morselli E, Zhu C, Harper F, Nannmark U, Samara C, Pinton P, Vicencio JM, Carnuccio R, Moll UM, Madeo F, Paterlini-Brechot P, Rizzuto R, Szabadkai G, Pierron G, Blomgren K, Tavernarakis N, Codogno P, Cecconi F, Kroemer G (2008) Regulation of autophagy by cytoplasmic p53. Nat Cell Biol 10:676-687
-
(2008)
Nat Cell Biol
, vol.10
, pp. 676-687
-
-
Tasdemir, E.1
Maiuri, M.C.2
Galluzzi, L.3
Vitale, I.4
Djavaheri-Mergny, M.5
D'Amelio, M.6
Criollo, A.7
Morselli, E.8
Zhu, C.9
Harper, F.10
Nannmark, U.11
Samara, C.12
Pinton, P.13
Vicencio, J.M.14
Carnuccio, R.15
Moll, U.M.16
Madeo, F.17
Paterlini-Brechot, P.18
Rizzuto, R.19
Szabadkai, G.20
Pierron, G.21
Blomgren, K.22
Tavernarakis, N.23
Codogno, P.24
Cecconi, F.25
Kroemer, G.26
more..
-
84
-
-
41549138483
-
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
-
18296641 1:CAS:528:DC%2BD1cXjtlKkt78%3D 10.1073/pnas.0712145105
-
Lee IH, Cao L, Mostoslavsky R, Lombard DB, Liu J, Bruns NE, Tsokos M, Alt FW, Finkel T (2008) A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci USA 105:3374-3379
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 3374-3379
-
-
Lee, I.H.1
Cao, L.2
Mostoslavsky, R.3
Lombard, D.B.4
Liu, J.5
Bruns, N.E.6
Tsokos, M.7
Alt, F.W.8
Finkel, T.9
-
85
-
-
3242721268
-
MTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells
-
15254238 1:CAS:528:DC%2BD2cXmtlKltbY%3D 10.1128/MCB.24.15.6710-6718.2004
-
Murakami M, Ichisaka T, Maeda M, Oshiro N, Hara K, Edenhofer F, Kiyama H, Yonezawa K, Yamanaka S (2004) mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol Cell Biol 24:6710-6718
-
(2004)
Mol Cell Biol
, vol.24
, pp. 6710-6718
-
-
Murakami, M.1
Ichisaka, T.2
Maeda, M.3
Oshiro, N.4
Hara, K.5
Edenhofer, F.6
Kiyama, H.7
Yonezawa, K.8
Yamanaka, S.9
-
86
-
-
53349091768
-
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
-
18809716 1:CAS:528:DC%2BD1cXht1SrtLnM 10.1084/jem.20081297
-
Chen C, Liu Y, Liu R, Ikenoue T, Guan KL, Zheng P (2008) TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med 205:2397-2408
-
(2008)
J Exp Med
, vol.205
, pp. 2397-2408
-
-
Chen, C.1
Liu, Y.2
Liu, R.3
Ikenoue, T.4
Guan, K.L.5
Zheng, P.6
-
87
-
-
77955861146
-
Autophagy in health and disease. 5. Mitophagy as a way of life
-
20357180 1:CAS:528:DC%2BC3cXhtVOht7jK 10.1152/ajpcell.00097.2010
-
Gottlieb RA, Carreira RS (2010) Autophagy in health and disease. 5. Mitophagy as a way of life. Am J Physiol Cell Physiol 299:C203-C210
-
(2010)
Am J Physiol Cell Physiol
, vol.299
-
-
Gottlieb, R.A.1
Carreira, R.S.2
-
88
-
-
75549090275
-
MTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
-
Chen C, Liu Y, Zheng P (2009) mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal (98):ra75
-
(2009)
Sci Signal
, Issue.98
-
-
Chen, C.1
Liu, Y.2
Zheng, P.3
-
89
-
-
1142275269
-
Age-related changes in lymphocyte development and function
-
14749784 1:CAS:528:DC%2BD2cXntFWmsQ%3D%3D 10.1038/ni1033
-
Linton PJ, Dorshkind K (2004) Age-related changes in lymphocyte development and function. Nat Immunol 5:133-139
-
(2004)
Nat Immunol
, vol.5
, pp. 133-139
-
-
Linton, P.J.1
Dorshkind, K.2
-
90
-
-
2942700206
-
Reduction in the developmental potential of intrathymic T cell progenitors with age
-
15210781 1:CAS:528:DC%2BD2cXltVajtbY%3D
-
Min H, Montecino-Rodriguez E, Dorshkind K (2004) Reduction in the developmental potential of intrathymic T cell progenitors with age. J Immunol 173:245-250
-
(2004)
J Immunol
, vol.173
, pp. 245-250
-
-
Min, H.1
Montecino-Rodriguez, E.2
Dorshkind, K.3
-
91
-
-
67651151156
-
Immunosenescence and vaccine failure in the elderly
-
19571643 1:CAS:528:DC%2BD1MXpsFGrtb0%3D
-
Grubeck-Loebenstein B, Della Bella S, Iorio AM, Michel JP, Pawelec G, Solana R (2009) Immunosenescence and vaccine failure in the elderly. Aging Clin Exp Res 21:201-209
-
(2009)
Aging Clin Exp Res
, vol.21
, pp. 201-209
-
-
Grubeck-Loebenstein, B.1
Della Bella, S.2
Iorio, A.M.3
Michel, J.P.4
Pawelec, G.5
Solana, R.6
-
92
-
-
0035929650
-
The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway
-
11477064 1:CAS:528:DC%2BD3MXntFaitbo%3D 10.1074/jbc.C100319200
-
Arico S, Petiot A, Bauvy C, Dubbelhuis PF, Meijer AJ, Codogno P, Ogier-Denis E (2001) The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 276:35243-35246
-
(2001)
J Biol Chem
, vol.276
, pp. 35243-35246
-
-
Arico, S.1
Petiot, A.2
Bauvy, C.3
Dubbelhuis, P.F.4
Meijer, A.J.5
Codogno, P.6
Ogier-Denis, E.7
-
93
-
-
77949737971
-
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis
-
20197621 1:CAS:528:DC%2BC3cXjtV2nsrc%3D 10.1172/JCI40535
-
Alimonti A, Nardella C, Chen Z, Clohessy JG, Carracedo A, Trotman LC, Cheng K, Varmeh S, Kozma SC, Thomas G, Rosivatz E, Woscholski R, Cognetti F, Scher HI, Pandolfi PP (2010) A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest 120:681-693
-
(2010)
J Clin Invest
, vol.120
, pp. 681-693
-
-
Alimonti, A.1
Nardella, C.2
Chen, Z.3
Clohessy, J.G.4
Carracedo, A.5
Trotman, L.C.6
Cheng, K.7
Varmeh, S.8
Kozma, S.C.9
Thomas, G.10
Rosivatz, E.11
Woscholski, R.12
Cognetti, F.13
Scher, H.I.14
Pandolfi, P.P.15
-
94
-
-
2342646219
-
Acute regulation of the tumour suppressor phosphatase, PTEN, by anionic lipids and reactive oxygen species
-
15046604 1:CAS:528:DC%2BD2cXjtVSgu7s%3D 10.1042/BST0320338
-
Downes CP, Walker S, McConnachie G, Lindsay Y, Batty IH, Leslie NR (2004) Acute regulation of the tumour suppressor phosphatase, PTEN, by anionic lipids and reactive oxygen species. Biochem Soc Trans 32:338-342
-
(2004)
Biochem Soc Trans
, vol.32
, pp. 338-342
-
-
Downes, C.P.1
Walker, S.2
McConnachie, G.3
Lindsay, Y.4
Batty, I.H.5
Leslie, N.R.6
-
95
-
-
64349123107
-
Autophagy mediates the mitotic senescence transition
-
19279323 1:CAS:528:DC%2BD1MXks1SrtbY%3D 10.1101/gad.519709
-
Young AR, Narita M, Ferreira M, Kirschner K, Sadaie M, Darot JF, Tavare S, Arakawa S, Shimizu S, Watt FM (2009) Autophagy mediates the mitotic senescence transition. Genes Dev 23:798-803
-
(2009)
Genes Dev
, vol.23
, pp. 798-803
-
-
Young, A.R.1
Narita, M.2
Ferreira, M.3
Kirschner, K.4
Sadaie, M.5
Darot, J.F.6
Tavare, S.7
Arakawa, S.8
Shimizu, S.9
Watt, F.M.10
-
96
-
-
33749167092
-
Ageing: Balancing regeneration and cancer
-
16957734 1:CAS:528:DC%2BD28XhtVSns7fF 10.1038/nature05221
-
Beausejour CM, Campisi J (2006) Ageing: balancing regeneration and cancer. Nature 443:404-405
-
(2006)
Nature
, vol.443
, pp. 404-405
-
-
Beausejour, C.M.1
Campisi, J.2
-
97
-
-
33749172559
-
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
-
16957735 1:CAS:528:DC%2BD28XhtVSns7fE
-
Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT (2006) Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 443:421-426
-
(2006)
Nature
, vol.443
, pp. 421-426
-
-
Janzen, V.1
Forkert, R.2
Fleming, H.E.3
Saito, Y.4
Waring, M.T.5
Dombkowski, D.M.6
Cheng, T.7
Depinho, R.A.8
Sharpless, N.E.9
Scadden, D.T.10
-
98
-
-
33749171885
-
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
-
16957738 1:CAS:528:DC%2BD28XhtVSns7bL 10.1038/nature05091
-
Molofsky AV, Slutsky SG, Joseph NM, He S, Pardal R, Krishnamurthy J, Sharpless NE, Morrison SJ (2006) Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443:448-452
-
(2006)
Nature
, vol.443
, pp. 448-452
-
-
Molofsky, A.V.1
Slutsky, S.G.2
Joseph, N.M.3
He, S.4
Pardal, R.5
Krishnamurthy, J.6
Sharpless, N.E.7
Morrison, S.J.8
-
99
-
-
22344449361
-
Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways
-
15964994 1:CAS:528:DC%2BD2MXlslChurc%3D 10.1101/gad.1299505
-
Molofsky AV, He S, Bydon M, Morrison SJ, Pardal R (2005) Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev 19:1432-1437
-
(2005)
Genes Dev
, vol.19
, pp. 1432-1437
-
-
Molofsky, A.V.1
He, S.2
Bydon, M.3
Morrison, S.J.4
Pardal, R.5
-
100
-
-
33749187810
-
P16INK4a induces an age-dependent decline in islet regenerative potential
-
16957737 1:CAS:528:DC%2BD28XhtVSns7bE 10.1038/nature05092
-
Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, Bonner-Weir S, Sharpless NE (2006) p16INK4a induces an age-dependent decline in islet regenerative potential. Nature 443:453-457
-
(2006)
Nature
, vol.443
, pp. 453-457
-
-
Krishnamurthy, J.1
Ramsey, M.R.2
Ligon, K.L.3
Torrice, C.4
Koh, A.5
Bonner-Weir, S.6
Sharpless, N.E.7
-
101
-
-
35848937781
-
Autophagy is required for dietary restriction-mediated life span extension in C. elegans
-
17912023
-
Jia K, Levine B (2007) Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy 3:597-599
-
(2007)
Autophagy
, vol.3
, pp. 597-599
-
-
Jia, K.1
Levine, B.2
-
102
-
-
38949159709
-
Effects of dietary restriction on hematopoietic stem-cell aging are genetically regulated
-
17947508 1:CAS:528:DC%2BD1cXhvFeis78%3D 10.1182/blood-2007-01-069807
-
Ertl RP, Chen J, Astle CM, Duffy TM, Harrison DE (2008) Effects of dietary restriction on hematopoietic stem-cell aging are genetically regulated. Blood 111:1709-1716
-
(2008)
Blood
, vol.111
, pp. 1709-1716
-
-
Ertl, R.P.1
Chen, J.2
Astle, C.M.3
Duffy, T.M.4
Harrison, D.E.5
-
103
-
-
0034113064
-
When lysosomes get old
-
10767573 1:CAS:528:DC%2BD3cXitlOku70%3D 10.1016/S0531-5565(00)00075-9
-
Cuervo AM, Dice JF (2000) When lysosomes get old. Exp Gerontol 35:119-131
-
(2000)
Exp Gerontol
, vol.35
, pp. 119-131
-
-
Cuervo, A.M.1
Dice, J.F.2
-
104
-
-
0031889998
-
Lipofuscin: Mechanisms of formation and increase with age
-
9531959 1:CAS:528:DyaK1cXhvFynsb8%3D 10.1111/j.1699-0463.1998.tb01346.x
-
Terman A, Brunk UT (1998) Lipofuscin: mechanisms of formation and increase with age. APMIS 106:265-276
-
(1998)
APMIS
, vol.106
, pp. 265-276
-
-
Terman, A.1
Brunk, U.T.2
-
105
-
-
33744513898
-
Age-related impairment of mesenchymal progenitor cell function
-
16842494 1:CAS:528:DC%2BD28XmsVSqt7Y%3D 10.1111/j.1474-9726.2006.00213.x
-
Stolzing A, Scutt A (2006) Age-related impairment of mesenchymal progenitor cell function. Aging Cell 5:213-224
-
(2006)
Aging Cell
, vol.5
, pp. 213-224
-
-
Stolzing, A.1
Scutt, A.2
-
106
-
-
39149093357
-
Age-related changes in human bone marrow-derived mesenchymal stem cells: Consequences for cell therapies
-
18241911 1:CAS:528:DC%2BD1cXhsl2htLY%3D 10.1016/j.mad.2007.12.002
-
Stolzing A, Jones E, McGonagle D, Scutt A (2008) Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies. Mech Ageing Dev 129:163-173
-
(2008)
Mech Ageing Dev
, vol.129
, pp. 163-173
-
-
Stolzing, A.1
Jones, E.2
McGonagle, D.3
Scutt, A.4
-
107
-
-
79953326332
-
Lysosome positioning coordinates mTORC1 activity and autophagy
-
21460804 10.1038/ncb0411-342 1:CAS:528:DC%2BC3MXktFWjtrs%3D
-
Pous C, Codogno P (2011) Lysosome positioning coordinates mTORC1 activity and autophagy. Nat Cell Biol 13:342-344
-
(2011)
Nat Cell Biol
, vol.13
, pp. 342-344
-
-
Pous, C.1
Codogno, P.2
-
108
-
-
77649337122
-
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy
-
20075865 1:CAS:528:DC%2BC3cXhvFGisg%3D%3D 10.1038/emboj.2009.405
-
Lee JY, Koga H, Kawaguchi Y, Tang W, Wong E, Gao YS, Pandey UB, Kaushik S, Tresse E, Lu J, Taylor JP, Cuervo AM, Yao TP (2010) HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J 29:969-980
-
(2010)
EMBO J
, vol.29
, pp. 969-980
-
-
Lee, J.Y.1
Koga, H.2
Kawaguchi, Y.3
Tang, W.4
Wong, E.5
Gao, Y.S.6
Pandey, U.B.7
Kaushik, S.8
Tresse, E.9
Lu, J.10
Taylor, J.P.11
Cuervo, A.M.12
Yao, T.P.13
-
109
-
-
80955177196
-
TFEB links autophagy to lysosomal biogenesis
-
21617040 1:CAS:528:DC%2BC3MXntlOltLw%3D 10.1126/science.1204592
-
Settembre C, Di Malta C, Polito VA, Garcia Arencibia M, Vetrini F, Erdin S, Erdin SU, Huynh T, Medina D, Colella P, Sardiello M, Rubinsztein DC, Ballabio A (2011) TFEB links autophagy to lysosomal biogenesis. Science 332:1429-1433
-
(2011)
Science
, vol.332
, pp. 1429-1433
-
-
Settembre, C.1
Di Malta, C.2
Polito, V.A.3
Garcia Arencibia, M.4
Vetrini, F.5
Erdin, S.6
Erdin, S.U.7
Huynh, T.8
Medina, D.9
Colella, P.10
Sardiello, M.11
Rubinsztein, D.C.12
Ballabio, A.13
-
110
-
-
84861983563
-
Autophagy activation. A novel mechanism of atorvastatin to protect mesenchymal stem cells from hypoxia and serum deprivation via AMP-activated protein kinase/mammalian target of rapamycin pathway
-
Zhang Q, Yang YJ, Wang H, Dong QT, Wang TJ, Qian HY, Xu H (2012) Autophagy activation. A novel mechanism of atorvastatin to protect mesenchymal stem cells from hypoxia and serum deprivation via AMP-activated protein kinase/mammalian target of rapamycin pathway. Stem Cells Dev
-
(2012)
Stem Cells Dev
-
-
Zhang, Q.1
Yang, Y.J.2
Wang, H.3
Dong, Q.T.4
Wang, T.J.5
Qian, H.Y.6
Xu, H.7
-
111
-
-
0037186524
-
Functional neurogenesis in the adult hippocampus
-
11875571 10.1038/4151030a 1:CAS:528:DC%2BD38XhvVWjsbs%3D
-
van Praag H, Schinder AF, Christie BR, Toni N, Palmer TD, Gage FH (2002) Functional neurogenesis in the adult hippocampus. Nature 415:1030-1034
-
(2002)
Nature
, vol.415
, pp. 1030-1034
-
-
Van Praag, H.1
Schinder, A.F.2
Christie, B.R.3
Toni, N.4
Palmer, T.D.5
Gage, F.H.6
-
112
-
-
0035182533
-
Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations
-
11687494 1:CAS:528:DC%2BD3MXos1Omsbw%3D 10.1146/annurev.cellbio.17.1.387
-
Weissman IL, Anderson DJ, Gage F (2001) Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu Rev Cell Dev Biol 17:387-403
-
(2001)
Annu Rev Cell Dev Biol
, vol.17
, pp. 387-403
-
-
Weissman, I.L.1
Anderson, D.J.2
Gage, F.3
-
113
-
-
61649122814
-
Insulin withdrawal-induced cell death in adult hippocampal neural stem cells as a model of autophagic cell death
-
19158478 1:CAS:528:DC%2BD1MXovFeiu70%3D 10.4161/auto.5.2.7641
-
Baek SH, Kim EK, Goudreau JL, Lookingland KJ, Kim SW, Yu SW (2009) Insulin withdrawal-induced cell death in adult hippocampal neural stem cells as a model of autophagic cell death. Autophagy 5:277-279
-
(2009)
Autophagy
, vol.5
, pp. 277-279
-
-
Baek, S.H.1
Kim, E.K.2
Goudreau, J.L.3
Lookingland, K.J.4
Kim, S.W.5
Yu, S.W.6
-
114
-
-
84856431622
-
The end of autophagic cell death?
-
Shen S, Kepp O, Kroemer G (2012) The end of autophagic cell death? Autophagy 8:1-3
-
(2012)
Autophagy
, vol.8
, pp. 1-3
-
-
Shen, S.1
Kepp, O.2
Kroemer, G.3
-
115
-
-
80053302394
-
Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity
-
21384342 1:CAS:528:DC%2BC3MXht1eqsLrJ 10.1002/ijc.25975
-
Zhuang W, Li B, Long L, Chen L, Huang Q, Liang Z (2011) Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity. Int J Cancer 129:2720-2731
-
(2011)
Int J Cancer
, vol.129
, pp. 2720-2731
-
-
Zhuang, W.1
Li, B.2
Long, L.3
Chen, L.4
Huang, Q.5
Liang, Z.6
-
116
-
-
74149087187
-
Autophagy impairment inhibits differentiation of glioma stem/progenitor cells
-
20004652 1:CAS:528:DC%2BC3cXnvFKrsg%3D%3D 10.1016/j.brainres.2009.12.004
-
Zhao Y, Huang Q, Yang J, Lou M, Wang A, Dong J, Qin Z, Zhang T (2010) Autophagy impairment inhibits differentiation of glioma stem/progenitor cells. Brain Res 1313:250-258
-
(2010)
Brain Res
, vol.1313
, pp. 250-258
-
-
Zhao, Y.1
Huang, Q.2
Yang, J.3
Lou, M.4
Wang, A.5
Dong, J.6
Qin, Z.7
Zhang, T.8
-
117
-
-
34748880650
-
Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: Role of autophagic cell death
-
17848677 1:CAS:528:DC%2BD2sXht1aiu7vL 10.1093/jnci/djm102
-
Jiang H, Gomez-Manzano C, Aoki H, Alonso MM, Kondo S, McCormick F, Xu J, Kondo Y, Bekele BN, Colman H, Lang FF, Fueyo J (2007) Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death. J Natl Cancer Inst 99:1410-1414
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 1410-1414
-
-
Jiang, H.1
Gomez-Manzano, C.2
Aoki, H.3
Alonso, M.M.4
Kondo, S.5
McCormick, F.6
Xu, J.7
Kondo, Y.8
Bekele, B.N.9
Colman, H.10
Lang, F.F.11
Fueyo, J.12
-
118
-
-
0038067837
-
Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production
-
12620992 1:CAS:528:DC%2BD3sXjtlOlu7Y%3D 10.1242/dev.00392
-
Kimura T, Suzuki A, Fujita Y, Yomogida K, Lomeli H, Asada N, Ikeuchi M, Nagy A, Mak TW, Nakano T (2003) Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production. Development 130:1691-1700
-
(2003)
Development
, vol.130
, pp. 1691-1700
-
-
Kimura, T.1
Suzuki, A.2
Fujita, Y.3
Yomogida, K.4
Lomeli, H.5
Asada, N.6
Ikeuchi, M.7
Nagy, A.8
Mak, T.W.9
Nakano, T.10
-
119
-
-
31944448885
-
Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation
-
16432235 1:CAS:528:DC%2BD28Xhs1Gns7k%3D 10.1073/pnas.0510652103
-
Wang S, Garcia AJ, Wu M, Lawson DA, Witte ON, Wu H (2006) Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. Proc Natl Acad Sci USA 103:1480-1485
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 1480-1485
-
-
Wang, S.1
Garcia, A.J.2
Wu, M.3
Lawson, D.A.4
Witte, O.N.5
Wu, H.6
-
120
-
-
33646376411
-
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
-
16598206 1:CAS:528:DC%2BD28XkvVykurY%3D 10.1038/nature04703
-
Yilmaz OH, Valdez R, Theisen BK, Guo W, Ferguson DO, Wu H, Morrison SJ (2006) Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441:475-482
-
(2006)
Nature
, vol.441
, pp. 475-482
-
-
Yilmaz, O.H.1
Valdez, R.2
Theisen, B.K.3
Guo, W.4
Ferguson, D.O.5
Wu, H.6
Morrison, S.J.7
-
121
-
-
40949143108
-
Gemcitabine resistance in pancreatic cancer: Picking the key players
-
18316544 1:CAS:528:DC%2BD1cXislSku7k%3D 10.1158/1078-0432.CCR-07-2247
-
Kim MP, Gallick GE (2008) Gemcitabine resistance in pancreatic cancer: picking the key players. Clin Cancer Res 14:1284-1285
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1284-1285
-
-
Kim, M.P.1
Gallick, G.E.2
-
122
-
-
0037451783
-
Autophagy: A barrier or an adaptive response to cancer
-
12618311 1:CAS:528:DC%2BD3sXhs1eiu7g%3D
-
Ogier-Denis E, Codogno P (2003) Autophagy: a barrier or an adaptive response to cancer. Biochim Biophys Acta 1603:113-128
-
(2003)
Biochim Biophys Acta
, vol.1603
, pp. 113-128
-
-
Ogier-Denis, E.1
Codogno, P.2
-
123
-
-
84863011357
-
Autophagy driven by a master regulator of hematopoiesis
-
22025678 10.1128/MCB.06166-11 1:CAS:528:DC%2BC38Xjt12msL0%3D
-
Kang YA, Sanalkumar R, O'Geen H, Linnemann AK, Chang CJ, Bouhassira EE, Farnham PJ, Keles S, Bresnick EH (2011) Autophagy driven by a master regulator of hematopoiesis. Mol Cell Biol 32:226-239
-
(2011)
Mol Cell Biol
, vol.32
, pp. 226-239
-
-
Kang, Y.A.1
Sanalkumar, R.2
O'Geen, H.3
Linnemann, A.K.4
Chang, C.J.5
Bouhassira, E.E.6
Farnham, P.J.7
Keles, S.8
Bresnick, E.H.9
-
124
-
-
0036285034
-
C-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability
-
12049739 1:CAS:528:DC%2BD38XksFKjtLc%3D 10.1016/S1097-2765(02)00520-8
-
Vafa O, Wade M, Kern S, Beeche M, Pandita TK, Hampton GM, Wahl GM (2002) c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell 9:1031-1044
-
(2002)
Mol Cell
, vol.9
, pp. 1031-1044
-
-
Vafa, O.1
Wade, M.2
Kern, S.3
Beeche, M.4
Pandita, T.K.5
Hampton, G.M.6
Wahl, G.M.7
-
125
-
-
80052819789
-
Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells
-
21615676 1:CAS:528:DC%2BC3MXhtlShtLvM 10.1111/j.1474-9726.2011.00722.x
-
Chen T, Shen L, Yu J, Wan H, Guo A, Chen J, Long Y, Zhao J, Pei G (2011) Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells. Aging Cell 10:908-911
-
(2011)
Aging Cell
, vol.10
, pp. 908-911
-
-
Chen, T.1
Shen, L.2
Yu, J.3
Wan, H.4
Guo, A.5
Chen, J.6
Long, Y.7
Zhao, J.8
Pei, G.9
-
126
-
-
77950603770
-
Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway
-
19642865 1:CAS:528:DC%2BC3cXktlygsbg%3D 10.1089/scd.2009.0147
-
Lee KW, Yook JY, Son MY, Kim MJ, Koo DB, Han YM, Cho YS (2010) Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway. Stem Cells Dev 19:557-568
-
(2010)
Stem Cells Dev
, vol.19
, pp. 557-568
-
-
Lee, K.W.1
Yook, J.Y.2
Son, M.Y.3
Kim, M.J.4
Koo, D.B.5
Han, Y.M.6
Cho, Y.S.7
-
127
-
-
80655140600
-
MTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: A roadmap from energy metabolism to stem cell renewal and aging
-
Menendez JA, Vellon L, Oliveras-Ferraros C, Cufi S, Vazquez-Martin A (2011) mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: A roadmap from energy metabolism to stem cell renewal and aging. Cell Cycle 10:3658-3677
-
(2011)
Cell Cycle
, vol.10
, pp. 3658-3677
-
-
Menendez, J.A.1
Vellon, L.2
Oliveras-Ferraros, C.3
Cufi, S.4
Vazquez-Martin, A.5
-
128
-
-
23244460597
-
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
-
16079851 1:CAS:528:DC%2BD2MXmvFenu78%3D 10.1038/nature03918
-
Chen Z, Trotman LC, Shaffer D, Lin HK, Dotan ZA, Niki M, Koutcher JA, Scher HI, Ludwig T, Gerald W, Cordon-Cardo C, Pandolfi PP (2005) Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436:725-730
-
(2005)
Nature
, vol.436
, pp. 725-730
-
-
Chen, Z.1
Trotman, L.C.2
Shaffer, D.3
Lin, H.K.4
Dotan, Z.A.5
Niki, M.6
Koutcher, J.A.7
Scher, H.I.8
Ludwig, T.9
Gerald, W.10
Cordon-Cardo, C.11
Pandolfi, P.P.12
-
129
-
-
59049094829
-
Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation
-
19017649 1:CAS:528:DC%2BD1MXlvFeisA%3D%3D 10.1074/jbc.M806088200
-
Young JE, Martinez RA, La Spada AR (2009) Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation. J Biol Chem 284:2363-2373
-
(2009)
J Biol Chem
, vol.284
, pp. 2363-2373
-
-
Young, J.E.1
Martinez, R.A.2
La Spada, A.R.3
|