메뉴 건너뛰기




Volumn 8, Issue , 2012, Pages 531-569

Hepadnaviruses and hepatocellular carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; CIRCULAR DNA; HEPATITIS B VACCINE; HEPATITIS B VIRUS X PROTEIN; MESSENGER RNA; VIRUS DNA; VIRUS ENVELOPE PROTEIN; VIRUS RNA;

EID: 84870764117     PISSN: 09400745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-0016-5_22     Document Type: Article
Times cited : (1)

References (320)
  • 1
    • 0023891946 scopus 로고
    • Enzyme-altered liver cell foci in woodchucks infected with woodchuck hepatitis virus
    • Abe K, Kurata T, Shikata T, Tennant BC (1988). Enzyme-altered liver cell foci in woodchucks infected with woodchuck hepatitis virus. Jpn J Cancer Res 79:466-472
    • (1988) Jpn J Cancer Res , vol.79 , pp. 466-472
    • Abe, K.1    Kurata, T.2    Shikata, T.3    Tennant, B.C.4
  • 2
    • 58449135983 scopus 로고    scopus 로고
    • Stem cells in liver regeneration, fibrosis and cancer: The good, the bad and the ugly
    • Alison MR, Islam S, Lim S (2009). Stem cells in liver regeneration, fibrosis and cancer: the good, the bad and the ugly. J Pathol 217:282-298
    • (2009) J Pathol , vol.217 , pp. 282-298
    • Alison, M.R.1    Islam, S.2    Lim, S.3
  • 3
    • 0024942656 scopus 로고
    • State of hepatitis B viral genomes in cirrhotic and hepatocellular carcinoma nodules
    • Aoki N, Robinson WS (1989). State of hepatitis B viral genomes in cirrhotic and hepatocellular carcinoma nodules. Mol Biol Med 6:395-408
    • (1989) Mol Biol Med , vol.6 , pp. 395-408
    • Aoki, N.1    Robinson, W.S.2
  • 5
    • 0025190103 scopus 로고
    • The hepatitis B virus X-gene product trans-activates both RNA polymerase II and III promoters
    • Aufiero B, Schneider RJ (1990). The hepatitis B virus X-gene product trans-activates both RNA polymerase II and III promoters. EMBO J 9:497-504
    • (1990) EMBO J , vol.9 , pp. 497-504
    • Aufiero, B.1    Schneider, R.J.2
  • 7
    • 0025861850 scopus 로고
    • Full-length and truncated versions of the hepatitis B virus (HBV) X protein (pX) transactivate the cmyc protooncogene at the transcriptional level
    • Balsano C, Avantaggiati ML, Natoli G, De Marzio E, Will H, Perricaudet M, Levrero M (1991) Full-length and truncated versions of the hepatitis B virus (HBV) X protein (pX) transactivate the cmyc protooncogene at the transcriptional level. Biochem Biophys Res Commun 176:985-992
    • (1991) Biochem Biophys Res Commun , vol.176 , pp. 985-992
    • Balsano, C.1    Avantaggiati, M.L.2    Natoli, G.3    de Marzio, E.4    Will, H.5    Perricaudet, M.6    Levrero, M.7
  • 9
    • 0030878836 scopus 로고    scopus 로고
    • The hepatitis B virus X protein enhances the DNA binding potential and transcription efficacy of bZip transcription factors
    • Barnabas S, Hai T, Andrisani OM (1997). The hepatitis B virus X protein enhances the DNA binding potential and transcription efficacy of bZip transcription factors. J Biol Chem 272:20684-20690
    • (1997) J Biol Chem , vol.272 , pp. 20684-20690
    • Barnabas, S.1    Hai, T.2    Andrisani, O.M.3
  • 10
    • 0020060218 scopus 로고
    • Hepatitis B virus as the etiologic agent in hepatocellular carcinoma: Epidemiologic considerations
    • Beasley RP (1982). Hepatitis B virus as the etiologic agent in hepatocellular carcinoma: epidemiologic considerations. Hepatology 2:21S-26S
    • (1982) Hepatology , vol.2
    • Beasley, R.P.1
  • 11
    • 0023933449 scopus 로고
    • Hepatitis B virus: The major etiology of hepatocellular carcinoma
    • Beasley RP (1988). Hepatitis B virus: the major etiology of hepatocellular carcinoma. Cancer 61:1942-1956
    • (1988) Cancer , vol.61 , pp. 1942-1956
    • Beasley, R.P.1
  • 12
    • 0019451351 scopus 로고
    • Hepatocellular carcinoma and hepatitis B virus
    • Beasley RP, Lin CC, Hwang LY, Chien CS (1981). Hepatocellular carcinoma and hepatitis B virus. Lancet 2:1129-1133
    • (1981) Lancet , vol.2 , pp. 1129-1133
    • Beasley, R.P.1    Lin, C.C.2    Hwang, L.Y.3    Chien, C.S.4
  • 13
    • 0031985778 scopus 로고    scopus 로고
    • Hepatitis B virus X protein interferes with cellular DNA repair
    • Becker SA, Lee TH, Butel JS, Slagle BL (1998). Hepatitis B virus X protein interferes with cellular DNA repair. J Virol 72:266-272
    • (1998) J Virol , vol.72 , pp. 266-272
    • Becker, S.A.1    Lee, T.H.2    Butel, J.S.3    Slagle, B.L.4
  • 14
    • 0033529094 scopus 로고    scopus 로고
    • The proapoptotic effect of hepatitis B virus HBx protein correlates with its transactivation activity in stably transfected cell lines
    • Bergametti F, Prigent S, Luber B, Benoit A, Tiollais P, Sarasin A, Transy C (1999). The proapoptotic effect of hepatitis B virus HBx protein correlates with its transactivation activity in stably transfected cell lines. Oncogene 18:2860-2871
    • (1999) Oncogene , vol.18 , pp. 2860-2871
    • Bergametti, F.1    Prigent, S.2    Luber, B.3    Benoit, A.4    Tiollais, P.5    Sarasin, A.6    Transy, C.7
  • 15
    • 3342946559 scopus 로고    scopus 로고
    • Genomic DNA double-strand breaks are targets for hepadnaviral DNA integration
    • Bill CA, Summers J (2004). Genomic DNA double-strand breaks are targets for hepadnaviral DNA integration. Proc Natl Acad Sci USA 101:11135-11140
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 11135-11140
    • Bill, C.A.1    Summers, J.2
  • 16
    • 0020380797 scopus 로고
    • Hepatitis B virus: Pathogenesis and prevention of primary cancer of the liver
    • Blumberg BS, London WT (1982). Hepatitis B virus: pathogenesis and prevention of primary cancer of the liver. Cancer 50:2657-2665
    • (1982) Cancer , vol.50 , pp. 2657-2665
    • Blumberg, B.S.1    London, W.T.2
  • 19
    • 62849115345 scopus 로고    scopus 로고
    • Subcellular mislocalization of mutant hepatitis B X proteins contributes to modulation of STAT/SOCS signaling in hepatocellular carcinoma
    • Bock CT, Toan NL, Koeberlein B, Song le H, Chin R, Zentgraf H, Kandolf R, Torresi J (2008) Subcellular mislocalization of mutant hepatitis B X proteins contributes to modulation of STAT/SOCS signaling in hepatocellular carcinoma. Intervirology 51:432-443
    • (2008) Intervirology , vol.51 , pp. 432-443
    • Bock, C.T.1    Toan, N.L.2    Koeberlein, B.3    Song le, H.4    Chin, R.5    Zentgraf, H.6    Kandolf, R.7    Torresi, J.8
  • 21
    • 0035048023 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein activation of cyclin A-cyclin-dependent kinase 2 complexes and G1 transit via a Src kinase pathway
    • Bouchard M, Giannakopoulos S, Wang EH, Tanese N, Schneider RJ (2001a). Hepatitis B virus HBx protein activation of cyclin A-cyclin-dependent kinase 2 complexes and G1 transit via a Src kinase pathway. J Virol 75:4247-4257
    • (2001) J Virol , vol.75 , pp. 4247-4257
    • Bouchard, M.1    Giannakopoulos, S.2    Wang, E.H.3    Tanese, N.4    Schneider, R.J.5
  • 22
    • 0035861455 scopus 로고    scopus 로고
    • Calcium signaling by HBx protein in hepatitis B virus DNA replication
    • Bouchard MJ, Wang LH, Schneider RJ (2001b). Calcium signaling by HBx protein in hepatitis B virus DNA replication. Science 294:2376-2378
    • (2001) Science , vol.294 , pp. 2376-2378
    • Bouchard, M.J.1    Wang, L.H.2    Schneider, R.J.3
  • 23
    • 0019313239 scopus 로고
    • Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma
    • Brechot C, Pourcel C, Louise A, Rain B, Tiollais P (1980). Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma. Nature 286:533-535
    • (1980) Nature , vol.286 , pp. 533-535
    • Brechot, C.1    Pourcel, C.2    Louise, A.3    Rain, B.4    Tiollais, P.5
  • 24
    • 0019426273 scopus 로고
    • Detection of hepatitis B virus DNA in liver and serum: A direct appraisal of the chronic carrier state
    • Brechot C, Hadchouel M, Scotto J, Degos F, Charnay P, Trepo C, Tiollais P (1981a). Detection of hepatitis B virus DNA in liver and serum: a direct appraisal of the chronic carrier state. Lancet 2:765-768
    • (1981) Lancet , vol.2 , pp. 765-768
    • Brechot, C.1    Hadchouel, M.2    Scotto, J.3    Degos, F.4    Charnay, P.5    Trepo, C.6    Tiollais, P.7
  • 25
    • 0019870047 scopus 로고
    • State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and-negative liver diseases
    • Brechot C, Hadchouel M, Scotto J, Fonck M, Potet F, Vyas GN, Tiollais P (1981b). State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and-negative liver diseases. Proc Natl Acad Sci USA 78:3906-3910
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 3906-3910
    • Brechot, C.1    Hadchouel, M.2    Scotto, J.3    Fonck, M.4    Potet, F.5    Vyas, G.N.6    Tiollais, P.7
  • 26
    • 0034813206 scopus 로고    scopus 로고
    • Endothelial cell-mediated uptake of a hepatitis B virus: A new concept of liver targeting of hepatotropic microorganisms
    • Breiner KM, Schaller H, Knolle PA (2001). Endothelial cell-mediated uptake of a hepatitis B virus: a new concept of liver targeting of hepatotropic microorganisms. Hepatology 34:803-808
    • (2001) Hepatology , vol.34 , pp. 803-808
    • Breiner, K.M.1    Schaller, H.2    Knolle, P.A.3
  • 27
    • 0030949436 scopus 로고    scopus 로고
    • Folding and assembly of hepatitis B virus core protein: A new model proposal
    • Bringas R (1997). Folding and assembly of hepatitis B virus core protein: a new model proposal. J Struct Biol 118:189-196
    • (1997) J Struct Biol , vol.118 , pp. 189-196
    • Bringas, R.1
  • 29
    • 0033541954 scopus 로고    scopus 로고
    • Activation of the N-myc2 oncogene by woodchuck hepatitis virus integration in the linked downstream b3n locus in woodchuck hepatocellular carcinoma
    • Bruni R, D'Ugo E, Giuseppetti R, Argentini C, Rapicetta M (1999). Activation of the N-myc2 oncogene by woodchuck hepatitis virus integration in the linked downstream b3n locus in woodchuck hepatocellular carcinoma. Virology 257:483-490
    • (1999) Virology , vol.257 , pp. 483-490
    • Bruni, R.1    D'Ugo, E.2    Giuseppetti, R.3    Argentini, C.4    Rapicetta, M.5
  • 30
    • 5144223035 scopus 로고    scopus 로고
    • The win locus involved in activation of the distal N-myc2 gene upon WHV integration in woodchuck liver tumors harbors S/MAR elements
    • Bruni R, D'Ugo E, Villano U, Fourel G, Buendia MA, Rapicetta M (2004). The win locus involved in activation of the distal N-myc2 gene upon WHV integration in woodchuck liver tumors harbors S/MAR elements. Virology 329:1-10
    • (2004) Virology , vol.329 , pp. 1-10
    • Bruni, R.1    D'Ugo, E.2    Villano, U.3    Fourel, G.4    Buendia, M.A.5    Rapicetta, M.6
  • 31
    • 30844455365 scopus 로고    scopus 로고
    • Lack of WHV integration nearby N-myc2 and in the downstream b3n and win loci in a considerable fraction of liver tumors with activated N-myc2 from naturally infected wild woodchucks
    • Bruni R, Conti I, Villano U, Giuseppetti R, Palmieri G, Rapicetta M (2006). Lack of WHV integration nearby N-myc2 and in the downstream b3n and win loci in a considerable fraction of liver tumors with activated N-myc2 from naturally infected wild woodchucks. Virology 345:258-269
    • (2006) Virology , vol.345 , pp. 258-269
    • Bruni, R.1    Conti, I.2    Villano, U.3    Giuseppetti, R.4    Palmieri, G.5    Rapicetta, M.6
  • 32
    • 0026034960 scopus 로고
    • The role of envelope proteins in hepatitis B virus assembly
    • Bruss V, Ganem D (1991). The role of envelope proteins in hepatitis B virus assembly. Proc Natl Acad Sci USA 88:1059-1063
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 1059-1063
    • Bruss, V.1    Ganem, D.2
  • 33
    • 0028874697 scopus 로고
    • Functions of the internal pre-S domain of the large surface protein in hepatitis B virus particle morphogenesis
    • Bruss V, Vieluf K (1995). Functions of the internal pre-S domain of the large surface protein in hepatitis B virus particle morphogenesis. J Virol 69:6652-6657
    • (1995) J Virol , vol.69 , pp. 6652-6657
    • Bruss, V.1    Vieluf, K.2
  • 34
    • 33747029250 scopus 로고    scopus 로고
    • Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
    • Budhu A, Forgues M, Ye QH, Jia HL, He P, Zanetti KA, Kammula US, Chen Y, Qin LX, Tang ZY, Wang XW (2006). Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell 10:99-111
    • (2006) Cancer Cell , vol.10 , pp. 99-111
    • Budhu, A.1    Forgues, M.2    Ye, Q.H.3    Jia, H.L.4    He, P.5    Zanetti, K.A.6    Kammula, U.S.7    Chen, Y.8    Qin, L.X.9    Tang, Z.Y.10    Wang, X.W.11
  • 35
    • 0020051385 scopus 로고
    • Hepatitis B virus DNA detection by in situ cytohybridization: Implications for viral replication strategy and pathogenesis of chronic hepatitis
    • Burrell CJ, Gowans EJ, Jilbert AR, Lake JR, Marmion BP (1982). Hepatitis B virus DNA detection by in situ cytohybridization: implications for viral replication strategy and pathogenesis of chronic hepatitis. Hepatology 2:85S-91S
    • (1982) Hepatology , vol.2
    • Burrell, C.J.1    Gowans, E.J.2    Jilbert, A.R.3    Lake, J.R.4    Marmion, B.P.5
  • 36
    • 0021329928 scopus 로고
    • Correlation between liver histology and markers of hepatitis B virus replication in infected patients: A study by in situ hybridization
    • Burrell CJ, Gowans EJ, Rowland R, Hall P, Jilbert AR, Marmion BP (1984). Correlation between liver histology and markers of hepatitis B virus replication in infected patients: a study by in situ hybridization. Hepatology 4:20-24
    • (1984) Hepatology , vol.4 , pp. 20-24
    • Burrell, C.J.1    Gowans, E.J.2    Rowland, R.3    Hall, P.4    Jilbert, A.R.5    Marmion, B.P.6
  • 37
    • 59749099611 scopus 로고    scopus 로고
    • Pre-P is a secreted glycoprotein encoded as an N-terminal extension of the duck hepatitis B virus polymerase gene
    • Cao F, Scougall CA, Jilbert AR, Tavis JE (2009). Pre-P is a secreted glycoprotein encoded as an N-terminal extension of the duck hepatitis B virus polymerase gene. J Virol 83:1368-1378
    • (2009) J Virol , vol.83 , pp. 1368-1378
    • Cao, F.1    Scougall, C.A.2    Jilbert, A.R.3    Tavis, J.E.4
  • 38
    • 0344121220 scopus 로고    scopus 로고
    • Hepatitis B virus X protein does not influence essential steps of nucleotide excision repair effected by human liver extracts
    • Capovilla A, Arbuthnot P (2003). Hepatitis B virus X protein does not influence essential steps of nucleotide excision repair effected by human liver extracts. Biochem Biophys Res Commun 312:806-810
    • (2003) Biochem Biophys Res Commun , vol.312 , pp. 806-810
    • Capovilla, A.1    Arbuthnot, P.2
  • 39
    • 0030978733 scopus 로고    scopus 로고
    • The hepatitis B virus MHBst167 protein is a pleiotropic transactivator mediating its effect via ubiquitous cellular transcription factors
    • Caselmann WH, Renner M, Schluter V, Hofschneider PH, Koshy R, Meyer M (1997). The hepatitis B virus MHBst167 protein is a pleiotropic transactivator mediating its effect via ubiquitous cellular transcription factors. J Gen Virol 78:1487-1495
    • (1997) J Gen Virol , vol.78 , pp. 1487-1495
    • Caselmann, W.H.1    Renner, M.2    Schluter, V.3    Hofschneider, P.H.4    Koshy, R.5    Meyer, M.6
  • 41
    • 61849176483 scopus 로고    scopus 로고
    • Hepatitis B vaccination: The key towards elimination and eradication of hepatitis B
    • Chen DS (2009). Hepatitis B vaccination: the key towards elimination and eradication of hepatitis B. J Hepatol 50:805-816
    • (2009) J Hepatol , vol.50 , pp. 805-816
    • Chen, D.S.1
  • 42
    • 34249945923 scopus 로고    scopus 로고
    • Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress
    • Chen J, Siddiqui A (2007). Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress. J Virol 81:6757-6760
    • (2007) J Virol , vol.81 , pp. 6757-6760
    • Chen, J.1    Siddiqui, A.2
  • 44
    • 84984539148 scopus 로고    scopus 로고
    • High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases
    • Chen BF, Liu CJ, Jow GM, Chen PJ, Kao JH, Chen DS (2006). High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases. Gastroenterology 130:1153-1168
    • (2006) Gastroenterology , vol.130 , pp. 1153-1168
    • Chen, B.F.1    Liu, C.J.2    Jow, G.M.3    Chen, P.J.4    Kao, J.H.5    Chen, D.S.6
  • 45
    • 35649014367 scopus 로고    scopus 로고
    • Pre-S deletion and complex mutations of hepatitis B virus related to advanced liver disease in HBeAgnegative patients
    • [see comment]
    • Chen CH, Hung CH, Lee CM, Hu TH, Wang JH, Wang JC, Lu SN, Changchien CS (2007). Pre-S deletion and complex mutations of hepatitis B virus related to advanced liver disease in HBeAgnegative patients. Gastroenterology 133:1466-1474 [see comment] Chen JD, Yang HI, Iloeje UH, You SL, Lu SN, Wang LY, Su J, Sun CA, Liaw YF, Chen CJ, Risk
    • (2007) Gastroenterology , vol.133 , pp. 1466-1474
    • Chen, C.H.1    Hung, C.H.2    Lee, C.M.3    Hu, T.H.4    Wang, J.H.5    Wang, J.C.6    Lu, S.N.7    Changchien, C.S.8
  • 46
    • 77951670101 scopus 로고    scopus 로고
    • Carriers of inactive hepatitis B virus are still at risk for hepatocellular carcinoma and liverrelated death
    • Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer in HBVSG
    • Chen JD, Yang HI, Iloeje UH, You SL, Lu SN, Wang LY, Su J, Sun CA, Liaw YF, Chen CJ, Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer in HBVSG (2010) Carriers of inactive hepatitis B virus are still at risk for hepatocellular carcinoma and liverrelated death. Gastroenterology 138:1747-1754
    • (2010) Gastroenterology , vol.138 , pp. 1747-1754
    • Chen, J.D.1    Yang, H.I.2    Iloeje, U.H.3    You, S.L.4    Lu, S.N.5    Wang, L.Y.6    Su, J.7    Sun, C.A.8    Liaw, Y.F.9    Chen, C.J.10
  • 47
    • 70449394392 scopus 로고    scopus 로고
    • Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase
    • Cheng P, Li Y, Yang L, Wen Y, Shi W, Mao Y, Chen P, Lv H, Tang Q, Wei Y (2009). Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase. Oncol Rep 22:1101-1107
    • (2009) Oncol Rep , vol.22 , pp. 1101-1107
    • Cheng, P.1    Li, Y.2    Yang, L.3    Wen, Y.4    Shi, W.5    Mao, Y.6    Chen, P.7    Lv, H.8    Tang, Q.9    Wei, Y.10
  • 48
    • 0346786526 scopus 로고    scopus 로고
    • Short-term lamivudine therapy in patients with chronic hepatitis B
    • Chien RN, Liaw YF (2003). Short-term lamivudine therapy in patients with chronic hepatitis B. Intervirology 46:362-366
    • (2003) Intervirology , vol.46 , pp. 362-366
    • Chien, R.N.1    Liaw, Y.F.2
  • 49
    • 58949102948 scopus 로고    scopus 로고
    • Nucleos(t)ide analogues for hepatitis B virus: Strategies for long-term success
    • Chien RN, Liaw YF (2008). Nucleos(t)ide analogues for hepatitis B virus: strategies for long-term success. Best Pract Res Clin Gastroenterol 22:1081-1092
    • (2008) Best Pract Res Clin Gastroenterol , vol.22 , pp. 1081-1092
    • Chien, R.N.1    Liaw, Y.F.2
  • 52
    • 47049100688 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential
    • Clippinger AJ, Bouchard MJ (2008). Hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential. J Virol 82:6798-6811
    • (2008) J Virol , vol.82 , pp. 6798-6811
    • Clippinger, A.J.1    Bouchard, M.J.2
  • 53
    • 77951481786 scopus 로고    scopus 로고
    • Hepatitis B virus activates deoxynucleotide synthesis in nondividing hepatocytes by targeting the R2 gene
    • Cohen D, Adamovich Y, Reuven N, Shaul Y (2010). Hepatitis B virus activates deoxynucleotide synthesis in nondividing hepatocytes by targeting the R2 gene. Hepatology 51:1538-1546
    • (2010) Hepatology , vol.51 , pp. 1538-1546
    • Cohen, D.1    Adamovich, Y.2    Reuven, N.3    Shaul, Y.4
  • 54
    • 0024391379 scopus 로고
    • Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication
    • Colgrove R, Simon G, Ganem D (1989). Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication. J Virol 63:4019-4026
    • (1989) J Virol , vol.63 , pp. 4019-4026
    • Colgrove, R.1    Simon, G.2    Ganem, D.3
  • 55
    • 0036215352 scopus 로고    scopus 로고
    • The European approach to hepatocellular carcinoma
    • Colombo M, Sangiovanni A (2002). The European approach to hepatocellular carcinoma. Hepatogastroenterology 49:12-16
    • (2002) Hepatogastroenterology , vol.49 , pp. 12-16
    • Colombo, M.1    Sangiovanni, A.2
  • 57
    • 33745700700 scopus 로고    scopus 로고
    • Separate origins of hepatitis B virus surface antigen-negative foci and hepatocellular carcinomas in transgenic HBsAg (alb/psx) mice
    • Crawford DR, Ostrowski S, Vakharia D, Ilic Z, Sell S (2006). Separate origins of hepatitis B virus surface antigen-negative foci and hepatocellular carcinomas in transgenic HBsAg (alb/psx) mice. Am J Pathol 169:223-232
    • (2006) Am J Pathol , vol.169 , pp. 223-232
    • Crawford, D.R.1    Ostrowski, S.2    Vakharia, D.3    Ilic, Z.4    Sell, S.5
  • 58
    • 0027305913 scopus 로고
    • Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases
    • Cross JC, Wen P, Rutter WJ (1993). Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases. Proc Natl Acad Sci USA 90:8078-8082
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8078-8082
    • Cross, J.C.1    Wen, P.2    Rutter, W.J.3
  • 59
  • 60
    • 0022547592 scopus 로고
    • Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma
    • Dejean A, Bougueleret L, Grzeschik KH, Tiollais P (1986). Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma. Nature 322:70-72
    • (1986) Nature , vol.322 , pp. 70-72
    • Dejean, A.1    Bougueleret, L.2    Grzeschik, K.H.3    Tiollais, P.4
  • 62
    • 0031724106 scopus 로고    scopus 로고
    • RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein
    • Dorjsuren D, Lin Y, Wei W, Yamashita T, Nomura T, Hayashi N, Murakami S (1998). RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein. Mol Cell Biol 18:7546-7555
    • (1998) Mol Cell Biol , vol.18 , pp. 7546-7555
    • Dorjsuren, D.1    Lin, Y.2    Wei, W.3    Yamashita, T.4    Nomura, T.5    Hayashi, N.6    Murakami, S.7
  • 65
    • 0023442448 scopus 로고
    • A precursor-product relationship exists between oval cells and hepatocytes in rat liver
    • Evarts RP, Nagy P, Marsden E, Thorgeirsson SS (1987). A precursor-product relationship exists between oval cells and hepatocytes in rat liver. Carcinogenesis 8:1737-1740
    • (1987) Carcinogenesis , vol.8 , pp. 1737-1740
    • Evarts, R.P.1    Nagy, P.2    Marsden, E.3    Thorgeirsson, S.S.4
  • 66
    • 0034043673 scopus 로고    scopus 로고
    • Identification of a pre-S2 mutant in hepatocytes expressing a novel marginal pattern of surface antigen in advanced diseases of chronic hepatitis B virus infection
    • Fan YF, Lu CC, Chang YC, Chang TT, Lin PW, Lei HY, Su IJ (2000). Identification of a pre-S2 mutant in hepatocytes expressing a novel marginal pattern of surface antigen in advanced diseases of chronic hepatitis B virus infection. J Gastroenterol Hepatol 15:519-528
    • (2000) J Gastroenterol Hepatol , vol.15 , pp. 519-528
    • Fan, Y.F.1    Lu, C.C.2    Chang, Y.C.3    Chang, T.T.4    Lin, P.W.5    Lei, H.Y.6    Su, I.J.7
  • 67
    • 2542601615 scopus 로고    scopus 로고
    • Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells
    • Fausto N (2004). Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells. Hepatology 39:1477-1486
    • (2004) Hepatology , vol.39 , pp. 1477-1486
    • Fausto, N.1
  • 68
    • 0030902570 scopus 로고    scopus 로고
    • Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma
    • Feitelson MA, Duan LX (1997). Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma. Am J Pathol 150:1141-1157
    • (1997) Am J Pathol , vol.150 , pp. 1141-1157
    • Feitelson, M.A.1    Duan, L.X.2
  • 69
    • 70350136670 scopus 로고    scopus 로고
    • Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease
    • Feitelson MA, Reis HM, Tufan NL, Sun B, Pan J, Lian Z (2009). Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease. Cancer Lett 286:69-79
    • (2009) Cancer Lett , vol.286 , pp. 69-79
    • Feitelson, M.A.1    Reis, H.M.2    Tufan, N.L.3    Sun, B.4    Pan, J.5    Lian, Z.6
  • 70
    • 0027295660 scopus 로고
    • Infectious hepatitis B virus variant defective in pre-S2 protein expression in a chronic carrier
    • Fernholz D, Galle PR, Stemler M, Brunetto M, Bonino F, Will H (1993). Infectious hepatitis B virus variant defective in pre-S2 protein expression in a chronic carrier. Virology 194:137-148
    • (1993) Virology , vol.194 , pp. 137-148
    • Fernholz, D.1    Galle, P.R.2    Stemler, M.3    Brunetto, M.4    Bonino, F.5    Will, H.6
  • 71
    • 0031780718 scopus 로고    scopus 로고
    • Woodchuck hepatitis virus enhancer I and enhancer II are both involved in N-myc2 activation in woodchuck liver tumors
    • Flajolet M, Tiollais P, Buendia MA, Fourel G (1998). Woodchuck hepatitis virus enhancer I and enhancer II are both involved in N-myc2 activation in woodchuck liver tumors. J Virol 72:6175-6180
    • (1998) J Virol , vol.72 , pp. 6175-6180
    • Flajolet, M.1    Tiollais, P.2    Buendia, M.A.3    Fourel, G.4
  • 72
    • 0034630505 scopus 로고    scopus 로고
    • Activation of promoters for cellular lipogenic genes by hepatitis B virus large surface protein
    • Foo NC, Yen TS (2000). Activation of promoters for cellular lipogenic genes by hepatitis B virus large surface protein. Virology 269:420-425
    • (2000) Virology , vol.269 , pp. 420-425
    • Foo, N.C.1    Yen, T.S.2
  • 74
  • 78
    • 0023869660 scopus 로고
    • Macroregenerative nodule of the liver. A clinicopathologic study of 345 autopsy cases of chronic liver disease
    • Furuya K, Nakamura M, Yamamoto T, Togel K, Otsuka H (1988). Macroregenerative nodule of the liver. A clinicopathologic study of 345 autopsy cases of chronic liver disease. Cancer 61:99-105
    • (1988) Cancer , vol.61 , pp. 99-105
    • Furuya, K.1    Nakamura, M.2    Yamamoto, T.3    Togel, K.4    Otsuka, H.5
  • 79
    • 1542316127 scopus 로고    scopus 로고
    • Hepatitis B virus infection-natural history and clinical consequences
    • Ganem D, Prince AM (2004). Hepatitis B virus infection-natural history and clinical consequences. N Engl J Med 350:1118-1129
    • (2004) N Engl J Med , vol.350 , pp. 1118-1129
    • Ganem, D.1    Prince, A.M.2
  • 80
    • 77649112712 scopus 로고    scopus 로고
    • The hepatitis B virus X protein modulates hepatocyte proliferation pathways to stimulate viral replication
    • Gearhart TL, Bouchard MJ (2010). The hepatitis B virus X protein modulates hepatocyte proliferation pathways to stimulate viral replication. J Virol 84:2675-2686
    • (2010) J Virol , vol.84 , pp. 2675-2686
    • Gearhart, T.L.1    Bouchard, M.J.2
  • 82
    • 0016658001 scopus 로고
    • Incidence and nature of cytoplasmic hepatitis B antigen in hepatocytes
    • Gerber MA, Hadziyannis S, Vernace S, Vissoulis C (1975). Incidence and nature of cytoplasmic hepatitis B antigen in hepatocytes. Lab Invest 32:251-256
    • (1975) Lab Invest , vol.32 , pp. 251-256
    • Gerber, M.A.1    Hadziyannis, S.2    Vernace, S.3    Vissoulis, C.4
  • 83
    • 0030058333 scopus 로고    scopus 로고
    • Loss and acquisition of duck hepatitis B virus integrations in lineages of LMH-D2 chicken hepatoma cells
    • Gong SS, Jensen AD, Rogler CE (1996). Loss and acquisition of duck hepatitis B virus integrations in lineages of LMH-D2 chicken hepatoma cells. J Virol 70:2000-2007
    • (1996) J Virol , vol.70 , pp. 2000-2007
    • Gong, S.S.1    Jensen, A.D.2    Rogler, C.E.3
  • 84
    • 0032948951 scopus 로고    scopus 로고
    • Double-stranded linear duck hepatitis B virus (DHBV) stably integrates at a higher frequency than wild-type DHBV in LMH chicken hepatoma cells
    • Gong SS, Jensen AD, Chang CJ, Rogler CE (1999). Double-stranded linear duck hepatitis B virus (DHBV) stably integrates at a higher frequency than wild-type DHBV in LMH chicken hepatoma cells. J Virol 73:1492-1502
    • (1999) J Virol , vol.73 , pp. 1492-1502
    • Gong, S.S.1    Jensen, A.D.2    Chang, C.J.3    Rogler, C.E.4
  • 85
    • 0025008573 scopus 로고
    • Study of preneoplastic changes in liver cells by immunohistochemical and molecular hybridization techniques
    • Govindarajan S, Conrad A, Lim B, Valinluck B, Kim AM, Schmid P (1990). Study of preneoplastic changes in liver cells by immunohistochemical and molecular hybridization techniques. Arch Path Lab Med 114:1042-1045
    • (1990) Arch Path Lab Med , vol.114 , pp. 1042-1045
    • Govindarajan, S.1    Conrad, A.2    Lim, B.3    Valinluck, B.4    Kim, A.M.5    Schmid, P.6
  • 86
    • 0019785519 scopus 로고
    • Detection of hepatitis B virus DNA sequences in infected hepatocytes by in situ cytohybridisation
    • Gowans EJ, Burrell CJ, Jilbert AR, Marmion BP (1981). Detection of hepatitis B virus DNA sequences in infected hepatocytes by in situ cytohybridisation. J Med Virol 8:67-78
    • (1981) J Med Virol , vol.8 , pp. 67-78
    • Gowans, E.J.1    Burrell, C.J.2    Jilbert, A.R.3    Marmion, B.P.4
  • 88
    • 0033052604 scopus 로고    scopus 로고
    • Downregulation of DNA excision repair by the hepatitis B virus-x protein occurs in p53-proficient and p53-deficient cells
    • Groisman IJ, Koshy R, Henkler F, Groopman JD, Alaoui-Jamali MA (1999). Downregulation of DNA excision repair by the hepatitis B virus-x protein occurs in p53-proficient and p53-deficient cells. Carcinogenesis 20:479-483
    • (1999) Carcinogenesis , vol.20 , pp. 479-483
    • Groisman, I.J.1    Koshy, R.2    Henkler, F.3    Groopman, J.D.4    Alaoui-Jamali, M.A.5
  • 89
    • 42949160573 scopus 로고    scopus 로고
    • Protective interventions to prevent aflatoxin-induced carcinogenesis in developing countries
    • Groopman JD, Kensler TW, Wild CP (2008). Protective interventions to prevent aflatoxin-induced carcinogenesis in developing countries. Annu Rev Public Health 29:187-203
    • (2008) Annu Rev Public Health , vol.29 , pp. 187-203
    • Groopman, J.D.1    Kensler, T.W.2    Wild, C.P.3
  • 90
    • 17544403729 scopus 로고    scopus 로고
    • Analysis of hepatitis B virus populations in an interferon-alpha-treated patient reveals predominant mutations in the C-gene and changing e-antigenicity
    • Gunther S, Paulij W, Meisel H, Will H (1998). Analysis of hepatitis B virus populations in an interferon-alpha-treated patient reveals predominant mutations in the C-gene and changing e-antigenicity. Virology 244:146-160
    • (1998) Virology , vol.244 , pp. 146-160
    • Gunther, S.1    Paulij, W.2    Meisel, H.3    Will, H.4
  • 92
    • 13944282885 scopus 로고    scopus 로고
    • Identification and characterization of avihepadnaviruses isolated from exotic anseriformes maintained in captivity
    • Guo H, Mason WS, Aldrich CE, Saputelli JR, Miller DS, Jilbert AR, Newbold JE (2005) Identification and characterization of avihepadnaviruses isolated from exotic anseriformes maintained in captivity. J Virol 79:2729-2742
    • (2005) J Virol , vol.79 , pp. 2729-2742
    • Guo, H.1    Mason, W.S.2    Aldrich, C.E.3    Saputelli, J.R.4    Miller, D.S.5    Jilbert, A.R.6    Newbold, J.E.7
  • 93
    • 0028567172 scopus 로고
    • Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma
    • Hagen TM, Huang S, Curnutte J, Fowler P, Martinez V, Wehr CM, Ames BN, Chisari FV (1994) Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma. Proc Natl Acad Sci USA 91:12808-12812
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12808-12812
    • Hagen, T.M.1    Huang, S.2    Curnutte, J.3    Fowler, P.4    Martinez, V.5    Wehr, C.M.6    Ames, B.N.7    Chisari, F.V.8
  • 94
    • 0020805940 scopus 로고
    • Viral nucleic acid synthesis and antigen accumulation in pancreas and kidney of Pekin ducks infected with duck hepatitis B virus
    • Halpern MS, England JM, Deery DT, Petcu DJ, Mason WS, Molnar-Kimber KL (1983). Viral nucleic acid synthesis and antigen accumulation in pancreas and kidney of Pekin ducks infected with duck hepatitis B virus. Proc Natl Acad Sci USA 80:4865-4869
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 4865-4869
    • Halpern, M.S.1    England, J.M.2    Deery, D.T.3    Petcu, D.J.4    Mason, W.S.5    Molnar-Kimber, K.L.6
  • 95
    • 0027507230 scopus 로고
    • Differential activation of myc gene family members in hepatic carcinogenesis by closely related hepatitis B viruses
    • Hansen LJ, Tennant BC, Seeger C, Ganem D (1993). Differential activation of myc gene family members in hepatic carcinogenesis by closely related hepatitis B viruses. Mol Cell Biol 13:659-667
    • (1993) Mol Cell Biol , vol.13 , pp. 659-667
    • Hansen, L.J.1    Tennant, B.C.2    Seeger, C.3    Ganem, D.4
  • 96
    • 0031932893 scopus 로고    scopus 로고
    • Hepatitis B virus pX targets TFIIB in transcription coactivation
    • Haviv I, Shamay M, Doitsh G, Shaul Y (1998). Hepatitis B virus pX targets TFIIB in transcription coactivation. Mol Cell Biol 18:1562-1569
    • (1998) Mol Cell Biol , vol.18 , pp. 1562-1569
    • Haviv, I.1    Shamay, M.2    Doitsh, G.3    Shaul, Y.4
  • 97
    • 0019504253 scopus 로고
    • Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis
    • Hayward WS, Neel BG, Astrin SM (1981). Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis. Nature 290:475-480
    • (1981) Nature , vol.290 , pp. 475-480
    • Hayward, W.S.1    Neel, B.G.2    Astrin, S.M.3
  • 100
    • 0030296929 scopus 로고    scopus 로고
    • The hepatitis B virus large surface protein (LHBs) is a transcriptional activator
    • Hildt E, Saher G, Bruss V, Hofschneider PH (1996). The hepatitis B virus large surface protein (LHBs) is a transcriptional activator. Virology 225:235-239
    • (1996) Virology , vol.225 , pp. 235-239
    • Hildt, E.1    Saher, G.2    Bruss, V.3    Hofschneider, P.H.4
  • 101
    • 0037084160 scopus 로고    scopus 로고
    • The PreS2 activator MHBs(t) of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice
    • Hildt E, Munz B, Saher G, Reifenberg K, Hofschneider PH (2002). The PreS2 activator MHBs(t) of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice. EMBO J 21:525-535
    • (2002) EMBO J , vol.21 , pp. 525-535
    • Hildt, E.1    Munz, B.2    Saher, G.3    Reifenberg, K.4    Hofschneider, P.H.5
  • 102
    • 0033839986 scopus 로고    scopus 로고
    • Acute exacerbation of chronic hepatitis B virus infection after withdrawal of lamivudine therapy
    • Honkoop P, de Man RA, Niesters HG, Zondervan PE, Schalm SW (2000). Acute exacerbation of chronic hepatitis B virus infection after withdrawal of lamivudine therapy. Hepatology 32:635-639
    • (2000) Hepatology , vol.32 , pp. 635-639
    • Honkoop, P.1    de Man, R.A.2    Niesters, H.G.3    Zondervan, P.E.4    Schalm, S.W.5
  • 103
    • 66149190943 scopus 로고    scopus 로고
    • Reactivation of hepatitis B
    • Hoofnagle JH (2009). Reactivation of hepatitis B. Hepatology 49:S156-S165
    • (2009) Hepatology , vol.49
    • Hoofnagle, J.H.1
  • 105
    • 0026447566 scopus 로고
    • Occurrence of oval-type cells in hepatitis B virus-associated human hepatocarcinogenesis
    • Hsia CC, Evarts RP, Nakatsukasa H, Marsden ER, Thorgeirsson SS (1992). Occurrence of oval-type cells in hepatitis B virus-associated human hepatocarcinogenesis. Hepatology 16:1327-1333
    • (1992) Hepatology , vol.16 , pp. 1327-1333
    • Hsia, C.C.1    Evarts, R.P.2    Nakatsukasa, H.3    Marsden, E.R.4    Thorgeirsson, S.S.5
  • 106
    • 0028342783 scopus 로고
    • Expression of hepatitis B surface and core antigens and transforming growth factor-alpha in "oval cells" of the liver in patients with hepatocellular carcinoma
    • Hsia CC, Thorgeirsson SS, Tabor E (1994). Expression of hepatitis B surface and core antigens and transforming growth factor-alpha in "oval cells" of the liver in patients with hepatocellular carcinoma. J Med Virol 43:216-221
    • (1994) J Med Virol , vol.43 , pp. 216-221
    • Hsia, C.C.1    Thorgeirsson, S.S.2    Tabor, E.3
  • 107
    • 6444242588 scopus 로고    scopus 로고
    • Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage
    • Hsieh YH, Su IJ, Wang HC, Chang WW, Lei HY, Lai MD, Chang WT, Huang W (2004). Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage. Carcinogenesis 25:2023-2032
    • (2004) Carcinogenesis , vol.25 , pp. 2023-2032
    • Hsieh, Y.H.1    Su, I.J.2    Wang, H.C.3    Chang, W.W.4    Lei, H.Y.5    Lai, M.D.6    Chang, W.T.7    Huang, W.8
  • 108
    • 35948946094 scopus 로고    scopus 로고
    • Hepatitis B virus pre-S2 mutant surface antigen induces degradation of cyclin-dependent kinase inhibitor p27Kip1 through c-Jun activation domain-binding protein
    • Hsieh YH, Su IJ, Wang HC, Tsai JH, Huang YJ, Chang WW, Lai MD, Lei HY, Huang W (2007) Hepatitis B virus pre-S2 mutant surface antigen induces degradation of cyclin-dependent kinase inhibitor p27Kip1 through c-Jun activation domain-binding protein. Mol Cancer Res 5:1063-1072
    • (2007) Mol Cancer Res , vol.5 , pp. 1063-1072
    • Hsieh, Y.H.1    Su, I.J.2    Wang, H.C.3    Tsai, J.H.4    Huang, Y.J.5    Chang, W.W.6    Lai, M.D.7    Lei, H.Y.8    Huang, W.9
  • 109
    • 0024524670 scopus 로고
    • Biologic significance of the detection of HBsAg and HBcAg in liver and tumor from 204 HBsAg-positive patients with primary hepatocellular carcinoma
    • Hsu HC, Wu TT, Sheu JC, Wu CY, Chiou TJ, Lee CS, Chen DS (1989). Biologic significance of the detection of HBsAg and HBcAg in liver and tumor from 204 HBsAg-positive patients with primary hepatocellular carcinoma. Hepatology 9:747-750
    • (1989) Hepatology , vol.9 , pp. 747-750
    • Hsu, H.C.1    Wu, T.T.2    Sheu, J.C.3    Wu, C.Y.4    Chiou, T.J.5    Lee, C.S.6    Chen, D.S.7
  • 110
    • 0030035038 scopus 로고    scopus 로고
    • Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase
    • Hu J, Seeger C (1996). Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase. Proc Natl Acad Sci USA 93:1060-1064
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1060-1064
    • Hu, J.1    Seeger, C.2
  • 111
    • 0031018112 scopus 로고    scopus 로고
    • Hepadnavirus assembly and reverse transcription require a multicomponent chaperone complex which is incorporated into nucleocapsids
    • Hu J, Toft DO, Seeger C (1997). Hepadnavirus assembly and reverse transcription require a multicomponent chaperone complex which is incorporated into nucleocapsids. EMBO J 16:59-68
    • (1997) EMBO J , vol.16 , pp. 59-68
    • Hu, J.1    Toft, D.O.2    Seeger, C.3
  • 112
    • 0028966041 scopus 로고
    • Strong, sustained hepatocellular proliferation precedes hepatocarcinogenesis in hepatitis B surface antigen transgenic mice
    • Huang SN, Chisari FV (1995). Strong, sustained hepatocellular proliferation precedes hepatocarcinogenesis in hepatitis B surface antigen transgenic mice. Hepatology 21:620-626
    • (1995) Hepatology , vol.21 , pp. 620-626
    • Huang, S.N.1    Chisari, F.V.2
  • 113
    • 23844454276 scopus 로고    scopus 로고
    • Activation of hepatitis B virus S promoter by a cell type-restricted IRE1-dependent pathway induced by endoplasmic reticulum stress
    • Huang ZM, Tan T, Yoshida H, Mori K, Ma Y, Yen TS (2005). Activation of hepatitis B virus S promoter by a cell type-restricted IRE1-dependent pathway induced by endoplasmic reticulum stress. Mol Cell Biol 25:7522-7533
    • (2005) Mol Cell Biol , vol.25 , pp. 7522-7533
    • Huang, Z.M.1    Tan, T.2    Yoshida, H.3    Mori, K.4    Ma, Y.5    Yen, T.S.6
  • 115
    • 0027514088 scopus 로고
    • High-capacity in vitro assessment of anti-hepatitis B virus compound selectivity by a virion-specific polymerase chain reaction assay
    • Jansen RW, Johnson LC, Averett DR (1993). High-capacity in vitro assessment of anti-hepatitis B virus compound selectivity by a virion-specific polymerase chain reaction assay. Antimicrob Agents Chemother 37:441-447
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 441-447
    • Jansen, R.W.1    Johnson, L.C.2    Averett, D.R.3
  • 116
    • 68949148878 scopus 로고    scopus 로고
    • Dynamic changes of HBV quasispecies and deletion patterns in a chronic hepatitis B patient
    • Ji F, Zhou L, Ma S, Li F, Ding H, Zeng C (2009). Dynamic changes of HBV quasispecies and deletion patterns in a chronic hepatitis B patient. J Med Virol 81:1551-1559
    • (2009) J Med Virol , vol.81 , pp. 1551-1559
    • Ji, F.1    Zhou, L.2    Ma, S.3    Li, F.4    Ding, H.5    Zeng, C.6
  • 117
    • 0033559939 scopus 로고    scopus 로고
    • Hepatitis B virus X protein inhibits nucleotide excision repair
    • Jia L, Wang XW, Harris CC (1999). Hepatitis B virus X protein inhibits nucleotide excision repair. Int J Cancer 80:875-879
    • (1999) Int J Cancer , vol.80 , pp. 875-879
    • Jia, L.1    Wang, X.W.2    Harris, C.C.3
  • 119
    • 0025045477 scopus 로고
    • A short cis-acting sequence is required for hepatitis B virus pregenome encapsidation and sufficient for packaging of foreign RNA
    • Junker-Niepmann M, Bartenschlager R, Schaller H (1990). A short cis-acting sequence is required for hepatitis B virus pregenome encapsidation and sufficient for packaging of foreign RNA. EMBO J 9:3389-3396
    • (1990) EMBO J , vol.9 , pp. 3389-3396
    • Junker-Niepmann, M.1    Bartenschlager, R.2    Schaller, H.3
  • 120
    • 0027941175 scopus 로고
    • Woodchuck hepatitis virus infections: Very rapid recovery after a prolonged viremia and infection of virtually every hepatocyte
    • Kajino K, Jilbert AR, Saputelli J, Aldrich CE, Cullen J, Mason WS (1994). Woodchuck hepatitis virus infections: very rapid recovery after a prolonged viremia and infection of virtually every hepatocyte. J Virol 68:5792-5803
    • (1994) J Virol , vol.68 , pp. 5792-5803
    • Kajino, K.1    Jilbert, A.R.2    Saputelli, J.3    Aldrich, C.E.4    Cullen, J.5    Mason, W.S.6
  • 121
    • 67649460609 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein localized to the nucleus restores HBx-deficient virus replication in HepG2 cells and in vivo in hydrodynamically-injected mice
    • Keasler VV, Hodgson AJ, Madden CR, Slagle BL (2009). Hepatitis B virus HBx protein localized to the nucleus restores HBx-deficient virus replication in HepG2 cells and in vivo in hydrodynamically-injected mice. Virology 390:122-129
    • (2009) Virology , vol.390 , pp. 122-129
    • Keasler, V.V.1    Hodgson, A.J.2    Madden, C.R.3    Slagle, B.L.4
  • 122
    • 0025098651 scopus 로고
    • The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator
    • Kekule AS, Lauer U, Meyer M, Caselmann WH, Hofschneider PH, Koshy R (1990). The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator. Nature 343:457-461
    • (1990) Nature , vol.343 , pp. 457-461
    • Kekule, A.S.1    Lauer, U.2    Meyer, M.3    Caselmann, W.H.4    Hofschneider, P.H.5    Koshy, R.6
  • 123
    • 0025907983 scopus 로고
    • HBx gene of hepatitis B virus induces liver cancer in transgenic mice
    • Kim CM, Koike K, Saito I, Miyamura T, Jay G (1991). HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 351:317-320
    • (1991) Nature , vol.351 , pp. 317-320
    • Kim, C.M.1    Koike, K.2    Saito, I.3    Miyamura, T.4    Jay, G.5
  • 125
    • 70350566149 scopus 로고    scopus 로고
    • Hepatitis B virus X gene is implicated in liver carcinogenesis
    • Koike K (2009). Hepatitis B virus X gene is implicated in liver carcinogenesis. Cancer Lett 286:60-68
    • (2009) Cancer Lett , vol.286 , pp. 60-68
    • Koike, K.1
  • 126
    • 0028230728 scopus 로고
    • High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic mice
    • Koike K, Moriya K, Iino S, Yotsuyanagi H, Endo Y, Miyamura T, Kurokawa K (1994). High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic mice. Hepatology 19:810-819
    • (1994) Hepatology , vol.19 , pp. 810-819
    • Koike, K.1    Moriya, K.2    Iino, S.3    Yotsuyanagi, H.4    Endo, Y.5    Miyamura, T.6    Kurokawa, K.7
  • 127
    • 0034693076 scopus 로고    scopus 로고
    • Direct binding of hepatitis B virus X protein and retinoid X receptor contributes to phosphoenolpyruvate carboxykinase gene transactivation
    • Kong HJ, Hong SH, Lee MY, Kim HD, Lee JW, Cheong J (2000). Direct binding of hepatitis B virus X protein and retinoid X receptor contributes to phosphoenolpyruvate carboxykinase gene transactivation. FEBS Lett 483:114-118
    • (2000) FEBS Lett , vol.483 , pp. 114-118
    • Kong, H.J.1    Hong, S.H.2    Lee, M.Y.3    Kim, H.D.4    Lee, J.W.5    Cheong, J.6
  • 128
    • 0142182771 scopus 로고    scopus 로고
    • Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2
    • Kong HJ, Park MJ, Hong S, Yu HJ, Lee YC, Choi YH, Cheong J (2003). Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2. Hepatology 38:1258-1266
    • (2003) Hepatology , vol.38 , pp. 1258-1266
    • Kong, H.J.1    Park, M.J.2    Hong, S.3    Yu, H.J.4    Lee, Y.C.5    Choi, Y.H.6    Cheong, J.7
  • 132
    • 0035821645 scopus 로고    scopus 로고
    • The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner
    • Lara-Pezzi E, Roche S, Andrisani OM, Sanchez-Madrid F, Lopez-Cabrera M (2001b). The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner. Oncogene 20:3323-3331
    • (2001) Oncogene , vol.20 , pp. 3323-3331
    • Lara-Pezzi, E.1    Roche, S.2    Andrisani, O.M.3    Sanchez-Madrid, F.4    Lopez-Cabrera, M.5
  • 133
    • 0026808738 scopus 로고
    • The hepatitis B virus pre-S/S(t) transactivator is generated by 3 ¢ truncations within a defined region of the S gene
    • Lauer U, Weiss L, Hofschneider PH, Kekule AS (1992). The hepatitis B virus pre-S/S(t) transactivator is generated by 3 ¢ truncations within a defined region of the S gene. J Virol 66:5284-5289
    • (1992) J Virol , vol.66 , pp. 5284-5289
    • Lauer, U.1    Weiss, L.2    Hofschneider, P.H.3    Kekule, A.S.4
  • 134
    • 1642410856 scopus 로고    scopus 로고
    • Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures
    • Lavanchy D (2004). Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 11:97-107
    • (2004) J Viral Hepat , vol.11 , pp. 97-107
    • Lavanchy, D.1
  • 135
    • 0034688143 scopus 로고    scopus 로고
    • Transcriptional repression of the human P53 gene by hepatitis B viral X protein
    • Lee SG, Rho HM (2000). Transcriptional repression of the human P53 gene by hepatitis B viral X protein. Oncogene 19:468-471
    • (2000) Oncogene , vol.19 , pp. 468-471
    • Lee, S.G.1    Rho, H.M.2
  • 136
    • 0025222293 scopus 로고
    • Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice
    • Lee TH, Finegold MJ, Shen RF, DeMayo JL, Woo SL, Butel JS (1990). Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice. J Virol 64:5939-5947
    • (1990) J Virol , vol.64 , pp. 5939-5947
    • Lee, T.H.1    Finegold, M.J.2    Shen, R.F.3    DeMayo, J.L.4    Woo, S.L.5    Butel, J.S.6
  • 137
    • 0030006486 scopus 로고    scopus 로고
    • Novel pre-C/C gene mutants of hepatitis B virus in chronic active hepatitis: Naturally occurring escape mutants
    • Lee YI, Hur GM, Suh DJ, Kim SH (1996). Novel pre-C/C gene mutants of hepatitis B virus in chronic active hepatitis: naturally occurring escape mutants. J Gen Virol 77:1129-1138
    • (1996) J Gen Virol , vol.77 , pp. 1129-1138
    • Lee, Y.I.1    Hur, G.M.2    Suh, D.J.3    Kim, S.H.4
  • 138
    • 0037040927 scopus 로고    scopus 로고
    • Hepatitis B virus X protein differentially regulates cell cycle progression in X-transforming versus nontransforming hepatocyte (AML12) cell lines
    • Lee S, Tarn C, Wang WH, Chen S, Hullinger RL, Andrisani OM (2002). Hepatitis B virus X protein differentially regulates cell cycle progression in X-transforming versus nontransforming hepatocyte (AML12) cell lines. J Biol Chem 277:8730-8740
    • (2002) J Biol Chem , vol.277 , pp. 8730-8740
    • Lee, S.1    Tarn, C.2    Wang, W.H.3    Chen, S.4    Hullinger, R.L.5    Andrisani, O.M.6
  • 140
    • 68249116458 scopus 로고    scopus 로고
    • Chromosomal instability, telomere shortening, and inactivation of p21(WAF1/CIP1) in dysplastic nodules of hepatitis B virus-associated multistep hepatocarcinogenesis
    • Lee YH, Oh BK, Yoo JE, Yoon SM, Choi J, Kim KS, Park YN (2009). Chromosomal instability, telomere shortening, and inactivation of p21(WAF1/CIP1) in dysplastic nodules of hepatitis B virus-associated multistep hepatocarcinogenesis. Mod Pathol 22:1121-1131
    • (2009) Mod Pathol , vol.22 , pp. 1121-1131
    • Lee, Y.H.1    Oh, B.K.2    Yoo, J.E.3    Yoon, S.M.4    Choi, J.5    Kim, K.S.6    Park, Y.N.7
  • 141
    • 0032506099 scopus 로고    scopus 로고
    • Competition in vivo between a cytopathic variant and a wild-type duck hepatitis B virus
    • Lenhoff RJ, Luscombe CA, Summers J (1998). Competition in vivo between a cytopathic variant and a wild-type duck hepatitis B virus. Virology 251:85-95
    • (1998) Virology , vol.251 , pp. 85-95
    • Lenhoff, R.J.1    Luscombe, C.A.2    Summers, J.3
  • 143
    • 54149088014 scopus 로고    scopus 로고
    • Identification of functionally important amino acid residues in the mitochondria targeting sequence of hepatitis B virus X protein
    • Li SK, Ho SF, Tsui KW, Fung KP, Waye MY (2008). Identification of functionally important amino acid residues in the mitochondria targeting sequence of hepatitis B virus X protein. Virology 381:81-88
    • (2008) Virology , vol.381 , pp. 81-88
    • Li, S.K.1    Ho, S.F.2    Tsui, K.W.3    Fung, K.P.4    Waye, M.Y.5
  • 144
    • 77449113802 scopus 로고    scopus 로고
    • A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery
    • Li T, Robert EI, van Breugel PC, Strubin M, Zheng N (2010). A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. Nat Struct Mol Biol 17:105-111
    • (2010) Nat Struct Mol Biol , vol.17 , pp. 105-111
    • Li, T.1    Robert, E.I.2    van Breugel, P.C.3    Strubin, M.4    Zheng, N.5
  • 146
    • 59149086601 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis B virus infection and long-term outcome under treatment
    • Liaw YF (2009). Natural history of chronic hepatitis B virus infection and long-term outcome under treatment. Liver Int 29:S100-S107.
    • Liver Int , vol.29
    • Liaw, Y.F.1
  • 148
    • 0033645595 scopus 로고    scopus 로고
    • Deep intralobular extension of human hepatic 'progenitor cells' correlates with parenchymal inflammation in chronic viral hepatitis: Can 'progenitor cells' migrate?
    • Libbrecht L, Desmet V, Van Damme B, Roskams T (2000). Deep intralobular extension of human hepatic 'progenitor cells' correlates with parenchymal inflammation in chronic viral hepatitis: can 'progenitor cells' migrate? J Pathol 192:373-378
    • (2000) J Pathol , vol.192 , pp. 373-378
    • Libbrecht, L.1    Desmet, V.2    van Damme, B.3    Roskams, T.4
  • 149
    • 77951254206 scopus 로고    scopus 로고
    • HBx targeting to mitochondria and ROS generation are necessary but insufficient for HBV-induced cyclooxygenase-2 expression
    • Lim W, Kwon SH, Cho H, Kim S, Lee S, Ryu WS (2010). HBx targeting to mitochondria and ROS generation are necessary but insufficient for HBV-induced cyclooxygenase-2 expression. J Mol Med 88:359-369
    • (2010) J Mol Med , vol.88 , pp. 359-369
    • Lim, W.1    Kwon, S.H.2    Cho, H.3    Kim, S.4    Lee, S.5    Ryu, W.S.6
  • 150
    • 0030989802 scopus 로고    scopus 로고
    • Hepatitis B virus X protein is a transcriptional modulator that communicates with transcription factor IIB and the RNA polymerase II subunit 5
    • Lin Y, Nomura T, Cheong J, Dorjsuren D, Iida K, Murakami S (1997). Hepatitis B virus X protein is a transcriptional modulator that communicates with transcription factor IIB and the RNA polymerase II subunit 5. J Biol Chem 272:7132-7139
    • (1997) J Biol Chem , vol.272 , pp. 7132-7139
    • Lin, Y.1    Nomura, T.2    Cheong, J.3    Dorjsuren, D.4    Iida, K.5    Murakami, S.6
  • 151
    • 0030916598 scopus 로고    scopus 로고
    • Production of hepatitis B virus covalently closed circular DNA in transfected cells is independent of surface antigen synthesis
    • Ling R, Harrison TJ (1997). Production of hepatitis B virus covalently closed circular DNA in transfected cells is independent of surface antigen synthesis. J Gen Virol 78:1463-1467
    • (1997) J Gen Virol , vol.78 , pp. 1463-1467
    • Ling, R.1    Harrison, T.J.2
  • 152
    • 30344458192 scopus 로고    scopus 로고
    • Cellular and virological mechanisms of HBV drug resistance
    • Locarnini S, Mason WS (2005). Cellular and virological mechanisms of HBV drug resistance. J Hepatol 44:422-431
    • (2005) J Hepatol , vol.44 , pp. 422-431
    • Locarnini, S.1    Mason, W.S.2
  • 153
    • 33847701354 scopus 로고    scopus 로고
    • Chronic hepatitis B: AAALD practice guidelines
    • Lok ASF, McMahon BJ (2007). Chronic hepatitis B: AAALD practice guidelines. Hepatology 45:507-539
    • (2007) Hepatology , vol.45 , pp. 507-539
    • Lok, A.S.F.1    McMahon, B.J.2
  • 154
    • 0026526978 scopus 로고
    • Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C
    • Lucito R, Schneider RJ (1992). Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C. J Virol 66:983-991
    • (1992) J Virol , vol.66 , pp. 983-991
    • Lucito, R.1    Schneider, R.J.2
  • 155
    • 33846473749 scopus 로고    scopus 로고
    • Hepatitis B virus-induced oncogenesis
    • Lupberger J, Hildt E (2007). Hepatitis B virus-induced oncogenesis. World J Gastroenterol 13:74-81
    • (2007) World J Gastroenterol , vol.13 , pp. 74-81
    • Lupberger, J.1    Hildt, E.2
  • 157
    • 0035659925 scopus 로고    scopus 로고
    • Stimulation of cellular proliferation by hepatitis B virus X protein
    • Madden CR, Slagle BL (2001). Stimulation of cellular proliferation by hepatitis B virus X protein. Dis Markers 17:153-157
    • (2001) Dis Markers , vol.17 , pp. 153-157
    • Madden, C.R.1    Slagle, B.L.2
  • 158
    • 0035084167 scopus 로고    scopus 로고
    • Hepatitis B virus X protein acts as a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions
    • Madden CR, Finegold MJ, Slagle BL (2001). Hepatitis B virus X protein acts as a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions. J Virol 75:3851-3858
    • (2001) J Virol , vol.75 , pp. 3851-3858
    • Madden, C.R.1    Finegold, M.J.2    Slagle, B.L.3
  • 159
    • 21244472975 scopus 로고    scopus 로고
    • IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • Maeda S, Kamata H, Luo JL, Leffert H, Karin M (2005). IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121:977-990
    • (2005) Cell , vol.121 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3    Leffert, H.4    Karin, M.5
  • 160
    • 0025784335 scopus 로고
    • HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions
    • Maguire HF, Hoeffler JP, Siddiqui A (1991). HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. Science 252:842-844
    • (1991) Science , vol.252 , pp. 842-844
    • Maguire, H.F.1    Hoeffler, J.P.2    Siddiqui, A.3
  • 161
    • 0025768552 scopus 로고
    • Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor kB and CCAAT/enhancer-binding protein-like cis-elements
    • Mahe Y, Mukaida N, Kuno K, Akiyama M, Ikeda N, Matsushima K, Murakami S (1991). Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor kB and CCAAT/enhancer-binding protein-like cis-elements. J Biol Chem 266:13759-13763
    • (1991) J Biol Chem , vol.266 , pp. 13759-13763
    • Mahe, Y.1    Mukaida, N.2    Kuno, K.3    Akiyama, M.4    Ikeda, N.5    Matsushima, K.6    Murakami, S.7
  • 162
  • 164
  • 165
    • 56149087784 scopus 로고    scopus 로고
    • Hepatitis B virus X protein affects S phase progression leading to chromosome segregation defects by binding to damaged DNA binding protein 1
    • Martin-Lluesma S, Schaeffer C, Robert EI, van Breugel PC, Leupin O, Hantz O, Strubin M (2008) Hepatitis B virus X protein affects S phase progression leading to chromosome segregation defects by binding to damaged DNA binding protein 1. Hepatology 48:1467-1476
    • (2008) Hepatology , vol.48 , pp. 1467-1476
    • Martin-Lluesma, S.1    Schaeffer, C.2    Robert, E.I.3    van Breugel, P.C.4    Leupin, O.5    Hantz, O.6    Strubin, M.7
  • 167
    • 0027362665 scopus 로고
    • Clonal analysis by study of X chromosome inactivation in formalin-fixed paraffin-embedded tissue
    • Mashal RD, Lester SC, Sklar J (1993). Clonal analysis by study of X chromosome inactivation in formalin-fixed paraffin-embedded tissue. Cancer Res 53:4676-4679
    • (1993) Cancer Res , vol.53 , pp. 4676-4679
    • Mashal, R.D.1    Lester, S.C.2    Sklar, J.3
  • 168
    • 0019133611 scopus 로고
    • Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus
    • Mason WS, Seal G, Summers J (1980). Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus. J Virol 36:829-836
    • (1980) J Virol , vol.36 , pp. 829-836
    • Mason, W.S.1    Seal, G.2    Summers, J.3
  • 170
    • 12844283883 scopus 로고    scopus 로고
    • Clonal expansion of hepatocytes during chronic woodchuck hepatitis virus infection
    • Mason WS, Jilbert AR, Summers J (2005). Clonal expansion of hepatocytes during chronic woodchuck hepatitis virus infection. Proc Natl Acad Sci USA 102:1139-1144
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1139-1144
    • Mason, W.S.1    Jilbert, A.R.2    Summers, J.3
  • 171
    • 69749084253 scopus 로고    scopus 로고
    • Immune selection during chronic hepadnavirus infection
    • Mason WS, Litwin S, Jilbert AR (2008). Immune selection during chronic hepadnavirus infection. Hepatol Int 2:3-16
    • (2008) Hepatol Int , vol.2 , pp. 3-16
    • Mason, W.S.1    Litwin, S.2    Jilbert, A.R.3
  • 173
    • 77954991668 scopus 로고    scopus 로고
    • Clonal expansion of normal appearing human hepatocytes during chronic HBV infection
    • Mason WS, Liu C, Aldrich CE, Litwin S, Yeh MM (2010). Clonal expansion of normal appearing human hepatocytes during chronic HBV infection. J Virol 84:8308-8315
    • (2010) J Virol , vol.84 , pp. 8308-8315
    • Mason, W.S.1    Liu, C.2    Aldrich, C.E.3    Litwin, S.4    Yeh, M.M.5
  • 174
    • 4344634335 scopus 로고    scopus 로고
    • Expression of hepatitis B virus X oncoprotein inhibits transcription-coupled nucleotide excision repair in human cells
    • Mathonnet G, Lachance S, Alaoui-Jamali M, Drobetsky EA (2004). Expression of hepatitis B virus X oncoprotein inhibits transcription-coupled nucleotide excision repair in human cells. Mutat Res 554:305-318
    • (2004) Mutat Res , vol.554 , pp. 305-318
    • Mathonnet, G.1    Lachance, S.2    Alaoui-Jamali, M.3    Drobetsky, E.A.4
  • 175
    • 0019012443 scopus 로고
    • Type B hepatitis: A review of current prospects for a safe and effective vaccine
    • McAuliffe VJ, Purcell RH, Gerin JL (1980). Type B hepatitis: a review of current prospects for a safe and effective vaccine. Rev Infect Dis 2:470-492
    • (1980) Rev Infect Dis , vol.2 , pp. 470-492
    • McAuliffe, V.J.1    Purcell, R.H.2    Gerin, J.L.3
  • 176
  • 178
    • 36249026297 scopus 로고    scopus 로고
    • Persistent occult hepatitis B virus infection: Experimental findings and clinical implications
    • Mulrooney-Cousins PM, Michalak TI (2007). Persistent occult hepatitis B virus infection: experimental findings and clinical implications. World J Gastroenterol 13:5682-5686
    • (2007) World J Gastroenterol , vol.13 , pp. 5682-5686
    • Mulrooney-Cousins, P.M.1    Michalak, T.I.2
  • 179
    • 22644435919 scopus 로고    scopus 로고
    • Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas
    • Murakami Y, Saigo K, Takashima H, Minami M, Okanoue T, Brechot C, Paterlini-Brechot P (2005). Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas. Gut 54:1162-1168
    • (2005) Gut , vol.54 , pp. 1162-1168
    • Murakami, Y.1    Saigo, K.2    Takashima, H.3    Minami, M.4    Okanoue, T.5    Brechot, C.6    Paterlini-Brechot, P.7
  • 181
    • 0015122188 scopus 로고
    • Hepatocellular carcinoma, positive Australia (hepatitisassociated) antigen and sarcoidosis
    • Myerson RM, Soroush A, Skerrett PV (1971). Hepatocellular carcinoma, positive Australia (hepatitisassociated) antigen and sarcoidosis. Am J Dig Dis 16:857-862
    • (1971) Am J Dig Dis , vol.16 , pp. 857-862
    • Myerson, R.M.1    Soroush, A.2    Skerrett, P.V.3
  • 182
    • 0019966544 scopus 로고
    • Growth of human hepatoma cell line with differentiated functions in chemically defined medium
    • Nakabayashi H, Taketa K, Miyano K, Yamane T, Sato J (1982). Growth of human hepatoma cell line with differentiated functions in chemically defined medium. Cancer Res 42:3858-3863
    • (1982) Cancer Res , vol.42 , pp. 3858-3863
    • Nakabayashi, H.1    Taketa, K.2    Miyano, K.3    Yamane, T.4    Sato, J.5
  • 185
    • 77949654113 scopus 로고    scopus 로고
    • Mechanisms of HBV-related hepatocarcinogenesis
    • Neuveut C, Wei Y, Buendia MA (2010). Mechanisms of HBV-related hepatocarcinogenesis. J Hepatol 52:594-604
    • (2010) J Hepatol , vol.52 , pp. 594-604
    • Neuveut, C.1    Wei, Y.2    Buendia, M.A.3
  • 186
    • 0029037074 scopus 로고
    • The covalently closed duplex form of the hepadnavirus genome exists in situ as a heterogeneous population of viral minichromosomes
    • Newbold JE, Xin H, Tencza M, Sherman G, Dean J, Bowden S, Locarnini S (1995). The covalently closed duplex form of the hepadnavirus genome exists in situ as a heterogeneous population of viral minichromosomes. J Virol 69:3350-3357
    • (1995) J Virol , vol.69 , pp. 3350-3357
    • Newbold, J.E.1    Xin, H.2    Tencza, M.3    Sherman, G.4    Dean, J.5    Bowden, S.6    Locarnini, S.7
  • 188
    • 39749131737 scopus 로고    scopus 로고
    • Purification of fetal liver stem/progenitor cells containing all the repopulation potential for normal adult rat liver
    • Oertel M, Menthena A, Chen YQ, Teisner B, Jensen CH, Shafritz DA (2008). Purification of fetal liver stem/progenitor cells containing all the repopulation potential for normal adult rat liver. Gastroenterology 134:823-832
    • (2008) Gastroenterology , vol.134 , pp. 823-832
    • Oertel, M.1    Menthena, A.2    Chen, Y.Q.3    Teisner, B.4    Jensen, C.H.5    Shafritz, D.A.6
  • 189
    • 0027992963 scopus 로고
    • Hepatitis B virus with mutations in the core promoter for an e antigennegative phenotype in carriers with antibody to e antigen
    • Okamoto H, Tsuda F, Akahane Y, Sugai Y, Yoshiba M, Moriyama K, Tanaka T, Miyakawa Y, Mayumi M (1994). Hepatitis B virus with mutations in the core promoter for an e antigennegative phenotype in carriers with antibody to e antigen. J Virol 68:8102-8110
    • (1994) J Virol , vol.68 , pp. 8102-8110
    • Okamoto, H.1    Tsuda, F.2    Akahane, Y.3    Sugai, Y.4    Yoshiba, M.5    Moriyama, K.6    Tanaka, T.7    Miyakawa, Y.8    Mayumi, M.9
  • 190
    • 0028265897 scopus 로고
    • A dramatic shift in the transmembrane topology of a viral envelope glycoprotein accompanies hepatitis B viral morphogenesis
    • Ostapchuk P, Hearing P, Ganem D (1994). A dramatic shift in the transmembrane topology of a viral envelope glycoprotein accompanies hepatitis B viral morphogenesis. EMBO J 13:1048-1057
    • (1994) EMBO J , vol.13 , pp. 1048-1057
    • Ostapchuk, P.1    Hearing, P.2    Ganem, D.3
  • 191
    • 0023094424 scopus 로고
    • Regulation of secretion of the hepatitis B virus major surface antigen by the preS-1 protein
    • Ou JH, Rutter WJ (1987). Regulation of secretion of the hepatitis B virus major surface antigen by the preS-1 protein. J Virol 61:782-786
    • (1987) J Virol , vol.61 , pp. 782-786
    • Ou, J.H.1    Rutter, W.J.2
  • 192
    • 0035155733 scopus 로고    scopus 로고
    • Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-kappa B
    • Pan J, Duan LX, Sun BS, Feitelson MA (2001). Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-kappa B. J Gen Virol 82:171-182
    • (2001) J Gen Virol , vol.82 , pp. 171-182
    • Pan, J.1    Duan, L.X.2    Sun, B.S.3    Feitelson, M.A.4
  • 194
    • 0037942914 scopus 로고    scopus 로고
    • Genome replication, virion secretion, and e antigen expression of naturally occurring hepatitis B virus core promoter mutants
    • Parekh S, Zoulim F, Ahn SH, Tsai A, Li J, Kawai S, Khan N, Trepo C, Wands J, Tong S (2003) Genome replication, virion secretion, and e antigen expression of naturally occurring hepatitis B virus core promoter mutants. J Virol 77:6601-6612
    • (2003) J Virol , vol.77 , pp. 6601-6612
    • Parekh, S.1    Zoulim, F.2    Ahn, S.H.3    Tsai, A.4    Li, J.5    Kawai, S.6    Khan, N.7    Trepo, C.8    Wands, J.9    Tong, S.10
  • 195
    • 0034644192 scopus 로고    scopus 로고
    • Hepatitis B virus-X protein upregulates the expression of p21waf1/cip1 and prolongs G1->S transition via a p53-independent pathway in human hepatoma cells
    • Park US, Park SK, Lee YI, Park JG (2000). Hepatitis B virus-X protein upregulates the expression of p21waf1/cip1 and prolongs G1->S transition via a p53-independent pathway in human hepatoma cells. Oncogene 19:3384-3394
    • (2000) Oncogene , vol.19 , pp. 3384-3394
    • Park, U.S.1    Park, S.K.2    Lee, Y.I.3    Park, J.G.4
  • 196
    • 0037663314 scopus 로고    scopus 로고
    • Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene
    • Paterlini-Brechot P, Saigo K, Murakami Y, Chami M, Gozuacik D, Mugnier C, Lagorce D, Brechot C (2003). Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene. Oncogene 22:3911-3916
    • (2003) Oncogene , vol.22 , pp. 3911-3916
    • Paterlini-Brechot, P.1    Saigo, K.2    Murakami, Y.3    Chami, M.4    Gozuacik, D.5    Mugnier, C.6    Lagorce, D.7    Brechot, C.8
  • 197
    • 0030700415 scopus 로고    scopus 로고
    • Clonality of large regenerative nodules in liver cirrhosis
    • Piao Z, Park YN, Kim H, Park C (1997). Clonality of large regenerative nodules in liver cirrhosis. Liver 17:251-256
    • (1997) Liver , vol.17 , pp. 251-256
    • Piao, Z.1    Park, Y.N.2    Kim, H.3    Park, C.4
  • 199
    • 0029953814 scopus 로고    scopus 로고
    • Analysis of liver development, regeneration, and carcinogenesis by genetic marking studies
    • Ponder KP (1996). Analysis of liver development, regeneration, and carcinogenesis by genetic marking studies. FASEB J 10:673-682
    • (1996) FASEB J , vol.10 , pp. 673-682
    • Ponder, K.P.1
  • 201
    • 0036151941 scopus 로고    scopus 로고
    • Complex HBV populations with mutations in core promoter, C gene, and pre-S region are associated with development of cirrhosis in long-term renal transplant recipients
    • Preikschat P, Gunther S, Reinhold S, Will H, Budde K, Neumayer HH, Kruger DH, Meisel H (2002). Complex HBV populations with mutations in core promoter, C gene, and pre-S region are associated with development of cirrhosis in long-term renal transplant recipients. Hepatology 35:466-477
    • (2002) Hepatology , vol.35 , pp. 466-477
    • Preikschat, P.1    Gunther, S.2    Reinhold, S.3    Will, H.4    Budde, K.5    Neumayer, H.H.6    Kruger, D.H.7    Meisel, H.8
  • 203
    • 0028890351 scopus 로고
    • Hepatitis B virus transactivator protein X interacts with the TATA-binding protein
    • Qadri I, Maguire HF, Siddiqui A (1995). Hepatitis B virus transactivator protein X interacts with the TATA-binding protein. Proc Natl Acad Sci USA 92:1003-1007
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1003-1007
    • Qadri, I.1    Maguire, H.F.2    Siddiqui, A.3
  • 204
    • 0029743407 scopus 로고    scopus 로고
    • Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH
    • Qadri I, Conaway JW, Conaway RC, Schaack J, Siddiqui A (1996). Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH. Proc Natl Acad Sci USA 93:10578-10583
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10578-10583
    • Qadri, I.1    Conaway, J.W.2    Conaway, R.C.3    Schaack, J.4    Siddiqui, A.5
  • 206
    • 0033802836 scopus 로고    scopus 로고
    • Hepadnaviral hepatocarcinogenesis: In situ visualization of viral antigens, cytoplasmic compartmentation, enzymic patterns, and cellular proliferation in preneoplastic hepatocellular lineages in woodchucks
    • Radaeva S, Li Y, Hacker HJ, Burger V, Kopp-Schneider A, Bannasch P (2000). Hepadnaviral hepatocarcinogenesis: in situ visualization of viral antigens, cytoplasmic compartmentation, enzymic patterns, and cellular proliferation in preneoplastic hepatocellular lineages in woodchucks. J Hepatol 33:580-600
    • (2000) J Hepatol , vol.33 , pp. 580-600
    • Radaeva, S.1    Li, Y.2    Hacker, H.J.3    Burger, V.4    Kopp-Schneider, A.5    Bannasch, P.6
  • 207
    • 0342905085 scopus 로고    scopus 로고
    • Hepatitis B virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential
    • Rahmani Z, Huh KW, Lasher R, Siddiqui A (2000). Hepatitis B virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential. J Virol 74:2840-2846
    • (2000) J Virol , vol.74 , pp. 2840-2846
    • Rahmani, Z.1    Huh, K.W.2    Lasher, R.3    Siddiqui, A.4
  • 208
    • 57649116077 scopus 로고    scopus 로고
    • Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy
    • Rakotomalala L, Studach L, Wang WH, Gregori G, Hullinger RL, Andrisani O (2008). Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy. J Biol Chem 283:28729-28740
    • (2008) J Biol Chem , vol.283 , pp. 28729-28740
    • Rakotomalala, L.1    Studach, L.2    Wang, W.H.3    Gregori, G.4    Hullinger, R.L.5    Andrisani, O.6
  • 209
    • 80052453168 scopus 로고    scopus 로고
    • The persistence in the liver of residual duck hepatitis B virus covalently closed circular DNA is not dependent upon new viral DNA synthesis
    • Reaiche GY, Le Mire MF, Mason WS, Jilbert AR (2010). The persistence in the liver of residual duck hepatitis B virus covalently closed circular DNA is not dependent upon new viral DNA synthesis. Virology 406(2):286-292
    • (2010) Virology , vol.406 , Issue.2 , pp. 286-292
    • Reaiche, G.Y.1    Le Mire, M.F.2    Mason, W.S.3    Jilbert, A.R.4
  • 210
    • 0029838758 scopus 로고    scopus 로고
    • The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response
    • Rehermann B, Ferrari C, Pasquinelli C, Chisari FV (1996a). The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response. Nat Med 2:1104-1108
    • (1996) Nat Med , vol.2 , pp. 1104-1108
    • Rehermann, B.1    Ferrari, C.2    Pasquinelli, C.3    Chisari, F.V.4
  • 211
    • 0030008076 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection
    • Rehermann B, Lau D, Hoofnagle JH, Chisari FV (1996b). Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection. J Clin Invest 97:1655-1665
    • (1996) J Clin Invest , vol.97 , pp. 1655-1665
    • Rehermann, B.1    Lau, D.2    Hoofnagle, J.H.3    Chisari, F.V.4
  • 212
    • 0034682340 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in WHV/N-myc2 transgenic mice: Oncogenic mutations of beta-catenin and synergistic effect of p53 null alleles
    • Renard CA, Fourel G, Bralet MP, Degott C, De La Coste A, Perret C, Tiollais P, Buendia MA (2000). Hepatocellular carcinoma in WHV/N-myc2 transgenic mice: oncogenic mutations of beta-catenin and synergistic effect of p53 null alleles. Oncogene 19:2678-2686
    • (2000) Oncogene , vol.19 , pp. 2678-2686
    • Renard, C.A.1    Fourel, G.2    Bralet, M.P.3    Degott, C.4    de La Coste, A.5    Perret, C.6    Tiollais, P.7    Buendia, M.A.8
  • 213
    • 0025339437 scopus 로고
    • Hepadnaviruses in cirrhotic liver and hepatocellular carcinoma
    • Robinson WS, Klote L, Aoki N (1990). Hepadnaviruses in cirrhotic liver and hepatocellular carcinoma. J Med Virol 31:18-32
    • (1990) J Med Virol , vol.31 , pp. 18-32
    • Robinson, W.S.1    Klote, L.2    Aoki, N.3
  • 214
    • 0025765845 scopus 로고
    • Cellular and molecular mechanisms of hepatocarcinogenesis associated with hepadnavirus infection
    • Rogler CE (1991). Cellular and molecular mechanisms of hepatocarcinogenesis associated with hepadnavirus infection. Curr Top Microbiol Immunol 168:103-140
    • (1991) Curr Top Microbiol Immunol , vol.168 , pp. 103-140
    • Rogler, C.E.1
  • 215
    • 33745533559 scopus 로고    scopus 로고
    • Liver stem cells and their implications in hepatocellular and cholangiocarcinoma
    • Roskams T (2006). Liver stem cells and their implications in hepatocellular and cholangiocarcinoma. Oncogene 25:3818-3822
    • (2006) Oncogene , vol.25 , pp. 3818-3822
    • Roskams, T.1
  • 216
    • 62549136153 scopus 로고    scopus 로고
    • Expansion of CD133-expressing liver cancer stem cells in liver-specific phosphatase and tensin homolog deleted on chromosome 10-deleted mice
    • Rountree CB, Ding W, He L, Stiles B (2009). Expansion of CD133-expressing liver cancer stem cells in liver-specific phosphatase and tensin homolog deleted on chromosome 10-deleted mice. Stem Cells 27:290-299
    • (2009) Stem Cells , vol.27 , pp. 290-299
    • Rountree, C.B.1    Ding, W.2    He, L.3    Stiles, B.4
  • 217
    • 28844435781 scopus 로고    scopus 로고
    • Interaction of the hepatitis B virus protein HBx with the human transcription regulatory protein p120E4F in vitro
    • Rui E, Moura PR, Goncalves KA, Rooney RJ, Kobarg J (2006). Interaction of the hepatitis B virus protein HBx with the human transcription regulatory protein p120E4F in vitro. Virus Res 115:31-42
    • (2006) Virus Res , vol.115 , pp. 31-42
    • Rui, E.1    Moura, P.R.2    Goncalves, K.A.3    Rooney, R.J.4    Kobarg, J.5
  • 218
    • 0026766735 scopus 로고
    • Hepatitis B virus genomes that cannot synthesize pre-S2 proteins occur frequently and as dominant virus populations in chronic carriers in Italy
    • Santantonio T, Jung MC, Schneider R, Fernholz D, Milella M, Monno L, Pastore G, Pape GR, Will H (1992). Hepatitis B virus genomes that cannot synthesize pre-S2 proteins occur frequently and as dominant virus populations in chronic carriers in Italy. Virology 188:948-952
    • (1992) Virology , vol.188 , pp. 948-952
    • Santantonio, T.1    Jung, M.C.2    Schneider, R.3    Fernholz, D.4    Milella, M.5    Monno, L.6    Pastore, G.7    Pape, G.R.8    Will, H.9
  • 220
    • 0034708234 scopus 로고    scopus 로고
    • Induction of apoptosis by the transactivating domains of the hepatitis B virus X gene leads to suppression of oncogenic transformation of primary rat embryo fibroblasts
    • Schuster R, Gerlich WH, Schaefer S (2000). Induction of apoptosis by the transactivating domains of the hepatitis B virus X gene leads to suppression of oncogenic transformation of primary rat embryo fibroblasts. Oncogene 19:1173-1180
    • (2000) Oncogene , vol.19 , pp. 1173-1180
    • Schuster, R.1    Gerlich, W.H.2    Schaefer, S.3
  • 221
    • 34547755447 scopus 로고    scopus 로고
    • Hepadnaviruses
    • Lippincott, Williams & Wilkins
    • Seeger C, Zoulim F, Mason WS (2006). Hepadnaviruses. In: Fields virology. Lippincott, Williams & Wilkins, pp 2977-3030.
    • (2006) Fields virology , pp. 2977-3030
    • Seeger, C.1    Zoulim, F.2    Mason, W.S.3
  • 222
    • 0023066055 scopus 로고
    • Cellular events during hepatocarcinogenesis and the question of premalignancy
    • Sell S, Hunt JM, Knoll BJ, Dunsford HA (1987). Cellular events during hepatocarcinogenesis and the question of premalignancy. Adv Cancer Res 48:37-111
    • (1987) Adv Cancer Res , vol.48 , pp. 37-111
    • Sell, S.1    Hunt, J.M.2    Knoll, B.J.3    Dunsford, H.A.4
  • 223
    • 6344221929 scopus 로고    scopus 로고
    • Translation of duck hepatitis B virus reverse transcriptase by ribosomal shunting
    • Sen N, Cao F, Tavis JE (2004). Translation of duck hepatitis B virus reverse transcriptase by ribosomal shunting. J Virol 78:11751-11757
    • (2004) J Virol , vol.78 , pp. 11751-11757
    • Sen, N.1    Cao, F.2    Tavis, J.E.3
  • 224
    • 0031304325 scopus 로고    scopus 로고
    • Lack of colocalization of HBxAg and insulin like growth factor II in the livers of patients with chronic hepatitis B, cirrhosis and hepatocellular carcinoma
    • Seo JH, Kim KW, Murakami S, Park BC (1997). Lack of colocalization of HBxAg and insulin like growth factor II in the livers of patients with chronic hepatitis B, cirrhosis and hepatocellular carcinoma. J Korean Med Sci 12:523-531
    • (1997) J Korean Med Sci , vol.12 , pp. 523-531
    • Seo, J.H.1    Kim, K.W.2    Murakami, S.3    Park, B.C.4
  • 225
    • 0025176474 scopus 로고
    • Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors
    • Seto E, Mitchell PJ, Yen TS (1990). Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors. Nature 344:72-74
    • (1990) Nature , vol.344 , pp. 72-74
    • Seto, E.1    Mitchell, P.J.2    Yen, T.S.3
  • 226
    • 0019797004 scopus 로고
    • Identification of integrated hepatitis B virus DNA sequences in human hepatocellular carcinomas
    • Shafritz DA, Kew MC (1981). Identification of integrated hepatitis B virus DNA sequences in human hepatocellular carcinomas. Hepatology 1:1-8
    • (1981) Hepatology , vol.1 , pp. 1-8
    • Shafritz, D.A.1    Kew, M.C.2
  • 227
    • 0019791877 scopus 로고
    • Integration of hepatitis B virus DNA into the genome of liver cells in chronic liver disease and hepatocellular carcinoma. Studies in percutaneous liver biopsies and post-mortem tissue specimens
    • Shafritz DA, Shouval D, Sherman HI, Hadziyannis SJ, Kew MC (1981). Integration of hepatitis B virus DNA into the genome of liver cells in chronic liver disease and hepatocellular carcinoma. Studies in percutaneous liver biopsies and post-mortem tissue specimens. N Engl J Med 305:1067-1073
    • (1981) N Engl J Med , vol.305 , pp. 1067-1073
    • Shafritz, D.A.1    Shouval, D.2    Sherman, H.I.3    Hadziyannis, S.J.4    Kew, M.C.5
  • 228
    • 0037155818 scopus 로고    scopus 로고
    • Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription
    • Shamay M, Barak O, Doitsh G, Ben-Dor I, Shaul Y (2002). Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription. J Biol Chem 277:9982-9988
    • (2002) J Biol Chem , vol.277 , pp. 9982-9988
    • Shamay, M.1    Barak, O.2    Doitsh, G.3    Ben-Dor, I.4    Shaul, Y.5
  • 229
    • 0035194169 scopus 로고    scopus 로고
    • Small tumor virus genomes are integrated near nuclear matrix attachment regions in transformed cells
    • Shera KA, Shera CA, McDougal JK (2001). Small tumor virus genomes are integrated near nuclear matrix attachment regions in transformed cells. J Virol 75:12339-12346
    • (2001) J Virol , vol.75 , pp. 12339-12346
    • Shera, K.A.1    Shera, C.A.2    McDougal, J.K.3
  • 230
    • 0038158319 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces cell death by causing loss of mitochondrial membrane potential
    • Shirakata Y, Koike K (2003). Hepatitis B virus X protein induces cell death by causing loss of mitochondrial membrane potential. J Biol Chem 278:22071-22078
    • (2003) J Biol Chem , vol.278 , pp. 22071-22078
    • Shirakata, Y.1    Koike, K.2
  • 231
  • 233
    • 0033607041 scopus 로고    scopus 로고
    • Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx
    • Sirma H, Giannini C, Poussin K, Paterlini P, Kremsdorf D, Brechot C (1999). Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx. Oncogene 18:4848-4859
    • (1999) Oncogene , vol.18 , pp. 4848-4859
    • Sirma, H.1    Giannini, C.2    Poussin, K.3    Paterlini, P.4    Kremsdorf, D.5    Brechot, C.6
  • 234
    • 0034618405 scopus 로고    scopus 로고
    • UVDDB p127-binding modulates activities and intracellular distribution of hepatitis B virus X protein
    • Sitterlin D, Bergametti F, Transy C (2000). UVDDB p127-binding modulates activities and intracellular distribution of hepatitis B virus X protein. Oncogene 19:4417-4426
    • (2000) Oncogene , vol.19 , pp. 4417-4426
    • Sitterlin, D.1    Bergametti, F.2    Transy, C.3
  • 235
    • 0029870749 scopus 로고    scopus 로고
    • Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene
    • Slagle BL, Lee TH, Medina D, Finegold MJ, Butel JS (1996). Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene. Mol Carcinog 15:261-269
    • (1996) Mol Carcinog , vol.15 , pp. 261-269
    • Slagle, B.L.1    Lee, T.H.2    Medina, D.3    Finegold, M.J.4    Butel, J.S.5
  • 236
    • 0015385691 scopus 로고
    • Immunoepidemiological and in vitro studies of possible relationships between Australia antigen and hepatocellular carcinoma
    • Smith JA, Francis TI (1972). Immunoepidemiological and in vitro studies of possible relationships between Australia antigen and hepatocellular carcinoma. Cancer Res 32:1713-1720
    • (1972) Cancer Res , vol.32 , pp. 1713-1720
    • Smith, J.A.1    Francis, T.I.2
  • 237
    • 0023833938 scopus 로고
    • trans-activation of viral enhancers by the hepatitis B virus X protein
    • Spandau DF, Lee CH (1988). trans-activation of viral enhancers by the hepatitis B virus X protein. J Virol 62:427-434
    • (1988) J Virol , vol.62 , pp. 427-434
    • Spandau, D.F.1    Lee, C.H.2
  • 238
    • 0023803399 scopus 로고
    • Isolation and characterization of a hepatitis B virus endemic in herons
    • Sprengel R, Kaleta EF, Will H (1988). Isolation and characterization of a hepatitis B virus endemic in herons. J Virol 62:3832-3839
    • (1988) J Virol , vol.62 , pp. 3832-3839
    • Sprengel, R.1    Kaleta, E.F.2    Will, H.3
  • 239
    • 0026033997 scopus 로고
    • Mutations affecting hepadnavirus plus-strand DNA synthesis dissociate primer cleavage from translocation and reveal the origin of linear viral DNA
    • Staprans S, Loeb DD, Ganem D (1991). Mutations affecting hepadnavirus plus-strand DNA synthesis dissociate primer cleavage from translocation and reveal the origin of linear viral DNA. J Virol 65:1255-1262
    • (1991) J Virol , vol.65 , pp. 1255-1262
    • Staprans, S.1    Loeb, D.D.2    Ganem, D.3
  • 240
    • 68949169033 scopus 로고    scopus 로고
    • Polo-like kinase 1 inhibition suppresses hepatitis B virus X protein-induced transformation in an in vitro model of liver cancer progression
    • Studach LL, Rakotomalala L, Wang WH, Hullinger RL, Cairo S, Buendia MA, Andrisani OM (2009). Polo-like kinase 1 inhibition suppresses hepatitis B virus X protein-induced transformation in an in vitro model of liver cancer progression. Hepatology 50:414-423
    • (2009) Hepatology , vol.50 , pp. 414-423
    • Studach, L.L.1    Rakotomalala, L.2    Wang, W.H.3    Hullinger, R.L.4    Cairo, S.5    Buendia, M.A.6    Andrisani, O.M.7
  • 241
    • 0030787584 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alpha
    • Su F, Schneider RJ (1997). Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alpha. Proc Natl Acad Sci USA 94:8744-8749
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8744-8749
    • Su, F.1    Schneider, R.J.2
  • 242
    • 0031898616 scopus 로고    scopus 로고
    • Expression of hepatitis B virus X protein in HBV-infected human livers and hepatocellular carcinomas
    • Su Q, Schroder CH, Hofmann WJ, Otto G, Pichlmayr R, Bannasch P (1998). Expression of hepatitis B virus X protein in HBV-infected human livers and hepatocellular carcinomas. Hepatology 27:1109-1120
    • (1998) Hepatology , vol.27 , pp. 1109-1120
    • Su, Q.1    Schroder, C.H.2    Hofmann, W.J.3    Otto, G.4    Pichlmayr, R.5    Bannasch, P.6
  • 243
    • 0019949367 scopus 로고
    • Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate
    • Summers J, Mason WS (1982). Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell 29:403-415
    • (1982) Cell , vol.29 , pp. 403-415
    • Summers, J.1    Mason, W.S.2
  • 245
    • 0018084546 scopus 로고
    • A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks
    • Summers J, Smolec JM, Snyder R (1978b). A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks. Proc Natl Acad Sci USA 75:4533-7453
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 4533-7453
    • Summers, J.1    Smolec, J.M.2    Snyder, R.3
  • 246
    • 0025334855 scopus 로고
    • Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification
    • Summers J, Smith PM, Horwich AL (1990). Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification. J Virol 64:2819-2824
    • (1990) J Virol , vol.64 , pp. 2819-2824
    • Summers, J.1    Smith, P.M.2    Horwich, A.L.3
  • 248
    • 48549084860 scopus 로고    scopus 로고
    • Stem-like cells in hepatitis B virus-associated cirrhotic livers and adjacent tissue to hepatocellular carcinomas possess the capacity of tumorigenicity
    • Sun YL, Yin SY, Xie HY, Zhou L, Xue F, Wu LM, Gao F, Zheng SS (2008). Stem-like cells in hepatitis B virus-associated cirrhotic livers and adjacent tissue to hepatocellular carcinomas possess the capacity of tumorigenicity. J Gastroenterol Hepatol 23:1280-1286
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 1280-1286
    • Sun, Y.L.1    Yin, S.Y.2    Xie, H.Y.3    Zhou, L.4    Xue, F.5    Wu, L.M.6    Gao, F.7    Zheng, S.S.8
  • 249
    • 0027219650 scopus 로고
    • Risk of liver cirrhosis and hepatocellular carcinoma in subjects with hepatitis B and delta virus infection: A study from Kure, Japan
    • Tamura I, Kurimura O, Koda T, Ichimura H, Katayama S, Kurimura T, Inaba Y (1993). Risk of liver cirrhosis and hepatocellular carcinoma in subjects with hepatitis B and delta virus infection: a study from Kure, Japan. J Gastroenterol Hepatol 8:433-436
    • (1993) J Gastroenterol Hepatol , vol.8 , pp. 433-436
    • Tamura, I.1    Kurimura, O.2    Koda, T.3    Ichimura, H.4    Katayama, S.5    Kurimura, T.6    Inaba, Y.7
  • 251
    • 38348998612 scopus 로고    scopus 로고
    • Responses of nontransformed human hepatocytes to conditional expression of full-length hepatitis C virus open reading frame
    • Tang W, Lazaro CA, Campbell JS, Parks WT, Katze MG, Fausto N (2007). Responses of nontransformed human hepatocytes to conditional expression of full-length hepatitis C virus open reading frame. Am J Pathol 171:1831-1846
    • (2007) Am J Pathol , vol.171 , pp. 1831-1846
    • Tang, W.1    Lazaro, C.A.2    Campbell, J.S.3    Parks, W.T.4    Katze, M.G.5    Fausto, N.6
  • 253
    • 0015238555 scopus 로고
    • Hepatitis-associated antigen and hepatocellular carcinoma
    • Teres J, Guardia J, Bruguera M, Rodes J (1971). Hepatitis-associated antigen and hepatocellular carcinoma. Lancet 2:215
    • (1971) Lancet , vol.2 , pp. 215
    • Teres, J.1    Guardia, J.2    Bruguera, M.3    Rodes, J.4
  • 256
    • 0037213545 scopus 로고    scopus 로고
    • CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection
    • Thimme R, Wieland S, Steiger C, Ghrayeb J, Reimann KA, Purcell RH, Chisari FV (2003). CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J Virol 77:68-76
    • (2003) J Virol , vol.77 , pp. 68-76
    • Thimme, R.1    Wieland, S.2    Steiger, C.3    Ghrayeb, J.4    Reimann, K.A.5    Purcell, R.H.6    Chisari, F.V.7
  • 257
    • 0036699940 scopus 로고    scopus 로고
    • Molecular pathogenesis of human hepatocellular carcinoma
    • Thorgeirsson SS, Grisham JW (2002). Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 31:339-346
    • (2002) Nat Genet , vol.31 , pp. 339-346
    • Thorgeirsson, S.S.1    Grisham, J.W.2
  • 259
    • 0025036898 scopus 로고
    • Phenotypic patterns of preneoplastic and neoplastic hepatic lesions in woodchucks infected with woodchuck hepatitis virus
    • Toshkov I, Hacker HJ, Roggendorf M, Bannasch P (1990). Phenotypic patterns of preneoplastic and neoplastic hepatic lesions in woodchucks infected with woodchuck hepatitis virus. J Cancer Res Clin Oncol 116:581-590
    • (1990) J Cancer Res Clin Oncol , vol.116 , pp. 581-590
    • Toshkov, I.1    Hacker, H.J.2    Roggendorf, M.3    Bannasch, P.4
  • 260
    • 0026517303 scopus 로고
    • Frequent amplification of c-myc in ground squirrel liver tumors associated with past or ongoing infection with a hepadnavirus
    • Transy C, Fourel G, Robinson WS, Tiollais P, Marion PL, Buendia MA (1992). Frequent amplification of c-myc in ground squirrel liver tumors associated with past or ongoing infection with a hepadnavirus. Proc Natl Acad Sci USA 89:3874-3878
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 3874-3878
    • Transy, C.1    Fourel, G.2    Robinson, W.S.3    Tiollais, P.4    Marion, P.L.5    Buendia, M.A.6
  • 261
    • 0028225970 scopus 로고
    • Analysis of integrated ground squirrel hepatitis virus and flanking host DNA in two hepatocellular carcinomas
    • Transy C, Renard CA, Buendia MA (1994). Analysis of integrated ground squirrel hepatitis virus and flanking host DNA in two hepatocellular carcinomas. J Virol 68:5291-5295
    • (1994) J Virol , vol.68 , pp. 5291-5295
    • Transy, C.1    Renard, C.A.2    Buendia, M.A.3
  • 263
    • 0023028191 scopus 로고
    • Formation of the pool of covalently closed circular viral DNA in hepadnavirus-infected cells
    • Tuttleman JS, Pourcel C, Summers J (1986a). Formation of the pool of covalently closed circular viral DNA in hepadnavirus-infected cells. Cell 47:451-460
    • (1986) Cell , vol.47 , pp. 451-460
    • Tuttleman, J.S.1    Pourcel, C.2    Summers, J.3
  • 264
    • 0022504551 scopus 로고
    • In vitro experimental infection of primary duck hepatocyte cultures with duck hepatitis B virus
    • Tuttleman JS, Pugh JC, Summers JW (1986b). In vitro experimental infection of primary duck hepatocyte cultures with duck hepatitis B virus. J Virol 58:17-25
    • (1986) J Virol , vol.58 , pp. 17-25
    • Tuttleman, J.S.1    Pugh, J.C.2    Summers, J.W.3
  • 265
    • 0023627343 scopus 로고
    • Transcriptional trans-activating function of hepatitis B virus
    • Twu JS, Schloemer RH (1987). Transcriptional trans-activating function of hepatitis B virus. J Virol 61:3448-3453
    • (1987) J Virol , vol.61 , pp. 3448-3453
    • Twu, J.S.1    Schloemer, R.H.2
  • 266
    • 0027317952 scopus 로고
    • Activation of protooncogene c-jun by the X protein of hepatitis B virus
    • Twu JS, Lai MY, Chen DS, Robinson WS (1993). Activation of protooncogene c-jun by the X protein of hepatitis B virus. Virology 192:346-350
    • (1993) Virology , vol.192 , pp. 346-350
    • Twu, J.S.1    Lai, M.Y.2    Chen, D.S.3    Robinson, W.S.4
  • 267
    • 0029976343 scopus 로고    scopus 로고
    • Activation of N-myc2 gene expression by cis-acting elements of oncogenic hepadnaviral genomes: Key role of enhancer II
    • Ueda K, Wei Y, Ganem D (1996). Activation of N-myc2 gene expression by cis-acting elements of oncogenic hepadnaviral genomes: key role of enhancer II. Virology 217:413-417
    • (1996) Virology , vol.217 , pp. 413-417
    • Ueda, K.1    Wei, Y.2    Ganem, D.3
  • 268
    • 0015211644 scopus 로고
    • Primary carcinoma of the liver associated with Australia antigen
    • Velasco M, Sorensen R, Daiber A, Carmona A, Katz R (1971). Primary carcinoma of the liver associated with Australia antigen. Lancet 1:1183-1184
    • (1971) Lancet , vol.1 , pp. 1183-1184
    • Velasco, M.1    Sorensen, R.2    Daiber, A.3    Carmona, A.4    Katz, R.5
  • 270
    • 0015358179 scopus 로고
    • Hepatitis-associated antigen and antibody in hepatocellular carcinoma: Results of a continuing study
    • Vogel CL, Anthony PP, Sadikali F, Barker LF, Peterson MR (1972). Hepatitis-associated antigen and antibody in hepatocellular carcinoma: results of a continuing study. J Natl Cancer Inst 48:1583-1588
    • (1972) J Natl Cancer Inst , vol.48 , pp. 1583-1588
    • Vogel, C.L.1    Anthony, P.P.2    Sadikali, F.3    Barker, L.F.4    Peterson, M.R.5
  • 272
    • 0019066157 scopus 로고
    • Liver cancer, liver disease background and virus-like particles in serum among ducks from high incidence area of human hepatocellular carcinoma
    • Wang N, Sun Z, Pang Q, Xia Q (1980). Liver cancer, liver disease background and virus-like particles in serum among ducks from high incidence area of human hepatocellular carcinoma. Clin J Oncol 2:176-178
    • (1980) Clin J Oncol , vol.2 , pp. 176-178
    • Wang, N.1    Sun, Z.2    Pang, Q.3    Xia, Q.4
  • 273
    • 0025022001 scopus 로고
    • Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma
    • Wang J, Chenivesse X, Henglein B, Brechot C (1990). Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma. Nature 343:555-557
    • (1990) Nature , vol.343 , pp. 555-557
    • Wang, J.1    Chenivesse, X.2    Henglein, B.3    Brechot, C.4
  • 275
    • 0031753448 scopus 로고    scopus 로고
    • Regulation of RNA polymerase I-dependent promoters by the hepatitis B virus X protein via activated Ras and TATA-binding protein
    • Wang HD, Trivedi A, Johnson DL (1998). Regulation of RNA polymerase I-dependent promoters by the hepatitis B virus X protein via activated Ras and TATA-binding protein. Mol Cell Biol 18:7086-7094
    • (1998) Mol Cell Biol , vol.18 , pp. 7086-7094
    • Wang, H.D.1    Trivedi, A.2    Johnson, D.L.3
  • 276
    • 0345707640 scopus 로고    scopus 로고
    • Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress
    • Wang HC, Wu HC, Chen CF, Fausto N, Lei HY, Su IJ (2003). Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress. Am J Pathol 163:2441-2449
    • (2003) Am J Pathol , vol.163 , pp. 2441-2449
    • Wang, H.C.1    Wu, H.C.2    Chen, C.F.3    Fausto, N.4    Lei, H.Y.5    Su, I.J.6
  • 277
    • 16244375544 scopus 로고    scopus 로고
    • Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes
    • Wang HC, Chang WT, Chang WW, Wu HC, Huang W, Lei HY, Lai MD, Fausto N, Su IJ (2005) Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes. Hepatology 41:761-770
    • (2005) Hepatology , vol.41 , pp. 761-770
    • Wang, H.C.1    Chang, W.T.2    Chang, W.W.3    Wu, H.C.4    Huang, W.5    Lei, H.Y.6    Lai, M.D.7    Fausto, N.8    Su, I.J.9
  • 278
    • 33745593035 scopus 로고    scopus 로고
    • Hepatitis B virus pre-S mutants, endoplasmic reticulum stress and hepatocarcinogenesis
    • Wang HC, Huang W, Lai MD, Su IJ (2006). Hepatitis B virus pre-S mutants, endoplasmic reticulum stress and hepatocarcinogenesis. Cancer Sci 97:683-688
    • (2006) Cancer Sci , vol.97 , pp. 683-688
    • Wang, H.C.1    Huang, W.2    Lai, M.D.3    Su, I.J.4
  • 281
    • 0034774463 scopus 로고    scopus 로고
    • Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress
    • Waris G, Huh KW, Siddiqui A (2001). Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress. Mol Cell Biol 21:7721-7730
    • (2001) Mol Cell Biol , vol.21 , pp. 7721-7730
    • Waris, G.1    Huh, K.W.2    Siddiqui, A.3
  • 282
    • 0026558151 scopus 로고
    • Multiple rearrangements and activated expression of c-myc induced by woodchuck hepatitis virus integration in a primary liver tumour
    • Wei Y, Ponzetto A, Tiollais P, Buendia MA (1992). Multiple rearrangements and activated expression of c-myc induced by woodchuck hepatitis virus integration in a primary liver tumour. Res Virol 143:89-96
    • (1992) Res Virol , vol.143 , pp. 89-96
    • Wei, Y.1    Ponzetto, A.2    Tiollais, P.3    Buendia, M.A.4
  • 283
    • 0029843989 scopus 로고    scopus 로고
    • Relationship between viral DNA synthesis and virion envelopment in hepatitis B viruses
    • Wei Y, Tavis JE, Ganem D (1996). Relationship between viral DNA synthesis and virion envelopment in hepatitis B viruses. J Virol 70:6455-6458
    • (1996) J Virol , vol.70 , pp. 6455-6458
    • Wei, Y.1    Tavis, J.E.2    Ganem, D.3
  • 284
    • 0033869327 scopus 로고    scopus 로고
    • Dissociation of DDB1-binding and transactivation properties of the hepatitis B virus X protein
    • Wentz MJ, Becker SA, Slagle BL (2000). Dissociation of DDB1-binding and transactivation properties of the hepatitis B virus X protein. Virus Res 68:87-92
    • (2000) Virus Res , vol.68 , pp. 87-92
    • Wentz, M.J.1    Becker, S.A.2    Slagle, B.L.3
  • 286
  • 287
    • 1242341936 scopus 로고    scopus 로고
    • Expansion and contraction of the hepatitis B virus transcriptional template in infected chimpanzees
    • Wieland SF, Spangenberg HC, Thimme R, Purcell RH, Chisari FV (2004b). Expansion and contraction of the hepatitis B virus transcriptional template in infected chimpanzees. Proc Natl Acad Sci USA 101:2129-2134
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2129-2134
    • Wieland, S.F.1    Spangenberg, H.C.2    Thimme, R.3    Purcell, R.H.4    Chisari, F.V.5
  • 288
    • 74049147153 scopus 로고    scopus 로고
    • Mycotoxins and human disease: A largely ignored global health issue
    • Wild CP, Gong YY (2010). Mycotoxins and human disease: a largely ignored global health issue. Carcinogenesis 31:71-82
    • (2010) Carcinogenesis , vol.31 , pp. 71-82
    • Wild, C.P.1    Gong, Y.Y.2
  • 289
    • 0026563646 scopus 로고
    • Hepatocyte regeneration in acute fulminant and nonfulminant hepatitis: A study of proliferating cell nuclear antigen expression
    • Wolf HK, Michalopoulos GK (1992). Hepatocyte regeneration in acute fulminant and nonfulminant hepatitis: a study of proliferating cell nuclear antigen expression. Hepatology 15:707-713
    • (1992) Hepatology , vol.15 , pp. 707-713
    • Wolf, H.K.1    Michalopoulos, G.K.2
  • 290
    • 0033152857 scopus 로고    scopus 로고
    • The crystal structure of the human hepatitis B virus capsid
    • Wynne SA, Crowther RA, Leslie AG (1999). The crystal structure of the human hepatitis B virus capsid. Mol Cell 3:771-780
    • (1999) Mol Cell , vol.3 , pp. 771-780
    • Wynne, S.A.1    Crowther, R.A.2    Leslie, A.G.3
  • 291
    • 0030756523 scopus 로고    scopus 로고
    • Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum
    • Xu Z, Jensen G, Yen TS (1997). Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum. J Virol 71:7387-7392
    • (1997) J Virol , vol.71 , pp. 7387-7392
    • Xu, Z.1    Jensen, G.2    Yen, T.S.3
  • 292
    • 0036171745 scopus 로고    scopus 로고
    • Enhancement of hepatitis B virus replication by its X protein in transgenic mice
    • Xu Z, Yen TS, Wu L, Madden CR, Tan W, Slagle BL, Ou JH (2002). Enhancement of hepatitis B virus replication by its X protein in transgenic mice. J Virol 76:2579-2584
    • (2002) J Virol , vol.76 , pp. 2579-2584
    • Xu, Z.1    Yen, T.S.2    Wu, L.3    Madden, C.R.4    Tan, W.5    Slagle, B.L.6    Ou, J.H.7
  • 293
    • 0023201790 scopus 로고
    • Multiple integration site of hepatitis B virus DNA in hepatocellular carcinoma and chronic active hepatitis tissues from children
    • Yaginuma K, Kobayashi H, Kobayashi M, Morishima T, Matsuyama K, Koike K (1987). Multiple integration site of hepatitis B virus DNA in hepatocellular carcinoma and chronic active hepatitis tissues from children. J Virol 61:1808-1813
    • (1987) J Virol , vol.61 , pp. 1808-1813
    • Yaginuma, K.1    Kobayashi, H.2    Kobayashi, M.3    Morishima, T.4    Matsuyama, K.5    Koike, K.6
  • 294
    • 77953155085 scopus 로고    scopus 로고
    • Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation
    • Yamashita T, Honda M, Nio K, Nakamoto Y, Takamura H, Tani T, Zen Y, Kaneko S (2010) Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation. Cancer Res 70:4687-4697
    • (2010) Cancer Res , vol.70 , pp. 4687-4697
    • Yamashita, T.1    Honda, M.2    Nio, K.3    Nakamoto, Y.4    Takamura, H.5    Tani, T.6    Zen, Y.7    Kaneko, S.8
  • 295
    • 0031686750 scopus 로고    scopus 로고
    • Infection of ducklings with virus particles containing linear double-stranded duck hepatitis B virus DNA: Illegitimate replication and reversion
    • Yang W, Summers J (1998). Infection of ducklings with virus particles containing linear double-stranded duck hepatitis B virus DNA: illegitimate replication and reversion. J Virol 72:8710-8717
    • (1998) J Virol , vol.72 , pp. 8710-8717
    • Yang, W.1    Summers, J.2
  • 296
    • 0032736596 scopus 로고    scopus 로고
    • Integration of hepadnavirus DNA in infected liver: Evidence for a linear precursor
    • Yang W, Summers J (1999). Integration of hepadnavirus DNA in infected liver: evidence for a linear precursor. J Virol 73:9710-9717
    • (1999) J Virol , vol.73 , pp. 9710-9717
    • Yang, W.1    Summers, J.2
  • 297
    • 0027205094 scopus 로고
    • Coordinate expression of N-myc 2 and insulin-like growth factor II in precancerous altered hepatic foci in woodchuck hepatitis virus carriers
    • Yang D, Alt E, Rogler CE (1993). Coordinate expression of N-myc 2 and insulin-like growth factor II in precancerous altered hepatic foci in woodchuck hepatitis virus carriers. Cancer Res 53:2020-2027
    • (1993) Cancer Res , vol.53 , pp. 2020-2027
    • Yang, D.1    Alt, E.2    Rogler, C.E.3
  • 298
    • 0029793573 scopus 로고    scopus 로고
    • Insulin-like growth factor II blocks apoptosis of N-myc2-expressing woodchuck liver epithelial cells
    • Yang D, Faris R, Hixson D, Affigne S, Rogler CE (1996a). Insulin-like growth factor II blocks apoptosis of N-myc2-expressing woodchuck liver epithelial cells. J Virol 70:6260-6268
    • (1996) J Virol , vol.70 , pp. 6260-6268
    • Yang, D.1    Faris, R.2    Hixson, D.3    Affigne, S.4    Rogler, C.E.5
  • 299
    • 0029936171 scopus 로고    scopus 로고
    • Covalently closed circular viral DNA formed from two types of linear DNA in woodchuck hepatitis virus-infected liver
    • Yang W, Mason WS, Summers J (1996b). Covalently closed circular viral DNA formed from two types of linear DNA in woodchuck hepatitis virus-infected liver. J Virol 70:4567-4575
    • (1996) J Virol , vol.70 , pp. 4567-4575
    • Yang, W.1    Mason, W.S.2    Summers, J.3
  • 300
    • 68949091981 scopus 로고    scopus 로고
    • Enhanced expression of vascular endothelial growth factor-A in ground glass hepatocytes and its implication in hepatitis B virus hepatocarcinogenesis
    • Yang JC, Teng CF, Wu HC, Tsai HW, Chuang HC, Tsai TF, Hsu YH, Huang W, Wu LW, Su IJ (2009). Enhanced expression of vascular endothelial growth factor-A in ground glass hepatocytes and its implication in hepatitis B virus hepatocarcinogenesis. Hepatology 49:1962-1971
    • (2009) Hepatology , vol.49 , pp. 1962-1971
    • Yang, J.C.1    Teng, C.F.2    Wu, H.C.3    Tsai, H.W.4    Chuang, H.C.5    Tsai, T.F.6    Hsu, Y.H.7    Huang, W.8    Wu, L.W.9    Su, I.J.10
  • 301
    • 0033851105 scopus 로고    scopus 로고
    • The majority of duck hepatitis B virus reverse transcriptase in cells is nonencapsidated and is bound to a cytoplasmic structure
    • Yao E, Gong Y, Chen N, Tavis JE (2000). The majority of duck hepatitis B virus reverse transcriptase in cells is nonencapsidated and is bound to a cytoplasmic structure. J Virol 74:8648-8657
    • (2000) J Virol , vol.74 , pp. 8648-8657
    • Yao, E.1    Gong, Y.2    Chen, N.3    Tavis, J.E.4
  • 303
    • 33644506166 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis B virus infection: What we knew in 1981 and what we know in 2005
    • Yim HJ, Lok AS (2006). Natural history of chronic hepatitis B virus infection: what we knew in 1981 and what we know in 2005. Hepatology 43:S173-S181
    • (2006) Hepatology , vol.43
    • Yim, H.J.1    Lok, A.S.2
  • 304
    • 0030032374 scopus 로고    scopus 로고
    • Regulation of transforming growth factor-beta 1 expression by the hepatitis B virus (HBV) X transactivator. Role in HBV pathogenesis
    • Yoo YD, Ueda H, Park K, Flanders KC, Lee YI, Jay G, Kim SJ (1996). Regulation of transforming growth factor-beta 1 expression by the hepatitis B virus (HBV) X transactivator. Role in HBV pathogenesis. J Clin Invest 97:388-395
    • (1996) J Clin Invest , vol.97 , pp. 388-395
    • Yoo, Y.D.1    Ueda, H.2    Park, K.3    Flanders, K.C.4    Lee, Y.I.5    Jay, G.6    Kim, S.J.7
  • 306
    • 0030002765 scopus 로고    scopus 로고
    • Promoters for synthesis of the pre-C and pregenomic mRNAs of human hepatitis B virus are genetically distinct and differentially regulated
    • Yu X, Mertz JE (1996). Promoters for synthesis of the pre-C and pregenomic mRNAs of human hepatitis B virus are genetically distinct and differentially regulated. J Virol 70:8719-8726
    • (1996) J Virol , vol.70 , pp. 8719-8726
    • Yu, X.1    Mertz, J.E.2
  • 307
    • 14844307045 scopus 로고    scopus 로고
    • Hepatitis B virus X protein promotes cell migration by inducing matrix metalloproteinase-3
    • Yu FL, Liu HJ, Lee JW, Liao MH, Shih WL (2005). Hepatitis B virus X protein promotes cell migration by inducing matrix metalloproteinase-3. J Hepatol 42:520-527
    • (2005) J Hepatol , vol.42 , pp. 520-527
    • Yu, F.L.1    Liu, H.J.2    Lee, J.W.3    Liao, M.H.4    Shih, W.L.5
  • 308
    • 0011014310 scopus 로고    scopus 로고
    • A defective interference-like phenomenon of human hepatitis B virus in chronic carriers
    • Yuan TT, Lin MH, Chen DS, Shih C (1998). A defective interference-like phenomenon of human hepatitis B virus in chronic carriers. J Virol 72:578-584
    • (1998) J Virol , vol.72 , pp. 578-584
    • Yuan, T.T.1    Lin, M.H.2    Chen, D.S.3    Shih, C.4
  • 309
    • 0033064976 scopus 로고    scopus 로고
    • The mechanism of an immature secretion phenotype of a highly frequent naturally occurring missense mutation at codon 97 of human hepatitis B virus core antigen
    • Yuan TT, Sahu GK, Whitehead WE, Greenberg R, Shih C (1999). The mechanism of an immature secretion phenotype of a highly frequent naturally occurring missense mutation at codon 97 of human hepatitis B virus core antigen. J Virol 73:5731-5740
    • (1999) J Virol , vol.73 , pp. 5731-5740
    • Yuan, T.T.1    Sahu, G.K.2    Whitehead, W.E.3    Greenberg, R.4    Shih, C.5
  • 311
    • 0035178992 scopus 로고    scopus 로고
    • X-deficient woodchuck hepatitis virus mutants behave like attenuated viruses and induce protective immunity in vivo
    • Zhang Z, Torii N, Hu Z, Jacob J, Liang TJ (2001). X-deficient woodchuck hepatitis virus mutants behave like attenuated viruses and induce protective immunity in vivo. J Clin Invest 108:1523-1531
    • (2001) J Clin Invest , vol.108 , pp. 1523-1531
    • Zhang, Z.1    Torii, N.2    Hu, Z.3    Jacob, J.4    Liang, T.J.5
  • 312
    • 23944462455 scopus 로고    scopus 로고
    • HBx protein of hepatitis B virus (HBV) can form complex with mitochondrial HSP60 and HSP70
    • Zhang SM, Sun DC, Lou S, Bo XC, Lu Z, Qian XH, Wang SQ (2005a). HBx protein of hepatitis B virus (HBV) can form complex with mitochondrial HSP60 and HSP70. Arch Virol 150:1579-1590
    • (2005) Arch Virol , vol.150 , pp. 1579-1590
    • Zhang, S.M.1    Sun, D.C.2    Lou, S.3    Bo, X.C.4    Lu, Z.5    Qian, X.H.6    Wang, S.Q.7
  • 314
    • 14544306104 scopus 로고    scopus 로고
    • Effects of hepatitis B virus X protein on human telomerase reverse transcriptase expression and activity in hepatoma cells
    • Zhang X, Dong N, Zhang H, You J, Wang H, Ye L (2005c). Effects of hepatitis B virus X protein on human telomerase reverse transcriptase expression and activity in hepatoma cells. J Lab Clin Med 145:98-104
    • (2005) J Lab Clin Med , vol.145 , pp. 98-104
    • Zhang, X.1    Dong, N.2    Zhang, H.3    You, J.4    Wang, H.5    Ye, L.6
  • 315
    • 70349235485 scopus 로고    scopus 로고
    • Is microRNA-143 really a turncoat of tumor suppressor microRNA in hepatitis B virus-related hepatocellular carcinoma?
    • Zhang R, Wang L, Yang AG (2009). Is microRNA-143 really a turncoat of tumor suppressor microRNA in hepatitis B virus-related hepatocellular carcinoma? Hepatology 50:987
    • (2009) Hepatology , vol.50 , pp. 987
    • Zhang, R.1    Wang, L.2    Yang, A.G.3
  • 316
    • 33846432330 scopus 로고    scopus 로고
    • Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice
    • Zheng Y, Chen WL, Louie SG, Yen TS, Ou JH (2007). Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice. Hepatology 45:16-21
    • (2007) Hepatology , vol.45 , pp. 16-21
    • Zheng, Y.1    Chen, W.L.2    Louie, S.G.3    Yen, T.S.4    Ou, J.H.5
  • 318
    • 0346671161 scopus 로고    scopus 로고
    • Transgenic mice expressing hepatitis B virus X protein are more susceptible to carcinogen induced hepatocarcinogenesis
    • Zhu H, Wang Y, Chen J, Cheng G, Xue J (2004). Transgenic mice expressing hepatitis B virus X protein are more susceptible to carcinogen induced hepatocarcinogenesis. Exp Mol Pathol 76:44-50
    • (2004) Exp Mol Pathol , vol.76 , pp. 44-50
    • Zhu, H.1    Wang, Y.2    Chen, J.3    Cheng, G.4    Xue, J.5
  • 319
    • 0030930426 scopus 로고    scopus 로고
    • Localization of the C terminus of the assembly domain of hepatitis B virus capsid protein: Implications for morphogenesis and organization of encapsidated RNA
    • Zlotnick A, Cheng N, Stahl SJ, Conway JF, Steven AC, Wingfield PT (1997). Localization of the C terminus of the assembly domain of hepatitis B virus capsid protein: implications for morphogenesis and organization of encapsidated RNA. Proc Natl Acad Sci USA 94:9556-9561
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 9556-9561
    • Zlotnick, A.1    Cheng, N.2    Stahl, S.J.3    Conway, J.F.4    Steven, A.C.5    Wingfield, P.T.6
  • 320
    • 0028013064 scopus 로고
    • Woodchuck hepatitis virus X protein is required for viral infection in vivo
    • Zoulim F, Saputelli J, Seeger C (1994). Woodchuck hepatitis virus X protein is required for viral infection in vivo. J Virol 68:2026-2030
    • (1994) J Virol , vol.68 , pp. 2026-2030
    • Zoulim, F.1    Saputelli, J.2    Seeger, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.