Hepatocyte nuclear factor 1α plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine

Journal of Biological Chemistry

Volumn 284, Issue 42, 2009, Pages 28885-28895

  Li, Hai ^a   Dong, Bin ^a   Park, Sahng Wook ^b   Lee, Hyun Sook ^b   Chen, Wei ^a   Liu, Jingwen ^a  

^a VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL HOMEOSTASIS; CRITICAL SEQUENCE; EXTRACELLULAR DOMAINS; FUNCTIONAL ASSAYS; GENE TRANSCRIPTIONS; HEPATOCYTE NUCLEAR FACTOR 1; HEPG2 CELLS; INTRACELLULAR DEGRADATION; PROMOTER ACTIVITIES; REGULATORY NETWORK; REGULATORY PATHWAY; REGULATORY SEQUENCES; RESPONSE ELEMENTS; SEQUENCE MOTIFS; STATINS; TRANSCRIPTIONAL LEVELS; UP-REGULATION;

ALCOHOLS; BINDING ENERGY; BINDING SITES; ENZYME ACTIVITY; LAWS AND LEGISLATION;

TRANSCRIPTION;

BERBERINE; FLUINDOSTATIN; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; MEVINOLIN; PCSK9 PROTEIN; SERINE PROTEINASE; SIMVASTATIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEPG2; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DRUG BINDING SITE; GENE REGULATORY NETWORK; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; MUTATION; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; REGULATORY SEQUENCE; STEROL RESPONSE ELEMENT; TRANSACTIVATION; TRANSCRIPTION REGULATION;

ANTICHOLESTEREMIC AGENTS; BASE SEQUENCE; BERBERINE; BINDING SITES; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PROMOTER REGIONS, GENETIC; RECEPTORS, LDL; RNA, SMALL INTERFERING; SEQUENCE HOMOLOGY, NUCLEIC ACID; SERINE ENDOPEPTIDASES; TRANSCRIPTION, GENETIC;

EID: 70350389729     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.052407     Document Type: Article

References (46)

1. Abifadel, M., Varret, M., Rabès, J. P., Allard, D., Ouguerram, K., Devillers, M., Cruaud, C., Benjannet, S., Wickham, L., Erlich, D., Derré, A., Villegér, L., Farnier, M., Beucler, I., Bruckert, E., Chambaz, J., Chanu, B., Lecerf, J. M., Luc, G., Moulin, P., Weissenbach, J., Prat, A., Krempf, M., Junien, C., Seidah, N. G., and Boileau, C. (2003) Nat. Genet. 34, 154-156
2. Kathiresan, S., Melander, O., Guiducci, C., Surti, A., Burtt, N. P., Rieder, M. J., Cooper, G. M., Roos, C., Voight, B. F., Havulinna, A. S., Wahlstrand, B., Hedner, T., Corella, D., Tai, E. S., Ordovas, J. M., Berglund, G., Vartiainen, E., Jousilahti, P., Hedblad, B., Taskinen, M. R., Newton-Cheh, C., Salomaa, V., Peltonen, L., Groop, L., Altshuler, D. M., and Orho-Melander, M. (2008) Nat. Genet. 40, 189-197
3. Willer, C. J., Sanna, S., Jackson, A. U., Scuteri, A., Bonnycastle, L. L., Clarke, R., Heath, S. C., Timpson, N. J., Najjar, S. S., Stringham, H. M., Strait, J., Duren, W. L., Maschio, A., Busonero, F., Mulas, A., Albai, G., Swift, A. J., Morken, M. A., Narisu, N., Bennett, D., Parish, S., Shen, H., Galan, P., Meneton, P., Hercberg, S., Zelenika, D., Chen, W. M., Li, Y., Scott, L. J., Scheet, P. A., Sundvall, J., Watanabe, R. M., Nagaraja, R., Ebrahim, S., Lawlor, D. A., Ben-Shlomo, Y., Davey-Smith, G., Shuldiner, A. R., Collins, R., Bergman, R. N., Uda, M., Tuomilehto, J., Cao, A., Collins, F. S., Lakatta, E., Lathrop, G. M., Boehnke, M., Schlessinger, D., Mohlke, K. L., and Abecasis, G. R. (2008) Nat. Genet. 40, 161-169
4. Timms, K. M., Wagner, S., Samuels, M. E., Forbey, K., Goldfine, H., Jammulapati, S., Skolnick, M. H., Hopkins, P. N., Hunt, S. C., and Shattuck, D. M. (2004) Hum. Genet. 114, 349-353
5. Leren, T. P. (2004) Clin. Genet. 65, 419-422
6. Cohen, J., Pertsemlidis, A., Kotowski, I. K., Graham, R., Garcia, C. K., and Hobbs, H. H. (2005) Nat. Genet. 37, 161-165
7. Maxwell, K. N., and Breslow, J. L. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 7100-7105
8. Park, S. W., Moon, Y. A., and Horton, J. D. (2004) J. Biol. Chem. 279, 50630-50638
9. Qian, Y. W., Schmidt, R. J., Zhang, Y., Chu, S., Lin, A., Wang, H., Wang, X., Beyer, T. P., Bensch, W. R., Li, W., Ehsani, M. E., Lu, D., Konrad, R. J., Eacho, P. I., Moller, D. E., Karathanasis, S. K., and Cao, G. (2007) J. Lipid Res. 48, 1488-1498
10. Horton, J. D., Cohen, J. C., and Hobbs, H. H. (2007) Trends Biochem. Sci. 32, 71-77
11. Seidah, N. G. (2009) Expert Opin. Ther. Targets 13, 19-28
12. Cao, G., Qian, Y. W., Kowala, M. C., and Konrad, R. J. (2008) Endocr. Metab. Immune Disord. Drug Targets 8, 238-243
13. Seidah, N. G., Benjannet, S., Wickham, L., Marcinkiewicz, J., Jasmin, S. B., Stifani, S., Basak, A., Prat, A., and Chrétien, M. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 928-933
14. Benjannet, S., Rhainds, D., Essalmani, R., Mayne, J., Wickham, L., Jin, W., Asselin, M. C., Hamelin, J., Varret, M., Allard, D., Trillard, M., Abifadel, M., Tebon, A., Attie, A. D., Rader, D. J., Boileau, C., Brissette, L., Chrétien, M., Prat, A., and Seidah, N. G. (2004) J. Biol. Chem. 279, 48865-48875
15. Zhang, D. W., Lagace, T. A., Garuti, R., Zhao, Z., McDonald, M., Horton, J. D., Cohen, J. C., and Hobbs, H. H. (2007) J. Biol. Chem. 282, 18602-18612
16. McNutt, M. C., Kwon, H. J., Chen, C., Chen, J. R., Horton, J. D., and Lagace, T. A. (2009) J. Biol. Chem. 284, 10561-10570
17. Horton, J. D., Shah, N. A., Warrington, J. A., Anderson, N. N., Park, S. W., Brown, M. S., and Goldstein, J. L. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 12027-12032
18. Maxwell, K. N., Soccio, R. E., Duncan, E. M., Sehayek, E., and Breslow, J. L. (2003) J. Lipid Res. 44, 2109-2119
19. Dubuc, G., Chamberland, A., Wassef, H., Davignon, J., Seidah, N. G., Bernier, L., and Prat, A. (2004) Arterioscler. Thromb. Vasc. Biol. 24, 1454-1459
20. Costet, P., Cariou, B., Lambert, G., Lalanne, F., Lardeux, B., Jarnoux, A. L., Grefhorst, A., Staels, B., and Krempf, M. (2006) J. Biol. Chem. 281, 6211-6218
21. Jeong, H. J., Lee, H. S., Kim, K. S., Kim, Y. K., Yoon, D., and Park, S. W. (2008) J. Lipid Res. 49, 399-409
22. Attie, A. D., and Seidah, N. G. (2005) Cell Metab. 1, 290-292
23. Rashid, S., Curtis, D. E., Garuti, R., Anderson, N. N., Bashmakov, Y., Ho, Y. K., Hammer, R. E., Moon, Y. A., and Horton, J. D. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 5374-5379
24. Kourimate, S., Le May, C., Langhi, C., Jarnoux, A. L., Ouguerram, K., Zaïr, Y., Nguyen, P., Krempf, M., Cariou, B., and Costet, P. (2008) J. Biol. Chem. 283, 9666-9673
25. Careskey, H. E., Davis, R. A., Alborn, W. E., Troutt, J. S., Cao, G., and Konrad, R. J. (2008) J. Lipid Res. 49, 394-398
26. Langhi, C., Le May, C., Kourimate, S., Caron, S., Staels, B., Krempf, M., Costet, P., and Cariou, B. (2008) FEBS Lett. 582, 949-955
27. Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., Wang, Y., Wang, Z., Si, S., Pan, H., Wang, Y., Wu, J., Li, Z., Liu, J., and Jiang, J. D. (2004) Nat. Med. 10, 1344-1352
28. Abidi, P., Zhou, Y., Jiang, J. D., and Liu, J. (2005) Arterioscler. Thromb. Vasc. Biol. 25, 2170-2176
29. Abidi, P., Chen, W., Kraemer, F. B., Li, H., and Liu, J. (2006) J. Lipid Res. 47, 2134-2147
30. Li, H., Chen, W., Zhou, Y., Abidi, P., Sharpe, O., Robinson, W. H., Kraemer, F. B., and Liu, J. (2009) J. Lipid Res. 50, 820-831
31. Cameron, J., Ranheim, T., Kulseth, M. A., Leren, T. P., and Berge, K. E. (2008) Atherosclerosis 201, 266-273
32. Mendel, D. B., Hansen, L. P., Graves, M. K., Conley, P. B., and Crabtree, G. R. (1991) Genes Dev. 5, 1042-1056
33. Odom, D. T., Zizlsperger, N., Gordon, D. B., Bell, G. W., Rinaldi, N. J., Murray, H. L., Volkert, T. L., Schreiber, J., Rolfe, P. A., Gifford, D. K., Fraenkel, E., Bell, G. I., and Young, R. A. (2004) Science 303, 1378-1381
34. Rey-Campos, J., Chouard, T., Yaniv, M., and Cereghini, S. (1991) EMBO J. 10, 1445-1457
35. Rowley, C. W., Staloch, L. J., Divine, J. K., McCaul, S. P., and Simon, T. C. (2006) Am. J. Physiol. Gastrointest. liver Physiol. 290, G466-G475
36. Qadri, I., Hu, L. J., Iwahashi, M., Al-Zuabi, S., Quattrochi, L. C., and Simon, F. R. (2009) Toxicol. Appl. Pharmacol. 234, 281-292
37. Sanchez, H. B., Yieh, L., and Osborne, T. F. (1995) J. Biol. Chem. 270, 1161-1169
38. Magaña, M. M., Koo, S. H., Towle, H. C., and Osborne, T. F. (2000) J. Biol. Chem. 275, 4726-4733
39. Egea, M., Metón, I., Córdoba, M., Fernández, F., and Baanante, I. V. (2008) Gen. Comp. Endocrinol. 155, 359-367
40. Horton, J. D., Goldstein, J. L., and Brown, M. S. (2002) J. Clin. Invest. 109, 1125-1131
41. Brown, M. S., and Goldstein, J. L. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 11041-11048
42. Brown, M. S., and Goldstein, J. L. (1997) Cell 89, 331-340
43. Servitja, J. M., Pignatelli, M., Maestro, M. A., Cardalda, C., Boj, S. F., Lozano, J., Blanco, E., Lafuente, A., McCarthy, M. I., Sumoy, L., Guigo, R., and Ferrer, J. (2009) Mol. Cell. Biol. 29, 2945-2959
44. Graham, M. J., Lemonidis, K. M., Whipple, C. P., Subramaniam, A., Monia, B. P., Crooke, S. T., and Crooke, R. M. (2007) J. Lipid Res. 48, 763-767
45. Frank-Kamenetsky, M., Grefhorst, A., Anderson, N. N., Racie, T. S., Bramlage, B., Akinc, A., Butler, D., Charisse, K., Dorkin, R., Fan, Y., Gamba-Vitalo, C., Hadwiger, P., Jayaraman, M., John, M., Jayaprakash, K. N., Maier, M., Nechev, L., Rajeev, K. G., Read, T., Röhl, I., Soutschek, J., Tan, P., Wong, J., Wang, G., Zimmermann, T., De Fougerolles, A., Vornlocher, H. P., Langer, R., Anderson, D. G., Manoharan, M., Koteliansky, V., Horton, J. D., and Fitzgerald, K. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 11915-11920
46. Kong, W. J., Zhang, H., Song, D. Q., Xue, R., Zhao, W., Wei, J., Wang, Y. M., Shan, N., Zhou, Z. X., Yang, P., You, X. F., Li, Z. R., Si, S. Y., Zhao, L. X., Pan, H. N., and Jiang, J. D. (2009) Metabolism 58, 109-119