Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU-5 cell line

World Journal of Gastroenterology

Volumn 12, Issue 1, 2006, Pages 21-28

  Lin, Jing Pin ^a   Yang, Jai Sing ^b   Lee, Jau Hong ^a   Hsieh, Wen Tsong ^a   Chung, Jing Gung ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b YUANPEI UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Berberine; Caspase 3; Cell cycle; MMP; ROS; SNU 5 cells

Indexed keywords

BERBERINE; CALCIUM ION; CASPASE 3; CYCLIN B; CYCLIN DEPENDENT KINASE 1; CYTOCHROME C; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CANCER CELL CULTURE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PROTEIN EXPRESSION; STOMACH CARCINOMA; UPREGULATION; WESTERN BLOTTING;

EID: 31144440676     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v12.i1.21     Document Type: Article

References (26)

1. Kerr JFR, Wylie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics. Cancer 1972, 26: 239-257
2. Ghosh AK, Bhaktachoryya FK, Ghosh DK. Amastigote inhibition and mode of action of berberine. Exp Parasitol 1985; 60: 404-413
3. Hano K. Pharmacological studies on metabolism of cancer tissues: pharmacological studies on carcinostatic effects of some plant components and their derivatives (1). Gann 1957; 48: 443-450
4. Hoshi A, Ikekawa T, Ikeda Y, Shirakawa S, Ligo M, Karetani K, Fukoka F. Antitumor activity of berberrubine derivatives. Gann 1976; 67: 321-325
5. Zhang RX. 1990. Laboratory studies of berberine used alone and in combination with 1,3-bis(2-chloroethyl)-1-nitrosourea to treat malignant brain tumors. Chin Med J 1990; 103: 658-665
6. Yamagish H. Interaction between nuclei acid and berberine sulfate. J Cell Biol 1962; 13: 589-592
7. Li YC, Tyan YS, Kuo HM, Chang WC, Hsia TC, Chung JG. Baicalein induced in vitro apoptosis undergo caspases activity in human promyelocytic leukemia HL-60 cells. Food Chem Toxicol 2004; 42: 37-43
8. Kuo CL, Chou CC, Yung BYM. Berberine complexes with DNA in berberine-induced apoptosis in human leukemia HL-60 cells. Cancer Lett 1995; 93: 193-200
9. Yang IW, Chou CC, Yung BY. Dose-dependent effects of berberine on cell cycle pause and apoptosis in Balb/c 3T3 cells. Naunyn Schmiedebergs Arch Pharmacol 1996; 354: 102-108
10. Lin JP, Lu HF, Lee JH, Lin JG, Hsia TC, Wu LT, Chung JG. (-)-Menthol inhibit DNA topoisomerases I, IIαandβ and promote NF-κB expression in human gastric cancer SNU-5 cells. Anticancer Res (in press), 2005.
11. Lu HF, Sue CC, Yu CS, Chen SC, Chen GW, Chung JG. Diallyl disulfide (DADS) induced apoptosis undergo caspase-3 activity in human bladder cancer T24 cells. Food Chem Toxicol 2004; 42: 1543-1552
12. Chung JG, Yeh KT, Wu SL, Hsu NY, Chen G.W, Yeh YW, Ho HC. Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display. Cancer Res 2001; 61: 8873-8879
13. Hahn FE, Ciak, J Antibiotics, Vol.3. Editors: Gottliele D. P D Shaw J.W. Cocoran. New York: Springer-Verlag, 1975: 577
14. Jantova S, Cipak L, Cermakova, Kost'alova D. Effect of berberine on proliferation, cell cycle and apoptosis in HeLa and L1210 cells. J Pharm Pharmacol 2003; 55: 1143-1149
15. Lin HL, Liu TY, Wu CW, Chi CW. Berberine modulates expression of mdri gene product and the responses of digestive track cancer cells to paclitaxel. Br J Cancer 1999; 81: 416-422
16. Dai X, Yamasaki K, Yang L, Sayama K, Shirakata Y, Tokumara S, Yahata Y, Tohyama M, Hashimoto K. Keratinocyte G2/M growth arrest by 1,25-dihydroxyvitamin D3 is caused by Cdc2 phosphorylation through Wee1 and Myt1 regulation. J Invest Dermatol 2004; 122: 1356-1364
17. Li KK, Motwani M, Tong W, Bornmann W, Schwartz G.K. Huanglian, a Chinese herbal extract, inhibits cell growth by suppressing the expression of cychn B1 and inhibiting CDC2 kinase activity in human cancer cells. Mol Pharmacol 2000; 58: 1287-1293
18. Yuan H, Kamata M, Xie YM, Chen IS. Increased levels of Wee-1 kinase in G(2) are necessary for Vpr- and gamma irradiation-induced G(2) arrest. J Virol 2004; 78: 183-190
19. Stumpff J, Duncan T, Homola E, Campbell SD, Su TT. Drosophila Wee1 kinase regulates Cdk1 and mitotic entry during embryogenesis. Curr Biol 2004; 14: 2143-2148
20. Martin SJ, O'Brien GA, Nishikoa WK, Mcgahon AJ, Mahboubi A, Saido TC, Green DR. Protease activation during apoptosis: Death by a thousand cuts? J Biol Chem 1997; 270: 6425-6431
21. Yang L, MacLellan WR, Han Z, Weiss JN, Qu Z. Multisite phosphorylation and network dynamics of cyclin-dependent kinase signaling in the eukaryotic cell cycle. Biophys J 2004; 86: 3432-3443
22. Krammer PH. CD95 (APO-1/Fas)-mediated apoptosis: live and let die. Adv Immunol 1999; 71: 163-210
23. Panaro NJ, Popescu SR, Harris SR, Thorgeirsson UP. Flavone acetic acid induces a G2/M cell ycle arrest in mammary carcinoma cells. Br J cancer 1999; 80: 1905-1911
24. Thornberry AT, Rosen A, Nicholson DW. Control of apoptosis by proteases. In: Kaufmann SH, ed., Apoptosis. San Diego: Acad Press. 1997: 155-168
25. Donaldson KL, Goolsby G.L, Kiene PA, Wahl AF. Activation of p34cdc2 coincident with taxol-induced apoptosis. Cell Growth Diff 1994; 5: 1041-1050
26. Wartenberg M, Budde P, De Marees M, Grunheck F, Tsang SY, Huang Y, Chen ZY, Hescheler J, Sauer H. Inhibition of tumor-induced angiogenesis and matrix-metalloproteinase expression in confrontation cultures of embryoid bodies and tumor spheroids by plant ingredients used in traditional chinese medicine. Lab Invest 2003; 83: 87-98