Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-κB and Akt pathways

European Journal of Pharmacology

Volumn 580, Issue 1-2, 2008, Pages 70-79

  Hu, Jin Ping ^a,b   Nishishita, Kazuhisa ^b   Sakai, Eiko ^b   Yoshida, Hajime ^b   Kato, Yuzo ^b   Tsukuba, Takayuki ^b   Okamoto, Kuniaki ^b  

^a JILIN UNIVERSITY   (China)

^b NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

Author keywords

Akt; Apoptosis; Berberine; NF B; Osteoclast; RANKL

Indexed keywords

BERBERINE; CASPASE 3; COLONY STIMULATING FACTOR 1; I KAPPA B ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN KINASE B; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; OSTEOCLAST; PRIORITY JOURNAL;

ANIMALS; BERBERINE; BONE MARROW CELLS; CASPASE 3; CELL SURVIVAL; CELLS, CULTURED; HUMANS; I-KAPPA B KINASE; MACROPHAGES; MICE; NF-KAPPA B; OSTEOCLASTS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RANK LIGAND; TRANSCRIPTION FACTOR RELA;

EID: 37648999717     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.11.013     Document Type: Article

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