Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells

EMBO Journal

Volumn 21, Issue 15, 2002, Pages 4081-4093

  Xu, Dakang ^a   Wilson, Trevor J ^a   Chan, David ^a   De Luca, Elisabetta ^a   Zhou, Jiong ^a   Hertzog, Paul J ^a   Kola, Ismail ^a,b  

^a MONASH UNIVERSITY   (Australia)

^b PFIZER INC   (United States)

Author keywords

Apoptosis; CBP; Ets1; p53; UV

Indexed keywords

DNA; HISTONE ACETYLTRANSFERASE; PROTEIN P53; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETS 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; DNA DAMAGE; DNA PROTEIN COMPLEX; EMBRYO; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL; STEM CELL; ULTRAVIOLET IRRADIATION;

ACETYLATION; ACETYLTRANSFERASES; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL COMPARTMENTATION; CELL CYCLE; CELLS, CULTURED; CHROMATIN; CREB-BINDING PROTEIN; CYCLINS; DNA; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENE TARGETING; GENES, P53; HISTONE ACETYLTRANSFERASES; HISTONES; MACROMOLECULAR SUBSTANCES; MEMBRANE PROTEINS; MICE; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEIN C-ETS-1; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-ETS; PROTO-ONCOGENE PROTEINS C-MDM2; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE PROTEINS; STEM CELLS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

ANIMALIA;

EID: 0036683054     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf413     Document Type: Article

References (71)

1. ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage
2. HTLV-1 tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration
3. PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family
4. Recruitment of p300/CBP in p53-dependent signal pathways
5. CBP-induced stimulation of c-Fos activity is abrogated by E1A
6. Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases
7. Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene
8. Tissue and cell-specific expression of the p53-target gene: Bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice
9. Growth factor modulation of p53-mediated growth arrest versus apoptosis
10. p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage
11. Thymocyte apoptosis induced by p53-dependent and independent pathways
12. P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells
13. CBP as a transcriptional coactivator of c-Myb
14. 1 arrest
15. Definition of a consensus binding site for p53
16. WAF1, a potential mediator of p53 tumor suppression
17. Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment
18. A selective procedure for DNA extraction from apoptotic cells applicable for ge1 electrophoresis and flow cytometry
19. 1-phase checkpoint by low-oxygen conditions is independent of p53 status
20. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
21. The human blastocyst: Cell number, death and allocation during late preimplantation development in vitro
22. Mdm2 promotes the rapid degradation of p53
23. Hypersensitivity to DNA damage leads to increased apoptosis during early mouse development
24. A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons α and β and alters macrophage responses
25. p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2
26. p300/cAMP-responsive element-binding protein interactions with ets-1 and ets-2 in the transcriptional activation of the human stromelysin promoter
27. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
28. Functional activation of p53 via phosphorylation following DNA damage by UV but not γ radiation
29. p53: Puzzle and paradigm
30. The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formation
31. Regulation of p53 stability by Mdm2
32. Phosphorylation of p53 serine 15 increases interaction with CBP
33. Adenovirus E1A downregulates cJun- and JunB-mediated transcription by targeting their coactivator p300
34. The Ets family contains transcriptional activators and repressors involved in angiogenesis
35. p53, the cellular gatekeeper for growth and division
36. The p42 variant of ETS1 protein rescues defective Fas-induced apoptosis in colon carcinoma cells
37. EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes
38. Binding and modulation of p53 by p300/CBP coactivators
39. 1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
40. The phosphoprotein p53 is down-regulated post transcriptionally during embryogenesis in vertebrates
41. p53 is required for radiation-induced apoptosis in mouse thymocytes
42. Ultraviolet radiation, but not γ radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389
43. Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP
44. Differential expression of ets-1 and ets-2 proto-oncogenes during murine embryogenesis
45. The mitochondrial F0F1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells
46. Multisite phosphorylation and the integration of stress signals at p53
47. Defective activation and survival of T cells lacking the Ets-1 transcription factor
48. Angiogenesis inhibition by transdominant mutant ets1
49. Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type I interferon receptor, IFNAR 2
50. The mdm-2 gene is induced in response to UV light in a p53-dependent manner
51. Regulation of ES cell differentiation by functional and conformational modulation of p53
52. DNA damage activates p53 through a phosphorylation-acetylation cascade
53. Contrasting patterns of retinoblastoma protein expression in mouse embryonic stem cells and embryonic fibroblasts
54. Expression of p53 during mouse embryogenesis
55. A family of octamer-specific proteins present during mouse embryogenesis: Evidence for germline-specific expression of an Oct factor
56. Regulation of the human stress response gene GADD153 expression: Role of ETS1 and FLI-1 gene products
57. Analysis of promoter binding by the E2F and pRB families in vivo: Distinct E2F proteins mediate activation and repression
58. Role of transcription factor Ets1 in the apoptosis of human vascular endothelial cells
59. ETS1 transactivates the human GM-CSF promoter in Jurkat T cells stimulated with PMA and ionomycin
60. The tumor suppressor protein p53 requires a cofactor to transcriptionally activate the human bax promoter
61. Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs)
62. Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
63. ETS1 and ETS2 in p53 regulation: Spatial separation of ETS binding sites (EBS) modulate protein: DNA interaction
64. Conserved mechanisms of Ras regulation of evolutionary related transcription factors, Ets1 and Pointed P2
65. ETS family of transcription factors
66. Development and characterization of recombinant adenoviruses encoding human p53 for gene therapy of cancer
67. Characterization of a pluripotent stem cell line derived from a mouse embryo
68. A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functions
69. Individual promoter and intron p53-binding motifs from the rat Cyclin G1 promoter region support transcriptional activation by p53 but do not show co-operative activation
70. Identification of p53 target genes through immune selection of genomic DNA: The cyclin G gene contains two distinct p53 binding sites
71. A functional p53-responsive intronic promoter is contained within the human mdm2 gene