Stem-like cells in hepatitis B virus-associated cirrhotic livers and adjacent tissue to hepatocellular carcinomas possess the capacity of tumorigenicity

Journal of Gastroenterology and Hepatology (Australia)

Volumn 23, Issue 8 PART1, 2008, Pages 1280-1286

  Sun, Yu Ling ^a   Yin, Sheng Yong ^a   Xie, Hai Yang ^a   Zhou, Lin ^a   Xue, Fei ^a   Wu, Li Ming ^a   Gao, Feng ^a   Zheng, Shu Sen ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b First Affiliated Hospital   (China)

Author keywords

Hepatitis B virus; Hepatocellular carcinoma; Stem cells; Tumorigenicity

Indexed keywords

CD133 ANTIGEN; CD34 ANTIGEN; STEM CELL FACTOR RECEPTOR; THY 1 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT; CARCINOGENICITY; CELL PROLIFERATION; CELL RENEWAL; CELL STRUCTURE; CONTROLLED STUDY; DISEASE ASSOCIATION; HEPATITIS B; IMMUNE DEFICIENCY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIVER CELL; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER PARENCHYMA; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; TISSUE CULTURE;

EID: 48549084860     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2008.05342.x     Document Type: Article

References (28)

1. Serakinci N, Guldberg P, Burns JS et al. Adult human mesenchymal stem cell as a target for neoplastic transformation. Oncogene 2004 23 : 5095 8.
2. Houghton J, Stoicov C, Nomura S et al. Gastric cancer originating from bone marrow-derived cells. Science 2004 26 : 1568 71.
3. Miyamoto T, Weissman IL, Akashi K. AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8; 21 chromosomal translocation. Proc. Natl. Acad. Sci. U.S.A. 2000 97 : 7521 6.
4. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2003 100 : 3983 8.
5. Fuchs E, Tumbar T, Guasch G. Socializing with the neighbors: stem cells and their niche. Cell 2004 116 : 769 78.
6. Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001 414 : 105 11.
7. Lowes KN, Brennan BA, Yeoh GC, Olynyk JK. Oval cell numbers in human chronic liver diseases are directly related to disease severity. Am. J. Pathol. 1999 154 : 537 41.
8. Dumble ML, Croager EJ, Yeoh GC, Quail EA. Generation and characterization of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma. Carcinogenesis 2002 23 : 435 45.
9. Tai MH, Chang CC, Kiupel M, Webster JD, Olson LK, Trosko JE. Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis. Carcinogenesis 2005 26 : 495 502.
10. Petrescu AD, Payne HR, Boedecker A et al. Physical and functional interaction of Acyl-CoA-binding protein with hepatocyte nuclear factor-4 alpha. J. Biol. Chem. 2003 278 : 51813 24.
11. Sun C, Jin XL, Xiao JC. Oval cells in hepatitis B virus-positive and hepatitis C virus-positive liver cirrhosis: histological and ultrastructural study. Histopathology 2006 48 : 546 55.
12. Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet 2001 357 : 539 45.
13. Li Q, Withoff S, Verma IM. Inflammation-associated cancer: NF-kappaB is the lynchpin. Trends Immunol. 2005 26 : 318 25.
14. Fausto N. Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells. Hepatology 2004 39 : 1477 87.
15. Seeger C, Mason WS. Hepatitis B virus biology. Microbiol. Mol. Biol. Rev. 2000 64 : 51 68.
16. Omori N, Omori M, Evarts RP et al. Partial cloning of rat CD34 cDNA and expression during stem cell-dependent liver regeneration in the adult rat. Hepatology 1997 26 : 720 7.
17. Sanchez A, Factor VM, Schroeder IS, Nagy P, Thorgeirsson SS. Activation of NF-kappaB and STAT3 in rat oval cells during 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration. Hepatology. 2004 39 : 376 85.
18. Shimano K, Satake M, Okaya A et al. Hepatic oval cells have the side population phenotype defined by expression of ATP-binding cassette transporter ABCG2/BCRP1. Am. J. Pathol. 2003 163 : 3 9.
19. Jaatinen T, Hemmoranta H, Hautaniemi S et al. Global gene expression profile human cord blood-derived CD133+ cells. Stem Cells 2006 24 : 631 41.
20. Tondreau T, Meuleman N, Delforge A et al. Mesenchymal stem cells derived from CD133-positive cells in mobilized peripheral blood and cord blood: proliferation, Oct4 expression, and plasticity. Stem Cells 2005 23 : 1105 12.
21. Chiba T, Kita K, Zheng YW et al. Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology 2006 44 : 240 51.
22. Ma S, Chan KW, Hu L et al. Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology 2007 132 : 2542 56.
23. Yin S, Li J, Hu C et al. CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity. Int. J. Cancer 2007 120 : 1444 50.
24. Toren A, Bielorai B, Jacob-Hirsch J et al. CD133-positive hematopoietic stem cell 'stemness' genes contain many genes mutated abnormally expressed leukemia. Stem Cells 2005 23 : 1142 53.
25. Cerec V, Glaise D, Garnier D et al. Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor. Hepatology 2007 45 : 957 67.
26. Petersen BE, Bowen WC, Patrene KD et al. Bone marrow as a potential source of hepatic oval cells. Science 1999 284 : 1168 70.
27. Ohmori S, Shiraki K, Sugimoto K et al. Expression of CD34-positive sinusoidal endothelial cells in patients with HBV-associated chronic liver diseases. Int. J. Mol. Med. 2004 14 : 179 84.
28. Wu XZ, Chen D. Origin of hepatocellular carcinoma: role of stem cells. J. Gastroenterol. Hepatol. 2006 21 : 1093 8.