Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells

Acta Pharmacologica Sinica

Volumn 31, Issue 5, 2010, Pages 578-584

  Wang, Zeng Si ^a   Lu, Fu Er ^a   Xu, Li Jun ^a   Dong, Hui ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Berberine; Endoplasmic reticulum stress; Hep G2 cells; Insulin resistance; Tunicamycin

Indexed keywords

BERBERINE; GLUCOSE; GLUCOSE OXIDASE; INITIATION FACTOR 2ALPHA; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; OXYGEN REGULATED PROTEIN 150; PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CANCER CELL CULTURE; CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; INSULIN RESISTANCE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANTI-INFLAMMATORY AGENTS; ANTIVIRAL AGENTS; BERBERINE; CELL SURVIVAL; ENDOPLASMIC RETICULUM; GLUCOSE; HEP G2 CELLS; HEPATOCYTES; HUMANS; INSULIN; INSULIN RESISTANCE; SIGNAL TRANSDUCTION; TUNICAMYCIN;

EID: 77952060625     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.30     Document Type: Article

References (35)

1. Wellen KE, Hotamisligil GS. Infammation, stress, and diabetes. J Clin Invest 2005;115:1111-9.
2. Eizirik DL, Cardozo AK, Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 2008;29:42-61.
3. Ozawa K, Miyazaki M, Matsuhisa M, Takano K, Nakatani Y, Hatazaki M, et al. The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes. Diabetes 2005;54:657-63. (Pubitemid 40322067)
4. Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001;414:799-806.
5. 2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser (307). J Biol Chem 2000;275:9047-54.
6. Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, et al. A central role for JNK in obesity and insulin resistance. Nature 2002;420:333-6.
7. Han KL, Choi JS, Lee JY, Song J, Joe MK, Jung MH, et al. Therapeutic potential of peroxisome proliferators - activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes. Diabetes 2008;57:737-45.
8. Nakatani Y, Kaneto H, Kawamori D, Yoshiuchi K, Hatazaki M, Matsuoka TA, et al. Involvement of endoplasmic reticulum stress in insulin resistance and diabetes. J Biol Chem 2005;280:847-51. (Pubitemid 40165054)
9. Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004;306:457-61.
10. Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006;313:1137-40.
11. Xie Q, Khaoustov VI, Chung CC, Sohn J, Krishnan B, Lewis DE, et al. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stressinduced caspase-12 activation. Hepatology 2002;36:592-601.
12. Takano K, Tabata Y, Kitao Y, Murakami R, Suzuki H, Yamada M, et al. Methoxyfavones protect cells against endoplasmic reticulum stress and neurotoxin. Am J Physiol Cell Physiol 2007;292: C353-61.
13. Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, et al. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesityand high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell Metab 2006;3:417-27.
14. Kong W, Wei J, Abidi P, Lin M, Inaba S, Li C, et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med 2004;10:1344-51.
15. Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, et al. Berberine, a natural plant product, activates AMP-activated protein kinase with benefcial metabolic effects in diabetic and insulin-resistant states. Diabetes 2006;55:2256-64.
16. Turner N, Li JY, Gosby A, To SW, Cheng Z, Miyoshi H, et al. Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Diabetes 2008;57:1414-8.
17. Leng SH, Lu FE, Xu LJ. Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion. Acta Pharmacol Sin 2004;25:496-502.
18. Yi P, Lu FE, Xu LJ, Chen G, Dong H, Wang KF. Berberine reverses freefatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta. World J Gastroenterol 2008;14:876-83.
19. Berg AH, Combs TP, du X, Brownlee M, Scherer PE. The adipocytesecreted protein Acrp30 enhances hepatic insulin action. Nat Med 2001;7:947-53.
20. Seoane J, Trinh K, O'Doherty RM, Gomez-Foix AM, Lange AJ, Newgard CB, et al. Metabolic impact of adenovirus-mediated overexpression of the glucose-6-phosphatase catalytic subunit in hepatocytes. J Biol Chem 1997;272:26972-7.
21. Lin YY, Lu JY, Zhang J, Walter W, Dang W, Wan J, et al. Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell 2009;136:1073-84.
22. Yin J, Hu R, Chen M, Tang J, Li F, Yang Y, et al. Effects of berberine on glucose metabolism in vitro. Metabolism 2002;51:1439-43.
23. Zhou L, Yang Y, Wang X, Liu S, Shang W, Yuan G, et al. Berberine stimulates glucose transport through a mechanism distinct from insulin. Metabolism 2007;56:405-12.
24. Vilatoba M, Eckstein C, Bilbao G, Smyth CA, Jenkins S, Thompson JA, et al. Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis. Surgery 2005;138:342-51.
25. Ota T, Gayet C, Ginsberg HN. Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents. J Clin Invest 2008;118:316-32.
26. Basu R, Chandramouli V, Dicke B, Landau B, Rizza R. Obesity and type 2 diabetes impair insulin-induced suppression of glycogenolysis as well as gluconeogenesis. Diabetes 2005;54:1942-8.
27. Savage DB, Petersen KF, Shulman GI. Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev 2007;87:507-20.
28. Collins QF, Xiong Y, Lupo EG Jr, Liu HY, Cao W. p38 Mitogen-activated protein kinase mediates free fatty acid-induced gluconeogenesis in hepatocytes. J Biol Chem 2006;281:24336-44.
29. Cherrington AD. Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo. Diabetes 1999;48:1198-214.
30. Kurukulasuriya R, Link JT, Madar DJ, Pei Z, Richards SJ, Rohde JJ, et al. Potential drug targets and progress towards pharmacologic inhibition of hepatic glucose production. Curr Med Chem 2003;10:123-53.
31. Kuwabara K, Matsumoto M, Ikeda J, Hori O, Ogawa S, Maeda Y, et al. Purifcation and characterization of a novel stress protein, the 150-kDa oxygen-regulated protein (ORP150), from cultured rat astrocytes and its expression in ischemic mouse brain. J Biol Chem 1996;271:5025-32.
32. Ozawa K, Kondo T, Hori O, Kitao Y, Stern DM, Eisenmenger W, et al. Expression of the oxygen-regulated protein ORP150 accelerates wound healing by modulating intracellular VEGF transport. J Clin Invest 2001;108:41-50.
33. Kovacs P, Yang X, Permana PA, Bogardus C, Baier LJ. Polymorphisms in the oxygen-regulated protein 150 gene (ORP150) are associated with insulin resistance in Pima Indians. Diabetes 2002;51:1618-21.
34. Pessin JE, Saltiel AR. Signaling pathways in insulin action: molecular targets of insulin resistance. J Clin Invest 2000;106:165-9.
35. Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest 2000;106:171-6.