Berberine modifies cysteine 179 of IκBα kinase, suppresses nuclear factor-κB-regulated antiapoptotic gene products, and potentiates apoptosis

Cancer Research

Volumn 68, Issue 13, 2008, Pages 5370-5379

  Pandey, Manoj K ^a   Sung, Bokyung ^a   Kunnumakkara, Ajaikumar B ^a   Sethi, Gautam ^a   Chaturvedi, Madan M ^a,b   Aggarwal, Bharat B ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF DELHI   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; BERBERINE; CARCINOGEN; CYCLIN D1; CYCLOOXYGENASE 2; CYSTEINE DERIVATIVE; FLICE INHIBITORY PROTEIN; GELATINASE B; GENE PRODUCT; I KAPPA B ALPHA; IAP1 PROTEIN; IAP2 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL XL; PROTEIN DERIVATIVE; REDUCING AGENT; SURVIVIN; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CYSTEINE; I KAPPA B KINASE;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL INVASION; CELL PROLIFERATION; CORRELATION ANALYSIS; DRUG EFFECT; DRUG INHIBITION; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SITE DIRECTED MUTAGENESIS; TUMOR CELL; BIOLOGICAL MODEL; CANCER INVASION; CELL CULTURE; CELL NUCLEUS; CHEMISTRY; DRUG ANTAGONISM; DRUG POTENTIATION; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; LEUKEMIA CELL LINE; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROTEIN PROCESSING; PROTEIN TRANSPORT;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BERBERINE; CARCINOGENS; CELL NUCLEUS; CELLS, CULTURED; CYSTEINE; DRUG EVALUATION, PRECLINICAL; DRUG SYNERGISM; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B KINASE; INFLAMMATION; JURKAT CELLS; MODELS, BIOLOGICAL; NEOPLASM INVASIVENESS; NF-KAPPA B; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; TUMOR NECROSIS FACTOR-ALPHA;

EID: 48549105216     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-0511     Document Type: Article

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