메뉴 건너뛰기




Volumn 97, Issue 2, 1996, Pages 388-395

Regulation of transforming growth factor-β1 expression by the hepatitis B virus (HBV) X transactivator: Role in HBV pathogenesis

Author keywords

Hepatitis B virus; Hepatocellular carcinoma; Immunohistochemistry; TGF 1; Transcription

Indexed keywords

HEPATITIS B ANTIGEN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA1;

EID: 0030032374     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118427     Document Type: Article
Times cited : (159)

References (67)
  • 1
    • 0019451351 scopus 로고
    • Hepatocellular carcinoma and hepatitis B virus
    • Beasley, R. P., C. C. Lin, L. Y Hwang, and C. S. Chien. 1981 Hepatocellular carcinoma and hepatitis B virus. Lancet, ii.1129-1133
    • (1981) Lancet , vol.2 , pp. 1129-1133
    • Beasley, R.P.1    Lin, C.C.2    Hwang, L.Y.3    Chien, C.S.4
  • 2
  • 3
    • 0022069746 scopus 로고
    • The HBV HBx gene expressed in E. coli is recognised by sera from hepatitis patients
    • Kay, A., E. Mandart, C. Trepo, and F. Galibert. 1985. The HBV HBx gene expressed in E. coli is recognised by sera from hepatitis patients EMBO (Ear. MoL Biol Organ.) J 4:1287-1292.
    • (1985) EMBO (Ear. MoL Biol Organ.) J , vol.4 , pp. 1287-1292
    • Kay, A.1    Mandart, E.2    Trepo, C.3    Galibert, F.4
  • 4
    • 0021917921 scopus 로고
    • Antibodies to peptides detect new hepatitis B antigen: Serologicai correlation with hepatocellular carcinoma
    • Moriarty, A. M., H. Alexander, R A. Lerner, and G. B. Thornton. 1985. Antibodies to peptides detect new hepatitis B antigen: serologicai correlation with hepatocellular carcinoma. Science (Wash. DC), 227:429-432.
    • (1985) Science (Wash. DC) , vol.227 , pp. 429-432
    • Moriarty, A.M.1    Alexander, H.2    Lerner, R.A.3    Thornton, G.B.4
  • 5
    • 0347483867 scopus 로고
    • Expression of the hepatitis B virus X gene in mammalian cells
    • Siddiqui, A , S Jameel, and J. Mapoles. 1987. Expression of the hepatitis B virus X gene in mammalian cells. Proc. Natl. Acad. Sci. USA. 84:2523-2517.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 2523-12517
    • Siddiqui, A.1    Jameel, S.2    Mapoles, J.3
  • 6
    • 0025858179 scopus 로고
    • HBxAg in the liver from carrier patients with chronic hepatitis and cirrhosis
    • Wang, W., W. T. London, L. Lega, and M. A. Feitelson. 1991. HBxAg in the liver from carrier patients with chronic hepatitis and cirrhosis. Hepatology. 14:29-37.
    • (1991) Hepatology , vol.14 , pp. 29-37
    • Wang, W.1    London, W.T.2    Lega, L.3    Feitelson, M.A.4
  • 8
    • 0025297619 scopus 로고
    • Hepatitis B virus X protein transactivates the long terminal repeats of human immunodeficiency virus type 1 and 2
    • Levrero, M., C. Balsano, G. Natoli, M. L. Avantaggiati, and E. Elfassi 1990. Hepatitis B virus X protein transactivates the long terminal repeats of human immunodeficiency virus type 1 and 2. J. Virol. 64:3082-3086.
    • (1990) J. Virol. , vol.64 , pp. 3082-3086
    • Levrero, M.1    Balsano, C.2    Natoli, G.3    Avantaggiati, M.L.4    Elfassi, E.5
  • 9
    • 0024784327 scopus 로고
    • Trans-activation by the hepatitis B virus X protein shows cell-type specificity
    • Seto, E., D.-X. Zhou, B. M. Peterlin, and T. S. B Yen. 1989 Trans-activation by the hepatitis B virus X protein shows cell-type specificity. Virology 173:764-766.
    • (1989) Virology , vol.173 , pp. 764-766
    • Seto, E.1    Zhou, D.-X.2    Peterlin, B.M.3    Yen, T.S.B.4
  • 10
    • 0024592788 scopus 로고
    • Trans-activation of viral enhancers including long terminal repeat of the human immunodeficiency virus by the hepatitis B virus X protein
    • Siddiqui, A., R. Gaynor, A. Srinivasan, J. Mapoles, and R. W. Farr. 1989. Trans-activation of viral enhancers including long terminal repeat of the human immunodeficiency virus by the hepatitis B virus X protein. Virology. 169:479-494.
    • (1989) Virology. , vol.169 , pp. 479-494
    • Siddiqui, A.1    Gaynor, R.2    Srinivasan, A.3    Mapoles, J.4    Farr, R.W.5
  • 11
    • 0023627343 scopus 로고
    • Transcriptional trans-activating function of hepatitis B virus
    • Twu. J. S., and R. H. Schloemer. 1987. Transcriptional trans-activating function of hepatitis B virus. J. Virol. 61:3448-3453.
    • (1987) J. Virol. , vol.61 , pp. 3448-3453
    • Twu, J.S.1    Schloemer, R.H.2
  • 12
    • 0345439377 scopus 로고
    • Hepatitis B virus X gene can transactivate heterologous viral sequence
    • Twu, J. S., and W. S. Robinson. 1989. Hepatitis B virus X gene can transactivate heterologous viral sequence. Proc. Natl Acad. Sci. USA. 86:2046-2050.
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 2046-2050
    • Twu, J.S.1    Robinson, W.S.2
  • 13
    • 0027317952 scopus 로고
    • Activation of the proto-oncogene c-Jun by the X protein of hepatitis B virus
    • Twu, J. S., M Y. Lai, D, S. Chen, and W. S. Robinson. 1993. Activation of the proto-oncogene c-Jun by the X protein of hepatitis B virus. Virology. 192-346-350.
    • (1993) Virology , vol.192 , pp. 346-350
    • Twu, J.S.1    Lai, M.Y.2    Chen, D.S.3    Robinson, W.S.4
  • 14
    • 0025176474 scopus 로고
    • Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors
    • Seto, E., P J. Mitchell, and T. S. B. Yen. 1990. Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors. Nature (Lond.). 344:72-74.
    • (1990) Nature (Lond.) , vol.344 , pp. 72-74
    • Seto, E.1    Mitchell, P.J.2    Yen, T.S.B.3
  • 15
    • 0025784335 scopus 로고
    • HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein inter-actions
    • Maguire, H. F., J. P Hoeffler, and A. Siddiqui. 1991. HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein inter-actions. Science (Wash. DC). 252:842-844.
    • (1991) Science (Wash. DC) , vol.252 , pp. 842-844
    • Maguire, H.F.1    Hoeffler, J.P.2    Siddiqui, A.3
  • 16
    • 0027409855 scopus 로고
    • Hepatitis B virus transactivator HBx uses a tumor promoter signalling pathway
    • Kekulé, A. S., U. Lauer. L. Weiss, B Luber, and P. H. Hofschneider 1993. Hepatitis B virus transactivator HBx uses a tumor promoter signalling pathway. Nature (Lond). 361:742-746.
    • (1993) Nature (Lond) , vol.361 , pp. 742-746
    • Kekulé, A.S.1    Lauer, U.2    Weiss, L.3    Luber, B.4    Hofschneider, P.H.5
  • 17
    • 0025907983 scopus 로고
    • HBx gene of hepatitis B virus induces liver cancer in transgenic mice
    • Kim, C-M., K. Koike, I. Saito, T. Miyamura, and G. Jay. 1991. HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature (Lond). 351:317-320.
    • (1991) Nature (Lond) , vol.351 , pp. 317-320
    • Kim, C.-M.1    Koike, K.2    Saito, I.3    Miyamura, T.4    Jay, G.5
  • 19
    • 0026021473 scopus 로고
    • Effects of cytokines on the liver
    • Andus, T. J. Bauer, and W Gerok. 1991 Effects of cytokines on the liver. Hepatology. 13:364-375.
    • (1991) Hepatology , vol.13 , pp. 364-375
    • Andus1    Bauer, T.J.2    Gerok, W.3
  • 20
    • 0000742819 scopus 로고
    • Transforming growth factor β mRNA increases during liver regeneration a possible paracrine mechanism of growth regulation
    • Braun, L , J E. Mead, M. Panzica, R. Mikumo, G. I. Bell, and N. Fausto. 1988. Transforming growth factor β mRNA increases during liver regeneration a possible paracrine mechanism of growth regulation. Proc. Natl. Acad. Sci USA 85:1539-1543.
    • (1988) Proc. Natl. Acad. Sci USA , vol.85 , pp. 1539-1543
    • Braun, L.1    Mead, J.E.2    Panzica, M.3    Mikumo, R.4    Bell, G.I.5    Fausto, N.6
  • 21
    • 0024548862 scopus 로고
    • Regulation of liver growth: Protooncogenes and transforming growth factors
    • Fausto. N., and J. E. Mead. 1989. Regulation of liver growth: protooncogenes and transforming growth factors. Lab. Invest 60:4-13.
    • (1989) Lab. Invest , vol.60 , pp. 4-13
    • Fausto, N.1    Mead, J.E.2
  • 22
    • 0022297755 scopus 로고
    • Inhibitory effect of transforming growth factor-β on DNA synthesis of adult rat hepatocytes in primary culture
    • Nakamura, T., Y. Tomita, R. Hirai, K. Yamaoka, K. Kaji, and A. Ichihara. 1985. Inhibitory effect of transforming growth factor-β on DNA synthesis of adult rat hepatocytes in primary culture. Biochem. Biophys. Res. Commun. 133:1042-1050.
    • (1985) Biochem. Biophys. Res. Commun. , vol.133 , pp. 1042-1050
    • Nakamura, T.1    Tomita, Y.2    Hirai, R.3    Yamaoka, K.4    Kaji, K.5    Ichihara, A.6
  • 24
    • 0025301290 scopus 로고
    • Cellular distribution of transforming growth factor-β1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis
    • Nakatsukasa, H., P Nagy, R. P. Evarts, L C. Hsia, E. Marsden. and S. S. Thorgeirsson. 1990. Cellular distribution of transforming growth factor-β1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis. J Clin. Invest. 85:1833-1843.
    • (1990) J Clin. Invest. , vol.85 , pp. 1833-1843
    • Nakatsukasa, H.1    Nagy, P.2    Evarts, R.P.3    Hsia, L.C.4    Marsden, E.5    Thorgeirsson, S.S.6
  • 25
    • 0025855367 scopus 로고
    • Transforming growth factor β1 and α in chronic liver disease: Effects of interferon-α therapy
    • Castilla, A., J. Prieto, and N. Fausto. 1991. Transforming growth factor β1 and α in chronic liver disease: effects of interferon-α therapy. N Eng. J. Med 324-933-940.
    • (1991) N Eng. J. Med , vol.324 , pp. 933-940
    • Castilla, A.1    Prieto, J.2    Fausto, N.3
  • 27
    • 0023549793 scopus 로고
    • Role of transforming growth factor β in the development of the mouse embryo
    • Heine, U. I., K. C. Flanders. A. B. Roberts, E. F. Munoz, and M. B. Sporn. 1987 Role of transforming growth factor β in the development of the mouse embryo J. Cell Biol. 105:2861-2876.
    • (1987) J. Cell Biol. , vol.105 , pp. 2861-2876
    • Heine, U.I.1    Flanders, K.C.2    Roberts, A.B.3    Munoz, E.F.4    Sporn, M.B.5
  • 29
    • 0027965988 scopus 로고
    • Nerve growth factor induces transcription of transforming growth factor-β1 through a specific promoter element in PC12 cells
    • Kim. S.-J., K. Park, B B. Rudkin, B. R. Dey, M. B. Sporn, and A. B. Roberts. 1994. Nerve growth factor induces transcription of transforming growth factor-β1 through a specific promoter element in PC12 cells. J Biol Chem. 269:3739-3744.
    • (1994) J Biol Chem. , vol.269 , pp. 3739-3744
    • Kim, S.-J.1    Park, K.2    Rudkin, B.B.3    Dey, B.R.4    Sporn, M.B.5    Roberts, A.B.6
  • 30
    • 0025317094 scopus 로고
    • Identification and characterization of the Egr-1 gene product, a DNA-binding protein induced by differentiation and growth signals
    • Cao, X , R. A. Koski, A Gashler, M. McKiernan, C. F. Morris, R. Gaffney, R. V. Hay, and V. P. Sukhatme. 1990. Identification and characterization of the Egr-1 gene product, a DNA-binding protein induced by differentiation and growth signals Mol Cell. Biol. 10.1931-1939.
    • (1990) Mol Cell. Biol. , vol.10 , pp. 1931-1939
    • Cao, X.1    Koski, R.A.2    Gashler, A.3    McKiernan, M.4    Morris, C.F.5    Gaffney, R.6    Hay, R.V.7    Sukhatme, V.P.8
  • 31
    • 0025284903 scopus 로고
    • A specific member of the ATF transcription factor family can mediate transcription activation by the adenovinis EIa protein
    • Liu, F., and M R. Green. 1990. A specific member of the ATF transcription factor family can mediate transcription activation by the adenovinis EIa protein. Cell. 61:1217-1224.
    • (1990) Cell. , vol.61 , pp. 1217-1224
    • Liu, F.1    Green, M.R.2
  • 32
    • 0025807509 scopus 로고
    • 2+-regulated transcription factor phosphorylated by calmodulin-deperident kinases
    • 2+-regulated transcription factor phosphorylated by calmodulin-deperident kinases. Science (Wash. DC) 252:1427-1430
    • (1991) Science (Wash. DC) , vol.252 , pp. 1427-1430
    • Sheng, M.1    Thompson, M.A.2    Greenberg, M.E.3
  • 33
    • 0024571802 scopus 로고
    • Transcription activation by the adenoviius E1A protein
    • Lillie, J W., and M. R. Green. 1989. Transcription activation by the adenoviius E1A protein. Nature (Lond.). 338:39-44.
    • (1989) Nature (Lond.) , vol.338 , pp. 39-44
    • Lillie, J.W.1    Green, M.R.2
  • 34
    • 0023697252 scopus 로고
    • GAL4-VP16 is an unusually potent transcriptional activator
    • Sadowski. I., J. Ma, S. Triszenberg. and M. Ptashne. 1988. GAL4-VP16 is an unusually potent transcriptional activator. Nature (Lond.) 335-563-564.
    • (1988) Nature (Lond.) , vol.335 , pp. 563-564
    • Sadowski, I.1    Ma, J.2    Triszenberg, S.3    Ptashne, M.4
  • 35
    • 0026013328 scopus 로고
    • The use of sarkosyl in generating soluble protein after bacterial expression
    • Frankel, S., R. Sohn, and L Leinwand. 1991. The use of sarkosyl in generating soluble protein after bacterial expression. Proc. Natl. Acad Sci, USA. 83:1192-1196.
    • (1991) Proc. Natl. Acad Sci, USA , vol.83 , pp. 1192-1196
    • Frankel, S.1    Sohn, R.2    Leinwand, L.3
  • 36
    • 0024496499 scopus 로고
    • Characterization of the promoter region of the human transforming growth factor-β1 gene
    • Kim, S.-J., A. Glick, M. B. Sporn, and A. B. Roberts. 1989. Characterization of the promoter region of the human transforming growth factor-β1 gene. J. Biol Chem. 264:402-408.
    • (1989) J. Biol Chem. , vol.264 , pp. 402-408
    • Kim, S.-J.1    Glick, A.2    Sporn, M.B.3    Roberts, A.B.4
  • 37
    • 0021770935 scopus 로고
    • The E4 transcriptional unit of Ad2: Far upstream sequences are required for its transactivation by E1A
    • Gilardi, P., and M. Perricaudet. 1984. The E4 transcriptional unit of Ad2: far upstream sequences are required for its transactivation by E1A. Nucleic Acids Res. 12.7877-7888.
    • (1984) Nucleic Acids Res. , vol.12 , pp. 7877-7888
    • Gilardi, P.1    Perricaudet, M.2
  • 38
    • 0026625616 scopus 로고
    • Alternate translation initiation on hepatitis B virus X mRNA produces multiple polypeptides that differentially transactivate class II and III promoters
    • Kwee, L., R. Lucito, B. Aufiero, and R. J. Schneider. 1992. Alternate translation initiation on hepatitis B virus X mRNA produces multiple polypeptides that differentially transactivate class II and III promoters. J. Virol. 66: 4382-4389.
    • (1992) J. Virol. , vol.66 , pp. 4382-4389
    • Kwee, L.1    Lucito, R.2    Aufiero, B.3    Schneider, R.J.4
  • 39
    • 0026549687 scopus 로고
    • Identification of three essential regions of hepatitis B virus X protein for transactivation function
    • Arii, M., S. Takada, and K. Koike. 1992. Identification of three essential regions of hepatitis B virus X protein for transactivation function. Oncogene. 7-397-403.
    • (1992) Oncogene. , vol.7 , pp. 397-403
    • Arii, M.1    Takada, S.2    Koike, K.3
  • 40
    • 0001655748 scopus 로고
    • Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3
    • Wang, X. W., K. Forrester, H. Yeh. M. A. Feitelson, J.-R. Gu, and C. C. Harris. 1994. Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proc. Natl. Acad. Sci. USA. 91:2230-2234.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 2230-2234
    • Wang, X.W.1    Forrester, K.2    Yeh, H.3    Feitelson, M.A.4    Gu, J.-R.5    Harris, C.C.6
  • 41
    • 0024391379 scopus 로고
    • Transcriptional activation of homologous and heterologous genes by the hepatitis B virus gene product in cells permissive for viral replication
    • Colgrove, R., S Gwynn, and D. Ganem. 1989. Transcriptional activation of homologous and heterologous genes by the hepatitis B virus gene product in cells permissive for viral replication. J Virol. 63:4019-4026.
    • (1989) J Virol. , vol.63 , pp. 4019-4026
    • Colgrove, R.1    Gwynn, S.2    Ganem, D.3
  • 42
    • 0023232695 scopus 로고
    • Cloning of tetradecanoyl phorbol ester-induced "primary response" sequences and their expression in density-arrested Swiss 3T3 cells and a TPA nonproliferative variant
    • Lim, R. W., B. C. Varnum, and H R Herschman. 1987. Cloning of tetradecanoyl phorbol ester-induced "primary response" sequences and their expression in density-arrested Swiss 3T3 cells and a TPA nonproliferative variant. Oncogene. 1:263-270.
    • (1987) Oncogene , vol.1 , pp. 263-270
    • Lim, R.W.1    Varnum, B.C.2    Herschman, H.R.3
  • 43
    • 0010207799 scopus 로고
    • Expression of a set of growth-related immediate early genes in BALB/c3T3 cells: Coordinate regulation with c-fos and c-myc
    • Lau, L. F., and D. Nathans. 1987. Expression of a set of growth-related immediate early genes in BALB/c3T3 cells: coordinate regulation with c-fos and c-myc. Proc. Natl. Acad. Sci. USA. 84:1182-1186.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 1182-1186
    • Lau, L.F.1    Nathans, D.2
  • 44
    • 0009416244 scopus 로고
    • A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with zinc finger sequences
    • Christy, B. A., L. F. Lau, and D. Nathans. 1988. A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with zinc finger sequences. Proc. Natl. Acad Sci. USA. 85:7857-7861.
    • (1988) Proc. Natl. Acad Sci. USA , vol.85 , pp. 7857-7861
    • Christy, B.A.1    Lau, L.F.2    Nathans, D.3
  • 45
    • 0024391088 scopus 로고
    • DNA binding site of the growth factor-inducible protein Zif268
    • Christy, B. A., and D. Nathans. 1989. DNA binding site of the growth factor-inducible protein Zif268 Proc. Natl Acd. Sci. USA. 86:8737-8741.
    • (1989) Proc. Natl Acd. Sci. USA , vol.86 , pp. 8737-8741
    • Christy, B.A.1    Nathans, D.2
  • 46
    • 0000275078 scopus 로고
    • Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells
    • Lemaire, P., O. Relevant, R. Bravo, and P. Charnay. 1988. Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells. Proc. Natl. Acad. Sci. USA 85:4691-4695.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 4691-4695
    • Lemaire, P.1    Relevant, O.2    Bravo, R.3    Charnay, P.4
  • 47
    • 0023491356 scopus 로고
    • A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor
    • Milbrandt, J. 1987. A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Science (Wash. DC). 238:797-799.
    • (1987) Science (Wash. DC) , vol.238 , pp. 797-799
    • Milbrandt, J.1
  • 48
    • 0025583537 scopus 로고
    • Early transcriptional events in cell growth: The Egr family
    • Sukhatme, V. P. 1990. Early transcriptional events in cell growth: the Egr family. J Am. Soc Nephrol 1:859-866
    • (1990) J Am. Soc Nephrol , vol.1 , pp. 859-866
    • Sukhatme, V.P.1
  • 50
    • 0025605969 scopus 로고
    • Binding of the Wilm's tumor locus zinc finger protein to the egr-1 consensus sequence
    • Rauscher III, F. J., J. F. Morris, T. J. Tournay, D. M. Cook, and T. Curran. 1990. Binding of the Wilm's tumor locus zinc finger protein to the egr-1 consensus sequence. Science (Wash. DC). 250:1258-1262.
    • (1990) Science (Wash. DC) , vol.250 , pp. 1258-1262
    • Rauscher III, F.J.1    Morris, J.F.2    Tournay, T.J.3    Cook, D.M.4    Curran, T.5
  • 52
    • 0025311110 scopus 로고
    • Trans-activation function of a 3' truncated X gene-cell fusion product from integrated hepatitis B virus DNA in chronic hepatitis tissues
    • Takada. S., and K. Koike. 1990. Trans-activation function of a 3' truncated X gene-cell fusion product from integrated hepatitis B virus DNA in chronic hepatitis tissues. Proc. Natl. Acad. Sci. USA. 87:5628-5632.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 5628-5632
    • Takada, S.1    Koike, K.2
  • 53
    • 0025299483 scopus 로고
    • The X-protein of the hepatitis B virus acts as a transcription factor when targeted to its responsive clement
    • Unger, T., and Y Shaul. 1990. The X-protein of the hepatitis B virus acts as a transcription factor when targeted to its responsive clement, EMBO (Eur. Mol. Biol. Organ.) J. 9:1889-1895.
    • (1990) EMBO (Eur. Mol. Biol. Organ.) J. , vol.9 , pp. 1889-1895
    • Unger, T.1    Shaul, Y.2
  • 54
    • 0025802779 scopus 로고
    • An internal domain of the hepatitis B virus antigen is necessary for transactivating activity
    • Ritter, S E., T. M. Whitten, A. T. Quets, and R. H. Schloemer. 1991. An internal domain of the hepatitis B virus antigen is necessary for transactivating activity. Virology. 182:841-845.
    • (1991) Virology , vol.182 , pp. 841-845
    • Ritter, S.E.1    Whitten, T.M.2    Quets, A.T.3    Schloemer, R.H.4
  • 55
    • 0026719682 scopus 로고
    • Retinoblastoma gene product activates expression of the human TGF-p2 gene through transcription factor ATF-2
    • Kim, S.-J., S. Wagner, F. Liu, M. A. O'Reilly, P D. Robbins, and M. R. Green. 1992. Retinoblastoma gene product activates expression of the human TGF-p2 gene through transcription factor ATF-2. Nature (Lond.). 358:331-334.
    • (1992) Nature (Lond.) , vol.358 , pp. 331-334
    • Kim, S.-J.1    Wagner, S.2    Liu, F.3    O'Reilly, M.A.4    Robbins, P.D.5    Green, M.R.6
  • 56
    • 0023712739 scopus 로고
    • Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB
    • Yamamoto, K. K., G. A. Gonzalez, W. H. Briggs III, and M. R. Montminy 1988. Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB. Nature (Lond.). 334:494-498.
    • (1988) Nature (Lond.). , vol.334 , pp. 494-498
    • Yamamoto, K.K.1    Gonzalez, G.A.2    Briggs III, W.H.3    Montminy, M.R.4
  • 57
    • 0024445798 scopus 로고
    • Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
    • Gonzalez, G. A., and M. R. Montiminy. 1989. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell. 59:675-680.
    • (1989) Cell , vol.59 , pp. 675-680
    • Gonzalez, G.A.1    Montiminy, M.R.2
  • 58
  • 59
    • 0026029808 scopus 로고
    • Activation of protein kinase C decreases phosphorylation of c-Jun at serines that negatively regulate its DNA-binding activity
    • Boyle, W. J., T. Smeal. L. H. K. Defize, P. Angel, I. R. Woodgett, M. Karin, and T. Hunter. 1991. Activation of protein kinase C decreases phosphorylation of c-Jun at serines that negatively regulate its DNA-binding activity. Cell. 64:573-584
    • (1991) Cell , vol.64 , pp. 573-584
    • Boyle, W.J.1    Smeal, T.2    Defize, L.H.K.3    Angel, P.4    Woodgett, I.R.5    Karin, M.6    Hunter, T.7
  • 60
    • 0026587658 scopus 로고
    • Alteration of a cyclic AMP-dependent protein kinase phosphorylation site in the c-Fos protein augments its transforming potential
    • Tratner, J., R Ofir, and I M Verma. 1992. Alteration of a cyclic AMP-dependent protein kinase phosphorylation site in the c-Fos protein augments its transforming potential. Mol. Cell Biol 12:998-1006.
    • (1992) Mol. Cell Biol , vol.12 , pp. 998-1006
    • Tratner, J.1    Ofir, R.2    Verma, I.M.3
  • 63
    • 0021958679 scopus 로고
    • Autocrine growth factors and cancer
    • Sporn, M. B., and A. B. Roberts. 1985. Autocrine growth factors and cancer. Nature (Lond.). 313.747-749.
    • (1985) Nature (Lond.) , vol.313 , pp. 747-749
    • Sporn, M.B.1    Roberts, A.B.2
  • 64
    • 0023100052 scopus 로고
    • Synthesis of messenger RNAs for transforming growth factors αand β and the epidermal growth factor receptor by human tumors
    • Derynck, R., D. V Goeddel. A. Ullrich, J V. Gutterman. R D Williams, T. S. Bringman, and W. H. Berger. 1987. Synthesis of messenger RNAs for transforming growth factors αand β and the epidermal growth factor receptor by human tumors Cancer Res. 47:707-712.
    • (1987) Cancer Res. , vol.47 , pp. 707-712
    • Derynck, R.1    Goeddel, D.V.2    Ullrich, A.3    Gutterman, J.V.4    Williams, R.D.5    Bringman, T.S.6    Berger, W.H.7
  • 65
    • 0025287105 scopus 로고
    • Transactivation of the transforming growth factor β1 (TGF-β1) gene by human T lymphotrophic virus type 1 tax: A potential mechanism for increased production of TGF-β1 in adult T cell leukemia
    • Kim. S.-J., J. H. Kehrl, J. Burton, C. L. Tendler, K.-T. Jeang, D. Danielpour, C. Thevenin, K. Y. Kim, M. B. Sporn, and A. B. Roberts. 1990. Transactivation of the transforming growth factor β1 (TGF-β1) gene by human T lymphotrophic virus type 1 tax: a potential mechanism for increased production of TGF-β1 in adult T cell leukemia. J. Exp. Med, 172:121-129
    • (1990) J. Exp. Med , vol.172 , pp. 121-129
    • Kim, S.-J.1    Kehrl, J.H.2    Burton, J.3    Tendler, C.L.4    Jeang, K.-T.5    Danielpour, D.6    Thevenin, C.7    Kim, K.Y.8    Sporn, M.B.9    Roberts, A.B.10
  • 67
    • 0026425628 scopus 로고
    • Hepatitis B x antigen in hepatitis B virus carrier patients with liver cancer
    • Wang, W., W. T London, and M. A. Feitelson. 1991. Hepatitis B x antigen in hepatitis B virus carrier patients with liver cancer. Cancer Res 51:4971-4977.
    • (1991) Cancer Res , vol.51 , pp. 4971-4977
    • Wang, W.1    London, W.T.2    Feitelson, M.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.