Berberine inhibits human neuroblastoma cell growth through induction of p53-dependent apoptosis

Anticancer Research

Volumn 28, Issue 6 A, 2008, Pages 3777-3784

  Myoung, Suk Choi ^a   Dong, Yeon Yuk ^a   Ju, Hoon Oh ^a   Hai, Young Jung ^a   Sang, Bae Han ^a   Dong, Cheul Moon ^a   Jin, Tae Hong ^a  

^a Chungbuk National University   (South Korea)

Author keywords

Apoptosis; Berberine; Cell cycle arrest; Neuroblastoma cells; p53

Indexed keywords

BERBERINE; CASPASE 3; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN E; PIFITHRIN ALPHA; PROTEIN P53; SMALL INTERFERING RNA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BRAIN CELL; BRAIN NERVE CELL; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SENSITIVITY; ENZYME ACTIVATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IC 50; NEUROBLASTOMA; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BERBERINE; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CELL NUCLEUS; FEMALE; G0 PHASE; G1 PHASE; HUMANS; NEUROBLASTOMA; PREGNANCY; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 58149163569     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Takase H, Yamamoto K, Ito K and Yumioka E: Pharmacological studies on antidiarrheal effects of berberine and geranin herb. Nippon Yakurigaku Zasshi 2: 101-112, 1993.
2. Huang WM, Wu ZD and Gan YQ: Effects of berberine on ischemic ventricular arrhythmia. Zhonghua Xin Xue Guan Bing Za Zhi 5: 300-301, 1989.
3. Kuo CL, Chi CW and Liu TY: The anti-inflammatory potential of berberine in vitro and in vivo. Cancer Lett 203: 127-137, 2004.
4. Hano K: Pharmacological studies on metabolism of cancer tissues: pharmacological studies on carcinostatic effects of some plant components and their derivatives. Gann 48: 443-450, 1957.
5. Hoshi A, Ikekawa T, Ikeda Y, Shirakawa S and Iigo M: Antitumor activity of berberrubine derivatives. Gann 67: 321-325, 1976.
6. Liu LF: DNA topoisomerase poisons as antitumor drugs. Ann Rev Biochem 58: 351-375, 1989.
7. Mazzini S, Bellucci MC and Mondelli R: Mode of binding of the cytotoxic alkaloid berberine with the double helix oligonucleotide d(AAGAATTCTT)(2). Bioorg Med Chem 11: 505-514, 2003.
8. Qin Y, Pang JY, Chen WH, Cai Z and Jiang ZH: Synthesis, DNA-binding affinities, and binding mode of berberine dimers. Bioorg Med Chem 14: 25-32, 2006.
9. Mantena SK, Sharma SD and Katiyar SK: Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells. Mol Cancer Ther 5: 296-308, 2006
10. Mantena SK, Sharma SD and Katiyar SK: Berberine inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase 3 and PARP. Carcinogenesis 27: 2018-2027, 2006
11. Jantova S, Cipak L and Letasiova S: Berberine induces apoptosis through a mitochondrial/caspase pathway in human promonocytic U937 cells. Toxicol In Vitro 21: 25-31, 2007.
12. Lin JP, Yang JS, Lee JH, Hsieh WT and Chung JG: Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU-5 cell line. World J Gastroenterol 12: 21-28, 2006.
13. Hwang JM, Kuo HC, Tseng TH, Liu JY and Chu Cy: Berberine induces apoptosis through a mitochondria/caspases pathway in human hepatoma cells. Arch Toxicol 80: 62-73, 2006.
14. Fukuda K, Hibiya Y, Mutoh M, Koshiji M, Akao S and Fujiwara H: Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. J Ethnopharmacol 2: 227-233, 1999.
15. Lin JG, Chung JG, Wu LT, Chen GW, Chang HL and Wang TF: Effects of berberine on arylamine N-acetyltransferase activity in human colon tumor cells. Am J Chin Med 27: 265-275, 1999.
16. Hainaut P and Hollstein M: p53 and human cancer: the first ten thousand mutations. Adv Cancer Res 77: 81-137, 2000.
17. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R and Beach D: P21 is a universal inhibitor of cyclin kinases. Nature 366: 701-704, 1993.
18. Vousden KH and Lu X: Live or let die: the cell's response to p53. Nat Rev Cancer 2: 594-604, 2002.
19. Hoffman WH, Biade S, Zilfou JT, Chen J and Murphy M: Transcriptional repression of the anti-apoptotic survivin gene by wild-type p53. J Biol Chem 277: 3247-3257, 2002.
20. Olitvai ZN, Milliman CL and Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell-death. Cell 74: 609-619, 1993.
21. Wang X: The expanding role of mitochondria in apoptosis. Genes Dev 15: 2922-2933, 2001.
22. Weir NM, Selvendiran K, Kutala VK, Tong L, Vishwanath S, Rajaram M, Tridandapani S, Anant S and Kuppusamv P: Curcumin induces G(2)/m arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. Cancer Biol Ther 6: 178-184, 2007.
23. Kuo PL, Chiang LC and Lin CC: Resveratrol-induced apoptosis is mediated by p53-dependent pathway in Hep G2 cells. Life Sci 72: 23-34, 2002.
24. Hastak K, Gupta S, Ahmad N, Agarwal ML and Mukhtar H: Role of p53 and NF-kappaB in epigallocatechin-3-gallate-induced apoptosis of LNCaP cells. Oncogene 22: 4851-4859, 2003.
25. Ito K, Nakazato T, Yamamoto K, Miyakawa Y, Yamada T, Hozumi N, Segawa K, Ikeda Y and Kizaki M: Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: Implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species. Cancer Res 64: 1071-1078, 2004.
26. Ahn KS, Park KS, Jung KM, Jung HK, Lee SH, Chung SY, Yang KH, Yun YP, Pyo HB, Park YK, Yun YW, Kim DJ, Park SM and Hong JT: Inhibitory effect of glycolic acid on ultraviolet B-induced c-fos expression, AP-1 activation and p53-p21 response in a human keratinocyte cell line. Cancer Lett 186: 125-135, 2002.
27. Son DJ, Park MH, Chae SJ, Moon SO, Lee JW, Song HS, Moon DC, Kang SS, Kwon YE and Hong JT: Inhibitory effect of snake venom toxin from Vipera lebetina turanica on hormone-refractory human prostate cancer cell growth: induction of apoptosis through inactivation of nuclear factor kappaB. Mol Cancer Ther 6: 675-683, 2007.
28. Levine AJ: p53, the cellular gatekeeper for growth and division. Cell 88: 323-331, 1997.
29. Komarov PG, Komarova EA, Kondratov RV, Christov-Tselkov K, Chemov MV and Gudkov AV: A chemical inhibitor of p53 that protects mice from the side-effects of cancer therapy. Science 285: 1733-1737, 1999.
30. Kastan MB, Canman CE and Leonard CJ: P53, cell cycle control and apoptosis: implications for cancer. Cancer Metastasis Rev 14: 3-15, 1995.
31. Jiang XH, Wong BC, Yuen St, Jiang SH, Cho CH, Lai KC, Lin MC, Kung HF and Lam SK: Arsenic trioxide induces apoptosis in human gastric cancer cells through up-regulation of p53 and activation of caspase-3. Int J Cancer 91: 173-179, 2001.
32. Li TM, Chen GW, Su CC, Lin JG, Yeh CC, Cheng KC and Chung JG: Ellagic acid induced p53/p21 expression, G1 arrest and apoptosis in human bladder cancer T24 cells. Anticancer Res 25: 971-979, 2005.
33. Hsu YL, Cho CY, Kuo PL, Huang YT and Lin CC: Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase-mediated phosphorylation at serine 15 in vitro and in vivo. J Pharmacol Exp Ther 318: 484-494, 2006.
34. Lin CC, Kao ST, Chen GW, Ho HC and Chung JG: Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3. Anticancer Res 26: 227-242, 2006.
35. Hsu WH, Hsieh YS, Kuo HC, Teng CY, Huang HI, Wang CJ, Yang SF, Liou HS and Kuo WH: Berberine induced apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation JNK p38 MAPK and FASL. Arch Toxicol 81: 719-728, 2007.
36. Meeran SM, Katiyar S and Katiyar SK: Berberine-induced apoptosis in human cancer cells is initiated by reactive oxygen species generation. Toxicol Appl Pharmacol 229: 33-43, 2008.
37. Ozaki Y, Suzuki H and Satale M: Comparative studies on concentration of berberine in plasma after oral administration of Coptidis rhizoma extract, its cultured cells extract, and combined use of these extracts and Glycyrrhizae radix extract in rats. Yakugaku Zasshi 113: 63-69, 1993.
38. Wang X, Wang R, Xing D, Su H, Ma C, Ding Y and Du L: Kinetic difference of berberine between hippocampus and plasma in rat after intravenous administration of Coptidis rhizoma extract. Life Science 77: 3058-3067, 2005.