Identification of functionally important amino acid residues in the mitochondria targeting sequence of Hepatitis B virus X protein

Virology

Volumn 381, Issue 1, 2008, Pages 81-88

  Li, Sai Kam ^a   Ho, Sai Fan ^a   Tsui, Kwok Wing ^a   Fung, Kwok Pui ^a   Waye, M Y Mary ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

HBx gene; Hepatitis virus; Mitochondria targeting; Site directed mutagenesis

Indexed keywords

CYSTEINE; HEPATITIS B VIRUS X PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION;

AMINO ACIDS; CARCINOMA, HEPATOCELLULAR; CELL LINE; GENE EXPRESSION REGULATION, VIRAL; GREEN FLUORESCENT PROTEINS; HEPATITIS B VIRUS; HUMANS; MITOCHONDRIA; MUTATION; PROTEIN TRANSPORT; TRANS-ACTIVATORS;

HEPATITIS B VIRUS;

EID: 54149088014     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2008.07.037     Document Type: Article

References (30)

1. Benn J., Su F., Doria M., and Schneider R.J. Hepatitis B virus HBx protein induced transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases. J. Virol. 70 (1996) 4978-4985
2. 1 transit via a Src kinase pathway. J. Virol. 75 (2001) 4247-4257
3. Bouchard M.J., Wang L., and Schneider R.J. Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication. J. Virol. 80 (2006) 4406-4414
4. Chami M., Oulès B., and Paterlini-Bréchot P. Cytobiological consequences of calcium-signaling alterations induced by human viral proteins. Biochim. Biophys. Acta 1763 (2006) 1344-1362
5. Chen W.N., Oon C.J., Leong A.L., Koh S., and Teng S.W. Expression of integrated hepatitis B virus X variants in human hepatocellular carcinomas and its significance. Biochem. Bioph. Res. Co. 276 (2000) 885-892
6. Dandri M., Schirmacher P., and Rogler C.E. Woodchuck hepatitis virus X protein is present in chronically infected woodchuck liver and woodchuck hepatocellular carcinomas which are permissive for viral replication. J. Virol. 70 (1996) 5246-5254
7. de Moura P.R., Rui E., de Almeida Goncalves K., and Kobarg J. The cysteine residues of the hepatitis B virus oncoprotein HBx are not required for its interaction with mRNA or with human p53. Virus Res. 108 (2005) 121-131
8. Elmore L.W., Hancock A.R., Chang S.F., Wang X.W., Chang S., Callahan C.P., Geller D.A., Will H., and Harris C.C. Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 14707-14712
9. Feitelson M.A., and Lee J. Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis. Cancer Lett. 252 (2007) 157-170
10. Forgues M., Marrogi A.J., Spillare E.A., Wu C.G., Yang Q., Yoshida M., and Wang X.W. Interaction of the hepatitis B virus X protein with the Crm1-dependent nuclear export pathway. J. Biol. Chem. 276 (2001) 22797-22803
11. Gupta A., Mal T.K., Jayasuryan N., and Chauhan V.S. Assignment of disulphide bonds in the X protein (HBx) of hepatitis B virus. Biochem. Bioph. Res. Co. 212 (1995) 919-924
12. Henkler F., Hoare J., Waseem N., Goldin R.D., McGarvey M.J., Koshy R., and King I.A. Intracellular localization of the hepatitis B virus HBx protein. J. Gen. Virol. 82 (2001) 871-882
13. Hoare J., Henkler F., Dowling J.J., Errington W., Goldin R.D., Fish D., and McGarvey M.J. Subcellular localisation of the X protein in HBV infected hepatocytes. J. Med. Virol. 64 (2001) 419-426
14. Kim S., Kin H.Y., Lee S., Kim S.W., Sohn S., Kim K., and Cho H. Hepatitis B virus X protein induced perinuclear mitochondria clustering in microtubule and dynein dependent manners. J. Virol. 81 (2007) 1714-1726
15. Lucito R., and Schneider R.J. Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C. J. Virol. 66 (1992) 983-991
16. Maguire H.F., Hoeffler J.P., and Siddiqui A. HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. Science 252 (1991) 842-844
17. Mahé Y., Mukaida N., Kuno K., Akiyama M., Ikeda N., Mats, us hima K., and Murakami S. Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor kB and CCAAT/enhancer-binding protein-like cis elements. J. Biol. Chem. 266 (1991) 13759-13763
18. Neupert W. Protein import into mitochondria. Annu. Rev. Biochem. 66 (1997) 863-917
19. Ng R.K., Lau C.Y.L., Lee S.M.Y., Tsui S.K.W., Fung K.P., and Waye M.M.Y. cDNA microarray analysis of early gene expression profiles associated with hepatitis B virus X protein-mediated hepatocarcinogenesis. Biochem. Bioph. Res. Co. 322 (2004) 827-835
20. Oh J.C., Jeong D.L., Kim I.K., and Oh S.H. Activation of calcium signaling by hepatitis B virus-X protein in liver cells. Exp. Mol. Med. 35 (2003) 301-309
21. Poussin K., Dienes H., Sirma H., Urban S., Beaugran, d M., F ranco D., Schirmacher P., Bréchot C., and Paterlini Bréchot P. Expression of mutated hepatitis B virus X genes in human hepatocellular carcinomas. Int. J. Cancer 80 (1999) 497-505
22. Rahmani Z., Huh K.W., Lasher R., and Siddqui A. Hepatitis B virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential. J. Virol. 74 (2002) 2840-2846
23. Rui E., Moura P.R., Gonçalves Kde A., and Kobarg J. Expression and spectroscopic analysis of a mutant hepatitis B virus onco-protein HBx without cysteine residues. J. Virol. Methods 126 (2005) 65-74
24. Shirakata Y., and Koike K. Hepatitis B virus X protein induced cell death by causing loss of mitochondrial membrane potential. J. Biol. Chem. 278 (2003) 22071-22078
25. Takada S., Kaneiwa N., Tsuchida N., and Koike K. Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the hepatitis B virus X gene-transfected cells. Oncogene 15 (1997) 1895-1901
26. Tu H., Bouura C., Giannini C., Mouly H., Soussan P., Kew M., Paterlini-Bréchot P., Bréchot C., and Kremsdorf D. Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues. Cancer Res. 61 (2001) 7803-7810
27. Wang X.W., Forrester K., Yeh H., Feitelson M.A., Gu J.R., and Harris C.C. Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 2230-2234
28. Wang Y., Lau H., Sham J.S., Wu M.C., Wang T., and Guan X.Y. Characterization of HBV integrants in 14 hepatocellular carcinomas: association of truncated X gene and hepatocellular carcinogenesis. Oncogene 23 (2004) 142-148
29. Waris G., Huh K.W., and Siddiqui A. Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress. Mol. Cell. Biol. 21 (2001) 7721-7730
30. Williams J.S., and Andrisani O.M. The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 3819-3823