When lysosomes get old

Experimental Gerontology

Volumn 35, Issue 2, 2000, Pages 119-131

  Cuervo, Ana Maria ^a   Dice, J Fred ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

amyloid deposits; Aging; Endosomal system; Lipofuscin deposits; Lysosomal; Protein degradation; Senescence

Indexed keywords

ADVANCED GLYCATION END PRODUCT; AMYLOID BETA PROTEIN; BETA GALACTOSIDASE; CELL PROTEIN; CHAPERONE; HEAT SHOCK PROTEIN; LIPOFUSCIN;

AGING; AUTOPHAGY; CATABOLISM; ENDOCYTOSIS; GERIATRICS; HUMAN; LYSOSOME; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; SENESCENCE;

AGING; ANIMALS; HUMANS; LYSOSOMES; PEPTIDE HYDROLASES; PROTEINS;

EID: 0034113064     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(00)00075-9     Document Type: Review

References (69)

1. Afshari C., Barret J. Molecular genetics of in vitro cellular senescence. In N Holbrrok, G Martin & R Lockshin (Eds). Cellular Aging and Cell Death. 1996;109-121 Wiley-Liss Inc, New York.
2. Agarraberes F., Terlecky S.R., Dice J.F. An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation. J Cell Biol. 137:1997;825-834.
3. Araki N., Ueno N., Chacrabarti B., Morino Y., Horiuchi S. Immunochemical evidence for the presence of advanced glycation end products in human lens proteins and its positive correlation with aging. J Biol Chem. 267:1992;10211-10214.
4. Bednarski E., Ribak C.E., Lynch G. Suppression of cathepsins B and L causes a proliferation of lysosomes and the formation of meganeurites in hippocampus. J Neurosci. 17:1997;4006-4021.
5. Bi X., Pinkstaff J., Nguyen K., Gall C., Lynch G. Experimentally induced lysosomal dysfunction disrupts processing of hypothalamic releasing factors. J Comp Neurol. 401:1998;382-394.
6. Borg W., During M., Sherwin R., Borg M., Brines M., Shulman G. Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia. J Clinical Invest. 93:1994;1677-1682.
7. Bowers W. Christian de Duve and the discovery of lysosomes and peroxisomes. Trends Cell Biol. 8:1998;330-333.
8. Carafoli, E. & Molinari, M. (1998). Calpain - a protease in search of function [Review]. Biochem Biophys Res Comm 247, 193-203.
9. Choppra V., Moozar K., Mehindate K., Schipper H. A cellular stress model for the differential expression of glial lysosomal cathepsins in the aging nervous system. Exp Neurol. 147:1997;221-228.
10. Chu T., Tran T., Yang F., Beech W., Cole G., Frautschy S. Effect of chloroquine and leupeptin on intracellular accumulation of amyloid-beta (AB) 1-42 peptide in a murine N9 microglial cell line. FEBS Lett. 436:1998;439-444.
11. Cingle K., Kalski R., Bruner W., O'Brien C., Erhard P., Wyszynski R. Age-related changes of glycosidases in human retinal pigment epithelium. Curr Eye Res. 15:1996;433-438.
12. Cuervo A., Dice J. How do intracellular proteolytic systems change with age? Frontiers Biosci. 3:1998;25-43.
13. Cuervo A., Dice J.F. A receptor for the selective uptake and degradation of proteins by lysosomes. Science. 273:1996;501-503.
14. Cuervo A., Dice J. Lysosomes, a meeting point of proteins, chaperones, and proteases. J Mol Med. 76:1998;6-12.
15. Cuervo A., Dice J.F., Knecht E. A lysosomal population responsible for the hsc73-mediated degradation of cytosolic proteins in lysosomes. J Biol Chem. 272:1997;5606-5615.
16. Dean R., Stocker S.F.R., Davies M.J. Biochemistry and pathology of radical-mediated protein oxidation. Biochem J. 324:1997;1-18.
17. DeMartino G., Slaughter C. The proteasome, a novel protease regulated by multiple mechanisms [Review]. J Biol Chem. 274:1999;22123-22126.
18. Dice J.F. Altered degradation of proteins microinjected into senescent human fibroblasts. J Biol Chem. 257:1982;14624-14627.
19. Dice J. F. (1993). Cellular and molecular mechanisms of aging. Physiol Rev 73, 149-159.
20. Dice, J. F. (2000). Lysosomal Pathways of Protein Degradation Landes Bioscience, Austin, TX.
21. Dimri G., Lee X., Basile G., et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA. 92:1995;9363-9367.
22. Dini L., Rossi L., Marchese E., Tuzittu M., Rotilio G. Age-related changes in the binding and uptake of Cu, Zn superoxide dismutase in rat liver cells. Mech Ageing Dev. 90:1996;21-33.
23. Economou A., Wickner W. SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion. Cell. 78:1994;835-843.
24. Frautschy S., Horn D., Sigel J., Harris-White M., Mendoza J., Yang F., Saido T., Cole G. Protease inhibitor coinfusion with amyloid β-protein results in enhanced deposition and toxicity in rat brain. J Neurosci. 18:1998;8311-8321.
25. Gafni A. Structural modifications of proteins during aging. J Am Geriatric Soc. 45:1997;871-880.
26. +2-dependent thiol protease) in erythrocytes of young and old individuals. Proc Natl Acad Sci USA. 91:1994;7879-7883.
27. Gracy R., Talent J., Zvaigzne A. Molecular wear and tear leads to terminal marking and the unstable isoforms of aging. J Exp Zool. 282:1998;18-27.
28. Gurley R., Dice J.F. Degradation of endocytosed proteins is unaltered in senescent human fibroblasts. Cell Biol Int Rep. 12:1988;885-894.
29. Haas C., Mandelkow E. Proteolysis by presenilins and the renaissance of tau. Trends Cell Biol. 9:1999;241-246.
30. Harman D. The biologic clock the mitochondria? J Am Geriatr Soc. 20:1972;145-147.
31. He Y., Kwan W., Steinbrecher U. Effects of oxidized low density lipoprotein on endothelin secretion by cultured endothelial cells and macrophages. Atherosclerosis. 119:1996;107-118.
32. Hochschild, R. (1971). Lysosomes, membranes and aging. Exp Gerontol. 6, 153-166.
33. Jadot M., Wattiaux R., Mainferme F., Dubois F., Claessens A., Wattiaux-De Coninck S. Soluble form of Lamp II in purified rat liver lysosomes. Biochem Biophys Res Comm. 223:1996;353-359.
34. Jurivich D., Qiu L., Welk J.F. Attenuated stress responses in young and old human lymphocytes. Mech Ageing Develop. 94:1997;233-249.
35. Kominami, E., Ezaki, J.M., D, Ishido, K., Uenot, T., & Wolfe, L. (1992). Specific storage of subunit c of mitochondrial ATP synthase in lysosomes of neuronal ceroid lipofuscinosis (Batten's Disease). J Biochem 111, 278-282.
36. Lee H., Paz M.A., Gallop P.M. Low density lipoprotein receptor binding in aging human diploid fibroblasts in culture. J Biol Chem. 257:1982;8912-8918.
37. Lee H., Wei Y. Mutation and oxidative damage of mitochondrial DNA and defective turnover of mitochondria in human aging. J Formosan Med Assoc. 96:1997;770-778.
38. Li K., Greenwald I. HOP-1 a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 p, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling. Proc Nat Acad Sci. 94:1997;12204-12209.
39. Makrides S. Protein synthesis and degradation during aging and senescence. Biol Rev. 83:1983;393-422.
40. Malorni W., Testa U., Rainaldi G., Tritarelli E., Peschle C. Oxidative stress leads to a rapid alteration of transferrin receptor intravesicular trafficking. Exp Cell Res. 241:1998;102-116.
41. Martin G., Austad S., Johnson T. Genetic analysis of aging role of oxidative damage and evironmental stresses . Nature Genetics. 13:1996;25-30.
42. Miller, R. (1999). Aging and Immune Function. In W. Paul (Ed), Fundamental Immunology (pp. 947-966). Philadelphia: Lippincott-Raven Publishers.
43. Mizushima N., Noda T., Yoshimori T., Tanaka Y., Ishii T., George M.D., Klionsky D.J., Ohsumi M., Ohsumi Y.A. Protein conjugation system essential for autophagy. Nature. 395:1998;395-398.
44. Mortimore, G., Miotto, G., Venerando, R., & Kadowaki, M. (1996). Autophagy Biochem 27, 93-135.
45. Orr W., Sohal R. Extension of life span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science. 263:1994;1128-1130.
46. Paresce D., Chung H., Maxfield F. Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells. J Biol Chem. 272:1996;29390-29397.
47. Peterson S., Klabunde T., Lahuel H., Purkey H., Sacchettini J., Kelly J. Inhibition transthyretin conformational changes that lead to amyloid fibril formation. Proc Nat Acad Sci. 95:1998;12956-12960.
48. Prasanna H., Lane R. Protein degradation in aged nematodes (Turbatrix aceti). Biochem Biophys Res Comm. 86:1979;552-559.
49. Reznick A., Gershon D. The effect of age on the protein degradation system in the nematode Turbatrix aceti. Mech Ageing Develop. 11:1979;403-415.
50. Saito K., Elce J.S., Hamos J.E., Nixon R.A. Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer's disease a potential molecular basis for neuronal degeneration . Proc Natl Acad Sci USA. 90:1993;2628-2632.
51. Sakai Y., Koller A., Rangell L., Keller G., Subramani S. Peroxisome degradation by microautophagy in Pichia pastoris. Identification of specific steps and morphological intermediates. J Cell Biol. 141:1998;625-636.
52. Seglen P., Gordon P., Holen I. Nonselective autophagy. Semin Cell Biol. 1:1990;441-448.
53. Shang F., Gong X., Palmer H.J., Nowell T.R., Taylor A. Age-related decline in ubiquitin conjugation in response to oxidative stress in the lens. Exp Eye Res. 64:1997;21-30.
54. Shibatani T., Ward W. Effect of age and food restriction on alkaline protease activity in rat liver. J Gerontol. 51:1996;B316-B322.
55. Sinclair D., Guarente L. Extrachromosomal rDNA circles- A cause of aging in yeast. Cell. 91:1997;1033-1042.
56. Sleat D.E., Donnelly R.J., Lackland H., Liu C.G., Sohar I., Pullarkat R.K., Lobel P. Association of mutations in a lysosomal protein with classical late-infantile neuronal ceroid lipofuscinosis. Science. 277:1997;1802-1805.
57. Subramani S. Components involved in peroxisome import, biogenesis, proliferation, turnover, and movement. Physiol Rev. 78:1998;1-18.
58. Sukharev S., Pleshakova O., Moshinikova A., Sadovnikov V., Gaziev A. Age- and radiation-dependent changes in carbonyl content, susceptibility to proteolysis, and antigenicity of soluble rat liver proteins. Comp Biochem Physiol. 116:1997;333-338.
59. Terman A. The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocyte. Gerontology. 41:1995;319-325.
60. Terman, A. & Brunk, U. (1998). Lipofuscin - mechanisms of formation and increase with age [Review]. APMIS 106, 265-276.
61. Terman, A., Dalen, H., & Brunk, V.T. (1999). Ceroid/lipofuscin-loaded human fibroblasts show decreased survival time and diminished autophagocytosis during amino acid starvation. Exp Gerontol 34, 943-957.
62. Tomkinson B. Tripeptidyl peptidases enzymes that count . Trends Biochem Sci. 24:1999;355-359.
63. van den Hove M., Couvreur M., Authelet M., Neve P. Age delays thyroglobulin progression towards dense lysosomes in the cream hamster thyroid. Cell Tissue Res. 294:1998;125-135.
64. Vetvicka V., Tlaskalova-Hogenova A., Pospisil M. Impaired antigen presenting function of macrophages from aged mice. Immunol Invest. 14:1985;105-114.
65. Vines D., Warburton M.J. Purification and characterization of a tripeptidyl aminopeptidase I from rat spleen. Biochim Biophys Acta. 1384:1998;233-242.
66. Ward, W. & Shibatani, T. (1994). Dietary modulation of protein turnover. In B. Yu (Ed). Modulation of Aging Processes by Dietary Restriction (pp. 121-142). Boca Raton, FL: CRC Press.
67. Werb Z. ECM and cell surface proteolysis regulating cellular ecology . Cell. 91:1997;439-442.
68. Wright W., Brassiskyte D., Piatyszek M., Shay J. Experimental elongation of telomeres extends the lifespan of immortal x normal cell hybrids. EMBO J. 15:1996;1734-1741.
69. Yokota S. Formation of autophagosomes during degradation of excess peroxisomes induced by administration of dioctyl phthalate. Eur J Cell Biol. 61:1993;67-80.