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Volumn 279, Issue 2, 2009, Pages 155-162

Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-κB, u-PA and MMP-2 and -9

Author keywords

Berberine; Matrix metalloproteinases; Migration and invasion; SCC 4 cancer cells; Urokinase type plasminogen activator

Indexed keywords

BERBERINE; FOCAL ADHESION KINASE; FOCAL ADHESION KINASE 1; GELATINASE A; GELATINASE B; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; UROKINASE RECEPTOR;

EID: 67349103384     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.01.033     Document Type: Article
Times cited : (139)

References (59)
  • 1
    • 0033559933 scopus 로고    scopus 로고
    • Estimates of the worldwide incidence of 25 major cancers in 1990
    • Parkin D.M., Pisani P., and Ferlay J. Estimates of the worldwide incidence of 25 major cancers in 1990. International Journal of Cancer 80 (1999) 827-841
    • (1999) International Journal of Cancer , vol.80 , pp. 827-841
    • Parkin, D.M.1    Pisani, P.2    Ferlay, J.3
  • 3
    • 14644406144 scopus 로고    scopus 로고
    • Calculation of population attributable risk for bidi smoking and oral cancer in south Asia
    • Rahman M., Sakamoto J., and Fukui T. Calculation of population attributable risk for bidi smoking and oral cancer in south Asia. Preventive Medicine 40 (2005) 510-514
    • (2005) Preventive Medicine , vol.40 , pp. 510-514
    • Rahman, M.1    Sakamoto, J.2    Fukui, T.3
  • 5
    • 13444263617 scopus 로고    scopus 로고
    • Alcohol and public health
    • Room R., Babor T., and Rehm J. Alcohol and public health. Lancet 365 (2005) 519-530
    • (2005) Lancet , vol.365 , pp. 519-530
    • Room, R.1    Babor, T.2    Rehm, J.3
  • 7
    • 33748761925 scopus 로고    scopus 로고
    • Chapter 2: the burden of HPV-related cancers
    • Parkin D.M., and Bray F. Chapter 2: the burden of HPV-related cancers. Vaccine 24 suppl. 3 (2006) S11-S25
    • (2006) Vaccine , vol.24 , Issue.SUPPL. 3
    • Parkin, D.M.1    Bray, F.2
  • 10
    • 0028970207 scopus 로고
    • Review article: anti-diarrhoeal pharmacology and therapeutics
    • Schiller L.R. Review article: anti-diarrhoeal pharmacology and therapeutics. Alimentary Pharmacology & Therapeutics 9 (1995) 87-106
    • (1995) Alimentary Pharmacology & Therapeutics , vol.9 , pp. 87-106
    • Schiller, L.R.1
  • 11
    • 31144436796 scopus 로고    scopus 로고
    • Berberine induces apoptosis through a mitochondria/caspases pathway in human hepatoma cells
    • Hwang J.M., Kuo H.C., Tseng T.H., Liu J.Y., and Chu C.Y. Berberine induces apoptosis through a mitochondria/caspases pathway in human hepatoma cells. Archives of Toxicology 80 (2006) 62-73
    • (2006) Archives of Toxicology , vol.80 , pp. 62-73
    • Hwang, J.M.1    Kuo, H.C.2    Tseng, T.H.3    Liu, J.Y.4    Chu, C.Y.5
  • 13
    • 0022570233 scopus 로고
    • Berberine sulfate inhibits tumor-promoting activity of teleocidin in two-stage carcinogenesis on mouse skin
    • Nishino H., Kitagawa K., Fujiki H., and Iwashima A. Berberine sulfate inhibits tumor-promoting activity of teleocidin in two-stage carcinogenesis on mouse skin. Oncology 43 (1986) 131-134
    • (1986) Oncology , vol.43 , pp. 131-134
    • Nishino, H.1    Kitagawa, K.2    Fujiki, H.3    Iwashima, A.4
  • 14
    • 33745001816 scopus 로고    scopus 로고
    • Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2
    • Peng P.L., Hsieh Y.S., Wang C.J., Hsu J.L., and Chou F.P. Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Toxicology and Applied Pharmacology 214 (2006) 8-15
    • (2006) Toxicology and Applied Pharmacology , vol.214 , pp. 8-15
    • Peng, P.L.1    Hsieh, Y.S.2    Wang, C.J.3    Hsu, J.L.4    Chou, F.P.5
  • 15
    • 0033046099 scopus 로고    scopus 로고
    • Inhibition of activator protein 1 activity by berberine in human hepatoma cells
    • Fukuda K., Hibiya Y., Mutoh M., Koshiji M., Akao S., and Fujiwara H. Inhibition of activator protein 1 activity by berberine in human hepatoma cells. Planta Medica 65 (1999) 381-383
    • (1999) Planta Medica , vol.65 , pp. 381-383
    • Fukuda, K.1    Hibiya, Y.2    Mutoh, M.3    Koshiji, M.4    Akao, S.5    Fujiwara, H.6
  • 16
    • 0032985993 scopus 로고    scopus 로고
    • Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells
    • Fukuda K., Hibiya Y., Mutoh M., Koshiji M., Akao S., and Fujiwara H. Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. Journal of Ethnopharmacology 66 (1999) 227-233
    • (1999) Journal of Ethnopharmacology , vol.66 , pp. 227-233
    • Fukuda, K.1    Hibiya, Y.2    Mutoh, M.3    Koshiji, M.4    Akao, S.5    Fujiwara, H.6
  • 17
    • 0000116696 scopus 로고    scopus 로고
    • Induction of topoisomerase II-mediated DNA cleavage by a protoberberine alkaloid, berberrubine
    • Kim S.A., Kwon Y., Kim J.H., Muller M.T., and Chung I.K. Induction of topoisomerase II-mediated DNA cleavage by a protoberberine alkaloid, berberrubine. Biochemistry 37 (1998) 16316-16324
    • (1998) Biochemistry , vol.37 , pp. 16316-16324
    • Kim, S.A.1    Kwon, Y.2    Kim, J.H.3    Muller, M.T.4    Chung, I.K.5
  • 18
    • 33745526474 scopus 로고    scopus 로고
    • Berberine-antiproliferative activity in vitro and induction of apoptosis/necrosis of the U937 and B16 cells
    • Letasiova S., Jantova S., Cipak L., and Muckova M. Berberine-antiproliferative activity in vitro and induction of apoptosis/necrosis of the U937 and B16 cells. Cancer Letters 239 (2006) 254-262
    • (2006) Cancer Letters , vol.239 , pp. 254-262
    • Letasiova, S.1    Jantova, S.2    Cipak, L.3    Muckova, M.4
  • 19
    • 33748924524 scopus 로고    scopus 로고
    • Berberine inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase 3 and PARP
    • Mantena S.K., Sharma S.D., and Katiyar S.K. Berberine inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase 3 and PARP. Carcinogenesis 27 (2006) 2018-2027
    • (2006) Carcinogenesis , vol.27 , pp. 2018-2027
    • Mantena, S.K.1    Sharma, S.D.2    Katiyar, S.K.3
  • 21
    • 35348936077 scopus 로고    scopus 로고
    • Berberine induces apoptosis in human HSC-3 oral cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway
    • Lin C.C., Yang J.S., Chen J.T., Fan S., Yu F.S., Yang J.L., Lu C.C., Kao M.C., Huang A.C., Lu H.F., and Chung J.G. Berberine induces apoptosis in human HSC-3 oral cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway. Anticancer Research 27 (2007) 3371-3378
    • (2007) Anticancer Research , vol.27 , pp. 3371-3378
    • Lin, C.C.1    Yang, J.S.2    Chen, J.T.3    Fan, S.4    Yu, F.S.5    Yang, J.L.6    Lu, C.C.7    Kao, M.C.8    Huang, A.C.9    Lu, H.F.10    Chung, J.G.11
  • 22
    • 33646479753 scopus 로고    scopus 로고
    • Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo. Berberine improves neointima formation in a rat model
    • Lee S., Lim H.J., Park H.Y., Lee K.S., Park J.H., and Jang Y. Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo. Berberine improves neointima formation in a rat model. Atherosclerosis 186 (2006) 29-37
    • (2006) Atherosclerosis , vol.186 , pp. 29-37
    • Lee, S.1    Lim, H.J.2    Park, H.Y.3    Lee, K.S.4    Park, J.H.5    Jang, Y.6
  • 23
    • 34547817207 scopus 로고    scopus 로고
    • Crude extracts of Euchresta formosana radix inhibit invasion and migration of human hepatocellular carcinoma cells
    • Hsu S.C., Kuo C.L., Lin J.P., Lee J.H., Lin C.C., Su C.C., Yang M.D., and Chung J.G. Crude extracts of Euchresta formosana radix inhibit invasion and migration of human hepatocellular carcinoma cells. Anticancer Research 27 (2007) 2377-2384
    • (2007) Anticancer Research , vol.27 , pp. 2377-2384
    • Hsu, S.C.1    Kuo, C.L.2    Lin, J.P.3    Lee, J.H.4    Lin, C.C.5    Su, C.C.6    Yang, M.D.7    Chung, J.G.8
  • 25
    • 0036605041 scopus 로고    scopus 로고
    • Inhibitory effects of a luteinizing hormone-releasing hormone agonist on basal and epidermal growth factor-induced cell proliferation and metastasis-associated properties in human epidermoid carcinoma A431 cells
    • Huang Y.T., Hwang J.J., Lee L.T., Liebow C., Lee P.P., Ke F.C., Lo T.B., Schally A.V., and Lee M.T. Inhibitory effects of a luteinizing hormone-releasing hormone agonist on basal and epidermal growth factor-induced cell proliferation and metastasis-associated properties in human epidermoid carcinoma A431 cells. International Journal of Cancer 99 (2002) 505-513
    • (2002) International Journal of Cancer , vol.99 , pp. 505-513
    • Huang, Y.T.1    Hwang, J.J.2    Lee, L.T.3    Liebow, C.4    Lee, P.P.5    Ke, F.C.6    Lo, T.B.7    Schally, A.V.8    Lee, M.T.9
  • 26
    • 33644984254 scopus 로고    scopus 로고
    • Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells
    • Mantena S.K., Sharma S.D., and Katiyar S.K. Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells. Molecular Cancer Therapeutics 5 (2006) 296-308
    • (2006) Molecular Cancer Therapeutics , vol.5 , pp. 296-308
    • Mantena, S.K.1    Sharma, S.D.2    Katiyar, S.K.3
  • 29
    • 48549105216 scopus 로고    scopus 로고
    • Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis
    • Pandey M.K., Sung B., Kunnumakkara A.B., Sethi G., Chaturvedi M.M., and Aggarwal B.B. Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis. Cancer Research 68 (2008) 5370-5379
    • (2008) Cancer Research , vol.68 , pp. 5370-5379
    • Pandey, M.K.1    Sung, B.2    Kunnumakkara, A.B.3    Sethi, G.4    Chaturvedi, M.M.5    Aggarwal, B.B.6
  • 30
    • 40149095921 scopus 로고    scopus 로고
    • Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta
    • Yi P., Lu F.E., Xu L.J., Chen G., Dong H., and Wang K.F. Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta. World Journal of Gastroenterology 14 (2008) 876-883
    • (2008) World Journal of Gastroenterology , vol.14 , pp. 876-883
    • Yi, P.1    Lu, F.E.2    Xu, L.J.3    Chen, G.4    Dong, H.5    Wang, K.F.6
  • 31
    • 37648999717 scopus 로고    scopus 로고
    • Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-kappaB and Akt pathways
    • Hu J.P., Nishishita K., Sakai E., Yoshida H., Kato Y., Tsukuba T., and Okamoto K. Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-kappaB and Akt pathways. European Journal of Pharmacology 580 (2008) 70-79
    • (2008) European Journal of Pharmacology , vol.580 , pp. 70-79
    • Hu, J.P.1    Nishishita, K.2    Sakai, E.3    Yoshida, H.4    Kato, Y.5    Tsukuba, T.6    Okamoto, K.7
  • 32
    • 33751396630 scopus 로고    scopus 로고
    • Differential effect of Rhizoma coptidis and its main alkaloid compound berberine on TNF-alpha induced NFkappaB translocation in human keratinocytes
    • Enk R., Ehehalt R., Graham J.E., Bierhaus A., Remppis A., and Greten H.J. Differential effect of Rhizoma coptidis and its main alkaloid compound berberine on TNF-alpha induced NFkappaB translocation in human keratinocytes. Journal of Ethnopharmacology 109 (2007) 170-175
    • (2007) Journal of Ethnopharmacology , vol.109 , pp. 170-175
    • Enk, R.1    Ehehalt, R.2    Graham, J.E.3    Bierhaus, A.4    Remppis, A.5    Greten, H.J.6
  • 34
    • 0028073883 scopus 로고
    • The role of matrix metalloproteases and their inhibitors in tumour invasion, metastasis and angiogenesis
    • Ray J.M., and Stetler-Stevenson W.G. The role of matrix metalloproteases and their inhibitors in tumour invasion, metastasis and angiogenesis. European Respiratory Journal 7 (1994) 2062-2072
    • (1994) European Respiratory Journal , vol.7 , pp. 2062-2072
    • Ray, J.M.1    Stetler-Stevenson, W.G.2
  • 35
    • 0033134622 scopus 로고    scopus 로고
    • Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention
    • Stetler-Stevenson W.G. Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention. The Journal of Clinical Investigation 103 (1999) 1237-1241
    • (1999) The Journal of Clinical Investigation , vol.103 , pp. 1237-1241
    • Stetler-Stevenson, W.G.1
  • 36
    • 34250749644 scopus 로고    scopus 로고
    • Matrix metalloproteinase-induced malignancy in mammary epithelial cells
    • Stallings-Mann M., and Radisky D. Matrix metalloproteinase-induced malignancy in mammary epithelial cells. Cells, Tissues, Organs 185 (2007) 104-110
    • (2007) Cells, Tissues, Organs , vol.185 , pp. 104-110
    • Stallings-Mann, M.1    Radisky, D.2
  • 37
    • 0742323216 scopus 로고    scopus 로고
    • The expression of matrix metalloproteinase-2 and -9 in human gliomas of different pathological grades
    • Wang M., Wang T., Liu S., Yoshida D., and Teramoto A. The expression of matrix metalloproteinase-2 and -9 in human gliomas of different pathological grades. Brain Tumor Pathology 20 (2003) 65-72
    • (2003) Brain Tumor Pathology , vol.20 , pp. 65-72
    • Wang, M.1    Wang, T.2    Liu, S.3    Yoshida, D.4    Teramoto, A.5
  • 38
    • 13244291565 scopus 로고    scopus 로고
    • Expression and quantitative analysis of matrix metalloproteinase-2 and -9 in human gliomas
    • Komatsu K., Nakanishi Y., Nemoto N., Hori T., Sawada T., and Kobayashi M. Expression and quantitative analysis of matrix metalloproteinase-2 and -9 in human gliomas. Brain Tumor Pathology 21 (2004) 105-112
    • (2004) Brain Tumor Pathology , vol.21 , pp. 105-112
    • Komatsu, K.1    Nakanishi, Y.2    Nemoto, N.3    Hori, T.4    Sawada, T.5    Kobayashi, M.6
  • 39
    • 0025611427 scopus 로고
    • Type IV collagenases in tumor invasion and metastasis
    • Stetler-Stevenson W.G. Type IV collagenases in tumor invasion and metastasis. Cancer Metastasis Reviews 9 (1990) 289-303
    • (1990) Cancer Metastasis Reviews , vol.9 , pp. 289-303
    • Stetler-Stevenson, W.G.1
  • 40
    • 0033551899 scopus 로고    scopus 로고
    • Integrin signaling
    • New York, NY
    • Giancotti F.G., and Ruoslahti E. Integrin signaling. Science 285 (1999) 1028-1032 New York, NY
    • (1999) Science , vol.285 , pp. 1028-1032
    • Giancotti, F.G.1    Ruoslahti, E.2
  • 41
    • 0032904304 scopus 로고    scopus 로고
    • Loss of basement membrane type IV collagen is associated with increased expression of metalloproteinases 2 and 9 (MMP-2 and MMP-9) during human colorectal tumorigenesis
    • Zeng Z.S., Cohen A.M., and Guillem J.G. Loss of basement membrane type IV collagen is associated with increased expression of metalloproteinases 2 and 9 (MMP-2 and MMP-9) during human colorectal tumorigenesis. Carcinogenesis 20 (1999) 749-755
    • (1999) Carcinogenesis , vol.20 , pp. 749-755
    • Zeng, Z.S.1    Cohen, A.M.2    Guillem, J.G.3
  • 45
    • 0027383944 scopus 로고
    • Tissue inhibitor of metalloproteinases-2 inhibits bFGF-induced human microvascular endothelial cell proliferation
    • Murphy A.N., Unsworth E.J., and Stetler-Stevenson W.G. Tissue inhibitor of metalloproteinases-2 inhibits bFGF-induced human microvascular endothelial cell proliferation. Journal of Cellular Physiology 157 (1993) 351-358
    • (1993) Journal of Cellular Physiology , vol.157 , pp. 351-358
    • Murphy, A.N.1    Unsworth, E.J.2    Stetler-Stevenson, W.G.3
  • 46
    • 0028000141 scopus 로고
    • Inhibition of AIDS-Kaposi's sarcoma cell induced endothelial cell invasion by TIMP-2 and a synthetic peptide from the metalloproteinase propeptide: implications for an anti-angiogenic therapy
    • Benelli R., Adatia R., Ensoli B., Stetler-Stevenson W.G., Santi L., and Albini A. Inhibition of AIDS-Kaposi's sarcoma cell induced endothelial cell invasion by TIMP-2 and a synthetic peptide from the metalloproteinase propeptide: implications for an anti-angiogenic therapy. Oncology Research 6 (1994) 251-257
    • (1994) Oncology Research , vol.6 , pp. 251-257
    • Benelli, R.1    Adatia, R.2    Ensoli, B.3    Stetler-Stevenson, W.G.4    Santi, L.5    Albini, A.6
  • 47
    • 0032508674 scopus 로고    scopus 로고
    • Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-kappa B
    • Bond M., Fabunmi R.P., Baker A.H., and Newby A.C. Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-kappa B. FEBS Letters 435 (1998) 29-34
    • (1998) FEBS Letters , vol.435 , pp. 29-34
    • Bond, M.1    Fabunmi, R.P.2    Baker, A.H.3    Newby, A.C.4
  • 48
    • 0033015706 scopus 로고    scopus 로고
    • Transcriptional up-regulation of matrix metalloproteinase-9 expression during spontaneous epithelial to neuroblast phenotype conversion by SK-N-SH neuroblastoma cells, involved in enhanced invasivity, depends upon GT-box and nuclear factor kappaB elements
    • Farina A.R., Tacconelli A., Vacca A., Maroder M., Gulino A., and Mackay A.R. Transcriptional up-regulation of matrix metalloproteinase-9 expression during spontaneous epithelial to neuroblast phenotype conversion by SK-N-SH neuroblastoma cells, involved in enhanced invasivity, depends upon GT-box and nuclear factor kappaB elements. Cell Growth Differentiation 10 (1999) 353-367
    • (1999) Cell Growth Differentiation , vol.10 , pp. 353-367
    • Farina, A.R.1    Tacconelli, A.2    Vacca, A.3    Maroder, M.4    Gulino, A.5    Mackay, A.R.6
  • 49
    • 41549102101 scopus 로고    scopus 로고
    • Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide
    • Lin T.H., Kuo H.C., Chou F.P., and Lu F.J. Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide. BMC Cancer 8 (2008) 58
    • (2008) BMC Cancer , vol.8 , pp. 58
    • Lin, T.H.1    Kuo, H.C.2    Chou, F.P.3    Lu, F.J.4
  • 50
    • 0037245022 scopus 로고    scopus 로고
    • Inhibition of tumor-induced angiogenesis and matrix-metalloproteinase expression in confrontation cultures of embryoid bodies and tumor spheroids by plant ingredients used in traditional chinese medicine
    • Wartenberg M., Budde P., De Marees M., Grunheck F., Tsang S.Y., Huang Y., Chen Z.Y., Hescheler J., and Sauer H. Inhibition of tumor-induced angiogenesis and matrix-metalloproteinase expression in confrontation cultures of embryoid bodies and tumor spheroids by plant ingredients used in traditional chinese medicine. Laboratory Investigation 83 (2003) 87-98
    • (2003) Laboratory Investigation , vol.83 , pp. 87-98
    • Wartenberg, M.1    Budde, P.2    De Marees, M.3    Grunheck, F.4    Tsang, S.Y.5    Huang, Y.6    Chen, Z.Y.7    Hescheler, J.8    Sauer, H.9
  • 51
    • 0037632207 scopus 로고    scopus 로고
    • Anti-metastatic and anti-angiogenic activities of a new matrix metalloproteinase inhibitor, TN-6b
    • Lee S.J., Sakurai H., Oshima K., Kim S.H., and Saiki I. Anti-metastatic and anti-angiogenic activities of a new matrix metalloproteinase inhibitor, TN-6b. European Journal of Cancer 39 (2003) 1632-1641
    • (2003) European Journal of Cancer , vol.39 , pp. 1632-1641
    • Lee, S.J.1    Sakurai, H.2    Oshima, K.3    Kim, S.H.4    Saiki, I.5
  • 53
    • 0025193320 scopus 로고
    • Basement membrane type IV collagen degradation: evidence for the involvement of a proteolytic cascade independent of metalloproteinases
    • Mackay A.R., Corbitt R.H., Hartzler J.L., and Thorgeirsson U.P. Basement membrane type IV collagen degradation: evidence for the involvement of a proteolytic cascade independent of metalloproteinases. Cancer Research 50 (1990) 5997-6001
    • (1990) Cancer Research , vol.50 , pp. 5997-6001
    • Mackay, A.R.1    Corbitt, R.H.2    Hartzler, J.L.3    Thorgeirsson, U.P.4
  • 54
    • 0033565976 scopus 로고    scopus 로고
    • Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype
    • Aguirre Ghiso J.A., Alonso D.F., Farias E.F., Gomez D.E., and de Kier Joffe E.B. Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype. European Journal Biochemistry 263 (1999) 295-304
    • (1999) European Journal Biochemistry , vol.263 , pp. 295-304
    • Aguirre Ghiso, J.A.1    Alonso, D.F.2    Farias, E.F.3    Gomez, D.E.4    de Kier Joffe, E.B.5
  • 55
    • 35048812952 scopus 로고    scopus 로고
    • Urinary-type plasminogen activator (uPA) and its receptor (uPAR) in squamous cell carcinoma of the oral cavity
    • Shi Z., and Stack M.S. Urinary-type plasminogen activator (uPA) and its receptor (uPAR) in squamous cell carcinoma of the oral cavity. Biochemical Journal 407 (2007) 153-159
    • (2007) Biochemical Journal , vol.407 , pp. 153-159
    • Shi, Z.1    Stack, M.S.2
  • 57
    • 2942717090 scopus 로고    scopus 로고
    • Signaling pathways responsible for cancer cell invasion as targets for cancer therapy
    • Sliva D. Signaling pathways responsible for cancer cell invasion as targets for cancer therapy. Current Cancer Drug Targets 4 (2004) 327-336
    • (2004) Current Cancer Drug Targets , vol.4 , pp. 327-336
    • Sliva, D.1
  • 58
    • 0042168966 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1
    • Shishodia S., Potdar P., Gairola C.G., and Aggarwal B.B. Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1. Carcinogenesis 24 (2003) 1269-1279
    • (2003) Carcinogenesis , vol.24 , pp. 1269-1279
    • Shishodia, S.1    Potdar, P.2    Gairola, C.G.3    Aggarwal, B.B.4
  • 59
    • 0035819527 scopus 로고    scopus 로고
    • Development of matrix metalloproteinase inhibitors in cancer therapy
    • Hidalgo M., and Eckhardt S.G. Development of matrix metalloproteinase inhibitors in cancer therapy. Journal of the National Cancer Institute 93 (2001) 178-193
    • (2001) Journal of the National Cancer Institute , vol.93 , pp. 178-193
    • Hidalgo, M.1    Eckhardt, S.G.2


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