Efficacy of berberine in patients with type 2 diabetes mellitus

Metabolism: Clinical and Experimental

Volumn 57, Issue 5, 2008, Pages 712-717

  Yin, Jun ^a,b   Xing, Huili ^a,b   Ye, Jianping ^a,b  

^a XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACARBOSE; BERBERINE; CHOLESTEROL; GLUCOSE; HEMOGLOBIN A1C; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; SULFONYLUREA; TRIACYLGLYCEROL;

ABDOMINAL PAIN; ADULT; AGED; ARTICLE; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; DIET RESTRICTION; DRUG DOSE REDUCTION; DRUG EFFICACY; FEMALE; FLATULENCE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HUMAN; HYPOGLYCEMIA; INSULIN RESISTANCE; KIDNEY INJURY; LIVER INJURY; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; NON INSULIN DEPENDENT DIABETES MELLITUS; POSTPRANDIAL STATE; PRIORITY JOURNAL;

ADULT; AGED; BERBERINE; CHOLESTEROL, HDL; DIABETES MELLITUS, TYPE 2; DRUG THERAPY, COMBINATION; FEMALE; GLUCOSE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MALE; METFORMIN; MIDDLE AGED;

EID: 42949145899     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2008.01.013     Document Type: Article

References (21)

1. Jayaprakasam B., Olson L.K., Schutzki R.E., et al. Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). J Agric Food Chem 54 (2006) 243-248
2. Matsui T., Ueda T., Oki T., et al. Alpha-glucosidase inhibitory action of natural acylated anthocyanins. 2. Alpha-glucosidase inhibition by isolated acylated anthocyanins. J Agric Food Chem 49 (2001) 1952-1956
3. Yin J., Hu R., Chen M., et al. Effects of berberine on glucose metabolism in vitro. Metabolism 51 (2002) 1439-1443
4. Yin J., Chen M., Tang J., et al. Effects of berberine on glucose and lipid metabolism in animal experiment. Chin J Diabet 12 (2004) 215-218
5. Lee Y.S., Kim W.S., Kim K.H., et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 55 (2006) 2256-2264
6. Yin J., Gao Z., Liu D., et al. Berberine improves glucose metabolism through induction of glycolysis. Am J Physiol Endocrinol Metab 294 (2008) E148-E156
7. Matthews D.R., Hosker J.P., Rudenski A.S., et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 (1985) 412-419
8. Ni YX. Therapeutic effect of berberine on 60 patients with type II diabetes mellitus and experimental research. Zhong Xi Yi Jie He Za Zhi 1988;8:711-3, 707
9. DeFronzo R., and Goodman A. Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. N Engl J Med 333 (1995) 541-549
10. Ceriello A., Johns D., Widel M., et al. Comparison of effect of pioglitazone with metformin or sulfonylurea (monotherapy and combination therapy) on postload glycemia and composite insulin sensitivity index during an oral glucose tolerance test in patients with type 2 diabetes. Diabetes Care 28 (2005) 266-272
11. Tang L.Q., Wei W., Chen L.M., et al. Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. J Ethnopharmacol 108 (2006) 109-115
12. Zhou L., Yang Y., Wang X., et al. Berberine stimulates glucose transport through a mechanism distinct from insulin. Metabolism 56 (2007) 405-412
13. Gao C.R., Zhang J.Q., and Huang Q.L. Experimental study on berberin raised insulin sensitivity in insulin resistance rat models. Zhong Xi Yi Jie He Za Zhi 17 (1997) 162-164
14. Ko B.S., Choi S.B., Park S.K., et al. Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizoma. Biol Pharm Bull 28 (2005) 1431-1437
15. Pan G.Y., Wang G.J., Sun J.G., et al. Inhibitory action of berberine on glucose absorption. Yao Xue Xue Bao 38 (2003) 911-914
16. Pan G.Y., Huang Z.J., Wang G.J., et al. The antihyperglycaemic activity of berberine arises from a decrease of glucose absorption. Planta Med 69 (2003) 632-636
17. Kong W., Wei J., Abidi P., et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med 10 (2004) 1344-1351
18. Leng S.H., Lu F.E., and Xu L.J. Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion. Acta Pharmacol Sin 25 (2004) 496-502
19. Doggrell S.A. Berberine-a novel approach to cholesterol lowering. Expert Opin Investig Drugs 14 (2005) 683-685
20. Abidi P., Zhou Y., Jiang J.D., et al. Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine. Arterioscler Thromb Vasc Biol 25 (2005) 2170-2176
21. Brusq J.M., Ancellin N., Grondin P., et al. Inhibition of lipid synthesis through activation of AMP-kinase: an additional mechanism for the hypolipidemic effects of Berberine. J Lipid Res 47 (2006) 1281-1288