Predicting mab product yields from cultivation media components, using near-infrared and 2D-fluorescence spectroscopies

Biotechnology Progress

Volumn 27, Issue 5, 2011, Pages 1339-1346

  Jose, Gledson E ^a   Folque, Francisca ^a   Menezes, Jose C ^b   Werz, Silke ^c   Strauss, Ulrike ^c   Hakemeyer, Christian ^c  

^a Technology Services and Products   (Portugal)

^b INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^c ROCHE DIAGNOSTICS GMBH   (Germany)

Author keywords

Fermentation raw materials; Fluorescence spectroscopy; MIR spectroscopy; Monoclonal antibody cultivations; NIR spectroscopy

Indexed keywords

2D-FLUORESCENCE SPECTROSCOPY; CARBON AND NITROGEN; CULTIVATION CONDITIONS; CULTIVATION MEDIA; CULTIVATION PROCESS; FLUORESCENCE SPECTRA; INDUSTRIAL PROCESSS; INOCULA; MEDIA COMPONENTS; MEDIA FORMULATIONS; MIR SPECTROSCOPY; MONOCLONAL ANTIBODIES (MAB); MULTIPLE COMPONENTS; NEAR INFRARED; NIR SPECTROSCOPY; PREDICTIVE CONTROL; PREDICTIVE MODELS; PROCESS CONDITION; PROCESS PERFORMANCE; PRODUCT QUALITY; PRODUCT YIELDS; PRODUCTION PROCESS; SPECTRA PREPROCESSING; SPECTROSCOPIC TOOL; VIABLE CELLS; WAVELENGTH REGIONS;

CULTIVATION; FLUORESCENCE; FLUORESCENCE SPECTROSCOPY; FLUOROPHORES; INFRARED DEVICES; MATERIALS; MONOCLONAL ANTIBODIES; NEAR INFRARED SPECTROSCOPY; PREDICTIVE CONTROL SYSTEMS; SURFACE PLASMON RESONANCE;

PROCESS CONTROL;

MONOCLONAL ANTIBODY;

ANIMAL; ARTICLE; BIOSYNTHESIS; CHO CELL; CRICETULUS; CULTURE MEDIUM; HAMSTER; METHODOLOGY; NEAR INFRARED SPECTROSCOPY; SPECTROFLUOROMETRY; VALIDATION STUDY;

ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CRICETINAE; CRICETULUS; CULTURE MEDIA; SPECTROMETRY, FLUORESCENCE; SPECTROSCOPY, NEAR-INFRARED;

EID: 80053899041     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.638     Document Type: Article

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