The mechanism of an immature secretion phenotype of a highly frequent naturally occurring missense mutation at codon 97 of human hepatitis B virus core antigen

Journal of Virology

Volumn 73, Issue 7, 1999, Pages 5731-5740

  Yuan, Thomas Ta Tung ^a   Sahu, Gautam Kumar ^a   Whitehead, William E ^a   Greenberg, Richard ^a   Shih, Chiaho ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS ANTIGEN;

ARTICLE; HEPATITIS B VIRUS; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; VIRUS CARRIER; VIRUS CORE; VIRUS GENE;

EID: 0033064976     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.7.5731-5740.1999     Document Type: Article

References (59)

1. Ackrill, A. M., N. V. Naoumov, A. L. W. F. Eddleston, and R. Williams. 1993. Specific deletions in the hepatitis B virus core open reading frame in patients with chronic active hepatitis B. J. Med. Virol. 41:165-169.
2. Akarca, U. S., and A. S. F. Lok. 1995. Naturally occurring hepatitis B virus core gene mutations. Hepatology 22:50-60.
3. Beames, B., and R. E. Lanford. 1993. Carboxy-terminal truncations of the HBV core protein affect capsid formation and the apparent size of the encapsidated HBV RNA. Virology 194:597-607.
4. Birnbaum, F., and M. Nassal. 1990. Hepatitis B virus nucleocapsid assembly: primary structure requirements in the core protein. J. Virol. 64:3319-3330.
5. Bozkaya, H., B. Ayola, and A. S. F. Lok. 1996. High rate of mutations in the hepatitis B core gene during the immune clearance phase of chronic hepatitis B virus infection. Hepatology 24:32-37.
6. Bruss, V., and D. Ganem. 1991. The role of envelope proteins in hepatitis B virus assembly. Proc. Natl. Acad. Sci. USA 88:1059-1063.
7. Chang, C., K. S. Jeng, C. P. Hu, S. J. Lo, T. S. Su, L. P. Ting, C. K. Chou, S. H. Han, E. Pfatt, J. Salfeld, and H. Schaller, 1987. Production of hepatitis B virus in vitro by transient expression of cloned HBV DNA in a hepatoma cell line. EMBO J. 6:675-680.
8. Chen, D. S. 1993. From hepatitis to hepatoma: lessons from type B viral hepatitis. Science 262:369-370.
9. Chisari, F. V., and C. Ferrari. 1995. Hepatitis B virus immunopathogenesis. Annu. Rev. Immunol. 13:29-60.
10. Chuang, W. L., M. Omata, T. Ehata, O. Yokosuka, Y. Ito, and M. Ohto. 1993. Concentrating missense mutations in core gene of hepatitis B virus. Dig. Dis. Sci. 38:594-600.
11. Chuang, W. L., M. Omata, T. Ehata, O. Yokosuka, Y. Ito, F. Imazeki, S. N. Lu, W. Y. Chang, and M. Ohto. 1993. Precore mutations and core clustering mutations in chronic hepatitis B virus infection. Gastroenterology 104:263-271.
12. Ehata, T., M. Omata, O. Yokosuka, K. Hosoda, and M. Ohto. 1992. Variations in codons 84-101 in the core nucleotide sequence correlate with hepatocellular injury in chronic hepatitis B virus infection. J. Clin. Invest. 89: 332-338.
13. Ehata, T., M. Omata, W. L. Chuang, O. Yokosuka, Y. Ito, K. Hosoda, and M. Ohto. 1993. Mutations in core nucleotide sequence of hepatitis B virus correlate with fulminant and severe hepatitis. J. Clin. Invest. 91:1206-1213.
14. Galibert, F., E. Mandart, F. Fitoussi, P. Tiollais, and P. Charnay. 1979. Nucleotide sequence of the hepatitis B virus genome cloned in E. coli. Nature 281:646-650.
15. Gerelsaikhan, T., J. E. Tavis, and V. Bruss. 1996. Hepatitis B virus nucleocapsid envelopment does not occur without genomic DNA synthesis. J. Virol. 70:4269-4274.
16. Gotoh, K., S. Mima, T. Uchida, T. Shikata, K. Yoshizawa, M. Irie, and M. Mizui. 1995. Nucleotide sequence of hepatitis B virus isolated from subjects without serum anti-hepatitis B core antibody. J. Med. Virol. 46:201-206.
17. Gray, A. H., J. W. S. Fang, G. L. Davis, M. Mizokami, P. C. Wu, R. Williams, S. M. Schuster, and J. Y. N. Lau. 1997. Variations of hepatitis B virus core gene sequence in Western patients with chronic hepatitis B virus infection. J. Viral Hepatitis 4:371-378.
18. Gunther, S., S. Baginski, H. Kissel, P. Reinke, D. H. Kruger, H. Will, and H. Meisel. 1996. Accumulation and persistence of hepatitis B virus core gene deletion mutants in renal transplant patients are associated with end-stage liver disease. Hepatology 24:751-758.
19. Baton, T., S. Zhou, and D. N. Standring. 1992. RNA- and DNA-binding activities in hepatitis B virus capsid protein: a model for their roles in viral replication. J. Virol. 66:5232-5241.
20. Heermann, K. H., U. Goldmann, W. Schwartz, T. Seiffarth, H. Baumgarten, and W. H. Gerlich. 1984. Large surface proteins of hepatitis B virus containing the pre-S sequence. J. Virol. 52:396-402.
21. Hosono, S., P. C. Tai, W. Wang, M. Ambrose, D. Hwang, T. T. Yuan, B. H. Peng, C. S. Yang, C. S. Lee, and C. Shih. 1995. Core antigen mutations of human hepatitis B virus in hepatomas accumulate in MHC class H-restricted T cell epitopes. Virology 212:151-162.
22. Hur, G. M., Y. I. Lee, D. J. Sun, J. H. Lee, and Y. I. Lee. 1996. Gradual accumulation of mutations in precore/core region of HBV in patients with chronic active hepatitis: implication of clustering changes in a small region of the HBV core region. J. Med. Virol. 48:38-46.
23. + T-cell population during seroconversion to anti-HBe and anti-HBs in hepatitis B virus infection. J. Virol. 69:3358-3368.
24. Karasawa, T., T. Shirasawa, Y. Okawa, A. Kuramoto, N. Shimada, Y. Aizawa, M. Zeniya, and G. Toda. 1997. Association between frequency of amino acid changes in core region of hepatitis B virus (HBV) and the presence of precore mutation in Japanese HBV carriers. J. Gastroenterol. 32:611-622.
25. Kock, J., S. Wieland, H. E. Blum, and F. von Weizsacker. 1998. Duck hepatitis B virus nucleocapsids formed by N-terminally extended or C-terminally truncated core proteins disintegrate during viral DNA maturation. J. Virol. 72:9116-9120.
26. McMillan, J. S., D. S. Bowden, P. W. Angus, G. W. McCaughan, and S. A. Locarnini. 1996. Mutations in the hepatitis B virus precore/core and core promoter in patients with severe recurrent disease following liver transplantation. Hepatology 24:1371-1378.
27. Menne, S., J. Maschke, T. K. Tolle, M. Lu, and M. Roggendorf. 1997. Characterization of T cell response to woodchuck hepatitis core protein and protection of woodchucks from infection by immunization with peptides containing a T cell epitope. J. Virol. 71:65-74.
28. Milich, D. 1997. Immune response to the hepatitis B virus: infection, animal models, vaccination. Viral Hepatitis 3:63-103.
29. Milich, D. R., A. McLachlan, A. Moriarty, and G. B. Thornton. 1987. Immune response to hepatitis B virus core antigen (HBcAg): localization of T cell recognition sites within HBcAg/HBeAg. J. Immunol. 139:1223-1231.
30. Miska, S., S. Gunther, M. Vassilev, H. Meisel, G. Pape, and H. Will. 1993. Heterogeneity of hepatitis B virus C-gene sequences: implications for amplification and sequencing. J. Heptol. 18:53-61.
31. Nassal, M. 1992. The arginine-rich domain of the hepatitis B virus core protein is required for pregenome encapsidation and productive viral positive-strand DNA synthesis but not for virus assembly. J. Virol. 66:4107-4116.
32. Nassal, M., and H. Schaller. 1996. Hepatitis B virus replication - an update. J. Viral Hepatitis 3:217-226.
33. Okamoto, H., F. Tsuda, and M. Mayumi. 1987. Defective mutants of hepatitis B virus in the circulation of symptom-free carriers. Jpn. J. Exp. Med. 57:217-221.
34. Ou, J.-H., and W. J. Rutter. 1987. Regulation of secretion of the hepatitis B virus major surface antigen by the pre-S1 protein. J. Virol. 61:782-786.
35. Pollicino, T., S. Campo, and G. Raimondo. 1995. PreS and core gene heterogeneity in hepatitis B virus (HBV) genomes isolated from patients with long-lasting HBV chronic infection. Virology 208:672-677.
36. Pollicino, T. S., A. R. Zanetti, I. Cacciola, et al. 1997. Pre-S2 defective hepatitis B virus infection in patients with fulminant hepatitis. Hepatology 26:495-499.
37. Rodriguez-Frias, F., M. Buti, R. Jardi, M. Cotrina, L. Viladomiu, R. Esteban, and J. Guardia. 1995. Hepatitis B virus infection: precore mutants and its relation to viral genotypes and core mutations. Hepatology 22:1641-1647.
38. Roychoudhury, S., A. Faruqi, and C. Shih. 1991. Pregenomic RNA encapsidation analysis of eleven raissense and nonsense polymerase mutants of human hepatitis B virus. J. Virol. 65:3617-3624.
39. Sells, M. A., M. L. Chen, and G. Acs. 1987. Production of hepatitis B virus particles in HepG2 cells transfected with cloned hepatitis B virus DNA. Proc. Natl. Acad. Sci. USA 84:1005-1009.
40. Shafritz, D. A. 1991. Variants of hepatitis B virus associated with fulminant liver disease. N. Engl. J. Med. 324:1737-1739.
41. Shih, C., L. S. Li, S. Roychoudhury, and M. H. Ho. 1989. In vitro propagation of human hepatitis B virus in a rat hepatoma cell line. Proc. Natl. Acad. Sci. USA 86:6323-6327.
42. Shih, C., P.-C. Tai, W. Whitehead, S. Hosono, C.-S. Lee, and C.-S. Yang. 1996. Hepatitis B and C viruses and liver cancer, p. 824-834. In J. R. Bertino (ed.), Encyclopedia of cancer, vol. II. Academic Press, Inc., New York, N.Y.
43. Slagle, B. L., T. H. Lee, and J. S. Butel. 1992. Hepatitis B virus and hepatocellular carcinoma. Prog. Med. Virol. 39:167.
44. Summers, J., and W. S. Mason. 1982. Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell 29:403-415.
45. Sureau, C., J.-L. Romet-Lemonne, J. I. Mullins, and M. Essex. 1986. Production of hepatitis B virus by a differentiated human hepatoma cell line after transfection with cloned circular HBV DNA. Cell 47:37-47.
46. Tencza, M. G., and J. E. Newbold. 1997. Heterogeneous response for a mammalian hepadnavirus infection to acyclovir: drug-arrested intermediates of minus-strand viral DNA synthesis are enveloped and secreted from infected cells as virion-like particles. J. Med. Virol. 51:6-16.
47. Tsai, S. L., M. H. Chen, C. T. Yeh, C. M. Chu, A. N. Lin, F. H. Chiou, T. H. Chang, and Y. F. Liaw. 1996. Purification and characterization of a naturally processed hepatitis B virus peptide recognized by CD8 cytotoxic T lymphocytes. J. Clin. Invest. 97:577-584.
48. Tuttleman, J., J. C. Pugh, and J. Summers. 1986. In vitro experimental infection of primary duck hepatocyte cultures with duck hepatitis B virus. J. Virol. 58:17-25.
49. Tuttleman, J., C. Pourcel, and J. Summers. 1986. Formation of the pool of covalently closed viral DNA in hepadnavirus-infected cells. Cell 47:451-460.
50. Uchida, T., T. T. Aye, S. O. Becher, M. Hirashima, T. Shikata, F. Komine, M. Moriyama, Y. Arakawa, S. Takase, and S. Mima. 1993. Detection of precore/ core-mutant hepatitis B virus genome in patients with acute or fulminant hepatitis without serological markers for recent HBV infection. J. Hepatol. 18:369-372.
51. Uchida, T., T. T. Aye, T. Shihata, M. Yano, H. Yatsuhashi, M. Koga, and S. Mima. 1994. Evolution of the hepatitis B virus gene during chronic infection in seven patients. J. Med. Virol. 43:148-154.
52. Valliammai, T., S. P. Thyagarajan, A. J. Zuckerman, and T. J. Harrison. 1995. Precore and core mutations in HBV from individuals in India with chronic infection. J. Med. Virol. 45:321-325.
53. Wakita, T., S. Kakumu, M. Shibata, K. Yoshioka, Y. Ito, T. Shinagawa, T. Ishikawa, M. Takayanagl, and T. Morishima. 1991. Detection of pre-C and core region mutants of hepatitis B virus in chronic hepatitis B virus carriers. J. Clin. Invest. 88:1793-1801.
54. Wel, Y., E. Tavis, and D. Ganem. 1996. Relationship between viral DNA synthesis and virion envelopment in hepatitis B viruses. J. Virol. 70:6455-6458.
55. Yu, M., and J. Summers. 1991. A domain of the hepadnavirus capsid protein is specifically required for DNA maturation and virus assembly. J. Virol. 65:2511-2517.
56. Yuan, T.-T., and C. Shih. Unpublished results.
57. Yuan, T. T., A. Faruqi, J. W. K. Shih, and C. Shih. 1995. The mechanism of natural occurrence of two closely-linked HBV precore predominant mutations. Virology 211:144-156.
58. Yuan, T.-T., M. H. Lin, S. M. Qiu, and C. Shih. 1998. Functional characterization of naturally occurring variants of human hepatitis B virus containing the core internal deletion mutation. J. Virol. 72:2168-2176.
59. Yuan, T.-T., M. H. Lin, D. S. Chen, and C. Shih. 1998. A defective interference-like phenomenon of human hepatitis B virus in chronic carriers. J. Virol. 72:578-584.