Inhibitory effects of Zuo-Jin-Wan and its alkaloidal ingredients on activator protein 1, nuclear factor-κB, and cellular transformation in HepG2 cells

Fitoterapia

Volumn 82, Issue 4, 2011, Pages 696-703

  Chao, De Cheng ^a   Lin, Li Jen ^a   Kao, Shung Te ^a   Huang, Hui Chi ^a   Chang, Chih Shiang ^a   Liang, Ji An ^b   Wu, Shih Lu ^a   Hsiang, Chien Yun ^a   Ho, Tin Yun ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Activator protein 1; Chinese herbs; Hepatocellular carcinoma; Nuclear factor B; Zuo Jin Wan

Indexed keywords

BERBERINE; COPTIS CHINENSIS EXTRACT; EVODIA RUTAECARPA EXTRACT; EVODIAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PLANT EXTRACT; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN HEPG2; CELL TRANSFORMATION; CHINESE MEDICINE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; EVODIA RUTAECARPA; GROWTH INHIBITION; HEPATOBLASTOMA; HUMAN; HUMAN CELL; MEDICINAL PLANT; PRIORITY JOURNAL; ZUO JIN WAN;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BERBERINE; CARCINOMA, HEPATOCELLULAR; CELL TRANSFORMATION, NEOPLASTIC; COPTIS; DRUGS, CHINESE HERBAL; EVODIA; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; NF-KAPPA B; PLANT EXTRACTS; QUINAZOLINES; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR AP-1;

COPTIS CHINENSIS; EVODIA RUTAECARPA;

EID: 79955478204     PISSN: 0367326X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fitote.2011.02.009     Document Type: Article

References (39)

1. D.M. Parkin Global cancer statistics in the year 2000 Lancet Oncol 2 2001 533 543 (Pubitemid 33586866)
2. R.G. Simonetti, A. Liberati, C. Angiolini, and L. Pagliaro Treatment of hepatocellular carcinoma: a systematic review of randomized controlled trials Ann Oncol 8 1997 117 136 (Pubitemid 27112878)
3. M.A. Avila, C. Berasain, B. Sangro, and J. Prieto New therapies for hepatocellular carcinoma Oncogen 25 2006 3866 3884 (Pubitemid 43980482)
4. C.M. Schmidt, I.H. McKillop, P.A. Cahill, and J.V. Sitzmann Increased MAPK expression and activity in primary human hepatocellular carcinoma Biochem Biophys Res Commun 236 1997 54 58 (Pubitemid 27341838)
5. D.I. Tai, S.L. Tsai, Y.H. Chang, S.N. Huang, T.C. Chen, and K.S. Chang Constitutive activation of nuclear factor κB in hepatocellular carcinoma Cancer 89 2000 2274 2281
6. P. Angel, and M. Karin The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation Biochim Biophys Acta 1072 1991 129 157 (Pubitemid 121007534)
7. Z. Dong, M.J. Birrer, R.G. Watts, L.M. Matrisian, and N.H. Colburn Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells Proc Natl Acad Sci USA 91 1994 609 613 (Pubitemid 24041451)
8. H. Sawai, T. Okazaki, H. Yamamoto, H. Okano, Y. Takeda, and M. Tashima Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells J Biol Chem 270 1995 27326 27331
9. C. Huang, W.Y. Ma, M.R. Young, N. Colburn, and Z. Dong Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells Proc Natl Acad Sci USA 95 1998 156 161 (Pubitemid 28103923)
10. E. Saez, S.E. Rutberg, E. Mueller, H. Oppenheim, J. Smoluk, and S.H. Yuspa c-fos is required for malignant progression of skin tumors Cell 82 1995 721 732
11. J.A. Dumont, A.J. Bitonti, C.D. Wallace, R.J. Baumann, E.A. Cashman, and D.E. Cross-Doersen Progression of MCF-7 breast cancer cells to antiestrogen-resistant phenotype is accompanied by elevated levels of AP-1 DNA-binding activity Cell Growth Differ 7 1996 351 359 (Pubitemid 26360774)
12. M.R. Young, J.J. Li, M. Rincon, R.A. Flavell, B.K. Sathyanarayana, and R. Hunziker Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion Proc Natl Acad Sci USA 96 1999 9827 9832 (Pubitemid 29398817)
13. N. Chen, M. Nomura, Q.B. She, W.Y. Ma, A.M. Bode, and L. Wang Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice Cancer Res 61 2001 3908 3912 (Pubitemid 32720949)
14. G. Liu, A. Bode, W.Y. Ma, S. Sang, C.T. Ho, and Z. Dong Two novel glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line Cancer Res 61 2001 5749 5756 (Pubitemid 32769090)
15. M. Arsura, and L.G. Cavin Nuclear factor-κB and liver carcinogenesis Cancer Lett 229 2005 157 169
16. Y. Sato, J. Kato, R. Takimoto, K. Takada, Y. Kawano, and K. Miyanishi Hepatitis C virus core protein promotes proliferation of human hepatoma cells through enhancement of transforming growth factor alpha expression via activation of nuclear factor-κB Gut 55 2006 1801 1808 (Pubitemid 44893582)
17. W. Jochum, E. Passegue, and E.F. Wagner AP-1 in mouse development and tumorigenesis Oncogene 20 2001 2401 2412 (Pubitemid 32531298)
18. M. Karin NF-κB and cancer: mechanisms and targets Mol Carcinog 45 2006 355 361
19. P. Liu, E. Kimmoun, A. Legrand, A. Sauvanet, C. Degott, and B. Lardeux Activation of NF-κ B, AP-1 and STAT transcription factors is a frequent and early event in human hepatocellular carcinomas J Hepatol 37 2002 63 71 (Pubitemid 34713056)
20. A.L. Eisen-Vandervelde, S.N. Waggoner, Z.Q. Yao, E.M. Cale, C.S. Hahn, and Y.S. Hahn Hepatitis C virus core selectively suppresses interleukin-12 synthesis in human macrophages by interfering with AP-1 activation J Biol Chem 279 2004 43479 43486 (Pubitemid 39390647)
21. F.R. Greten, L. Eckmann, T.F. Greten, J.M. Park, Z.W. Li, and L.J. Egan IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer Cell 118 2004 285 296 (Pubitemid 39061110)
22. E. Pikarsky, R.M. Porat, I. Stein, R. Abramovitch, S. Amit, and S. Kasem NF-κB functions as a tumour promoter in inflammation-associated cancer Nature 431 2004 461 466 (Pubitemid 39329586)
23. Pharmacopoeia Commission of People's Republic of China Pharmacopoeia of People's Republic of China vol. 1 2005 Chemical Industry Press Beijing 412 413 (in Chinese)
24. C.Y. Hsiang, S.L. Wu, S.E. Cheng, and T.Y. Ho Acetaldehyde-induced interleukin-1beta and tumor necrosis factor-alpha production is inhibited by berberine through nuclear factor-κB signaling pathway in HepG2 cells J Biomed Sci 12 2005 791 801
25. C.Y. Hsiang, S.L. Wu, and T.Y. Ho Morin inhibits 12-O- tetradecanoylphorbol-13-acetate-induced hepatocellular transformation via activator protein 1 signaling pathway and cell cycle progression Biochem Pharmacol 69 2005 1603 1611
26. H. Fukazawa, S. Mizuno, and Y. Uehara A microplate assay for quantitation of anchorage-independent growth of transformed cells Anal Biochem 228 1995 83 90
27. S.I. Shin, V.H. Freedman, R. Risser, and R. Pollack Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro Proc Natl Acad Sci USA 72 1975 4435 4439
28. N. Shoji, A. Umeyama, T. Takemoto, A. Kajiwara, and Y. Ohizumi Isolation of evodiamine, a powerful cardiotonic principle, from Evodia rutaecarpa Bentham (Rutaceae) J Pharm Sci 75 1986 612 613 (Pubitemid 16098049)
29. C.W. Chi, Y.F. Chang, T.W. Chao, S.H. Chiang, F.K. P'Eng, and W.Y. Lui Flowcytometric analysis of the effect of berberine on the expression of glucocorticoid receptors in human hepatoma HepG2 cells Life Sci 54 1994 2099 2107
30. H. Oka, S. Yamamoto, T. Kuroki, S. Harihara, T. Marumo, and S.R. Kim Prospective study of chemoprevention of hepatocellular carcinoma with Sho-saiko-to (TJ-9) Cancer 76 1995 743 749
31. X.M. Li, C.K. Huang, T.F. Zhang, A.A. Teper, K. Srivastava, and B.H. Schofield The Chinese herbal medicine formula MSSM-002 suppresses allergic airway hyperreactivity and modulates TH1/TH2 responses in a murine model of allergic asthma J Allergy Clin Immunol 106 2000 660 668
32. C.C. Chen, C.Y. Hsiang, A.N. Chiang, H.Y. Lo, and C.I. Li Peroxisome proliferator-activated receptor gamma transactivation-mediated potentiation of glucose uptake by Bai-Hu-Tang J Ethnopharmacol 118 2008 46 50
33. C.Y. Hsiang, S.L. Wu, and T.Y. Ho Activation of activator protein 1 and extracellular signal-regulated kinases in human hepatocellular transformation Tumour Biol 25 2004 313 320
34. R. Sen, and D. Baltimore Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism Cell 47 1986 921 928 (Pubitemid 17005065)
35. M. Karin Nuclear factor-kappaB in cancer development and progression Nature 441 2006 431 436 (Pubitemid 44050137)
36. J. Jiang, and C. Hu Evodiamine: a novel anti-cancer alkaloid from Evodia rutaecarpa Molecules 14 2009 1852 1859
37. Y. Sun, K. Xun, Y. Wang, and X. Chen A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs Anticancer Drugs 20 2009 757 769
38. S.K. Kulkarni, and A. Dhir Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders Phytother Res 24 2010 317 324
39. S.M. Yuan, K. Gao, D.M. Wang, X.Z. Quan, J.N. Liu, C.M. Ma, C. Qin, L.F. Zhang, in press. Evodiamine improves congnitive abilities in SAMP8 and APP(swe)/PS1(ΔE9) transgenic mouse models of Alzheimer's disease, Acta Pharmacol Sin 2011;32:295-302.