메뉴 건너뛰기




Volumn 106, Issue 2, 1998, Pages 265-276

Lipofuscin: Mechanisms of formation and increase with age

Author keywords

Aging; Lipofuscin; Lysosomes

Indexed keywords

GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; LIPOFUSCIN; LYSOSOME ENZYME; REACTIVE OXYGEN METABOLITE;

EID: 0031889998     PISSN: 09034641     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1699-0463.1998.tb01346.x     Document Type: Review
Times cited : (332)

References (132)
  • 1
    • 0014766372 scopus 로고
    • Irreversible lysosomal damage induced by chloroquine in the retinae of pigmented and albino rats
    • Abraham, R. & Hendy, R. J.: Irreversible lysosomal damage induced by chloroquine in the retinae of pigmented and albino rats. Exp. Mol. Pathol. 12: 185-200, 1970.
    • (1970) Exp. Mol. Pathol. , vol.12 , pp. 185-200
    • Abraham, R.1    Hendy, R.J.2
  • 2
    • 0020402944 scopus 로고
    • Uptake and degradation of proteins by isolated rat liver lysosomes. Suggestion of a microautophagic pathway of proteolysis
    • Ahlberg, J., Marzella, L. & Glaumann, H.: Uptake and degradation of proteins by isolated rat liver lysosomes. Suggestion of a microautophagic pathway of proteolysis. Lab. Invest. 47: 523-532, 1982.
    • (1982) Lab. Invest. , vol.47 , pp. 523-532
    • Ahlberg, J.1    Marzella, L.2    Glaumann, H.3
  • 3
    • 0028886612 scopus 로고
    • Age-related changes in cellular localization and enzymatic activities of cathepsins B, L and D in the rat trigeminal ganglion neuron
    • Amano, T., Nakanishi, H., Kondo, T., Tanaka, T., Oka, M. & Yamamoto, K.: Age-related changes in cellular localization and enzymatic activities of cathepsins B, L and D in the rat trigeminal ganglion neuron. Mech. Ageing Dev. 83: 133-141, 1995.
    • (1995) Mech. Ageing Dev. , vol.83 , pp. 133-141
    • Amano, T.1    Nakanishi, H.2    Kondo, T.3    Tanaka, T.4    Oka, M.5    Yamamoto, K.6
  • 4
    • 0002569479 scopus 로고
    • Ceroid-lipofuscinosis, a model for aging
    • Sohal, R. S. (Ed.): Elsevier, Amsterdam
    • Armstrong, D. & Koppang, N.: Ceroid-lipofuscinosis, a model for aging. In: Sohal, R. S. (Ed.): Age Pigments. Elsevier, Amsterdam 1981, pp. 355-382.
    • (1981) Age Pigments , pp. 355-382
    • Armstrong, D.1    Koppang, N.2
  • 5
    • 0026689819 scopus 로고
    • The distribution of cathepsin D activity in adult and aging human brain regions
    • Banay-Schwartz, M., de Guzman, T., Kenessey, A., Palkovits, M. & Lajtha, A.: The distribution of cathepsin D activity in adult and aging human brain regions. J. Neurochem. 58: 2207-2211, 1992.
    • (1992) J. Neurochem. , vol.58 , pp. 2207-2211
    • Banay-Schwartz, M.1    De Guzman, T.2    Kenessey, A.3    Palkovits, M.4    Lajtha, A.5
  • 6
    • 0023465842 scopus 로고
    • Comparative morphological study of age related mitochondrial changes of the lymphocytes and skeletal muscle cells
    • Beregi, E. & Regius, O.: Comparative morphological study of age related mitochondrial changes of the lymphocytes and skeletal muscle cells. Acta Morphol. Hung. 35: 219-224, 1987.
    • (1987) Acta Morphol. Hung. , vol.35 , pp. 219-224
    • Beregi, E.1    Regius, O.2
  • 7
    • 0023882449 scopus 로고
    • Age-related changes in the skeletal muscle cells
    • Beregi, E., Regius, O., Huttl, T. & Gobl, Z.: Age-related changes in the skeletal muscle cells. Z. Gerontol. 21: 83-86, 1988.
    • (1988) Z. Gerontol. , vol.21 , pp. 83-86
    • Beregi, E.1    Regius, O.2    Huttl, T.3    Gobl, Z.4
  • 8
    • 0005344860 scopus 로고
    • Aging-like alterations at the neuronal membrane of young rats fed a vitamin e deficient diet
    • Zs.-Nagy, I. (Ed.): Lipofuscin 1987: State of the Art Amsterdam
    • Bertoni-Freddary, C., Meier-Ruge, W. & Ulrich, J.: Aging-like alterations at the neuronal membrane of young rats fed a vitamin E deficient diet. In: Zs.-Nagy, I. (Ed.): Lipofuscin 1987: State of the Art. Excerpta Medica, Amsterdam 1988, pp. 439-444.
    • (1988) Excerpta Medica , pp. 439-444
    • Bertoni-Freddary, C.1    Meier-Ruge, W.2    Ulrich, J.3
  • 9
    • 0006387169 scopus 로고
    • Isolated lipofuscin granules - A survey of a new field
    • Björkerud, S.: Isolated lipofuscin granules - a survey of a new field. Adv. Gerontol. Res. 21: 257-287, 1964.
    • (1964) Adv. Gerontol. Res. , vol.21 , pp. 257-287
    • Björkerud, S.1
  • 10
    • 0028081941 scopus 로고
    • Regional variation and age-related changes of lysosomal enzymes in the human retinal pigment epithelium
    • Boulton, M., Moriarty, P., Jarvis-Evans, J. & Marcyniuk, B.: Regional variation and age-related changes of lysosomal enzymes in the human retinal pigment epithelium. Br. J. Ophthalmol. 78: 125-129, 1994.
    • (1994) Br. J. Ophthalmol. , vol.78 , pp. 125-129
    • Boulton, M.1    Moriarty, P.2    Jarvis-Evans, J.3    Marcyniuk, B.4
  • 11
    • 0015359755 scopus 로고
    • Ultrastructural and cytochemical changes in cultured human lung cells
    • Brandes, D., Murphy, D. G., Anton, E. B. & Barnard, S.: Ultrastructural and cytochemical changes in cultured human lung cells. J. Ultrastruct. Res. 39: 465-483, 1972.
    • (1972) J. Ultrastruct. Res. , vol.39 , pp. 465-483
    • Brandes, D.1    Murphy, D.G.2    Anton, E.B.3    Barnard, S.4
  • 12
    • 0016156637 scopus 로고
    • Early appearance and regional differences in intraneuronal and extraneuronal lipofuscin accumulation with age in the brain of a nonhuman primate (Macaca mulatta)
    • Brizzee, K. R., Ordy, J. M. & Kaack, B.: Early appearance and regional differences in intraneuronal and extraneuronal lipofuscin accumulation with age in the brain of a nonhuman primate (Macaca mulatta). J. Gerontol. 29: 366-381, 1974.
    • (1974) J. Gerontol. , vol.29 , pp. 366-381
    • Brizzee, K.R.1    Ordy, J.M.2    Kaack, B.3
  • 13
    • 0015106710 scopus 로고
    • Comparative ultrastructure of chick fibroblasts in vitro at early and late stages during their growth span
    • Brock, M. A. & Hay, R. J.: Comparative ultrastructure of chick fibroblasts in vitro at early and late stages during their growth span. J. Ultrastruct. Res. 36: 291-311, 1971.
    • (1971) J. Ultrastruct. Res. , vol.36 , pp. 291-311
    • Brock, M.A.1    Hay, R.J.2
  • 14
    • 0014878377 scopus 로고
    • Histochemical indications for lysosomal localization of heavy metals in normal rat brain and liver
    • Brun, A. & Brunk, U.: Histochemical indications for lysosomal localization of heavy metals in normal rat brain and liver. J. Histochem. Cytochem. 18: 820-827, 1970.
    • (1970) J. Histochem. Cytochem. , vol.18 , pp. 820-827
    • Brun, A.1    Brunk, U.2
  • 15
    • 0015608201 scopus 로고
    • Distribution and shifts of ingested marker particles in residual bodies and other lysosomes
    • Brunk, U.: Distribution and shifts of ingested marker particles in residual bodies and other lysosomes. Exp. Cell Res. 79: 15-27, 1973.
    • (1973) Exp. Cell Res. , vol.79 , pp. 15-27
    • Brunk, U.1
  • 16
    • 0015611629 scopus 로고
    • Residual bodies and "aging" in cultured human glia cells. Effect of entrance into phase 3 and prolonged periods of confluence
    • Brunk, U., Ericsson, J. L., Ponten, J. & Westermark, B.: Residual bodies and "aging" in cultured human glia cells. Effect of entrance into phase 3 and prolonged periods of confluence. Exp. Cell. Res. 79: 1-14, 1973.
    • (1973) Exp. Cell. Res. , vol.79 , pp. 1-14
    • Brunk, U.1    Ericsson, J.L.2    Ponten, J.3    Westermark, B.4
  • 17
    • 0015264490 scopus 로고
    • Electron microscopical studies of rat brain neurons. Localization of acid phosphatase and mode of formation of lipofuscin bodies
    • Brunk, U. & Ericsson, J. L. E.: Electron microscopical studies of rat brain neurons. Localization of acid phosphatase and mode of formation of lipofuscin bodies. J. Ultrastruct. Res. 38: 1-15, 1972.
    • (1972) J. Ultrastruct. Res. , vol.38 , pp. 1-15
    • Brunk, U.1    Ericsson, J.L.E.2
  • 18
    • 0025141201 scopus 로고
    • On the origin of lipofuscin; the iron content of residual bodies, and the relation of these organelles to the lysosomal vacuome. A study on cultured human glial cells
    • Brunk, U. T.: On the origin of lipofuscin; the iron content of residual bodies, and the relation of these organelles to the lysosomal vacuome. A study on cultured human glial cells. Adv. Exp. Med. Biol. 266: 313-322, 1989.
    • (1989) Adv. Exp. Med. Biol. , vol.266 , pp. 313-322
    • Brunk, U.T.1
  • 19
    • 0002434987 scopus 로고
    • Lysosomes and age pigments in cultured cells
    • Sohal, R. S. (Ed.): Elsevier, Amsterdam
    • Brunk, U. T. & Collins, V. P.: Lysosomes and age pigments in cultured cells. In: Sohal, R. S. (Ed.): Age Pigments. Elsevier, Amsterdam 1981, pp. 243-264.
    • (1981) Age Pigments , pp. 243-264
    • Brunk, U.T.1    Collins, V.P.2
  • 20
    • 0026663037 scopus 로고
    • A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis
    • Brunk, U. T., Jones, C. B. & Sohal, R. S.: A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis. Mutat. Res. 275: 395-403, 1992.
    • (1992) Mutat. Res. , vol.275 , pp. 395-403
    • Brunk, U.T.1    Jones, C.B.2    Sohal, R.S.3
  • 21
    • 0022555284 scopus 로고
    • Lipofuscin accumulation in cultured non-dividing cells as a function of time and oxygen tension
    • Brunmark, A., Collins, V. P., Thaw, H. & Brunk, U.: Lipofuscin accumulation in cultured non-dividing cells as a function of time and oxygen tension. Scan. Electron Microsc. 189-192, 1986.
    • (1986) Scan. Electron Microsc. , pp. 189-192
    • Brunmark, A.1    Collins, V.P.2    Thaw, H.3    Brunk, U.4
  • 22
    • 0029618991 scopus 로고
    • Macrophages, lipid oxidation, ceroid accumulation and alpha-tocopherol depletion in human atherosclerotic lesions
    • Carpenter, K. L., van der Veen, C., Taylor, S. E., Hardwick, S. J., Clare, K., Hegyi, L. & Mitchinson, M. J.: Macrophages, lipid oxidation, ceroid accumulation and alpha-tocopherol depletion in human atherosclerotic lesions. Gerontology 41: 53-67, 1995.
    • (1995) Gerontology , vol.41 , pp. 53-67
    • Carpenter, K.L.1    Van Der Veen, C.2    Taylor, S.E.3    Hardwick, S.J.4    Clare, K.5    Hegyi, L.6    Mitchinson, M.J.7
  • 23
    • 0027360338 scopus 로고
    • Routes of excretion of neuronal lysosomal dense bodies after ventricular infusion of leupeptin in the rat: A study using ubiquitin and PGP 9.5 immunocytochemistry
    • Cavanagh, J. B., Nolan, C. C., Seville, M. P., Anderson, V. E. & Leigh, P. N.: Routes of excretion of neuronal lysosomal dense bodies after ventricular infusion of leupeptin in the rat: a study using ubiquitin and PGP 9.5 immunocytochemistry. J. Neurocytol. 22: 779-791, 1993.
    • (1993) J. Neurocytol. , vol.22 , pp. 779-791
    • Cavanagh, J.B.1    Nolan, C.C.2    Seville, M.P.3    Anderson, V.E.4    Leigh, P.N.5
  • 24
    • 0029563256 scopus 로고
    • Lipofuscin accumulation in neurons with restraint stress
    • Chaudhary, A., Sharma, S. P. & James, T. J.: Lipofuscin accumulation in neurons with restraint stress. Gerontology 41: 229-237, 1995.
    • (1995) Gerontology , vol.41 , pp. 229-237
    • Chaudhary, A.1    Sharma, S.P.2    James, T.J.3
  • 25
    • 0029741695 scopus 로고    scopus 로고
    • Substituted 2-hydroxy- 1,2-dihydropyrrol-3-ones: Fluorescent markers pertaining to oxidative stress and aging
    • Chen, P., Wiesler, D., Chmelik, J. & Novotny, M.: Substituted 2-hydroxy-1,2-dihydropyrrol-3-ones: fluorescent markers pertaining to oxidative stress and aging. Chem. Res. Toxicol. 9: 970-979, 1996.
    • (1996) Chem. Res. Toxicol. , vol.9 , pp. 970-979
    • Chen, P.1    Wiesler, D.2    Chmelik, J.3    Novotny, M.4
  • 26
    • 0022900613 scopus 로고
    • Prevention of lipofuscin development in neurons by anti-oxidants
    • Constantinides, P., Harkey, M. & McLaury, D.: Prevention of lipofuscin development in neurons by anti-oxidants. Virchows Arch. A 409: 583-593, 1986.
    • (1986) Virchows Arch. A , vol.409 , pp. 583-593
    • Constantinides, P.1    Harkey, M.2    McLaury, D.3
  • 28
    • 0029619837 scopus 로고
    • Diet-induced residual formation in pigs
    • de Gritz, B. G. & Rahko, T.: Diet-induced residual formation in pigs. Gerontology 41: 305-317, 1995.
    • (1995) Gerontology , vol.41 , pp. 305-317
    • De Gritz, B.G.1    Rahko, T.2
  • 29
    • 0028118581 scopus 로고
    • Diet-induced lipofuscin and ceroid formation in growing pigs
    • de Gritz, B. G., Rahko, T. & Korpela, H.: Diet-induced lipofuscin and ceroid formation in growing pigs. J. Comp. Pathol. 110: 11-24, 1994.
    • (1994) J. Comp. Pathol. , vol.110 , pp. 11-24
    • De Gritz, B.G.1    Rahko, T.2    Korpela, H.3
  • 32
    • 0025860425 scopus 로고
    • Transmural differences of lipofuscin pigment accumulation in the left ventricule of rat heart during growth and aging
    • del Roso, A., de Tata, V., Gori, Z. & Bergamini, E.: Transmural differences of lipofuscin pigment accumulation in the left ventricule of rat heart during growth and aging. Aging 3: 19-23, 1991.
    • (1991) Aging , vol.3 , pp. 19-23
    • Del Roso, A.1    De Tata, V.2    Gori, Z.3    Bergamini, E.4
  • 33
    • 0026800776 scopus 로고
    • Overexpression of the two-chain form of cathepsin B in senescent WI-38 cells
    • di Paolo, B. R., Pignolo, R. J. & Cristofalo, V. J.: Overexpression of the two-chain form of cathepsin B in senescent WI-38 cells. Exp. Cell. Res. 207: 500-505, 1992.
    • (1992) Exp. Cell. Res. , vol.207 , pp. 500-505
    • Di Paolo, B.R.1    Pignolo, R.J.2    Cristofalo, V.J.3
  • 34
    • 0024313979 scopus 로고
    • Altered intracellular protein degradation in aging: A possible cause of proliferative arrest
    • Dice, J. F.: Altered intracellular protein degradation in aging: a possible cause of proliferative arrest. Exp. Gerontol. 24: 451-459, 1989.
    • (1989) Exp. Gerontol. , vol.24 , pp. 451-459
    • Dice, J.F.1
  • 35
    • 0027410970 scopus 로고
    • Retinal age pigments generated by self-assembling lysosomotropic detergents
    • Eldred, G. E. & Lasky, M. R.: Retinal age pigments generated by self-assembling lysosomotropic detergents. Nature 361: 724-126, 1993.
    • (1993) Nature , vol.361 , pp. 724-1126
    • Eldred, G.E.1    Lasky, M.R.2
  • 36
    • 0029009245 scopus 로고
    • Tissue culture loading test with storage granules from animal models of neuronal ceroid-lipofuscinosis (Batten disease): Testing their lysosomal degradability by normal and Batten cells
    • Elleder, M., Drahota, Z., Lis, V., Mares. V., Mandys, V., Muller, J. & Palmer, D. N.: Tissue culture loading test with storage granules from animal models of neuronal ceroid-lipofuscinosis (Batten disease): testing their lysosomal degradability by normal and Batten cells. Am. J. Med. Genet. 57: 213-221, 1995.
    • (1995) Am. J. Med. Genet. , vol.57 , pp. 213-221
    • Elleder, M.1    Drahota, Z.2    Lis, V.3    Mares, V.4    Mandys, V.5    Muller, J.6    Palmer, D.N.7
  • 37
    • 0014556024 scopus 로고
    • Studies on induced cellular autophagy. II. Characterization of the membranes bordering autophagosomes in parenchymal liver cells
    • Ericsson, J. L.: Studies on induced cellular autophagy. II. Characterization of the membranes bordering autophagosomes in parenchymal liver cells. Exp. Cell. Res. 56: 393-405, 1969.
    • (1969) Exp. Cell. Res. , vol.56 , pp. 393-405
    • Ericsson, J.L.1
  • 38
    • 0001511853 scopus 로고
    • Human hepatocellular pigments and lysosomes
    • Essner, E. & Novikoff, A. V.: Human hepatocellular pigments and lysosomes. J. Ultrastruct. Res. 3: 374-391, 1960.
    • (1960) J. Ultrastruct. Res. , vol.3 , pp. 374-391
    • Essner, E.1    Novikoff, A.V.2
  • 39
    • 0029149381 scopus 로고
    • Aging of neurons in the mollusc Lymnaea stagnalis small parietal ganglion: A morphofunctional comparison in the same neuron
    • Frolkis, V. V., Kvitnitskaya-Ryzhova, T. & Martynenko, O. A.: Aging of neurons in the mollusc Lymnaea stagnalis small parietal ganglion: a morphofunctional comparison in the same neuron. Exp. Gerontol. 30: 533-544, 1995.
    • (1995) Exp. Gerontol. , vol.30 , pp. 533-544
    • Frolkis, V.V.1    Kvitnitskaya-Ryzhova, T.2    Martynenko, O.A.3
  • 40
    • 0028222890 scopus 로고
    • Influence of intracellular glutathione concentration of lipofuscin accumulation in cultured neonatal rat cardiac myocytes
    • Gao, G., Ollinger, K. & Brunk, U. T.: Influence of intracellular glutathione concentration of lipofuscin accumulation in cultured neonatal rat cardiac myocytes. Free Rad. Biol. Med. 16: 187-194, 1994.
    • (1994) Free Rad. Biol. Med. , vol.16 , pp. 187-194
    • Gao, G.1    Ollinger, K.2    Brunk, U.T.3
  • 41
    • 0023200006 scopus 로고
    • The fine structural morphology of the midgut of aged drosophila: A morphometric analysis
    • Gartner, L. P.: The fine structural morphology of the midgut of aged drosophila: a morphometric analysis. Exp. Gerontol. 222: 297-304, 1987.
    • (1987) Exp. Gerontol. , vol.222 , pp. 297-304
    • Gartner, L.P.1
  • 42
    • 1642468023 scopus 로고
    • Über den Nachweis von hydrolytischen Enzymen in Lipopigmenten
    • Gedigk, P. & Bouthe, E.: Über den Nachweis von hydrolytischen Enzymen in Lipopigmenten. Z. Zellforsch. 244: 495-518, 1956.
    • (1956) Z. Zellforsch. , vol.244 , pp. 495-518
    • Gedigk, P.1    Bouthe, E.2
  • 44
    • 0023584505 scopus 로고
    • Comparison of different autophagic vacuoles with regard to ultrastructure, enzymatic composition, and degradation capacity - Formation of crinosomes
    • Glaumann, H. & Ahlberg, J.: Comparison of different autophagic vacuoles with regard to ultrastructure, enzymatic composition, and degradation capacity - formation of crinosomes. Exp. Mol. Pathol. 47: 346-362, 1987.
    • (1987) Exp. Mol. Pathol. , vol.47 , pp. 346-362
    • Glaumann, H.1    Ahlberg, J.2
  • 45
    • 0028002924 scopus 로고
    • Pentamidine accumulates in rat liver lysosomes and inhibits phospholipid degradation
    • Glaumann, H., Bronner, U., Ericsson, O., Gustafsson, L. L. & Rombo, L.: Pentamidine accumulates in rat liver lysosomes and inhibits phospholipid degradation. Pharmacol. Toxicol. 74: 17-22. 1994.
    • (1994) Pharmacol. Toxicol. , vol.74 , pp. 17-22
    • Glaumann, H.1    Bronner, U.2    Ericsson, O.3    Gustafsson, L.L.4    Rombo, L.5
  • 46
    • 0019730097 scopus 로고
    • Mechanisms of intralysosomal degradation with special reference to autophagocytosis and heterophagocytosis of cell organelles
    • Glaumann, H., Ericsson, J. L. & Marzella, L.: Mechanisms of intralysosomal degradation with special reference to autophagocytosis and heterophagocytosis of cell organelles. Int. Rev. Cytol. 73: 149-182. 1981.
    • (1981) Int. Rev. Cytol. , vol.73 , pp. 149-182
    • Glaumann, H.1    Ericsson, J.L.2    Marzella, L.3
  • 47
    • 4243233580 scopus 로고
    • Removal of osmiophilic waste products, a lightmicroscopical and ultramicroscopical study
    • Totaro, E. A., Glees, P. & Pisanti, F. A. (Eds.): Pergamon Press, Oxford
    • Glees, P.: Removal of osmiophilic waste products, a lightmicroscopical and ultramicroscopical study. In: Totaro, E. A., Glees, P. & Pisanti, F. A. (Eds.): Advances in Age Pigment Research. Pergamon Press, Oxford 1987, pp. 101-110.
    • (1987) Advances in Age Pigment Research , pp. 101-110
    • Glees, P.1
  • 48
    • 0023928225 scopus 로고
    • Ultrastructural studies of the retina in infantile neuronal ceroid-lipofuscinosis
    • Goebel, H. H., Klein, H., Santavuori, P. & Sainio, K: Ultrastructural studies of the retina in infantile neuronal ceroid-lipofuscinosis. Retina 8: 59-66, 1988.
    • (1988) Retina , vol.8 , pp. 59-66
    • Goebel, H.H.1    Klein, H.2    Santavuori, P.3    Sainio, K.4
  • 49
    • 0025125447 scopus 로고
    • Glycoconjugates in storage cytosomes from ceroid-lipofuscinosis (Batten's disease) and in lipofuscin from old-age brain
    • Hall, N. A., Lake, B. D., Palmer, D. N., Jolly, R. D. & Patrick, A. D.: Glycoconjugates in storage cytosomes from ceroid-lipofuscinosis (Batten's disease) and in lipofuscin from old-age brain. Adv. Exp. Med. Biol. 266: 225-242, 1989.
    • (1989) Adv. Exp. Med. Biol. , vol.266 , pp. 225-242
    • Hall, N.A.1    Lake, B.D.2    Palmer, D.N.3    Jolly, R.D.4    Patrick, A.D.5
  • 50
    • 0029583483 scopus 로고
    • Immunological studies on sphingolipid activator proteins in the neuronal ceroid-lipofuscinoses
    • Haltia, M., Tyynela, J., Bawnann, M., Henseler, M. & Sandhoff, K.: Immunological studies on sphingolipid activator proteins in the neuronal ceroid-lipofuscinoses. Gerontology 41: 239-248. 1995.
    • (1995) Gerontology , vol.41 , pp. 239-248
    • Haltia, M.1    Tyynela, J.2    Bawnann, M.3    Henseler, M.4    Sandhoff, K.5
  • 51
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • Harman, D.: Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 211: 298-300, 1956.
    • (1956) J. Gerontol. , vol.211 , pp. 298-300
    • Harman, D.1
  • 52
    • 0028223426 scopus 로고
    • Free-radical theory of aging. Increasing the functional life span
    • Harman, D.: Free-radical theory of aging. Increasing the functional life span. Ann. N. Y. Acad. Sci. 717: 1-15, 1994.
    • (1994) Ann. N. Y. Acad. Sci. , vol.717 , pp. 1-15
    • Harman, D.1
  • 53
    • 0025074187 scopus 로고
    • Lipofuscin and ceroid formation: The cellular recycling system
    • Harman, D.: Lipofuscin and ceroid formation: the cellular recycling system. Adv. Exp. Med. Biol. 266: 3-15, 1989.
    • (1989) Adv. Exp. Med. Biol. , vol.266 , pp. 3-15
    • Harman, D.1
  • 54
    • 0013852510 scopus 로고
    • Enzymic activities of lipofuscin age pigments: Comparative histochemical and biochemical studies
    • Hendley, D. D. & Strehler, B. L.: Enzymic activities of lipofuscin age pigments: comparative histochemical and biochemical studies. Biochim. Biophys. Acta 99: 406-417, 1965.
    • (1965) Biochim. Biophys. Acta , vol.99 , pp. 406-417
    • Hendley, D.D.1    Strehler, B.L.2
  • 55
    • 0014629942 scopus 로고
    • The effect of chloroquine on rat heart lysosomes
    • Hendy, R. J., Abraham, R. & Grasso, P.: The effect of chloroquine on rat heart lysosomes. J. Ultrastruct. Res. 29: 485-495, 1969.
    • (1969) J. Ultrastruct. Res. , vol.29 , pp. 485-495
    • Hendy, R.J.1    Abraham, R.2    Grasso, P.3
  • 57
    • 0025981428 scopus 로고
    • Leupeptin causes an accumulation of lipofuscin-like substances in liver cells of young rats
    • Ivy, G. O., Kanai, S., Ohta, M., Sato, Y., Otsubo, K. & Kitani, K.: Leupeptin causes an accumulation of lipofuscin-like substances in liver cells of young rats. Mech. Ageing Dev. 57: 213-231, 1991.
    • (1991) Mech. Ageing Dev. , vol.57 , pp. 213-231
    • Ivy, G.O.1    Kanai, S.2    Ohta, M.3    Sato, Y.4    Otsubo, K.5    Kitani, K.6
  • 58
    • 0025032215 scopus 로고
    • Lipofuscin-like substances accumulate rapidly in brain, retina and internal organs with cysteine protease inhibition
    • Ivy, G. O., Kanai, S., Ohta, M., Smith, G., Sato, Y., Kobayashi, M. & Kitani, K.: Lipofuscin-like substances accumulate rapidly in brain, retina and internal organs with cysteine protease inhibition. Adv. Exp. Med. Biol. 266: 31-47, 1989.
    • (1989) Adv. Exp. Med. Biol. , vol.266 , pp. 31-47
    • Ivy, G.O.1    Kanai, S.2    Ohta, M.3    Smith, G.4    Sato, Y.5    Kobayashi, M.6    Kitani, K.7
  • 59
    • 0029784635 scopus 로고    scopus 로고
    • Leupeptin causes an accumulation of lipofuscin-like substances and other signs of aging in kidneys of young rats: Further evidence for the protease inhibitor model of aging
    • Ivy, G. O., Roopsingh, R., Kanai, S., Ohta, M., Sato, Y. & Kitani, K.: Leupeptin causes an accumulation of lipofuscin-like substances and other signs of aging in kidneys of young rats: further evidence for the protease inhibitor model of aging. Ann. N. Y. Acad. Sci. 786: 12-23, 1996.
    • (1996) Ann. N. Y. Acad. Sci. , vol.786 , pp. 12-23
    • Ivy, G.O.1    Roopsingh, R.2    Kanai, S.3    Ohta, M.4    Sato, Y.5    Kitani, K.6
  • 60
    • 0021675999 scopus 로고
    • Inhibitors of lysosomal enzymes: Accumulation of lipofuscin-like dense bodies in the brain
    • Ivy, G. O., Schottler, F., Wenzel, J., Baudry, M. & Lynch, G.: Inhibitors of lysosomal enzymes: accumulation of lipofuscin-like dense bodies in the brain. Science 226: 985-987, 1984.
    • (1984) Science , vol.226 , pp. 985-987
    • Ivy, G.O.1    Schottler, F.2    Wenzel, J.3    Baudry, M.4    Lynch, G.5
  • 61
    • 0023761382 scopus 로고
    • An electron microscopic examination of age-related changes in the rat liver. The influence of diet
    • Iwasaki, K., Maeda, H., Shimokawa, I., Hayashida, M., Yu, B. P., Masoro, E. J. & Ikeda, T.: An electron microscopic examination of age-related changes in the rat liver. The influence of diet. Acta Pathol. Jpn. 38: 1119-1130, 1988.
    • (1988) Acta Pathol. Jpn. , vol.38 , pp. 1119-1130
    • Iwasaki, K.1    Maeda, H.2    Shimokawa, I.3    Hayashida, M.4    Yu, B.P.5    Masoro, E.J.6    Ikeda, T.7
  • 62
    • 0021952327 scopus 로고
    • Cathepsin-B activity in human-skin fibroblasts from young, old and premature aging syndromes
    • Jahani, M. & Gracy, R. W.: Cathepsin-B activity in human-skin fibroblasts from young, old and premature aging syndromes. Fed. Proc. 44: 876-886, 1985.
    • (1985) Fed. Proc. , vol.44 , pp. 876-886
    • Jahani, M.1    Gracy, R.W.2
  • 63
    • 0029622988 scopus 로고
    • Regional and lobular variation in neuronal lipofuscinosis in rat cerebellum: Influence of age and protein malnourishment
    • James, T. J. & Sharma, S. P.: Regional and lobular variation in neuronal lipofuscinosis in rat cerebellum: influence of age and protein malnourishment. Gerontology 41: 213-228, 1995.
    • (1995) Gerontology , vol.41 , pp. 213-228
    • James, T.J.1    Sharma, S.P.2
  • 64
    • 15644378999 scopus 로고
    • Histochemical studies of age pigments in the human heart
    • Jayne, E. P.: Histochemical studies of age pigments in the human heart. J. Gerontol. 5: 319-325, 1950.
    • (1950) J. Gerontol. , vol.5 , pp. 319-325
    • Jayne, E.P.1
  • 65
    • 0029563691 scopus 로고
    • Lipofuscin in bovine muscle and brain: A model for studying age pigment
    • Jolly, R. D., Douglas, B. V., Davey, P. M. & Roiri, J. E.: Lipofuscin in bovine muscle and brain: a model for studying age pigment. Gerontology 41: 283-295, 1995.
    • (1995) Gerontology , vol.41 , pp. 283-295
    • Jolly, R.D.1    Douglas, B.V.2    Davey, P.M.3    Roiri, J.E.4
  • 66
    • 0005647766 scopus 로고
    • Clinical and experimental studies on lipofuscin in skeletal muscle fibers
    • Zs.-Nagy, I. (Ed.): Lipofuscin-1987: State of the Art Amsterdam
    • Karpati, G., Carpenter, S. & Wolfe, L. S.: Clinical and experimental studies on lipofuscin in skeletal muscle fibers. In: Zs.-Nagy, I. (Ed.): Lipofuscin-1987: State of the Art. Excerpta Medica, Amsterdam 1988, pp. 227-243.
    • (1988) Excerpta Medica , pp. 227-243
    • Karpati, G.1    Carpenter, S.2    Wolfe, L.S.3
  • 67
    • 0023222761 scopus 로고
    • Lipofuscin autofluorescence: Evidence for vitamin a involvement in the retina
    • Katz, M. L., Eldred, G. E. & Robison, W. G. Jr.: Lipofuscin autofluorescence: evidence for vitamin A involvement in the retina. Mech. Ageing Dev. 39: 81-90, 1987.
    • (1987) Mech. Ageing Dev. , vol.39 , pp. 81-90
    • Katz, M.L.1    Eldred, G.E.2    Robison Jr., W.G.3
  • 68
    • 0024339810 scopus 로고
    • Development of lipofuscin-like fluorescence in the retinal pigment epithelium in response to protease inhibitor treatment
    • Katz, M. L. & Shanker, M. J.: Development of lipofuscin-like fluorescence in the retinal pigment epithelium in response to protease inhibitor treatment. Mech. Ageing Dev. 49: 23-40, 1989.
    • (1989) Mech. Ageing Dev. , vol.49 , pp. 23-40
    • Katz, M.L.1    Shanker, M.J.2
  • 69
    • 0023447808 scopus 로고
    • Fluorescence of 1,4-dihydropyridine derivatives relevant to age pigments
    • Kikugawa, K., Nakahara, T. & Sakurai, K.: Fluorescence of 1,4-dihydropyridine derivatives relevant to age pigments. Chem. Pharm. Bull. 35: 4656-4660, 1987.
    • (1987) Chem. Pharm. Bull. , vol.35 , pp. 4656-4660
    • Kikugawa, K.1    Nakahara, T.2    Sakurai, K.3
  • 70
    • 0029562289 scopus 로고
    • Decline in glucose metabolism in the brain in neuronal ceroid lipofuscinosis (NCL) in English setter -evidence by positron emission tomography (PET)
    • Kitani, K., Senda, M., Toyama, H., Miyasaka, K., Kanai, S., Ohta, M., Ivy, G. O. & Koppang, N.: Decline in glucose metabolism in the brain in neuronal ceroid lipofuscinosis (NCL) in English setter -evidence by positron emission tomography (PET). Gerontology 41: 249-257, 1995.
    • (1995) Gerontology , vol.41 , pp. 249-257
    • Kitani, K.1    Senda, M.2    Toyama, H.3    Miyasaka, K.4    Kanai, S.5    Ohta, M.6    Ivy, G.O.7    Koppang, N.8
  • 71
    • 0017149860 scopus 로고
    • Lysosomal enzyme activities in parenchymal and nonparenchymal liver cells isolated from young, adult and old rats
    • Knook, D. L. & Sleyster, E. C.: Lysosomal enzyme activities in parenchymal and nonparenchymal liver cells isolated from young, adult and old rats. Mech. Ageing Dev. 5: 389-398, 1976.
    • (1976) Mech. Ageing Dev. , vol.5 , pp. 389-398
    • Knook, D.L.1    Sleyster, E.C.2
  • 72
    • 0011305357 scopus 로고
    • Lysosomes in the nervous system
    • Dingle, J. T. & Fell, H. B. (Eds.): North-Holland, Amsterdam
    • Koenig, H.: Lysosomes in the nervous system. In: Dingle, J. T. & Fell, H. B. (Eds.): Lysosomes in Biology and Pathology. Vol. 2. North-Holland, Amsterdam 1969, pp. 111-162.
    • (1969) Lysosomes in Biology and Pathology , vol.2 , pp. 111-162
    • Koenig, H.1
  • 73
    • 0023462628 scopus 로고
    • The ultrastructure of the gastric mucosa of the rat during ontogenesis
    • Kurz, H. G.: The ultrastructure of the gastric mucosa of the rat during ontogenesis. Z. Mikrosk. Anat. Forsch. 101: 737-768, 1987.
    • (1987) Z. Mikrosk. Anat. Forsch. , vol.101 , pp. 737-768
    • Kurz, H.G.1
  • 74
    • 15644381569 scopus 로고
    • Pattern of lipofuscin accumulation in nervous tissue and the way of its elimination as a marker of aging
    • Kitani, K., Ivy, G. O. & Shimasaki, H. (Eds.): Tokyo
    • Kvitnitskaya-Ryzhova, T. Y. & Mezhiborskaya, N. A.: Pattern of lipofuscin accumulation in nervous tissue and the way of its elimination as a marker of aging. In: Kitani, K., Ivy, G. O. & Shimasaki, H. (Eds.): International Gerontology Week Tokyo 1995. Part 2: Abstracts, Tokyo 1995, p. 30.
    • (1995) International Gerontology Week Tokyo 1995. Part 2: Abstracts , pp. 30
    • Kvitnitskaya-Ryzhova, T.Y.1    Mezhiborskaya, N.A.2
  • 75
    • 0023116341 scopus 로고
    • Aged skin: A study by light, transmission electron, and scanning electron microscopy
    • Lavker, R. M., Zheng, P. S. & Dong, G.: Aged skin: a study by light, transmission electron, and scanning electron microscopy. J. Invest. Dermatol. 88: 44s-51s, 1987.
    • (1987) J. Invest. Dermatol. , vol.88
    • Lavker, R.M.1    Zheng, P.S.2    Dong, G.3
  • 76
    • 0028254331 scopus 로고
    • Regulation of intracellular protein degradation with special reference to lysosomes: Role in cell physiology and pathology
    • Lee, H. K & Marzella, L.: Regulation of intracellular protein degradation with special reference to lysosomes: role in cell physiology and pathology. Int. Rev. Exp. Pathol. 35: 39-47, 1994.
    • (1994) Int. Rev. Exp. Pathol. , vol.35 , pp. 39-47
    • Lee, H.K.1    Marzella, L.2
  • 77
    • 0030506793 scopus 로고    scopus 로고
    • Effects of vitamin e on the blastogenic response of splenocytes and lipofuscin contents in the hearts and brains of aged mice
    • Ma, X. Y., Su, Y. B., Zhang, F. R. & Li, J. F.: Effects of vitamin E on the blastogenic response of splenocytes and lipofuscin contents in the hearts and brains of aged mice. J. Environ. Pathol. Toxicol. Oncol. 15: 51-53, 1996.
    • (1996) J. Environ. Pathol. Toxicol. Oncol. , vol.15 , pp. 51-53
    • Ma, X.Y.1    Su, Y.B.2    Zhang, F.R.3    Li, J.F.4
  • 78
    • 0344947139 scopus 로고
    • Some effects of prolonged vitamin E deficiency in rats
    • Martin, A. J. P. & Moore, T.: Some effects of prolonged vitamin E deficiency in rats. J. Hygiene 39: 643-650, 1939.
    • (1939) J. Hygiene , vol.39 , pp. 643-650
    • Martin, A.J.P.1    Moore, T.2
  • 79
    • 0025044090 scopus 로고
    • Effect of alpha-tocopherol and some metal chelators on lipofuscin accumulation in cultured neonatal rat cardiac myocytes
    • Marzabadi, M. R., Sohal, R. S. & Brunk, U. T.: Effect of alpha-tocopherol and some metal chelators on lipofuscin accumulation in cultured neonatal rat cardiac myocytes. Anal. Cell. Pathol. 2: 333-346, 1990.
    • (1990) Anal. Cell. Pathol. , vol.2 , pp. 333-346
    • Marzabadi, M.R.1    Sohal, R.S.2    Brunk, U.T.3
  • 80
    • 0024232942 scopus 로고
    • Effect of ferric iron and desferrioxamine on lipofuscin accumulation in cultured rat heart myocytes
    • Marzabadi, M. R., Sohal, R. S. & Brunk, U. T.: Effect of ferric iron and desferrioxamine on lipofuscin accumulation in cultured rat heart myocytes. Mech. Ageing Dev. 46: 145-157, 1988.
    • (1988) Mech. Ageing Dev. , vol.46 , pp. 145-157
    • Marzabadi, M.R.1    Sohal, R.S.2    Brunk, U.T.3
  • 81
    • 0025852359 scopus 로고
    • Mechanisms of lipofuscinogenesis: Effect of the inhibition of lysosomal proteinases and lipases under varying concentrations of ambient oxygen in cultured rat neonatal myocardial cells
    • Marzabadi, M. R., Sohal, R. S. & Brunk, U. T.: Mechanisms of lipofuscinogenesis: effect of the inhibition of lysosomal proteinases and lipases under varying concentrations of ambient oxygen in cultured rat neonatal myocardial cells. APMIS 99: 416-426, 1991.
    • (1991) APMIS , vol.99 , pp. 416-426
    • Marzabadi, M.R.1    Sohal, R.S.2    Brunk, U.T.3
  • 82
    • 0019506466 scopus 로고
    • Autophagy, heterophagy, microautophagy and crinophagy as the means for intracellular degradation
    • Marzella, L., Ahlberg, J. & Glaumann, H.: Autophagy, heterophagy, microautophagy and crinophagy as the means for intracellular degradation. Virchows Arch. B 36: 219-234, 1981.
    • (1981) Virchows Arch. B , vol.36 , pp. 219-234
    • Marzella, L.1    Ahlberg, J.2    Glaumann, H.3
  • 83
    • 0039693654 scopus 로고
    • The tocopherols, effects of deficiency: Pharmacology
    • Serbell, W. H. & Harris, R. S. (Eds.): Academic Press, New York
    • Mason, K E.: The tocopherols, effects of deficiency: pharmacology. In: Serbell, W. H. & Harris, R. S. (Eds.): Vitamins. Vol. 3. Academic Press, New York 1954, pp. 514-565.
    • (1954) Vitamins , vol.3 , pp. 514-565
    • Mason, K.E.1
  • 84
    • 0014190716 scopus 로고
    • Electron microscopic studies on the lipo-pigments in the cerebral cortex nerve cells of senile and vitamin E deficient rats
    • Miyagishi, T., Takahata, N. & Iizuka, R.: Electron microscopic studies on the lipo-pigments in the cerebral cortex nerve cells of senile and vitamin E deficient rats. Acta Neuropathol. 9: 7-17, 1967.
    • (1967) Acta Neuropathol. , vol.9 , pp. 7-17
    • Miyagishi, T.1    Takahata, N.2    Iizuka, R.3
  • 85
    • 0002195828 scopus 로고
    • Formation of fluorescent pigment in vitamin E deficiency
    • Moore, T. & Wang, Y. L.: Formation of fluorescent pigment in vitamin E deficiency. Br. J. Nutr. 1: 53-64, 1947.
    • (1947) Br. J. Nutr. , vol.1 , pp. 53-64
    • Moore, T.1    Wang, Y.L.2
  • 86
    • 0014271520 scopus 로고
    • Rate of accumulation of cardiac lipofuscin in the aging canine
    • Munnel, J. F. & Getty, R.: Rate of accumulation of cardiac lipofuscin in the aging canine. J. Gerontol. 23: 154-158, 1968.
    • (1968) J. Gerontol. , vol.23 , pp. 154-158
    • Munnel, J.F.1    Getty, R.2
  • 87
    • 0031022255 scopus 로고    scopus 로고
    • Increased expression of cathepsins E and D in neurons of the aged rat brain and their colocalization with lipofuscin and carboxy-terminal fragments of Alzheimer amyloid precursor protein
    • Nakanishi, H., Amano, T., Sastradipura, D. F., Yoshimine, Y., Tsukuba, T., Tanabe, K. Hirotsu, I., Ohono, T. & Yamamoto, K: Increased expression of cathepsins E and D in neurons of the aged rat brain and their colocalization with lipofuscin and carboxy-terminal fragments of Alzheimer amyloid precursor protein. J. Neurochem. 68: 739-749, 1997.
    • (1997) J. Neurochem. , vol.68 , pp. 739-749
    • Nakanishi, H.1    Amano, T.2    Sastradipura, D.F.3    Yoshimine, Y.4    Tsukuba, T.5    Tanabe, K.6    Hirotsu, I.7    Ohono, T.8    Yamamoto, K.9
  • 88
    • 0029099203 scopus 로고
    • Increased expression and specific localization of cathepsins E and D in vulnerable brain regions of aged and postischemic rats
    • Nakanishi, H., Tominaga, K. & Yamamoto, K: Increased expression and specific localization of cathepsins E and D in vulnerable brain regions of aged and postischemic rats. Adv. Exp. Med. Biol. 362: 335-339, 1995.
    • (1995) Adv. Exp. Med. Biol. , vol.362 , pp. 335-339
    • Nakanishi, H.1    Tominaga, K.2    Yamamoto, K.3
  • 89
    • 0027411974 scopus 로고
    • Accumulation of cardiac lipofuscin in crab-eating monkeys (Macaca fascicularis): The same rate of lipofuscin accumulation in several species of primates
    • Nakano, M., Mizuno, T. & Gotoh, S.: Accumulation of cardiac lipofuscin in crab-eating monkeys (Macaca fascicularis): the same rate of lipofuscin accumulation in several species of primates. Mech. Ageing Dev. 66: 243-248, 1993.
    • (1993) Mech. Ageing Dev. , vol.66 , pp. 243-248
    • Nakano, M.1    Mizuno, T.2    Gotoh, S.3
  • 90
    • 0029564967 scopus 로고
    • Age-related changes in the lipofuscin accumulation of brain and heart
    • Nakano, M., Oenzil, F., Mizuno, T. & Gotoh, S.: Age-related changes in the lipofuscin accumulation of brain and heart. Gerontology 41: 69-79, 1995.
    • (1995) Gerontology , vol.41 , pp. 69-79
    • Nakano, M.1    Oenzil, F.2    Mizuno, T.3    Gotoh, S.4
  • 91
    • 0011881235 scopus 로고
    • Experimental manipulations of lipofuscin formation in aging mammals
    • Zs.-Nagy, I. (Ed.): Lipofuscin-1987: State of the Art. Amsterdam
    • Nandy, K., Mostofsky, D. I., Idrobo, F., Blatt, L. & Nandy, S.: Experimental manipulations of lipofuscin formation in aging mammals. In: Zs.-Nagy, I. (Ed.): Lipofuscin-1987: State of the Art. Excerpta Medica, Amsterdam 1988, pp. 289-304.
    • (1988) Excerpta Medica , pp. 289-304
    • Nandy, K.1    Mostofsky, D.I.2    Idrobo, F.3    Blatt, L.4    Nandy, S.5
  • 92
    • 0020621305 scopus 로고
    • High levels of brain dolichols in neuronal ceroid-lipofuscinosis and senescence
    • Ng Ying Kin, N. M., Palo, J., Haltia, M. & Wolfe, L. S.: High levels of brain dolichols in neuronal ceroid-lipofuscinosis and senescence. J. Neurochem. 40: 1465-1473, 1983.
    • (1983) J. Neurochem. , vol.40 , pp. 1465-1473
    • Ng Ying Kin, N.M.1    Palo, J.2    Haltia, M.3    Wolfe, L.S.4
  • 93
    • 0018074885 scopus 로고
    • Endoplasmic reticulum and autophagy in rat hepatocytes
    • Novikoff, A. B. & Shin, W. Y.: Endoplasmic reticulum and autophagy in rat hepatocytes. Proc. Natl. Acad. Sci. USA 75: 5039-5042, 1978.
    • (1978) Proc. Natl. Acad. Sci. USA , vol.75 , pp. 5039-5042
    • Novikoff, A.B.1    Shin, W.Y.2
  • 94
    • 0027323894 scopus 로고
    • Ultrastructural observations on neuronal lipofuscin (age pigment) and dense bodies induced by a proteinase inhibitor, leupeptin, in rat hippocampus
    • Nunomura, A. & Miyagishi, T.: Ultrastructural observations on neuronal lipofuscin (age pigment) and dense bodies induced by a proteinase inhibitor, leupeptin, in rat hippocampus. Acta Neuropathol. 86: 319-328, 1993.
    • (1993) Acta Neuropathol. , vol.86 , pp. 319-328
    • Nunomura, A.1    Miyagishi, T.2
  • 95
    • 0029563692 scopus 로고
    • Hermansky-Pudlak syndrome; a case report with analysis of auto-fluorescent ceroid-like pigments
    • Ohbayashi, C., Kanomata, N., Imai, Y., Ito, H. & Shimasaki, H.: Hermansky-Pudlak syndrome; a case report with analysis of auto-fluorescent ceroid-like pigments. Gerontology 41: 297-303, 1995.
    • (1995) Gerontology , vol.41 , pp. 297-303
    • Ohbayashi, C.1    Kanomata, N.2    Imai, Y.3    Ito, H.4    Shimasaki, H.5
  • 96
    • 0002420494 scopus 로고
    • Lipofuscin and ceroid accumulation in experimental animals
    • Sohal, R. S. (Ed.): Elsevier, Amsterdam
    • Oliver, C.: Lipofuscin and ceroid accumulation in experimental animals. In: Sohal, R. S. (Ed.): Age Pigments. Elsevier, Amsterdam 1981, pp. 335-353.
    • (1981) Age Pigments , pp. 335-353
    • Oliver, C.1
  • 98
    • 0029591927 scopus 로고
    • Changes in cathepsin B and lipofuscin during development and aging in rat brain and heart
    • Porta, E., Llesuy, S., Monserrat, A. J., Benavides, S. & Travacio, M.: Changes in cathepsin B and lipofuscin during development and aging in rat brain and heart. Gerontology 41: 81-93, 1995.
    • (1995) Gerontology , vol.41 , pp. 81-93
    • Porta, E.1    Llesuy, S.2    Monserrat, A.J.3    Benavides, S.4    Travacio, M.5
  • 99
    • 0025862009 scopus 로고
    • Advances in age pigment research
    • Porta, E. A.: Advances in age pigment research. Arch. Gerontol. Geriatr. 272: 303-320, 1991.
    • (1991) Arch. Gerontol. Geriatr. , vol.272 , pp. 303-320
    • Porta, E.A.1
  • 100
    • 0003017930 scopus 로고
    • Differential features between lipofuscin (age pigment) and various experimentally produced 'ceroid pigments'
    • Zs.-Nagy, I. (Ed.): Lipofuscin-1987: State of the Art. Amsterdam
    • Porta, E. A., Mower, H. F., Moroye, M., Lee, C. & Palumbo, N. E.: Differential features between lipofuscin (age pigment) and various experimentally produced 'ceroid pigments'. In: Zs.-Nagy, I. (Ed.): Lipofuscin-1987: State of the Art. Excerpta Medica, Amsterdam 1988, pp. 341-374.
    • (1988) Excerpta Medica , pp. 341-374
    • Porta, E.A.1    Mower, H.F.2    Moroye, M.3    Lee, C.4    Palumbo, N.E.5
  • 101
    • 0020030177 scopus 로고
    • Effects of the type of dietary fat at two levels of vitamin E in Wistar male rats during development and aging. IV Biochemical and morphometric parameters of the heart
    • Porta, E. A., Sablan, H. M., Joun, N. S. & Chee, G.: Effects of the type of dietary fat at two levels of vitamin E in Wistar male rats during development and aging. IV Biochemical and morphometric parameters of the heart. Mech. Ageing Dev. 18: 159-199, 1982.
    • (1982) Mech. Ageing Dev. , vol.18 , pp. 159-199
    • Porta, E.A.1    Sablan, H.M.2    Joun, N.S.3    Chee, G.4
  • 102
    • 0014238948 scopus 로고
    • Lipofuscin pigment accumulation as a function of age and distribution in rodent brain
    • Reichel, E., Holander, J., Clark, H. J. & Strehler, B. L.: Lipofuscin pigment accumulation as a function of age and distribution in rodent brain. J. Gerontol. 23: 71-78, 1968.
    • (1968) J. Gerontol. , vol.23 , pp. 71-78
    • Reichel, E.1    Holander, J.2    Clark, H.J.3    Strehler, B.L.4
  • 103
    • 0018631851 scopus 로고
    • The effect of age on the protein degradation system in the nematode Turbatrix aceti
    • Reznick, A. Z. & Gershon, D.: The effect of age on the protein degradation system in the nematode Turbatrix aceti. Mech. Ageing Dev. 11: 403-415, 1979.
    • (1979) Mech. Ageing Dev. , vol.11 , pp. 403-415
    • Reznick, A.Z.1    Gershon, D.2
  • 104
    • 0014800006 scopus 로고
    • Morphologic changes accompanying senescence of cultured human diploid cells
    • Robbins, E., Levine, E. M. & Eagle, H.: Morphologic changes accompanying senescence of cultured human diploid cells. J. Exp. Med. 131: 1211-1222, 1970.
    • (1970) J. Exp. Med. , vol.131 , pp. 1211-1222
    • Robbins, E.1    Levine, E.M.2    Eagle, H.3
  • 105
    • 0024994169 scopus 로고
    • Cytochemical and morphometric analysis of autophagy in energy depleted rat hepatocytes
    • Schellens, J. P., Vreeling-Sindelarova, H., Plomp, P. J. & Meijer, A. J.: Cytochemical and morphometric analysis of autophagy in energy depleted rat hepatocytes. Cell Biol. Int. Rep. 14: 805-814, 1990.
    • (1990) Cell Biol. Int. Rep. , vol.14 , pp. 805-814
    • Schellens, J.P.1    Vreeling-Sindelarova, H.2    Plomp, P.J.3    Meijer, A.J.4
  • 106
    • 0025171955 scopus 로고
    • Hepatocyte fine structure during maturation end senescence
    • Schmucker, D. L.: Hepatocyte fine structure during maturation end senescence. J. Electron Microsc. Tech. 14: 106-125, 1990.
    • (1990) J. Electron Microsc. Tech. , vol.14 , pp. 106-125
    • Schmucker, D.L.1
  • 107
    • 0026584008 scopus 로고
    • Autophagy and other vacuolar protein degradation mechanisms
    • Seglen, P. O. & Bohley, P.: Autophagy and other vacuolar protein degradation mechanisms. Experientia 48: 158-172, 1992.
    • (1992) Experientia , vol.48 , pp. 158-172
    • Seglen, P.O.1    Bohley, P.2
  • 108
    • 0002755650 scopus 로고
    • Isolierung und Eigenschaften von Lipofuscin aus Herzgewebe des Menschen
    • Siebert, G., Diezel, P. B., Jahr, K., King, E. & Schmitt, A.: Isolierung und Eigenschaften von Lipofuscin aus Herzgewebe des Menschen. Histochemie 23: 17-45, 1962.
    • (1962) Histochemie , vol.23 , pp. 17-45
    • Siebert, G.1    Diezel, P.B.2    Jahr, K.3    King, E.4    Schmitt, A.5
  • 109
    • 0024550570 scopus 로고
    • Histopathologic characteristics and ultrastructure of aging skin
    • Smith, L.: Histopathologic characteristics and ultrastructure of aging skin. Cutis 243: 414-424, 1989.
    • (1989) Cutis , vol.243 , pp. 414-424
    • Smith, L.1
  • 110
    • 0024537069 scopus 로고
    • Effect of ambient oxygen concentration on lipofuscin accumulation in cultured rat heart myocytes - A novel in vitro model of lipofuscinogenesis
    • Sohal, R. S., Marzabadi, M. R., Galaris, D. & Brunk, U. T.: Effect of ambient oxygen concentration on lipofuscin accumulation in cultured rat heart myocytes - a novel in vitro model of lipofuscinogenesis. Free Rad. Biol. Med. 6: 23-30, 1989.
    • (1989) Free Rad. Biol. Med. , vol.6 , pp. 23-30
    • Sohal, R.S.1    Marzabadi, M.R.2    Galaris, D.3    Brunk, U.T.4
  • 111
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • Sohal, R. S. & Weindruch, R.: Oxidative stress, caloric restriction, and aging. Science 273: 59-63, 1996.
    • (1996) Science , vol.273 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 112
    • 0022842377 scopus 로고
    • Lipofuscin: Characteristics and significance
    • Sohal, R. S. & Wolfe, L. S.: Lipofuscin: characteristics and significance. Prog. Brain Res. 70: 1986.
    • (1986) Prog. Brain Res. , vol.70
    • Sohal, R.S.1    Wolfe, L.S.2
  • 113
    • 76549152982 scopus 로고
    • On the histochemistry and ultrastructure of age pigment
    • Strehler, B. L. (Ed.): Academic Press, New York
    • Strehler, B. L.: On the histochemistry and ultrastructure of age pigment. In: Strehler, B. L. (Ed.): Advances of Gerontological Research. Vol. 1. Academic Press, New York 1964, pp. 343-384.
    • (1964) Advances of Gerontological Research , vol.1 , pp. 343-384
    • Strehler, B.L.1
  • 114
    • 0000070901 scopus 로고
    • Rate of magnitude of age pigment accumulation in the human myocardium
    • Strehler, B. L., Mark, D. D., Mildvan, A. S. & Gee, M. V.: Rate of magnitude of age pigment accumulation in the human myocardium. J. Gerontol. 14: 430-439, 1959.
    • (1959) J. Gerontol. , vol.14 , pp. 430-439
    • Strehler, B.L.1    Mark, D.D.2    Mildvan, A.S.3    Gee, M.V.4
  • 115
    • 0028307620 scopus 로고
    • Age-related increase in liver retinyl palmitate. Relationship to lipofuscin
    • Szweda, L. I.: Age-related increase in liver retinyl palmitate. Relationship to lipofuscin. J. Biol. Chem. 269: 12-15, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 12-15
    • Szweda, L.I.1
  • 116
    • 0015910804 scopus 로고
    • Lipid peroxidation damage to cell components
    • Tappel, A. L.: Lipid peroxidation damage to cell components. Fed. Proc. 32: 1870-1874, 1973.
    • (1973) Fed. Proc. , vol.32 , pp. 1870-1874
    • Tappel, A.L.1
  • 117
    • 0029560552 scopus 로고
    • The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes
    • Terman, A.: The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes. Gerontology 41: 319-326, 1995.
    • (1995) Gerontology , vol.41 , pp. 319-326
    • Terman, A.1
  • 118
    • 15644365484 scopus 로고    scopus 로고
    • On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes
    • submitted
    • Terman, A. & Brunk, U. T.: On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes. Mech. Ageing Dev. (submitted) 1997.
    • (1997) Mech. Ageing Dev.
    • Terman, A.1    Brunk, U.T.2
  • 119
    • 0028231177 scopus 로고
    • Ultrastructural morphometric analysis of lipofuscin in pyramidal cells of the human Ammon's horn
    • Thal, D. R. & Schlote, W.: Ultrastructural morphometric analysis of lipofuscin in pyramidal cells of the human Ammon's horn. Arch. Gerontol. Geriatr. 218: 59-77, 1994.
    • (1994) Arch. Gerontol. Geriatr. , vol.218 , pp. 59-77
    • Thal, D.R.1    Schlote, W.2
  • 120
    • 0021351037 scopus 로고
    • Influence of oxygen tension, pro-oxidants and antioxidants on the formation of lipid peroxidation products (lipofuscin) in individual cultivated human glial cells
    • Thaw, H. H., Collins, V. P. & Brunk, U. T.: Influence of oxygen tension, pro-oxidants and antioxidants on the formation of lipid peroxidation products (lipofuscin) in individual cultivated human glial cells. Mech. Ageing Dev. 24: 211-223, 1984.
    • (1984) Mech. Ageing Dev. , vol.24 , pp. 211-223
    • Thaw, H.H.1    Collins, V.P.2    Brunk, U.T.3
  • 121
    • 0029564969 scopus 로고
    • Accumulation of aluminium and silicon in lipofuscin granules
    • Tokutake, S. & Oyanagi, S.: Accumulation of aluminium and silicon in lipofuscin granules. Gerontology 41: 131-144, 1995.
    • (1995) Gerontology , vol.41 , pp. 131-144
    • Tokutake, S.1    Oyanagi, S.2
  • 122
    • 0003130890 scopus 로고
    • Das Involutionsmuster des Nucleus Dentatus Cerebelli
    • Platt, D. (Ed.): Schattauer, Stuttgart
    • Treff, W. M.: Das Involutionsmuster des Nucleus Dentatus Cerebelli. In: Platt, D. (Ed.): Altern. Schattauer, Stuttgart 1974, pp. 37-54.
    • (1974) Altern , pp. 37-54
    • Treff, W.M.1
  • 123
    • 0029563352 scopus 로고
    • Age-related decline of macroautophagy and liver protein breakdown in the Sprague-Dawley rat: Protective effect of caloric restriction
    • Vittorini, S., Paradiso, C., Masini, M., Gori, Z., Pollera, M. & Bergamini, E.: Age-related decline of macroautophagy and liver protein breakdown in the Sprague-Dawley rat: Protective effect of caloric restriction. Aging Clin. Exp. Res. 7: 476-477, 1995.
    • (1995) Aging Clin. Exp. Res. , vol.7 , pp. 476-477
    • Vittorini, S.1    Paradiso, C.2    Masini, M.3    Gori, Z.4    Pollera, M.5    Bergamini, E.6
  • 125
    • 0025749689 scopus 로고
    • Effect of age on liver protein synthesis and degradation
    • Ward, W. & Richardson, A.: Effect of age on liver protein synthesis and degradation. Hepatology 14: 935-948, 1991.
    • (1991) Hepatology , vol.14 , pp. 935-948
    • Ward, W.1    Richardson, A.2
  • 126
    • 0029885437 scopus 로고    scopus 로고
    • Lipofuscin formation in cultured retinal pigment epithelial cells exposed to photoreceptor outer segment material under different oxygen concentrations
    • Wihlmark, U., Wrigstad, A., Roberg, K., Brunk, U. T. & Nilsson, S. E.: Lipofuscin formation in cultured retinal pigment epithelial cells exposed to photoreceptor outer segment material under different oxygen concentrations. APMIS 104: 265-271, 1996.
    • (1996) APMIS , vol.104 , pp. 265-271
    • Wihlmark, U.1    Wrigstad, A.2    Roberg, K.3    Brunk, U.T.4    Nilsson, S.E.5
  • 128
    • 0024254716 scopus 로고
    • Dolichol and dolichyl phosphate in the neuronal ceroid-lipofuscinoses and other diseases
    • Wolfe, L. S., Gauthier, S., Haltia, M. & Palo, J.: Dolichol and dolichyl phosphate in the neuronal ceroid-lipofuscinoses and other diseases. Am. J. Med. Genet. 5: 233-242, 1988.
    • (1988) Am. J. Med. Genet. , vol.5 , pp. 233-242
    • Wolfe, L.S.1    Gauthier, S.2    Haltia, M.3    Palo, J.4
  • 129
    • 0029972278 scopus 로고    scopus 로고
    • Biochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores
    • Yin, D.: Biochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores. Free Rad. Biol. Med. 21: 871-888, 1996.
    • (1996) Free Rad. Biol. Med. , vol.21 , pp. 871-888
    • Yin, D.1
  • 130
    • 0029042778 scopus 로고
    • Test-tube simulated lipofuscinogenesis. Effect of oxidative stress on autophagocytotic degradation
    • Yin, D., Yuan, X. & Brunk, U. T.: Test-tube simulated lipofuscinogenesis. Effect of oxidative stress on autophagocytotic degradation. Mech. Ageing Dev. 81: 37-50, 1995.
    • (1995) Mech. Ageing Dev. , vol.81 , pp. 37-50
    • Yin, D.1    Yuan, X.2    Brunk, U.T.3
  • 131
    • 0025774225 scopus 로고
    • Microfluorometric and fluorometric lipofuscin spectral discrepancies: A concentration-dependent metachromatic effect?
    • Yin, D. Z. & Brunk, U. T.: Microfluorometric and fluorometric lipofuscin spectral discrepancies: a concentration-dependent metachromatic effect? Mech. Ageing Dev. 59: 95-109, 1991.
    • (1991) Mech. Ageing Dev. , vol.59 , pp. 95-109
    • Yin, D.Z.1    Brunk, U.T.2
  • 132
    • 0029593549 scopus 로고
    • Induction of age pigment accumulation in the brain cells of young male rats through iron-injection into the cerebrospinal fluid
    • Zs.-Nagy, I., Steiber, J. & Jeney, F.: Induction of age pigment accumulation in the brain cells of young male rats through iron-injection into the cerebrospinal fluid. Gerontology 41: 145-158, 1995.
    • (1995) Gerontology , vol.41 , pp. 145-158
    • Zs.-Nagy, I.1    Steiber, J.2    Jeney, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.