Interaction of herbal compounds with biological targets: A case study with berberine

The Scientific World Journal

Volumn 2012, Issue , 2012, Pages

  Chen, Xiao Wu ^a   Di, Yuan Ming ^b   Zhang, Jian ^c   Zhou, Zhi Wei ^b   Li, Chun Guang ^b   Zhou, Shu Feng ^b,d  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b RMIT UNIVERSITY   (Australia)

^c Third Hospital of Nanchang   (China)

^d UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACTIVATING TRANSCRIPTION FACTOR 3; ALPHA FETOPROTEIN; AMYLOID PRECURSOR PROTEIN; ARYLAMINE ACETYLTRANSFERASE; BERBERINE; BREAST CANCER RESISTANCE PROTEIN; CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN E; CYTOCHROME C1; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; EZRIN; FLICE INHIBITORY PROTEIN; GELATINASE A; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 3; PROTEIN BCL X; PROTEIN BID; PROTEIN P53; BIOPOLYMER; HERBACEOUS AGENT;

ANGIOGENESIS; ANTIDIABETIC ACTIVITY; APOPTOSIS; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG TARGETING; HUMAN; HUNTINGTON CHOREA; INTRACELLULAR SIGNALING; REVIEW; SYSTEMATIC REVIEW; ARTICLE; CELL CULTURE; DRUG EFFECT; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

BERBERINE; BIOPOLYMERS; CELLS, CULTURED; DRUGS, CHINESE HERBAL; HUMANS; SIGNAL TRANSDUCTION;

EID: 84871393082     PISSN: 1537744X     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/2012/708292     Document Type: Review

References (125)

1. Zheng C. J., Han L. Y., Yap C. W., Xie B., Chen Y. Z., Trends in exploration of therapeutic targets. Drug News and Perspectives 2005 18 2 109 127 2-s2.0-18744405409 10.1358/dnp.2005.18.2.886480 (Pubitemid 40674901)
2. Bryant B., Knights K., Pharmacology for Health Professionals 2011 3rd Chatswood, Australia Mosby Elsevier
3. Hopkins A. L., Groom C. R., The druggable genome. Nature Reviews Drug Discovery 2002 1 9 727 730 2-s2.0-0036717194 (Pubitemid 37361545)
4. Zheng C. J., Han L. Y., Yap C. W., Ji Z. L., Cao Z. W., Chen Y. Z., Therapeutic targets: progress of their exploration and investigation of their characteristics. Pharmacological Reviews 2006 58 2 259 279 2-s2.0-33646754515 10.1124/pr.58.2.4
5. Drews J., Genomic sciences and the medicine of tomorrow. Nature Biotechnology 1996 14 11 1516 1518 2-s2.0-0030274647
6. Drews J., Ryser S., The role of innovation in drug development. Nature Biotechnology 1997 15 13 1318 1319 2-s2.0-0031304155
7. Lipinski C. A., Lombardo F., Dominy B. W., Feeney P. J., Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Advanced Drug Delivery Reviews 2001 46 1-3 3 26 2-s2.0-0035289779 10.1016/S0169-409X(00)00129-0 (Pubitemid 33653411)
8. Chen X., Zheng C. J., Han L. Y., Xie B., Chen Y. Z., Trends in the exploration of therapeutic targets for the treatment of endocrine, metabolic and immune disorders. Endocrine, Metabolic and Immune Disorders 2007 7 3 225 231 2-s2.0-34848920823 10.2174/187153007781662576 (Pubitemid 47496629)
9. Chen X., Ji Z. L., Chen Y. Z., TTD: therapeutic target database. Nucleic Acids Research 2002 30 1 412 415 2-s2.0-0036084258 (Pubitemid 34679600)
10. Qiu J., Traditional medicine: a culture in the balance. Nature 2007 448 7150 126 128 2-s2.0-34447512705 10.1038/448126a (Pubitemid 47067352)
11. Stone R., Biochemistry: lifting the veil on traditional Chinese medicine. Science 2008 319 5864 709 710 2-s2.0-38949153147 10.1126/science.319.5864.709 (Pubitemid 351225838)
12. Barnes P., Powell-Griner E., McFann K., Nahin R., Complementary and alternative medicine use among adults: United States, 2002. Advanced Data From Vital and Health Statistics 343 Hyattsville, Md, USA National Center for Health Statistics
13. Ernst E., Pittler M. H., Herbal medicine. Medical Clinics of North America 2002 86 1 149 161 2-s2.0-0036136476 10.1016/S0025-7125(03)00077-4 (Pubitemid 34028003)
14. Yin J., Xing H., Ye J., Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism: Clinical and Experimental 2008 57 5 712 717 2-s2.0-42949145899 10.1016/j.metabol.2008.01.013 (Pubitemid 351608234)
15. Grycová L., Dostál J., Marek R., Quaternary protoberberine alkaloids. Phytochemistry 2007 68 2 150 175 2-s2.0-33845898831 10.1016/j.phytochem.2006.10.004 (Pubitemid 46027170)
16. Xie W., Du L., Diabetes is an inflammatory disease: evidence from traditional Chinese medicines. Diabetes, Obesity and Metabolism 2011 13 4 289 301 2-s2.0-79951931336 10.1111/j.1463-1326.2010.01336.x
17. Schoenbart B., Ellen S., Traditional Chinese Medicine for the Digestive System. 2007, http://health.howstuffworks.com/wellness/natural-medicine/chinese/ traditional-chinese-medicine-for-the-digestive-system.htm
18. Ho Y. T., Lu C. C., Yang J. S., Chiang J. H., Li T. C., Ip S. W., Hsia T. C., Liao C. L., Lin J. G., Wood W. G., Chung J. G., Berberine induced apoptosis via promoting the expression of caspase-8, -9 and -3, apoptosis-inducing factor and endonuclease G in SCC-4 human tongue squamous carcinoma cancer cells. Anticancer Research 2009 29 10 4063 4070 2-s2.0-71949097349
19. Hsu W. H., Hsieh Y. S., Kuo H. C., Teng C. Y., Huang H. I., Wang C. J., Yang S. F., Liou Y. S., Kuo W. H., Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL. Archives of Toxicology 2007 81 10 719 728 2-s2.0-34848844388 10.1007/s00204-006-0169-y (Pubitemid 47512599)
20. Katiyar S. K., Meeran S. M., Katiyar N., Akhtar S., P53 cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo. Molecular Carcinogenesis 2009 48 1 24 37 2-s2.0-58849122415 10.1002/mc.20453
21. Mantena S. K., Sharma S. D., Katiyar S. K., Berberine inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase 3 and PARP. Carcinogenesis 2006 27 10 2018 2027 2-s2.0-33748924524 10.1093/carcin/bgl043 (Pubitemid 44530576)
22. Auyeung K. K. W., Ko J. K. S., Coptis chinensis inhibits hepatocellular carcinoma cell growth through nonsteroidal anti-inflammatory drug-activated gene activation. International Journal of Molecular Medicine 2009 24 4 571 577 2-s2.0-70350752049 10.3892/ijmm-00000267
23. Inoue K., Kulsum U., Chowdhury S. A., Fujisawa S. I., Ishihara M., Yokoe I., Sakagami H., Tumor-specific cytotoxicity and apoptosis-inducing activity of berberines. Anticancer Research 2005 25 6 4053 4059 2-s2.0-27944448368 (Pubitemid 41665185)
24. Lin J. P., Yang J. S., Lee J. H., Hsieh W. T., Chung J. G., Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU-5 cell line. World Journal of Gastroenterology 2006 12 1 21 28 2-s2.0-31144440676
25. Choi M. S., Yuk D. Y., Oh J. H., Jung H. Y., Han S. B., Moon D. C., Hong J. T., Berberine inhibits human neuroblastoma cell growth through induction of p53-dependent apoptosis. Anticancer Research 2008 28 6 3777 3784 2-s2.0-58149163569
26. Tang F., Wang D., Duan C., Huang D., Wu Y., Chen Y., Wang W., Xie C., Meng J., Wang L., Wu B., Liu S., Tian D., Zhu F., He Z., Deng F., Cao Y., Berberine inhibits metastasis of nasopharyngeal carcinoma 5-8F cells by targeting rho kinase-mediated ezrin phosphorylation at threonine 567. Journal of Biological Chemistry 2009 284 40 27456 27466 2-s2.0-70350459062 10.1074/jbc.M109.033795
27. Fukuda K., Hibiya Y., Mutoh M., Koshiji M., Akao S., Fujiwara H., Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. Journal of Ethnopharmacology 1999 66 2 227 233 2-s2.0-0032985993 10.1016/S0378-8741(98)00162-7 (Pubitemid 29307925)
28. Chung J. G., Chen G. W., Hung C. F., Lee J. H., Ho C. C., Ho H. C., Chang H. L., Lin J. G., Effects of berberine on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adduct formation in human leukemia cells. American Journal of Chinese Medicine 2000 28 2 227 238 2-s2.0-0033656074
29. Choi M. S., Oh J. H., Kim S. M., Jung H. Y., Yoo H. S., Lee Y. M., Moon D. C., Han S. B., Hong J. T., Berberine inhibits p53-dependent cell growth through induction of apoptosis of prostate cancer cells. International Journal of Oncology 2009 34 5 1221 1230 2-s2.0-67649438659 10.3892/ijo-00000250
30. Mantena S. K., Sharma S. D., Katiyar S. K., Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells. Molecular Cancer Therapeutics 2006 5 2 296 308 2-s2.0-33644984254 10.1158/1535-7163.MCT-05-0448
31. Lin C. C., Kao S. T., Chen G. W., Ho H. C., Chung J. G., Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3. Anticancer Research 2006 26 1 227 242 2-s2.0-32144452226
32. Luo Y., Hao Y., Shi T. P., Deng W. W., Li N., Berberine inhibits cyclin D1 expression via suppressed binding of AP-1 transcription factors to CCND1 AP-1 motif. Acta Pharmacologica Sinica 2008 29 5 628 633 2-s2.0-42649138316 10.1111/j.1745-7254.2008.00786.x (Pubitemid 351601448)
33. Jantova S., Cipak L., Letasiova S., Berberine induces apoptosis through a mitochondrial/caspase pathway in human promonocytic U937 cells. Toxicology in Vitro 2007 21 1 25 31 2-s2.0-33845219352 10.1016/j.tiv.2006.07.015 (Pubitemid 44855510)
34. Ho Y. T., Yang J. S., Li T. C., Lin J. J., Lin J. G., Lai K. C., Ma C. Y., Wood W. G., Chung J. G., Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF- B, u-PA and MMP-2 and -9. Cancer Letters 2009 279 2 155 162 2-s2.0-67349103384 10.1016/j.canlet.2009.01.033
35. Li H., Guo L., Jie S., Liu W., Zhu J., Du W., Fan L., Wang X., Fu B., Huang S., Berberine inhibits SDF-1-induced AML cells and leukemic stem cells migration via regulation of SDF-1 level in bone marrow stromal cells. Biomedicine and Pharmacotherapy 2008 62 9 573 578 2-s2.0-54049094704 10.1016/j.biopha.2008.08.003
36. + related to the cellular DNA damage response. Molecular and General Genetics 2001 265 2 264 275 2-s2.0-0035049319
37. Chen Y., Li Y., Wang Y., Wen Y., Sun C., Berberine improves free-fatty-acid-induced insulin resistance in L6 myotubes through inhibiting peroxisome proliferator-activated receptor γ and fatty acid transferase expressions. Metabolism: Clinical and Experimental 2009 58 12 1694 1702 2-s2.0-71849091184 10.1016/j.metabol.2009.06.009
38. Kong W. J., Zhang H., Song D. Q., Xue R., Zhao W., Wei J., Wang Y. M., Shan N., Zhou Z. X., Yang P., You X. F., Li Z. R., Si S. Y., Zhao L. X., Pan H. N., Jiang J. D., Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression. Metabolism: Clinical and Experimental 2009 58 1 109 119 2-s2.0-57049090579 10.1016/j.metabol.2008.08. 013
39. Pan G. Y., Huang Z. J., Wang G. J., Fawcett J. P., Liu X. D., Zhao X. C., Sun J. G., Xie Y. Y., The antihyperglycaemic activity of berberine arises from a decrease of glucose absorption. Planta Medica 2003 69 7 632 636 2-s2.0-0041379639 10.1055/s-2003-41121 (Pubitemid 37041059)
40. Wang Z. S., Lu F. E., Xu L. J., Dong H., Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells. Acta Pharmacologica Sinica 2010 31 5 578 584 2-s2.0-77952060625 10.1038/aps.2010.30
41. Yu Y., Liu L., Wang X., Liu X., Liu X., Xie L., Wang G., Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studies. Biochemical Pharmacology 2010 79 7 1000 1006 2-s2.0-77449089475 10.1016/j.bcp.2009.11.017
42. Yu J., Piao B. K., Pei Y. X., Qi X., Hua B. J., Protective effects of tetrahydropalmatine against γ -radiation induced damage to human endothelial cells. Life Sciences 2010 87 1-2 55 63 2-s2.0-77953959013 10.1016/j.lfs.2010.05.011
43. Liu L., Yu Y. L., Yang J. S., Li Y., Liu Y. W., Liang Y., Liu X. D., Xie L., Wang G. J., Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study. Naunyn-Schmiedeberg's Archives of Pharmacology 2010 381 4 371 381 2-s2.0-77953231411 10.1007/s00210-010-0502-0
44. Tang L. Q., Wei W., Chen L. M., Liu S., Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. Journal of Ethnopharmacology 2006 108 1 109 115 2-s2.0-33749327046 10.1016/j.jep.2006.04. 019 (Pubitemid 44498992)
45. Wang C., Li J., Lv X., Zhang M., Song Y., Chen L., Liu Y., Ameliorative effect of berberine on endothelial dysfunction in diabetic rats induced by high-fat diet and streptozotocin. European Journal of Pharmacology 2009 620 1-3 131 137 2-s2.0-70349157209 10.1016/j.ejphar.2009.07.027
46. Xia X., Yan J., Shen Y., Tang K., Yin J., Zhang Y., Yang D., Liang H., Ye J., Weng J., Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis. PLoS ONE 2011 6 2 2-s2.0-79751496044 10.1371/journal.pone.0016556 e16556
47. Wajchenberg B. L., β -cell failure in diabetes and preservation by clinical treatment. Endocrine Reviews 2007 28 2 187 218 2-s2.0-34249682591 10.1210/10.1210/er.2006-0038 (Pubitemid 46984834)
48. Giugliano D., Standl E., Vilsboll T., Betteridge J., Bonadonna R., Campbell I. W., Schernthaner G. H., Staels B., Trichopoulou A., Farinaro E., Is the current therapeutic armamentarium in diabetes enough to control the epidemic and its consequences? What are the current shortcomings? Acta Diabetologica 2009 46 3 173 181 2-s2.0-69849098540 10.1007/s00592-009-0134-3
49. Heine R. J., Diamant M., Mbanya J. C., Nathan D. M., Management of hyperglycaemia in type 2 diabetes. British Medical Journal 2006 333 7580 1200 1204 2-s2.0-33845569755 10.1136/bmj.39022.462546.80 (Pubitemid 44935386)
50. Lu S. S., Yu Y. L., Zhu H. J., Liu X. D., Liu L., Liu Y. W., Wang P., Xie L., Wang G. J., Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic rats. Journal of Endocrinology 2009 200 2 159 165 2-s2.0-67449164807 10.1677/JOE-08-0419
51. Zhou J., Zhou S., Tang J., Zhang K., Guang L., Huang Y., Xu Y., Ying Y., Zhang L., Li D., Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats. European Journal of Pharmacology 2009 606 1-3 262 268 2-s2.0-60949108484 10.1016/j.ejphar.2008.12. 056
52. Hone J., Accili D., Al-Gazali L. I., Lestringant G., Orban T., Taylor S. I., Homozygosity for a new mutation (Ile119→Met) in the insulin receptor gene in five sibs with familial insulin resistance. Journal of Medical Genetics 1994 31 9 715 716 2-s2.0-0028111140
53. Holst J. J., The physiology of glucagon-like peptide 1. Physiological Reviews 2007 87 4 1409 1439 2-s2.0-35748957503 10.1152/physrev.00034.2006 (Pubitemid 350041474)
54. Lee Y. S., Kim W. S., Kim K. H., Yoon M. J., Cho H. J., Shen Y., Ye J. M., Lee C. H., Oh W. K., Kim C. T., Hohnen-Behrens C., Gosby A., Kraegen E. W., James D. E., Kim J. B., Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 2006 55 8 2256 2264 2-s2.0-33749336146 10.2337/db06-0006 (Pubitemid 44743622)
55. Leng S. H., Lu F. E., Xu L. J., Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion. Acta Pharmacologica Sinica 2004 25 4 496 502 2-s2.0-1842708890
56. Wang Y., Campbell T., Perry B., Beaurepaire C., Qin L., Hypoglycemic and insulin-sensitizing effects of berberine in high-fat diet- and streptozotocin-induced diabetic rats. Metabolism: Clinical and Experimental 2011 60 2 298 305 2-s2.0-78751647742 10.1016/j.metabol.2010.02.005
57. Dong S. F., Hong Y., Liu M., Hao Y. Z., Yu H. S., Liu Y., Sun J. N., Berberine attenuates cardiac dysfunction in hyperglycemic and hypercholesterolemic rats. European Journal of Pharmacology 2011 660 2-3 368 374 2-s2.0-79956072587 10.1016/j.ejphar.2011.03.024
58. Zhou J. Y., Zhou S. W., Zhang K. B., Tang J. L., Guang L. X., Ying Y., Xu Y., Zhang L., Li D. D., Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats. Biological and Pharmaceutical Bulletin 2008 31 6 1169 1176 2-s2.0-45749144363 10.1248/bpb.31.1169 (Pubitemid 351871171)
59. Chang X., Yan H., Fei J., Jiang M., Zhu H., Lu D., Gao X., Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats. Journal of Lipid Research 2010 51 9 2504 2515 2-s2.0-77956864571 10.1194/jlr.M001958
60. Manley S., Haemoglobin A1c-a marker for complications of type 2 diabetes: the experience from the UK Prospective Diabetes Study (UKPDS). Clinical Chemistry and Laboratory Medicine 2003 41 9 1182 1190 2-s2.0-0142093127 10.1515/CCLM.2003.182 (Pubitemid 37265697)
61. Zhang Y., Li X., Zou D., Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. The Journal of Clinical Endocrinology & Metabolism 2008 93 2559 2565 10.1210/jc.2007-2404 (Pubitemid 352008520)
62. Zhang H., Wei J., Xue R., Wu J. D., Zhao W., Wang Z. Z., Wang S. K., Zhou Z. X., Song D. Q., Wang Y. M., Pan H. N., Kong W. J., Jiang J. D., Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism: Clinical and Experimental 2010 59 2 285 292 2-s2.0-74049139484 10.1016/j.metabol.2009.07.029
63. Emslie-Smith A., Boyle D. I. R., Evans J. M. M., Sullivan F., Morris A. D., Contraindications to metformin therapy in patients with type 2 diabetes-a population-based study of adherence to prescribing guidelines. Diabetic Medicine 2001 18 6 483 488 2-s2.0-0034901899 10.1046/j.1464-5491.2001.00509.x (Pubitemid 32738698)
64. Ehrman T. M., Barlow D. J., Hylands P. J., Phytochemical databases of Chinese herbal constituents and bioactive plant compounds with known target specificities. Journal of Chemical Information and Modeling 2007 47 2 254 263 2-s2.0-34247214505 10.1021/ci600288m (Pubitemid 46615931)
65. Newman D. J., Cragg G. M., Snader K. M., Natural products as sources of new drugs over the period 1981-2002. Journal of Natural Products 2003 66 7 1022 1037 2-s2.0-0042844744 10.1021/np030096l (Pubitemid 36909859)
66. Frantz S., Playing dirty. Nature 2005 437 7061 942 943 2-s2.0-27144443099 10.1038/437942a (Pubitemid 41486956)
67. Schreiber S. L., Target-oriented and diversity-oriented organic synthesis in drug discovery. Science 2000 287 5460 1964 1969 2-s2.0-0034678033 10.1126/science.287.5460.1964 (Pubitemid 30158663)
68. Drews J., Drug discovery: a historical perspective. Science 2000 287 5460 1960 1964 2-s2.0-0034677966 10.1126/science.287.5460.1960 (Pubitemid 30158662)
69. Gao J. L., Shi J. M., Lee S. M. Y., Zhang Q. W., Wang Y. T., Angiogenic pathway inhibition of Corydalis yanhusuo and berberine in human umbilical vein endothelial cells. Oncology Research 2009 17 11-12 519 526 2-s2.0-70350484962
70. Lin J. P., Yang J. S., Wu C. C., Lin S. S., Hsieh W. T., Lin M. L., Yu F. S., Yu C. S., Chen G. W., Chang Y. H., Chung J. G., Berberine induced down-regulation of matrix metalloproteinase-1, -2 and -9 in human gastric cancer cells (SNU-5) in vitro. In Vivo 2008 22 2 223 230 2-s2.0-42149164973
71. Lin T. H., Kuo H. C., Chou F. P., Lu F. J., Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide. BMC Cancer 2008 8, article 58 2-s2.0-41549102101 10.1186/1471-2407-8-58 (Pubitemid 351470841)
72. Peng P. L., Hsieh Y. S., Wang C. J., Hsu J. L., Chou F. P., Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Toxicology and Applied Pharmacology 2006 214 1 8 15 2-s2.0-33745001816 10.1016/j.taap.2005.11.010 (Pubitemid 43867664)
73. Brusq J. M., Ancellin N., Grondin P., Guillard R., Martin S., Saintillan Y., Issandou M., Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine. Journal of Lipid Research 2006 47 6 1281 1288 2-s2.0-33744804815 10.1194/jlr.M600020-JLR200 (Pubitemid 43830720)
74. Chi C. W., Chang Y. F., Chao T. W., Chiang S. H., P'eng F. K., Lui W. Y., Liu T. Y., Flowcytometric analysis of the effect of berberine on the expression of glucocorticoid receptors in human hepatoma HepG2 cells. Life Sciences 1994 54 26 2099 2107 2-s2.0-0028301101 10.1016/0024-3205(94)00719-5 (Pubitemid 24193358)
75. Asai M., Iwata N., Yoshikawa A., Aizaki Y., Ishiura S., Saido T. C., Maruyama K., Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease A β secretion. Biochemical and Biophysical Research Communications 2007 352 2 498 502 2-s2.0-33751509301 10.1016/j.bbrc.2006.11.043 (Pubitemid 44838513)
76. Hwang J. M., Kuo H. C., Tseng T. H., Liu J. Y., Chu C. Y., Berberine induces apoptosis through a mitochondria/caspases pathway in human hepatoma cells. Archives of Toxicology 2006 80 2 62 73 2-s2.0-31144436796 10.1007/s00204-005-0014-8 (Pubitemid 43130230)
77. Pandey M. K., Sung B., Kunnumakkara A. B., Sethi G., Chaturvedi M. M., Aggarwal B. B., Berberine modifies cysteine 179 of I B α kinase, suppresses nuclear factor- B-regulated antiapoptotic gene products, and potentiates apoptosis. Cancer Research 2008 68 13 5370 5379 2-s2.0-48549105216 10.1158/0008-5472.CAN-08-0511
78. Lin C. C., Ng L. T., Hsu F. F., Shieh D. E., Chiang L. C., Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth. Clinical and Experimental Pharmacology and Physiology 2004 31 1-2 65 69 2-s2.0-1242337439 10.1111/j.1440-1681.2004.03951.x (Pubitemid 38230750)
79. Lin J. G., Chung J. G., Wu L. T., Chen G. W., Chang H. L., Wang T. F., Effects of berberine on arylamine n-acetyltransferase activity in human colon tumor cells. American Journal of Chinese Medicine 1999 27 2 265 275 2-s2.0-0032617444
80. Wang D. Y., Yeh C. C., Lee J. H., Hung C. F., Chung J. G., Berberine inhibited arylamine N-acetyltransferase activity and gene expression and DNA adduct formation in human malignant astrocytoma (G9T/VGH) and brain glioblastoma multiforms (GBM 8401) cells. Neurochemical Research 2002 27 9 883 889 2-s2.0-0036745996 10.1023/A:1020335430016
81. Kim J. B., Ko E., Han W., Shin I., Park S. Y., Non D. Y., Berberine diminishes the side population and ABCG2 transporter expression in MCF-7 breast cancer cells. Planta Medica 2008 74 14 1693 1700 2-s2.0-57149096060 10.1055/s-0028-1088313
82. Liu J., He C., Zhou K., Wang J., Kang J. X., Coptis extracts enhance the anticancer effect of estrogen receptor antagonists on human breast cancer cells. Biochemical and Biophysical Research Communications 2009 378 2 174 178 2-s2.0-57049110383 10.1016/j.bbrc.2008.10.169
83. Wang X. H., Jiang S. M., Sun Q. W., Effects of berberine on human rheumatoid arthritis fibroblast-like synoviocytes. Experimental Biology and Medicine 2011 236 7 859 866 2-s2.0-79960682120 10.1258/ebm.2011.010366
84. Lin C. C., Lin S. Y., Chung J. G., Lin J. P., Chen G. W., Kao S. T., Down-regulation of cyclin B1 and Up-regulation of Wee1 by berberine promotes entry of leukemia cells into the G2/M-phase of the cell cycle. Anticancer Research 2006 26 2 1097 1104 2-s2.0-33645812966
85. Lin J. P., Yang J. S., Chang N. W., Chiu T. H., Su C. C., Lu K. W., Ho Y. T., Yeh C. C., Ang M. D., Lin H. J., Chung J. G., GADD153 mediates berberine-induced apoptosis in human cervical cancer Ca ski cells. Anticancer Research 2007 27 5 3379 3386 2-s2.0-35348994881
86. Ho Y. T., Yang J. S., Lu C. C., Chiang J. H., Li T. C., Lin J. J., Lai K. C., Liao C. L., Lin J. G., Chung J. G., Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model. Phytomedicine 2009 16 9 887 890 2-s2.0-67650696599 10.1016/j.phymed.2009.02.015
87. Meeran S. M., Katiyar S., Katiyar S. K., Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation. Toxicology and Applied Pharmacology 2008 229 1 33 43 2-s2.0-42749085774 10.1016/j.taap.2007.12.027
88. Nishida S., Kikuichi S., Yoshioka S., Tsubaki M., Fujii Y., Matsuda H., Kubo M., Irimajiri K., Induction of apoptosis in HL-60 cells treated with medicinal herbs. American Journal of Chinese Medicine 2003 31 4 551 562 2-s2.0-1542568491 10.1142/S0192415X03001211 (Pubitemid 41758810)
89. Yan K., Zhang C., Feng J., Hou L., Yan L., Zhou Z., Liu Z., Liu C., Fan Y., Zheng B., Xu Z., Induction of G1 cell cycle arrest and apoptosis by berberine in bladder cancer cells. European Journal of Pharmacology 2011 661 1-3 1 7 2-s2.0-79956225914 10.1016/j.ejphar.2011.04.021
90. Eom K. S., Hong J. M., Youn M. J., So H. S., Park R., Kim J. M., Kim T. Y., Berberine induces G1 arrest and apoptosis in human glioblastoma T98G cells through mitochondrial/caspases pathway. Biological and Pharmaceutical Bulletin 2008 31 4 558 562 2-s2.0-41849122326 10.1248/bpb.31.558 (Pubitemid 351500476)
91. Tsang C. M., Lau E. P. W., Di K., Cheung P. Y., Hau P. M., Ching Y. P., Wong Y. C., Cheung A. L. M., Wan T. S. K., Tong Y., Tsao S. W., Feng Y., Berberine inhibits Rho GTPases and cell migration at low doses but induces G2 arrest and apoptosis at high doses in human cancer cells. International Journal of Molecular Medicine 2009 24 1 131 138 2-s2.0-67649515350 10.3892/ijmm-00000216
92. Liu Z., Liu Q., Xu B., Wu J., Guo C., Zhu F., Yang Q., Gao G., Gong Y., Shao C., Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage. Mutation Research 2009 662 1-2 75 83 2-s2.0-60449106119 10.1016/j.mrfmmm.2008.12.009
93. Cui H. S., Hayasaka S., Zhang X. Y., Hayasaka Y., Chi Z. L., Zheng L. S., Effect of berberine on interleukin 8 and monocyte chemotactic protein 1 expression in a human retinal pigment epithelial cell line. Ophthalmic Research 2006 38 3 149 157 2-s2.0-33646860163 10.1159/000090672 (Pubitemid 43780874)
94. Piyanuch R., Sukhthankar M., Wandee G., Baek S. J., Berberine, a natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells. Cancer Letters 2007 258 2 230 240 2-s2.0-36148962372 10.1016/j.canlet.2007.09.007 (Pubitemid 350110378)
95. Khan M., Giessrigl B., Vonach C., Madlener S., Prinz S., Herbaceck I., Hölzl C., Bauer S., Viola K., Mikulits W., Quereshi R. A., Knasmüller S., Grusch M., Kopp B., Krupitza G., Berberine and a Berberis lycium extract inactivate Cdc25A and induce α -tubulin acetylation that correlate with HL-60 cell cycle inhibition and apoptosis. Mutation Research 2010 683 1-2 123 130 2-s2.0-71549126801 10.1016/j.mrfmmm.2009.11.001
96. Chatterjee P., Franklin M. R., Human cytochrome P450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metabolism and Disposition 2003 31 11 1391 1397 2-s2.0-0142181023 10.1124/dmd.31.11.1391 (Pubitemid 37310329)
97. Wu X., Li Q., Xin H., Yu A., Zhong M., Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. European Journal of Clinical Pharmacology 2005 61 8 567 572 2-s2.0-26244451259 10.1007/s00228-005-0952-3 (Pubitemid 41414240)
98. Budzinski J. W., Trudeau V. L., Drouin C. E., Panahi M., Arnason J. T., Foster B. C., Modulation of human cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp) in Caco-2 cell monolayers by selected commercial-source milk thistle and goldenseal products. Canadian Journal of Physiology and Pharmacology 2007 85 9 966 978 2-s2.0-36549007414 10.1139/Y07-091 (Pubitemid 350189740)
99. Al-Masri I. M., Mohammad M. K., Tahaa M. O., Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine. Journal of Enzyme Inhibition and Medicinal Chemistry 2009 24 5 1061 1066 2-s2.0-74549184604 10.1080/14756360802610761
100. Xu L., Liu Y., He X., Inhibitory effects of berberine on the activation and cell cycle progression of human peripheral lymphocytes. Cellular & Molecular Immunology 2005 2 4 295 300 2-s2.0-42649105371
101. Li H., Dong B., Park S. W., Lee H. S., Chen W., Liu J., Hepatocyte nuclear factor 1 α plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine. Journal of Biological Chemistry 2009 284 42 28885 28895 2-s2.0-70350389729 10.1074/jbc.M109.052407
102. Lin S., Tsai S. C., Lee C. C., Wang B. W., Liou J. Y., Shyu K. G., Berberine inhibits HIF-1 α expression via enhanced proteolysis. Molecular Pharmacology 2004 66 3 612 619 2-s2.0-4944248618 (Pubitemid 39329260)
103. Kuo C. L., Chi C. W., Liu T. Y., Modulation of apoptosis by berberine through inhibition of cyclooxygenase-2 and Mcl-1 expression in oral cancer cells. In Vivo 2005 19 1 247 252 2-s2.0-16244368845
104. Lee C. H., Chen J. C., Hsiang C. Y., Wu S. L., Wu H. C., Ho T. Y., Berberine suppresses inflammatory agents-induced interleukin-1 β and tumor necrosis factor- α productions via the inhibition of I B degradation in human lung cells. Pharmacological Research 2007 56 3 193 201 2-s2.0-34548206790 10.1016/j.phrs.2007.06.003 (Pubitemid 47321202)
105. Kim S., Kim Y., Kim J. E., Cho K. H., Chung J. H., Berberine inhibits TPA-induced MMP-9 and IL-6 expression in normal human keratinocytes. Phytomedicine 2008 15 5 340 347 2-s2.0-41949120203 10.1016/j.phymed.2007.09.011 (Pubitemid 351508395)
106. Abidi P., Zhou Y., Jiang J. D., Liu J., Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine. Arteriosclerosis, Thrombosis, and Vascular Biology 2005 25 10 2170 2176 2-s2.0-26244452375 10.1161/01.ATV.0000181761.16341.2b (Pubitemid 41416317)
107. Cameron J., Ranheim T., Kulseth M. A., Leren T. P., Berge K. E., Berberine decreases PCSK9 expression in HepG2 cells. Atherosclerosis 2008 201 2 266 273 2-s2.0-56649086377 10.1016/j.atherosclerosis.2008.02.004
108. Li Y., Ren G., Wang Y. X., Kong W. J., Yang P., Wang Y. M., Li Y. H., Yi H., Li Z. R., Song D. Q., Jiang J. D., Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes. Journal of Translational Medicine 2011 9, article 62 2-s2.0-79955800843 10.1186/1479-5876-9-62
109. Kim S., Chung J. H., Berberine prevents UV-induced MMP-1 and reduction of type I procollagen expression in human dermal fibroblasts. Phytomedicine 2008 15 9 749 753 2-s2.0-48649104437 10.1016/j.phymed.2007.11.004
110. Guo Y., Wang Q. Z., Li F. M., Jiang X., Zuo Y. F., Wang L., Biochemical pathways in the antiatherosclerotic effect of berberine. Chinese Medical Journal 2008 121 13 1197 1203 2-s2.0-50549086519
111. Min Y. D., Yang M. C., Lee K. H., Kim K. R., Choi S. U., Lee K. R., Protoberberine alkaloids and their reversal activity of P-gp expressed multidrug resistance (MDR) from the rhizome of Coptis japonica makino. Archives of Pharmacal Research 2006 29 9 757 761 2-s2.0-33749331556
112. Lee S., Lim H. J., Park J. H., Lee K. S., Jang Y., Park H. Y., Berberine-induced LDLR up-regulation involves JNK pathway. Biochemical and Biophysical Research Communications 2007 362 853 857 2-s2.0-45849151675 10.1016/j.bbrc.2008.05.111 (Pubitemid 47390652)
113. Hsiang C. Y., Wu S. L., Cheng S. E., Ho T. Y., Acetaldehyde-induced interleukin-1 β and tumor necrosis factor- α production is inhibited by berberine through nuclear factor- B signaling pathway in HepG2 cells. Journal of Biomedical Science 2005 12 5 791 801 2-s2.0-27744437536 10.1007/s11373-005- 9003-4 (Pubitemid 41625945)
114. Hu J. P., Nishishita K., Sakai E., Yoshida H., Kato Y., Tsukuba T., Okamoto K., Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF- B and Akt pathways. European Journal of Pharmacology 2008 580 1-2 70 79 2-s2.0-37648999717 10.1016/j.ejphar.2007.11.013
115. Chao D. C., Lin L. J., Kao S. T., Huang H. C., Chang C. S., Liang J. A., Wu S. L., Hsiang C. Y., Ho T. Y., Inhibitory effects of Zuo-Jin-Wan and its alkaloidal ingredients on activator protein 1, nuclear factor- B, and cellular transformation in HepG2 cells. Fitoterapia 2011 82 4 696 703 2-s2.0-79955478204 10.1016/j.fitote.2011.02.009
116. Wu H. L., Hsu C. Y., Liu W. H., Yung B. Y., Berberine-induced apoptosis of human leukemia HL-60 cells is associated with down-regulation of nucleophosmin/B23 and telomerase activity. International Journal of Cancer 1999 81 923 929 (Pubitemid 29249978)
117. Li Y., Wang P., Zhuang Y., Lin H., Li Y., Liu L., Meng Q., Cui T., Liu J., Li Z., Activation of AMPK by berberine promotes adiponectin multimerization in 3T3-L1 adipocytes. FEBS Letters 2011 585 12 1735 1740 2-s2.0-79958116611 10.1016/j.febslet.2011.04.051
118. Kuo C. L., Chi C. W., Liu T. Y., The anti-inflammatory potential of berberine in vitro and in vivo. Cancer Letters 2004 203 2 127 137 2-s2.0-0346724714 10.1016/j.canlet.2003.09.002 (Pubitemid 38063132)
119. Hsieh Y. S., Kuo W. H., Lin T. W., Chang H. R., Lin T. H., Chen P. N., Chu S. C., Protective effects of berberine against low-density lipoprotein (LDL) oxidation and oxidized LDL-induced cytotoxicity on endothelial cells. Journal of Agricultural and Food Chemistry 2007 55 25 10437 10445 2-s2.0-38049001548 10.1021/jf071868c
120. Hyun W. L., Jung H. S., Kim H. N., A Y. K., So Y. P., Chan S. S., Choi J. Y., Jae B. K., Berberine promotes osteoblast differentiation by Runx2 activation with p38 MAPK. Journal of Bone and Mineral Research 2008 23 8 1227 1237 2-s2.0-47949108989 10.1359/jbmr.080325 (Pubitemid 352042688)
121. Qin Y., Pang J. Y., Chen W. H., Zhao Z. Z., Liu L., Jiang Z. H., Inhibition of DNA topoisomerase I by natural and synthetic mono- and dimeric protoberberine alkaloids. Chemistry and Biodiversity 2007 4 3 481 487
122. Fukuda K., Hibiya Y., Mutoh M., Koshiji M., Akao S., Fujiwara H., Inhibition of activator protein 1 activity by berberine in human hepatoma cells. Planta Medica 1999 65 4 381 383 2-s2.0-0033046099 (Pubitemid 29249921)
123. Kim S., Jae H. C., Jong B. K., Seok J. N., Yang J. H., Kim J. H., Jeong E. L., Berberine suppresses TNF- α -induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast cancer cells. Molecules 2008 13 12 2975 2985 2-s2.0-58149252230 10.3390/molecules13122975
124. Mahata S., Bharti A. C., Shukla S., Tyagi A., Husain S. A., Das B. C., Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells. Molecular Cancer 2011 10, article 39 2-s2.0-79955085632 10.1186/1476-4598-10-39
125. Chen F. L., Yang Z. H., Liu Y., Li L. X., Liang W. C., Wang X. C., Zhou W. B., Yang Y. H., Hu R. M., Berberine inhibits the expression of TNFalpha, MCP-1, and IL-6 in AcLDL-stimulated macrophages through PPARgamma pathway. Endocrine 2008 33 3 331 337 2-s2.0-67449096759 10.1007/s12020-008-9089-3