The distinctive separation attributes of mixed-mode resins and their application in monoclonal antibody downstream purification process

Journal of Chromatography A

Volumn 1217, Issue 2, 2010, Pages 216-224

  Chen, Jie ^a   Tetrault, Jen ^a   Zhang, Yanyu ^a   Wasserman, Andy ^a   Conley, Greg ^a   DiLeo, Mike ^a   Haimes, Elliot ^a   Nixon, Andrew E ^a   Ley, Arthur ^a  

^a Dyax Corp   (United States)

Author keywords

Aggregates removal; Capto adhere; CHT; MEP; Mixed mode chromatography; Monoclonal antibody purification process

Indexed keywords

ANION EXCHANGE RESINS; CHROMATOGRAPHY RESIN; DOMINANT MECHANISM; DRUG MANUFACTURING; HIGH MOLECULAR WEIGHT; HIGH QUALITY; MEP; MIXED MODE; MIXED-MODE CHROMATOGRAPHY; MONOCLONAL ANTIBODIES (MAB); MONOCLONAL ANTIBODY PURIFICATION; MULTI-MODAL; PLATFORM STRATEGY; PROCESS EFFICIENCY; PRODUCT QUALITY; PURIFICATION PROCESS; SEPARATION TECHNOLOGIES;

AGGREGATES; ALLERGIES; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DRUG PRODUCTS PLANTS; MERGERS AND ACQUISITIONS; MONOCLONAL ANTIBODIES; PURIFICATION; SCALES (WEIGHING INSTRUMENTS); SEPARATION; STRATEGIC PLANNING; SURFACE PLASMON RESONANCE;

RESINS;

4 MERCAPTOETHYLPYRIDINE; CALCIUM PHOSPHATE; FLUORAPATITE; HYDROXYAPATITE; N BENZYL N METHYL ETHANOLAMINE; RESIN; UNCLASSIFIED DRUG;

ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; DOWNSTREAM PROCESSING; DRUG IMPURITY; ELUTION; HYDROPHOBIC CHARGE INDUCTION CHROMATOGRAPHY; LOADING TEST; MOLECULAR WEIGHT; MULTIMODAL ANION EXCHANGE CHROMATOGRAPHY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PURIFICATION; SEPARATION TECHNIQUE;

ANIMALS; ANTIBODIES, MONOCLONAL; APATITES; CHO CELLS; CHROMATOGRAPHY, ION EXCHANGE; CHROMATOGRAPHY, LIQUID; CRICETINAE; CRICETULUS; HUMANS; HYDROXYAPATITES; IMMUNOGLOBULIN G; ION EXCHANGE RESINS; PYRIDINES;

EID: 72449157567     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2009.09.047     Document Type: Article

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