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Volumn 277, Issue 30, 2002, Pages 26733-26740

Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human FcγRIII and antibody-dependent cellular toxicity

(8) Shields, Robert L a Lai, Jadine a Keck, Rodney a O'Connell, Lori Y a Hong, Kyu a Gloria Meng, Y a Weikert, Stefanie H A b Presta, Leonard G a,c

a Department of Immunology ^* (United States)

b GENENTECH INC (United States)

c MERCK RESEARCH LABORATORIES (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BLOOD; CARBOHYDRATES; CELLS; PROTEINS; TOXICITY;

MONOCYTES;

ANTIBODIES;

COMPLEMENT COMPONENT C1Q; FC RECEPTOR; FUCOSE; IMMUNOGLOBULIN G1; OLIGOSACCHARIDE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; BINDING AFFINITY; CHO CELL; COMPLEMENT ACTIVATION; CONTROLLED STUDY; CYTOTOXICITY; MONOCYTE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN POLYMORPHISM; RECEPTOR BINDING;

ANIMALS; ANTIBODIES, MONOCLONAL; ASPARAGINE; CARBOHYDRATES; CELL LINE; CHO CELLS; CRICETINAE; DIMERIZATION; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FUCOSE; HUMANS; IMMUNOGLOBULIN G; MICROSCOPY, FLUORESCENCE; POLYMORPHISM, GENETIC; PROTEIN BINDING; RECEPTORS, IGG; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRANSFECTION;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0037178791 PISSN: 00219258 EISSN: None Source Type: Journal
DOI: 10.1074/jbc.M202069200 Document Type: Article

Times cited : (1529)

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