Regulation of RNA polymerase I-dependent promoters by the hepatitis B virus X protein via activated Ras and TATA-binding protein

Molecular and Cellular Biology

Volumn 18, Issue 12, 1998, Pages 7086-7094

  Wang, Horng Dar ^a   Trivedi, Alpa ^a   Johnson, Deborah L ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DNA DIRECTED RNA POLYMERASE; RAS PROTEIN; RIBOSOME RNA; TATA BINDING PROTEIN; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

ANIMALIA; DNA VIRUSES; HEPATITIS B VIRUS;

EID: 0031753448     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.12.7086     Document Type: Article

References (69)

1. Allo, S. N., P. J. McDermott, L. L. Carl, and H. E. Morgan. 1991. Phorbol ester stimulation of protein kinase C activity and ribosomal DNA transcription. J. Biol. Chem. 266:22003-22009.
2. Aufiero, B., and R. J. Schneider. 1990. The hepatitis B virus X gene product transactivates both RNA polymerase II and III promoters. EMBO J. 9:497-504.
3. Benn, J., and R. J. Schneider. 1994. Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade. Proc. Natl. Acad. Sci. USA 91:10350-10354.
4. Benn, J., and R. J. Schneider. 1995. Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls. Proc. Natl. Acad. Sci. USA 92:11215-11219.
5. Benn, J., F. Su, M. Doria, and R. J. Schneider. 1996. Hepatitis B virus Hbx protein induces transcription factor AP-1 by activation of extracellular signal-related and c-Jun N-terminal mitogen-activated protein kinases. J. Virol. 70:4978-4985.
6. Cavanaugh, A. H., W. M. Hempel, L. J. Taylor, V. Rogalsky, G. Todorov, and L. I. Rothblum. 1995. Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product. Nature 374:177-180.
7. Chao, Y., and M. Pellegrini. 1993. In vitro transcription of Drosophila rRNA genes shows stimulation by a phorbol ester and serum. Mol. Cell. Biol. 13:934-941.
8. Chen, H.-S., S. Kaneko, R. Girones, R. W. Anderson, W. E. Hornbuckle, B. C. Tennant, P. J. Cote, J. L. Gerin, R. H. Purcell, and R. H. Miller. 1993. The woodchuck hepatitis B virus X gene is important for the establishment of virus infection in woodchucks. J. Virol. 67:1218-1226.
9. Cheong, J. H., M. Yi, Y. Lin, and S. Murakami. 1995. Human RPB5, a subunit shared by eucaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation. EMBO J. 14:142-150.
10. Clark, M. E., P. M. Lieberman, A. J. Berk, and A. Dasgupta. 1993. Direct cleavage of human TATA-binding protein by poliovirus protease 3C in vivo and in vitro. Mol. Cell. Biol. 13:1232-1237.
11. Colgan, J., and J. L. Manley. 1992. TFIID can be rate limiting in vivo for TATA-containing, but not TATA-lacking, RNA pol II promoters. Genes Dev. 6:304-315.
12. Cormack, B. P., and K. Struhl. 1993. Regional codon randomization: defining a TATA-binding protein surface required for RNA polymerase III transcription. Science 262:244-248.
13. Cross, J. C., P. Wen, and W. J. Rutter. 1993. Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases. Proc. Natl. Acad. Sci. USA 90:8078-8082.
14. Dandri, M., P. Schirmacher, and C. E. Rogler. 1996. Woodchuck hepatitis virus X protein is present in chronically infected woodchuck liver and woodchuck hepatocellular carcinomas which are permissive for viral replication. J. Virol. 70:5246-5254.
15. Darnell, J. E., M. Girard, D. Baltimore, D. F. Summers, and J. V. Maizel. 1967. The synthesis and translation of poliovirus RNA, p. 375-401. In J. Colter and W. Paranchych (ed.), The molecular biology of viruses. Academic Press, Inc., New York, N.Y.
16. Derenzini, M., D. Trere, A. Pession, L. Montanaro, V. Sirri, and R. L. Ochs. 1998. Nucleolar function and size in cancer cells. Am. J. Pathol. 152:1291-1297.
17. Doria, M., N. Klein, R. Lucito, and R. J. Schneider. 1995. The hepatitis B virus HbX protein is a dual specificity cytoplasmic activator of ras and nuclear activator of transcription factors. EMBO J. 14:4747-4757.
18. Feitelson, M. A., M. Zhu, L. X. Duan, and W. T. London. 1993. Hepatitis B x antigen and p53 are associated in vitro and in liver tissue from patients with primary hepatocellular carcinoma. Oncogene 8:1109-1117.
19. Fisher, M., L. Runkel, and H. Schaller. 1995. HBx protein of hepatitis B virus interacts with the C-terminal portion of a novel human proteosome alpha subunit. Virus Genes 10:99-102.
20. Garber, M., A. Vilalta, and D. L. Johnson. 1994. Induction of Drosophila RNA polymerase III gene expression by the phorbol ester, TPA, is mediated by TFIIIB. Mol. Cell. Biol. 14:339-347.
21. Han, K., M. S. Levine, and J. L. Manley. 1989. Synergistic activation and repression of transcription by Drosophila homeobox protein. Cell 56:573-583.
22. Haviv, I., Y. Matza, and Y. Shaul. 1998. pX, the HBV-encoded activator, suppresses the phenotypes of TBP and TAFII250 mutants. Genes Dev. 12:1217-1226.
23. Haviv, I., M. Shamay, G. Doitsh, and Y. Shaul. 1998. Hepatitis B virus pX targets TFIIB in transcription coactivation. Mol. Cell. Biol. 18:1562-1569.
24. Haviv, I., D. Vaizel, and Y. Shaul. 1995. The X protein of hepatitis B virus coactivates potent activation domains. Mol. Cell. Biol. 15:1079-1085.
25. Haviv, I., D. Vaizel, and Y. Shaul. 1996. pX, the HBV-encoded coactivator, interacts with components of the transcription machinery and stimulates transcription in a TAF-independent manner. EMBO J. 15:3413-3420.
26. Hernandez, N. 1993. TBP, a universal eukaryotic transcription factor? Genes Dev. 7:1291-1308.
27. Hohne, M., S. Schaefer, M. Seifer, M. A. Feitelson, D. Paul, and W. H. Gerlich. 1990. Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA EMBO J. 9:1137-1145.
28. Huang, J., J. Kwong, E. C. Y. Sun, and T. J. Liang. 1996. Proteasome complex as a potential cellular target of hepatitis B virus X protein. J. Virol. 70:5582-5591.
29. Jacob, S. T. 1995. Regulation of ribosomal gene transcription. Biochem. J. 306:617-626.
30. Kekule, A. S., U. Lauer, L. Weiss, B. Luber, and P. H. Hofschneider. 1993. Hepatitis B virus transactivator uses a tumor promoter signalling pathway. Science 361:742-745.
31. Kim, C. M., K. Koike, I. Saito, T. Miyamura, and G. Jay. 1991. HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 351:317-320.
32. Klein, N. P., and R. J. Schneider. 1997. Activation of Src family kinases by hepatitis B virus HBx protein and coupled signal to Ras. Mol. Cell. Biol. 17:6427-6436.
33. Koike, K., K. Moriya, H. Yotsuyanagi, S. Iino, and K. Kurokawa. 1994. Induction of cell cycle progression by hepatitis B virus HBx gene expression in quiescent mouse fibroblasts. J. Clin. Invest. 94:44-49.
34. Learned, R. M., and R. Tjian. 1982. In vitro transcription of human ribosomal RNA genes by RNA polymerase I. J. Mol. Appl. Genet. 1:575-584.
35. Lee, T. H., S. J. Elledge, and J. S. Butel. 1995. Hepatitis B virus X protein interacts with a probable cellular DNA repair protein. J. Virol. 69:1107-1114.
36. Lin, Y., T. Nomura, J. Cheong, D. Dorjsuren, K. Iida, and S. Murakami. 1997. Hepatitis B virus X protein is a transcriptional modulator that communicates with transcription factor IIB and the RNA polymerase II subunit 5. J. Biol. Chem. 272:7132-7139.
37. Lucito, R., and R. J. Schneider. 1992. Hepatitis B virus X protein activates transcription factor NF-κB without a requirement for protein kinase C. J. Virol. 66:983-991.
38. Maguire, H. F., J. P. Hoeffler, and A. Siddiqui. 1991. HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. Science 252:842-844.
39. Marais, R., Y. Light, C. Mason, H. Paterson, M. F. Olson, and C. J. Marshall. 1998. Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. Science 280:109-112.
40. Mittnacht, S., H. Paterson, M. F. Olson, and C. J. Marshall. 1997. Ras signalling is required for inactivation of the tumour suppressor pRB cell-cycle control protein. Curr. Biol. 7:219-221.
41. Moss, T., and V. Y. Stefanovsky. 1995. Promotion and regulation of ribosomal transcription in eukaryotes by RNA polymerase I. Prog. Nucleic Acid Res. Mol. Biol. 50:25-66.
42. Natoli, G., M. L. Avantaggiati, P. Chirillo, P. L. Puri, A. Ianni, C. Balsano, and M. Levrero. 1994. Ras- and Raf-dependent activation of c-Jun transcriptional activity by the hepatitis B virus transactivator pX. Oncogene 9:2837-2843.
43. Pöckl, E., and E. Wintersberger. 1980. Increased rate of RNA synthesis: early reaction of primary mouse kidney cells to infection with polyoma virus and simian virus 40. J. Virol. 35:8-19.
44. Qadri, I., H. F. Maguire, and A. Siddiqui. 1995. Hepatitis B virus transactivator protein X interacts with the TATA-binding protein. Proc. Natl. Acad. Sci. USA 92:1003-1007.
45. Qadri, I., J. W. Conaway, R. C. Conaway, J. Schaack, and A. Siddiqui. 1996. Hepatitis B virus transactivator protein, Hbx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH. Proc. Natl. Acad. Sci. USA 93:10578-10583.
46. Raskas, H., D. Thomas, and M. Green. 1970. Biochemical studies on adenovirus multiplication. XVII. Ribosome synthesis in uninfected and infected KB cells. Virology 40:893-902.
47. Rubinstein, S. J., T. Hammerle, E. Wimmer, and A. Dasgupta. 1992. Infection of HeLa cells with poliovirus results in modification of a complex that binds to the rRNA promoter. J. Virol. 66:3062-3068.
48. Sadovsky, Y., P. Webb, G. Lopez, J. D. Baxter, P. M. Fitzpatrick, E. Gizang-Ginsberg, V. Cavailles, M. G. Parker, and P. J. Kushner. 1995. Transcriptional activators differ in their responses to overexpression of TATA-box-binding protein. Mol. Cell. Biol. 15:1554-1563.
49. Schonwasser, D. C., R. M. Marais, C. J. Marshall, and P. J. Parker. 1998. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol. Cell. Biol. 18:790-798.
50. Slage, B. L., T. H. Lee, D. Medina, M. J. Finegold, and J. S. Butel. 1996. Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene. Mol. Carcinog. 15:261-269.
51. Soprano, K. J., V. G. Dev, C. M. Croce, and R. Baserga. 1979. Reactivation of silent rRNA genes by simian virus 40 in human-mouse hybrid cells. Proc. Natl. Acad. Sci. USA 76:3885-3889.
52. Trivedi, A., A. Vilalta, S. Gopalan, and D. L. Johnson. 1996. TATA-binding protein is limiting for both TATA-containing and TATA-lacking RNA polymerase III promoters in Drosophila cells. Mol. Cell. Biol. 16:6909-6916.
53. Ueda, H., S. J. Ullrich, J. D. Gangemi, C. A. Kappel, L. Ngo, M. A. Feitelson, and G. Jay. 1995. Functional inactivation but not structural mutation of p53 causes liver cancer. Nat. Genet. 9:41-47.
54. Vallett, A. M., M. Brudnak, M. Pellegrini, and H. W. Weber. 1993. In vivo regulation of rRNA transcription occurs rapidly in nondividing and dividing Drosophila cells in response to a phorbol ester and serum. Mol. Cell. Biol. 13:928-933.
55. Vilalta, A., A. Triyedi, Z. Wang, R. G. Roeder, and D. L. Johnson. 1997. An RNA polymerase III-defective mutation in TATA-binding protein disrupts its interaction with a transcription factor IIIB subunit in Drosophila cells. J. Biol. Chem. 272:18087-18092.
56. Voit, R., K. Schafer, and I. Grummt. 1997. Mechanism of repression of RNA polymerase I transcription by the retinoblastoma protein. Mol. Cell. Biol. 17:4230-4237.
57. Wada, C., K. Kasai, T. Kameya, and H. Ohtani. 1992. A general transcription factor, human transcription factor IID, overexpressed in human lung and breast carcinoma and rapidly induced with serum stimulation. Cancer Res. 52:307-313.
58. Wagner, E., and B. Roizman. 1969. Ribonucleic acid synthesis in cells infected with herpes simplex virus. I. Patterns of ribonucleic acid synthesis in productively infected cells. J. Virol. 4:36-57.
59. Waldron, C., and F. Lacroute. 1975. Effect of growth rate on the amounts of ribosomal and transfer ribonucleic acids in yeast. J. Bacteriol. 122:855-865.
60. Wang, H.-D., and D. L. Johnson. Unpublished data.
61. Wang, H.-D., A. Trivedi, and D. L. Johnson. 1997. Hepatitis B virus X protein induces RNA polymerase III-dependent gene transcription and increases the cellular TATA-binding protein by activating the Ras signaling pathway. Mol. Cell. Biol. 17:6838-6846.
62. Wang, H.-D., C.-H. Yuh, C. V. Dang, and D. L. Johnson. 1995. The hepatitis B virus increases the cellular level of TATA-binding protein which mediates transactivation of RNA polymerase III genes. Mol. Cell. Biol. 15:6720-6728.
63. Wang, X. W., K. Forrester, H. Yeh, M. A. Feitelson, J. R. Gu, and C. C. Harris. 1994. Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proc. Natl. Acad. Sci. USA 91:2230-2234.
64. Weber, H. W., S. Vallett, L. Neilson, M. Grotke, Y. Chao, M. Brudnak, A. S. Juan, and M. Pellegrini. 1993. Serum, insulin and phorbol esters stimulate rRNA and tRNA gene expression in both dividing and non-dividing Drosophila cells. Mol. Cell. Biochem. 104:201-207.
65. Williams, J. S., and O. M. Andrisani. 1995. The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB. Proc. Natl. Acad. Sci. USA 92:3819-3823.
66. Yen, T. S. B. 1996. Hepadnaviral X protein: review of recent progress. J. Biomed. Sci. 3:20-30.
67. 1 complex SL1 and coactivates ribosomal RNA transcription. Genes Dev. 11:1605-1617.
68. Zhou, Q., P. M. Lieberman, T. G. Boyer, and A. J. Berk. 1992. Holo-TFIID supports transcriptional stimulation by diverse activators and from a TATA-less promoter. Genes Dev. 6:1964-1974.
69. Zoulim, F., J. Saputelli, and C. Seeger. 1994. Woodchuck hepatitis B virus X protein is required for viral infection in vivo. J. Virol. 68:2026-2030.