Intracellular localization of the hepatitis B virus HBx protein

Journal of General Virology

Volumn 82, Issue 4, 2001, Pages 871-882

  Henkler, F ^a   Hoare, J ^a   Waseem, N ^a   Goldin, R D ^a   McGarvey, M J ^a   Koshy, R ^a   King, I A ^a  

^a UNIVERSITY OF STUTTGART   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOPLASM PROTEIN; NUCLEAR PROTEIN; VIRUS PROTEIN;

ARTICLE; CELL COMPARTMENTALIZATION; CELL GRANULE; CELL MEMBRANE; CELL NUCLEUS; CELL ORGANELLE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; ENDOPLASMIC RETICULUM; GENETIC TRANSFECTION; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; LIFE CYCLE; LIVER DISEASE; LYSOSOME; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TRANSCRIPTION INITIATION; VIROLOGY; VIRUS TRANSCRIPTION;

DNA VIRUSES; HEPATITIS B VIRUS;

EID: 0035057205     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-82-4-871     Document Type: Article

References (45)

1. Bowringia milbraedii agglutinin. Specificity of binding to early processing intermediates of asparagine-linked oligosaccharide and use as a marker of endoplasmic reticulum glycoproteins
2. The 17 kDa HBx protein encoded by hepatitis B virus interacts with the activation domains of Oct 1, and functions as a coactivator in the activation and repression of a human U6 promoter
3. Hepatitis B virus X protein interferes with cellular DNA repair
4. The hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signalling cascade
5. Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal regulated and c-Jun N-terminal mitogen activated protein kinases
6. Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X-transactivation
7. The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors
8. Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis
9. Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma
10. HBx protein of hepatitis B virus interacts with the C-terminal portion of a novel human proteasome alpha-subunit
11. Downregulation of DNA excision repair by the hepatitis B virus-X protein occurs in p53 proficient and p53-deficient cells
12. Expression of the X-protein and Hepatitis B virus replication in chronic hepatitis
13. Multiple functions of the hepatitis B virus X protein
14. Mutant p53, but not hepatitis B virus X protein is present in hepatitis B virus related human hepatocellular carcinoma
15. Erk-independent partial activation of AP-1 sites by the hepatitis B virus HBx protein
16. Hepatitis B virus X protein inhibits nucleotide excision repair
17. Detection of the hepatitis B virus X gene protein and antibody in type B chronic liver disease
18. Activation of Src Family Kinases by hepatitis B virus HBx protein and coupled signalling to Ras
19. Alternate translation initiation on hepatitis B virus X mRNA produces multiple polypeptides that differentially transactivate class II and III promoters
20. HBx protein of hepatitis B virus activates Jak1-STAT signaling
21. Hepatitis B virus X protein interacts with a probable cellular repair protein
22. HBV X protein alters the DNA binding specificity of CREB and ATF 2 by protein-protein interactions
23. Key to the mitochondrial gate
24. Effects of X protein on transactivation of hepatitis B virus promoters and viral replication
25. Ras and Raf dependent activation of c-Jun transcriptional activity by the hepatitis B virus transactivator pX
26. Analysis of mitochondrial morphology and function with novel fixable fluorescent stains
27. Hepatitis B virus transactivator protein X interacts with the TATA binding protein
28. Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIF
29. Hepatitis B virus X protein colocalizes to mitochondria with a human voltage dependent anion channel, HVDAC3 and alters its transmembrane potential
30. The hepatitis B virus X protein transactivates viral core gene expression in vivo
31. Transactivating function and expression of the X gene of hepatitis B virus
32. Induction of apoptosis by transactivating domains of the hepatitis B virus X gene leads to suppression of oncogenic transformation of primary rat embryo fibroblasts
33. Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx
34. Trans activation of viral enhancers by the hepatitis B virus X protein
35. Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumour necrosis factor alpha
36. Expression of hepatitis B virus X protein in HBV-infected human livers and hepatocellular carcinomas
37. Association of the hepatitis B virus X protein with mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death
38. p53 independent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitro
39. Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation
40. Transcriptional transactivating function of hepatitis B virus
41. Hepatitis B virus X protein inhibits sequence-specific DNA binding, transcriptional activity and association with transcription factor ERCC3
42. Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaB alpha
43. The hepatitis B virus X protein targets the basic region leucine zipper domain of CREB
44. The HBV X ORF encodes a transactivator: A potential factor in viral hepatocarcinogenesis