메뉴 건너뛰기




Volumn 13, Issue 1, 2007, Pages 74-81

Hepatitis B virus-induced oncogenesis

Author keywords

Hepatitis B virus; Hepatocellular carcinoma; Regulatory proteins; Signal transduction

Indexed keywords

HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VIRUS X PROTEIN; LAMIVUDINE; REGULATOR PROTEIN; TUMOR PROMOTER; VIRUS DNA;

EID: 33846473749     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v13.i1.74     Document Type: Review
Times cited : (242)

References (111)
  • 1
    • 7044231396 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Recent trends in the United States
    • El-Serag HB. Hepatocellular carcinoma: recent trends in the United States. Gastroenterology 2004; 127: S27-S34
    • (2004) Gastroenterology , vol.127
    • El-Serag, H.B.1
  • 3
    • 0034767957 scopus 로고    scopus 로고
    • Cancer burden in the year 2000. The global picture
    • Parkin DM, Bray FI, Devesa SS. Cancer burden in the year 2000. The global picture. Eur J Cancer 2001; 37 Suppl 8: S4-S66
    • (2001) Eur J Cancer , vol.37 , Issue.SUPPL. 8
    • Parkin, D.M.1    Bray, F.I.2    Devesa, S.S.3
  • 4
    • 0347885319 scopus 로고    scopus 로고
    • Global and regional estimates of cancer mortality and incidence by site: II. Results for the global burden of disease 2000
    • Shibuya K, Mathers CD, Boschi-Pinto C, Lopez AD, Murray CJ. Global and regional estimates of cancer mortality and incidence by site: II. Results for the global burden of disease 2000. BMC Cancer 2002; 2: 37
    • (2002) BMC Cancer , vol.2 , pp. 37
    • Shibuya, K.1    Mathers, C.D.2    Boschi-Pinto, C.3    Lopez, A.D.4    Murray, C.J.5
  • 5
    • 31144437639 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Therapy and prevention
    • Blum HE. Hepatocellular carcinoma: therapy and prevention. World J Gastroenterol 2005; 11: 7391-7400
    • (2005) World J Gastroenterol , vol.11 , pp. 7391-7400
    • Blum, H.E.1
  • 10
    • 0042968962 scopus 로고    scopus 로고
    • Molecular viral oncology of hepatocellular carcinoma
    • Block TM, Mehta AS, Fimmel CJ, Jordan R. Molecular viral oncology of hepatocellular carcinoma. Oncogene 2003; 22: 5093-5107
    • (2003) Oncogene , vol.22 , pp. 5093-5107
    • Block, T.M.1    Mehta, A.S.2    Fimmel, C.J.3    Jordan, R.4
  • 11
    • 0348013131 scopus 로고    scopus 로고
    • Synergistic interaction between aflatoxin B1 and hepatitis B virus in hepatocarcinogenesis
    • Kew MC. Synergistic interaction between aflatoxin B1 and hepatitis B virus in hepatocarcinogenesis. Liver Int 2003; 23: 405-409
    • (2003) Liver Int , vol.23 , pp. 405-409
    • Kew, M.C.1
  • 16
    • 0036019518 scopus 로고    scopus 로고
    • Hepatitis B viral genotypes: Clinical relevance and molecular characteristics
    • Kao JH. Hepatitis B viral genotypes: clinical relevance and molecular characteristics. J Gastroenterol Hepatol 2002; 17: 643-650
    • (2002) J Gastroenterol Hepatol , vol.17 , pp. 643-650
    • Kao, J.H.1
  • 17
    • 0346156071 scopus 로고    scopus 로고
    • Hepatitis B virus genotypes and hepatocellular carcinoma in Japan
    • Orito E, Mizokami M. Hepatitis B virus genotypes and hepatocellular carcinoma in Japan. Intervirology 2003; 46: 408-412
    • (2003) Intervirology , vol.46 , pp. 408-412
    • Orito, E.1    Mizokami, M.2
  • 19
    • 30744468144 scopus 로고    scopus 로고
    • Clinical significance of hepatitis B virus (HBV) genotypes and precore and core promoter mutations affecting HBV e antigen expression in Taiwan
    • Chen CH, Lee CM, Lu SN, Changchien CS, Eng HL, Huang CM, Wang JH, Hung CH, Hu TH. Clinical significance of hepatitis B virus (HBV) genotypes and precore and core promoter mutations affecting HBV e antigen expression in Taiwan. J Clin Microbiol 2005; 43: 6000-6006
    • (2005) J Clin Microbiol , vol.43 , pp. 6000-6006
    • Chen, C.H.1    Lee, C.M.2    Lu, S.N.3    Changchien, C.S.4    Eng, H.L.5    Huang, C.M.6    Wang, J.H.7    Hung, C.H.8    Hu, T.H.9
  • 20
    • 84984578737 scopus 로고    scopus 로고
    • Hepatitis B virus genotypes and spontaneous hepatitis B e antigen seroconversion in Taiwanese hepatitis B carriers
    • Kao JH, Chen PJ, Lai MY, Chen DS. Hepatitis B virus genotypes and spontaneous hepatitis B e antigen seroconversion in Taiwanese hepatitis B carriers. J Med Virol 2004; 72: 363-369
    • (2004) J Med Virol , vol.72 , pp. 363-369
    • Kao, J.H.1    Chen, P.J.2    Lai, M.Y.3    Chen, D.S.4
  • 24
    • 84984559412 scopus 로고    scopus 로고
    • Role of hepatitis B viral load and basal core promoter mutation in hepatocellular carcinoma in hepatitis B carriers
    • Liu CJ, Chen BF, Chen PJ, Lai MY, Huang WL, Kao JH, Chen DS. Role of hepatitis B viral load and basal core promoter mutation in hepatocellular carcinoma in hepatitis B carriers. J Infect Dis 2006; 193: 1258-1265
    • (2006) J Infect Dis , vol.193 , pp. 1258-1265
    • Liu, C.J.1    Chen, B.F.2    Chen, P.J.3    Lai, M.Y.4    Huang, W.L.5    Kao, J.H.6    Chen, D.S.7
  • 25
    • 33644858331 scopus 로고    scopus 로고
    • Predicting cirrhosis risk based on the level of circulating hepatitis B viral load
    • Iloeje UH, Yang HI, Su J, Jen CL, You SL, Chen CJ. Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 2006; 130: 678-686
    • (2006) Gastroenterology , vol.130 , pp. 678-686
    • Iloeje, U.H.1    Yang, H.I.2    Su, J.3    Jen, C.L.4    You, S.L.5    Chen, C.J.6
  • 26
    • 0019451351 scopus 로고
    • Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan
    • Beasley RP, Hwang LY, Lin CC, Chien CS. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet 1981; 2: 1129-1133
    • (1981) Lancet , vol.2 , pp. 1129-1133
    • Beasley, R.P.1    Hwang, L.Y.2    Lin, C.C.3    Chien, C.S.4
  • 27
    • 0019313239 scopus 로고
    • Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma
    • Brechot C, Pourcel C, Louise A, Rain B, Tiollais P. Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma. Nature 1980; 286: 533-535
    • (1980) Nature , vol.286 , pp. 533-535
    • Brechot, C.1    Pourcel, C.2    Louise, A.3    Rain, B.4    Tiollais, P.5
  • 28
    • 0037663314 scopus 로고    scopus 로고
    • Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene
    • Paterlini-Brechot P, Saigo K, Murakami Y, Chami M, Gozuacik D, Mugnier C, Lagorce D, Brechot C. Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene. Oncogene 2003; 22: 3911-3916
    • (2003) Oncogene , vol.22 , pp. 3911-3916
    • Paterlini-Brechot, P.1    Saigo, K.2    Murakami, Y.3    Chami, M.4    Gozuacik, D.5    Mugnier, C.6    Lagorce, D.7    Brechot, C.8
  • 29
    • 0036699940 scopus 로고    scopus 로고
    • Molecular pathogenesis of human hepatocellular carcinoma
    • Thorgeirsson SS, Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 2002; 31: 339-346
    • (2002) Nat Genet , vol.31 , pp. 339-346
    • Thorgeirsson, S.S.1    Grisham, J.W.2
  • 30
    • 5144223035 scopus 로고    scopus 로고
    • The win locus involved in activation of the distal N-myc2 gene upon WHV integration in woodchuck liver tumors harbors S/MAR elements
    • Bruni R, D'Ugo E, Villano U, Fourel G, Buendia MA, Rapicetta M. The win locus involved in activation of the distal N-myc2 gene upon WHV integration in woodchuck liver tumors harbors S/MAR elements. Virology 2004; 329: 1-10
    • (2004) Virology , vol.329 , pp. 1-10
    • Bruni, R.1    D'Ugo, E.2    Villano, U.3    Fourel, G.4    Buendia, M.A.5    Rapicetta, M.6
  • 31
    • 0031910239 scopus 로고    scopus 로고
    • Hepatitis B viruses and cancerogenesis
    • Buendia MA. Hepatitis B viruses and cancerogenesis. Biomed Pharmacother 1998; 52: 34-43
    • (1998) Biomed Pharmacother , vol.52 , pp. 34-43
    • Buendia, M.A.1
  • 33
    • 0024160809 scopus 로고
    • Activation of c-myc by woodchuck hepatitis virus insertion in hepatocellular carcinoma
    • Hsu T, Moroy T, Etiemble J, Louise A, Trepo C, Tiollais P, Buendia MA. Activation of c-myc by woodchuck hepatitis virus insertion in hepatocellular carcinoma. Cell 1988; 55: 627-635
    • (1988) Cell , vol.55 , pp. 627-635
    • Hsu, T.1    Moroy, T.2    Etiemble, J.3    Louise, A.4    Trepo, C.5    Tiollais, P.6    Buendia, M.A.7
  • 35
    • 0025022001 scopus 로고
    • Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma
    • Wang J, Chenivesse X, Henglein B, Brechot C. Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma. Nature 1990; 343: 555-557
    • (1990) Nature , vol.343 , pp. 555-557
    • Wang, J.1    Chenivesse, X.2    Henglein, B.3    Brechot, C.4
  • 36
    • 0033860678 scopus 로고    scopus 로고
    • Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC)
    • Brechot C, Gozuacik D, Murakami Y, Paterlini-Brechot P. Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Semin Cancer Biol 2000; 10: 211-231
    • (2000) Semin Cancer Biol , vol.10 , pp. 211-231
    • Brechot, C.1    Gozuacik, D.2    Murakami, Y.3    Paterlini-Brechot, P.4
  • 37
    • 22644435919 scopus 로고    scopus 로고
    • Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas
    • Murakami Y, Saigo K, Takashima H, Minami M, Okanoue T, Brechot C, Paterlini-Brechot P. Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas. Gut 2005; 54: 1162-1168
    • (2005) Gut , vol.54 , pp. 1162-1168
    • Murakami, Y.1    Saigo, K.2    Takashima, H.3    Minami, M.4    Okanoue, T.5    Brechot, C.6    Paterlini-Brechot, P.7
  • 38
    • 0035423134 scopus 로고    scopus 로고
    • cis-Activation of the human telomerase gene (hTERT) by the hepatitis B virus genome
    • Horikawa I, Barrett JC. cis-Activation of the human telomerase gene (hTERT) by the hepatitis B virus genome. J Natl Cancer Inst 2001; 93: 1171-1173
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1171-1173
    • Horikawa, I.1    Barrett, J.C.2
  • 39
    • 33645450751 scopus 로고    scopus 로고
    • Telomerase activation in human hepatocarcinogenesis
    • Hytiroglou P, Theise ND. Telomerase activation in human hepatocarcinogenesis. Am J Gastroenterol 2006; 101: 839-841
    • (2006) Am J Gastroenterol , vol.101 , pp. 839-841
    • Hytiroglou, P.1    Theise, N.D.2
  • 41
    • 0028053787 scopus 로고
    • Integrated hepatitis B virus X and 3′ truncated preS/S sequences derived from human hepatomas encode functionally active transactivators
    • Schluter V, Meyer M, Hofschneider PH, Koshy R, Caselmann WH. Integrated hepatitis B virus X and 3′ truncated preS/S sequences derived from human hepatomas encode functionally active transactivators. Oncogene 1994; 9: 3335-3344
    • (1994) Oncogene , vol.9 , pp. 3335-3344
    • Schluter, V.1    Meyer, M.2    Hofschneider, P.H.3    Koshy, R.4    Caselmann, W.H.5
  • 43
    • 0023627343 scopus 로고
    • Transcriptional trans-activating function of hepatitis B virus
    • Twu JS, Schloemer RH. Transcriptional trans-activating function of hepatitis B virus. J Virol 1987; 61: 3448-3453
    • (1987) J Virol , vol.61 , pp. 3448-3453
    • Twu, J.S.1    Schloemer, R.H.2
  • 44
    • 0024240296 scopus 로고
    • A transactivating function encoded in the hepatitis B virus X gene is conserved in the integrated state
    • Wollersheim M, Debelka U, Hofschneider PH. A transactivating function encoded in the hepatitis B virus X gene is conserved in the integrated state. Oncogene 1988; 3: 545-552
    • (1988) Oncogene , vol.3 , pp. 545-552
    • Wollersheim, M.1    Debelka, U.2    Hofschneider, P.H.3
  • 46
    • 31944438515 scopus 로고    scopus 로고
    • Effects of hepatitis B virus X protein on the development of liver cancer
    • Zhang X, Zhang H, Ye L. Effects of hepatitis B virus X protein on the development of liver cancer. J Lab Clin Med 2006; 147: 58-66
    • (2006) J Lab Clin Med , vol.147 , pp. 58-66
    • Zhang, X.1    Zhang, H.2    Ye, L.3
  • 47
    • 0028013064 scopus 로고
    • Woodchuck hepatitis virus X protein is required for viral infection in vivo
    • Zoulim F, Saputelli J, Seeger C. Woodchuck hepatitis virus X protein is required for viral infection in vivo. J Virol 1994; 68: 2026-2030
    • (1994) J Virol , vol.68 , pp. 2026-2030
    • Zoulim, F.1    Saputelli, J.2    Seeger, C.3
  • 49
    • 0042416572 scopus 로고    scopus 로고
    • Reconstitution of gene expression from a regulatory-protein-deficient hepatitis B virus genome by cell-permeable HBx protein
    • Hafner A, Brandenburg B, Hildt E. Reconstitution of gene expression from a regulatory-protein-deficient hepatitis B virus genome by cell-permeable HBx protein. EMBO Rep 2003; 4: 767-773
    • (2003) EMBO Rep , vol.4 , pp. 767-773
    • Hafner, A.1    Brandenburg, B.2    Hildt, E.3
  • 50
    • 0038192317 scopus 로고    scopus 로고
    • Integrity of c-Raf-1/MEK signal transduction cascade is essential for hepatitis B virus gene expression
    • Stockl L, Berting A, Malkowski B, Foerste R, Hofschneider PH, Hildt E. Integrity of c-Raf-1/MEK signal transduction cascade is essential for hepatitis B virus gene expression. Oncogene 2003; 22: 2604-2610
    • (2003) Oncogene , vol.22 , pp. 2604-2610
    • Stockl, L.1    Berting, A.2    Malkowski, B.3    Foerste, R.4    Hofschneider, P.H.5    Hildt, E.6
  • 51
    • 22544476234 scopus 로고    scopus 로고
    • Hepatitis B virus DNA replication is coordinated by core protein serine phosphorylation and HBx expression
    • Melegari M, Wolf SK, Schneider RJ. Hepatitis B virus DNA replication is coordinated by core protein serine phosphorylation and HBx expression. J Virol 2005; 79: 9810-9820
    • (2005) J Virol , vol.79 , pp. 9810-9820
    • Melegari, M.1    Wolf, S.K.2    Schneider, R.J.3
  • 53
    • 33646193810 scopus 로고    scopus 로고
    • Activation of focal adhesion kinase by hepatitis B virus HBx protein: Multiple functions in viral replication
    • Bouchard MJ, Wang L, Schneider RJ. Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication. J Virol 2006; 80: 4406-4414
    • (2006) J Virol , vol.80 , pp. 4406-4414
    • Bouchard, M.J.1    Wang, L.2    Schneider, R.J.3
  • 54
    • 0035861455 scopus 로고    scopus 로고
    • Calcium signaling by HBx protein in hepatitis B virus DNA replication
    • Bouchard MJ, Wang LH, Schneider RJ. Calcium signaling by HBx protein in hepatitis B virus DNA replication. Science 2001; 294: 2376-2378
    • (2001) Science , vol.294 , pp. 2376-2378
    • Bouchard, M.J.1    Wang, L.H.2    Schneider, R.J.3
  • 55
    • 0037397156 scopus 로고    scopus 로고
    • Regulatory mechanisms of viral hepatitis B and C
    • Waris G, Siddiqui A. Regulatory mechanisms of viral hepatitis B and C. J Biosci 2003; 28: 311-321
    • (2003) J Biosci , vol.28 , pp. 311-321
    • Waris, G.1    Siddiqui, A.2
  • 56
    • 33646337650 scopus 로고    scopus 로고
    • Hepatocellular carcinoma and hepatitis B virus
    • Chan HL, Sung JJ. Hepatocellular carcinoma and hepatitis B virus. Semin Liver Dis 2006; 26: 153-161
    • (2006) Semin Liver Dis , vol.26 , pp. 153-161
    • Chan, H.L.1    Sung, J.J.2
  • 57
    • 0036292006 scopus 로고    scopus 로고
    • Molecular mechanism of viral hepatocarcinogenesis
    • Koike K, Tsutsumi T, Fujie H, Shintani Y, Kyoji M. Molecular mechanism of viral hepatocarcinogenesis. Oncology 2002; 62 Suppl 1: 29-37
    • (2002) Oncology , vol.62 , Issue.SUPPL. 1 , pp. 29-37
    • Koike, K.1    Tsutsumi, T.2    Fujie, H.3    Shintani, Y.4    Kyoji, M.5
  • 59
    • 0035659925 scopus 로고    scopus 로고
    • Stimulation of cellular proliferation by hepatitis B virus X protein
    • Madden CR, Slagle BL. Stimulation of cellular proliferation by hepatitis B virus X protein. Dis Markers 2001; 17: 153-157
    • (2001) Dis Markers , vol.17 , pp. 153-157
    • Madden, C.R.1    Slagle, B.L.2
  • 61
    • 0027409855 scopus 로고
    • Hepatitis B virus transactivator HBx uses a turnour promoter signalling pathway
    • Kekule AS, Lauer U, Weiss L, Luber B, Hofschneider PH. Hepatitis B virus transactivator HBx uses a turnour promoter signalling pathway. Nature 1993; 361: 742-745
    • (1993) Nature , vol.361 , pp. 742-745
    • Kekule, A.S.1    Lauer, U.2    Weiss, L.3    Luber, B.4    Hofschneider, P.H.5
  • 62
    • 0027255308 scopus 로고
    • The hepatitis B virus transactivator HBx causes elevation of diacylglycerol and activation of protein kinase C
    • Luber B, Lauer U, Weiss L, Hohne M, Hofschneider PH, Kekule AS. The hepatitis B virus transactivator HBx causes elevation of diacylglycerol and activation of protein kinase C. Res Virol 1993; 144: 311-321
    • (1993) Res Virol , vol.144 , pp. 311-321
    • Luber, B.1    Lauer, U.2    Weiss, L.3    Hohne, M.4    Hofschneider, P.H.5    Kekule, A.S.6
  • 63
    • 0037084160 scopus 로고    scopus 로고
    • The PreS2 activator MHBs(t) of hepatitis B virus activates c-raf-l/Erk2 signaling in transgenic mice
    • Hildt E, Munz B, Saher G, Reifenberg K, Hofschneider PH. The PreS2 activator MHBs(t) of hepatitis B virus activates c-raf-l/Erk2 signaling in transgenic mice. EMBO J 2002; 21: 525-535
    • (2002) EMBO J , vol.21 , pp. 525-535
    • Hildt, E.1    Munz, B.2    Saher, G.3    Reifenberg, K.4    Hofschneider, P.H.5
  • 64
    • 0026526978 scopus 로고
    • Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C
    • Lucito R, Schneider RJ. Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C. J Virol 1992; 66: 983-991
    • (1992) J Virol , vol.66 , pp. 983-991
    • Lucito, R.1    Schneider, R.J.2
  • 65
    • 0028274952 scopus 로고
    • Transactivation of human hepatitis B virus X protein, HBx, operates through a mechanism distinct from protein kinase C and okadaic acid activation pathways
    • Murakami S, Cheong J, Ohno S, Matsushima K, Kaneko S. Transactivation of human hepatitis B virus X protein, HBx, operates through a mechanism distinct from protein kinase C and okadaic acid activation pathways. Virology 1994; 199: 243-246
    • (1994) Virology , vol.199 , pp. 243-246
    • Murakami, S.1    Cheong, J.2    Ohno, S.3    Matsushima, K.4    Kaneko, S.5
  • 66
    • 77954577665 scopus 로고
    • The function and mechanism of promoters of carcinogenesis
    • Boutwell RK. The function and mechanism of promoters of carcinogenesis. CRC Crit Rev Toxicol 1974; 2: 419-443
    • (1974) CRC Crit Rev Toxicol , vol.2 , pp. 419-443
    • Boutwell, R.K.1
  • 67
    • 0035084167 scopus 로고    scopus 로고
    • Hepatitis B virus X protein acts as a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions
    • Madden CR, Finegold MJ, Slagle BL. Hepatitis B virus X protein acts as a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions. J Virol 2001; 75: 3851-3858
    • (2001) J Virol , vol.75 , pp. 3851-3858
    • Madden, C.R.1    Finegold, M.J.2    Slagle, B.L.3
  • 68
    • 0346671161 scopus 로고    scopus 로고
    • Transgenic mice expressing hepatitis B virus X protein are more susceptible to carcinogen induced hepatocarcinogenesis
    • Zhu H, Wang Y, Chen J, Cheng G, Xue J. Transgenic mice expressing hepatitis B virus X protein are more susceptible to carcinogen induced hepatocarcinogenesis. Exp Mol Pathol 2004; 76: 44-50
    • (2004) Exp Mol Pathol , vol.76 , pp. 44-50
    • Zhu, H.1    Wang, Y.2    Chen, J.3    Cheng, G.4    Xue, J.5
  • 69
    • 0025907983 scopus 로고
    • HBx gene of hepatitis B virus induces liver cancer in transgenic mice
    • Kim CM, Koike K, Saito I, Miyamura T, Jay G. HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 1991; 351: 317-320
    • (1991) Nature , vol.351 , pp. 317-320
    • Kim, C.M.1    Koike, K.2    Saito, I.3    Miyamura, T.4    Jay, G.5
  • 70
    • 0028135497 scopus 로고
    • Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade
    • Benn J, Schneider RJ. Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade. Proc Natl Acad Sci USA 1994; 91: 10350-10354
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10350-10354
    • Benn, J.1    Schneider, R.J.2
  • 72
    • 0030764344 scopus 로고    scopus 로고
    • Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras
    • Klein NP, Schneider RJ. Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras. Mol Cell Biol 1997; 17: 6427-6436
    • (1997) Mol Cell Biol , vol.17 , pp. 6427-6436
    • Klein, N.P.1    Schneider, R.J.2
  • 73
    • 0032559971 scopus 로고    scopus 로고
    • Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome
    • Sirma H, Weil R, Rosmorduc O, Urban S, Israel A, Kremsdorf D, Brechot C. Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome. Oncogene 1998; 16: 2051-2063
    • (1998) Oncogene , vol.16 , pp. 2051-2063
    • Sirma, H.1    Weil, R.2    Rosmorduc, O.3    Urban, S.4    Israel, A.5    Kremsdorf, D.6    Brechot, C.7
  • 74
    • 0036208949 scopus 로고    scopus 로고
    • Characterization of the mitochondrial association of hepatitis B virus X protein, HBx
    • Huh KW, Siddiqui A. Characterization of the mitochondrial association of hepatitis B virus X protein, HBx. Mitochondrion 2002; 1: 349-359
    • (2002) Mitochondrion , vol.1 , pp. 349-359
    • Huh, K.W.1    Siddiqui, A.2
  • 76
    • 0034774463 scopus 로고    scopus 로고
    • Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress
    • Waris G, Huh KW, Siddiqui A. Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress. Mol Cell Biol 2001; 21: 7721-7730
    • (2001) Mol Cell Biol , vol.21 , pp. 7721-7730
    • Waris, G.1    Huh, K.W.2    Siddiqui, A.3
  • 77
    • 0025784335 scopus 로고
    • HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions
    • Maguire HF, Hoeffler JP, Siddiqui A. HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. Science 1991; 252: 842-844
    • (1991) Science , vol.252 , pp. 842-844
    • Maguire, H.F.1    Hoeffler, J.P.2    Siddiqui, A.3
  • 78
    • 0031932893 scopus 로고    scopus 로고
    • Hepatitis B virus pX targets TFIIB in transcription coactivation
    • Haviv I, Shamay M, Doitsh G, Shaul Y. Hepatitis B virus pX targets TFIIB in transcription coactivation. Mol Cell Biol 1998; 18: 1562-1569
    • (1998) Mol Cell Biol , vol.18 , pp. 1562-1569
    • Haviv, I.1    Shamay, M.2    Doitsh, G.3    Shaul, Y.4
  • 79
    • 0030056043 scopus 로고    scopus 로고
    • pX, the HBV-encoded coactivator, interacts with components of the transcription machinery and stimulates transcription in a TAF-independent manner
    • Haviv I, Vaizel D, Shaul Y. pX, the HBV-encoded coactivator, interacts with components of the transcription machinery and stimulates transcription in a TAF-independent manner. EMBO J 1996; 15: 3413-3420
    • (1996) EMBO J , vol.15 , pp. 3413-3420
    • Haviv, I.1    Vaizel, D.2    Shaul, Y.3
  • 80
    • 0031985778 scopus 로고    scopus 로고
    • Hepatitis B virus X protein interferes with cellular DNA repair
    • Becker SA, Lee TH, Butel JS, Slagle BL. Hepatitis B virus X protein interferes with cellular DNA repair. J Virol 1998; 72: 266-272
    • (1998) J Virol , vol.72 , pp. 266-272
    • Becker, S.A.1    Lee, T.H.2    Butel, J.S.3    Slagle, B.L.4
  • 81
    • 0033869327 scopus 로고    scopus 로고
    • Dissociation of DDB1-binding and transactivation properties of the hepatitis B virus X protein
    • Wentz MJ, Becker SA, Slagle BL. Dissociation of DDB1-binding and transactivation properties of the hepatitis B virus X protein. Virus Res 2000; 68: 87-92
    • (2000) Virus Res , vol.68 , pp. 87-92
    • Wentz, M.J.1    Becker, S.A.2    Slagle, B.L.3
  • 82
    • 0034022192 scopus 로고    scopus 로고
    • Expression of hepatitis B virus X protein does not alter the accumulation of spontaneous mutations in transgenic mice
    • Madden CR, Finegold MJ, Slagle BL. Expression of hepatitis B virus X protein does not alter the accumulation of spontaneous mutations in transgenic mice. J Virol 2000; 74: 5266-5272
    • (2000) J Virol , vol.74 , pp. 5266-5272
    • Madden, C.R.1    Finegold, M.J.2    Slagle, B.L.3
  • 83
    • 0034688143 scopus 로고    scopus 로고
    • Transcriptional repression of the human p53 gene by hepatitis B viral X protein
    • Lee SG, Rho HM. Transcriptional repression of the human p53 gene by hepatitis B viral X protein. Oncogene 2000; 19: 468-471
    • (2000) Oncogene , vol.19 , pp. 468-471
    • Lee, S.G.1    Rho, H.M.2
  • 86
    • 0025098651 scopus 로고
    • The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator
    • Kekule AS, Lauer U, Meyer M, Caselmann WH, Hofschneider PH, Koshy R. The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator. Nature 1990; 343: 457-461
    • (1990) Nature , vol.343 , pp. 457-461
    • Kekule, A.S.1    Lauer, U.2    Meyer, M.3    Caselmann, W.H.4    Hofschneider, P.H.5    Koshy, R.6
  • 87
    • 0025231364 scopus 로고
    • A trans-activator function is generated by integration of hepatitis B virus preS/S sequences in human hepatocellular carcinoma DNA
    • Caselmann WH, Meyer M, Kekule AS, Lauer U, Hofschneider PH, Koshy R. A trans-activator function is generated by integration of hepatitis B virus preS/S sequences in human hepatocellular carcinoma DNA. Proc Natl Acad Sci USA 1990; 87: 2970-2974
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 2970-2974
    • Caselmann, W.H.1    Meyer, M.2    Kekule, A.S.3    Lauer, U.4    Hofschneider, P.H.5    Koshy, R.6
  • 88
    • 0026808738 scopus 로고
    • The hepatitis B virus pre-S/S(t) transactivator is generated by 3′ truncations within a defined region of the S gene
    • Lauer U, Weiss L, Hofschneider PH, Kekule AS. The hepatitis B virus pre-S/S(t) transactivator is generated by 3′ truncations within a defined region of the S gene. J Virol 1992; 66: 5284-5289
    • (1992) J Virol , vol.66 , pp. 5284-5289
    • Lauer, U.1    Weiss, L.2    Hofschneider, P.H.3    Kekule, A.S.4
  • 92
    • 0027508379 scopus 로고
    • ER-localization and functional expression of the HBV transactivator MHBst
    • Hildt E, Urban S, Lauer U, Hofschneider PH, Kekule AS. ER-localization and functional expression of the HBV transactivator MHBst. Oncogene 1993; 8: 3359-3367
    • (1993) Oncogene , vol.8 , pp. 3359-3367
    • Hildt, E.1    Urban, S.2    Lauer, U.3    Hofschneider, P.H.4    Kekule, A.S.5
  • 93
    • 0026623154 scopus 로고
    • Hepatitis B virus transactivator MHBst: Activation of NF-kappa B, selective inhibition by antioxidants and integral membrane localization
    • Meyer M, Caselmann WH, Schluter V, Schreck R, Hofschneider PH, Baeuerle PA. Hepatitis B virus transactivator MHBst: activation of NF-kappa B, selective inhibition by antioxidants and integral membrane localization. EMBO J 1992; 11: 2991-3001
    • (1992) EMBO J , vol.11 , pp. 2991-3001
    • Meyer, M.1    Caselmann, W.H.2    Schluter, V.3    Schreck, R.4    Hofschneider, P.H.5    Baeuerle, P.A.6
  • 94
    • 0030978733 scopus 로고    scopus 로고
    • The hepatitis B virus MHBstl67 protein is a pleiotropic transactivator mediating its effect via ubiquitous cellular transcription factors
    • Caselmann WH, Renner M, Schluter V, Hofschneider PH, Koshy R, Meyer M. The hepatitis B virus MHBstl67 protein is a pleiotropic transactivator mediating its effect via ubiquitous cellular transcription factors. J Gen Virol 1997; 78 (Pt 6): 1487-1495
    • (1997) J Gen Virol , vol.78 , Issue.PART 6 , pp. 1487-1495
    • Caselmann, W.H.1    Renner, M.2    Schluter, V.3    Hofschneider, P.H.4    Koshy, R.5    Meyer, M.6
  • 96
    • 0030756523 scopus 로고    scopus 로고
    • Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum
    • Xu Z, Jensen G, Yen TS. Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum. J Virol 1997; 71: 7387-7392
    • (1997) J Virol , vol.71 , pp. 7387-7392
    • Xu, Z.1    Jensen, G.2    Yen, T.S.3
  • 97
    • 0028806817 scopus 로고
    • Characterization of essential domains for the functionality of the MHBst transcriptional activator and identification of a minimal MHBst activator
    • Hildt E, Urban S, Hofschneider PH. Characterization of essential domains for the functionality of the MHBst transcriptional activator and identification of a minimal MHBst activator. Oncogene 1995; 11: 2055-2066
    • (1995) Oncogene , vol.11 , pp. 2055-2066
    • Hildt, E.1    Urban, S.2    Hofschneider, P.H.3
  • 98
    • 0029815105 scopus 로고    scopus 로고
    • Isolation of highly purified, functional carboxy-terminally truncated hepatitis B virus middle surface protein activators from eucaryotic expression systems
    • Hildt E, Urban S, Eckerskorn C, Hofschneider PH. Isolation of highly purified, functional carboxy-terminally truncated hepatitis B virus middle surface protein activators from eucaryotic expression systems. Hepatology 1996; 24: 502-507
    • (1996) Hepatology , vol.24 , pp. 502-507
    • Hildt, E.1    Urban, S.2    Eckerskorn, C.3    Hofschneider, P.H.4
  • 99
    • 0028236042 scopus 로고
    • Post-translational alterations in transmembrane topology of the hepatitis B virus large envelope protein
    • Bruss V, Lu. X, Thomssen R, Gerlich WH. Post-translational alterations in transmembrane topology of the hepatitis B virus large envelope protein. EMBO J 1994; 13: 2273-2279
    • (1994) EMBO J , vol.13 , pp. 2273-2279
    • Bruss, V.1    Lu, X.2    Thomssen, R.3    Gerlich, W.H.4
  • 100
    • 0028265897 scopus 로고
    • A dramatic shift in the transmembrane topology of a viral envelope glycoprotein accompanies hepatitis B viral morphogenesis
    • Ostapchuk P, Hearing P, Ganem D. A dramatic shift in the transmembrane topology of a viral envelope glycoprotein accompanies hepatitis B viral morphogenesis. EMBO J 1994; 13: 1048-1057
    • (1994) EMBO J , vol.13 , pp. 1048-1057
    • Ostapchuk, P.1    Hearing, P.2    Ganem, D.3
  • 101
    • 0028859149 scopus 로고
    • Novel transmembrane topology of the hepatitis B virus envelope proteins
    • Prange R, Streeck RE. Novel transmembrane topology of the hepatitis B virus envelope proteins. EMBO J 1995; 14: 247-256
    • (1995) EMBO J , vol.14 , pp. 247-256
    • Prange, R.1    Streeck, R.E.2
  • 102
    • 0030296929 scopus 로고    scopus 로고
    • The hepatitis B virus large surface protein (LHBs) is a transcriptional activator
    • Hildt E, Saher G, Bruss V, Hofschneider PH. The hepatitis B virus large surface protein (LHBs) is a transcriptional activator. Virology 1996; 225: 235-239
    • (1996) Virology , vol.225 , pp. 235-239
    • Hildt, E.1    Saher, G.2    Bruss, V.3    Hofschneider, P.H.4
  • 104
    • 0034167525 scopus 로고    scopus 로고
    • Rous-Whipple Award Lecture. Viruses, immunity, and cancer: Lessons from hepatitis B
    • Chisari FV. Rous-Whipple Award Lecture. Viruses, immunity, and cancer: lessons from hepatitis B. Am J Pathol 2000; 156: 1117-1132
    • (2000) Am J Pathol , vol.156 , pp. 1117-1132
    • Chisari, F.V.1
  • 105
    • 0025334672 scopus 로고
    • Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice
    • Dunsford HA, Sell S, Chisari FV. Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice. Cancer Res 1990; 50: 3400-3407
    • (1990) Cancer Res , vol.50 , pp. 3400-3407
    • Dunsford, H.A.1    Sell, S.2    Chisari, F.V.3
  • 106
    • 0037325472 scopus 로고    scopus 로고
    • Immune responses in hepatitis B virus infection
    • Rehermann B. Immune responses in hepatitis B virus infection. Semin Liver Dis 2003; 23: 21-38
    • (2003) Semin Liver Dis , vol.23 , pp. 21-38
    • Rehermann, B.1
  • 107
    • 14944375587 scopus 로고    scopus 로고
    • Immunology of hepatitis B virus and hepatitis C virus infection
    • Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 2005; 5: 215-229
    • (2005) Nat Rev Immunol , vol.5 , pp. 215-229
    • Rehermann, B.1    Nascimbeni, M.2
  • 111
    • 33646344213 scopus 로고    scopus 로고
    • Immunopathogenesis: Role of innate and adaptive immune responses
    • Visvanathan K, Lewin SR. Immunopathogenesis: role of innate and adaptive immune responses. Semin Liver Dis 2006; 26: 104-115
    • (2006) Semin Liver Dis , vol.26 , pp. 104-115
    • Visvanathan, K.1    Lewin, S.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.