Towards protein crystallization as a process step in downstream processing of therapeutic antibodies: Screening and optimization at microbatch scale

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Zang, Yuguo ^a   Kammerer, Bernd ^a,c   Eisenkolb, Maike ^a   Lohr, Katrin ^b   Kiefer, Hans ^a  

^a BIBERACH UNIVERSITY OF APPLIED SCIENCES   (Germany)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G4; MONOCLONAL ANTIBODY; PROTEIN A; ANTIBODY; IMMUNOGLOBULIN G; PROTEIN; STAPHYLOCOCCUS PROTEIN A;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL CULTURE; CHROMATOGRAPHY; CONTROLLED STUDY; CRYSTALLIZATION; DIAFILTRATION; DOWNSTREAM PROCESSING; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROCESS OPTIMIZATION; PROTEIN ANALYSIS; PROTEIN PURIFICATION; SOLUBILITY; ANIMAL; CHEMISTRY; CHO CELL; HAMSTER; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY; PROTEIN BINDING;

ANIMALS; ANTIBODIES; ANTIBODIES, MONOCLONAL; CHO CELLS; CRICETINAE; CRYSTALLIZATION; IMMUNOGLOBULIN G; PROTEIN BINDING; PROTEINS; STAPHYLOCOCCAL PROTEIN A;

EID: 80053090101     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025282     Document Type: Article

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