Novel pre-C/C gene mutants of hepatitis B virus in chronic active hepatitis: Naturally occurring escape mutants

Journal of General Virology

Volumn 77, Issue 6, 1996, Pages 1129-1138

  Lee, Young Ik ^a   Hur, Gang Min ^a   Suh, Dong Jin ^b   Kim, Sun Hee ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CD4 ANTIGEN; EPITOPE; HEPATITIS E ANTIGEN;

ADULT; ARTICLE; CHRONIC ACTIVE HEPATITIS; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DELETION MUTANT; FEMALE; GENE MUTATION; HELPER CELL; HEPATITIS B VIRUS; HUMAN; MALE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; SERUM; VIRUS GENE; VIRUS MUTANT; VIRUS SHEDDING;

HEPATITIS B VIRUS;

EID: 0030006486     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-77-6-1129     Document Type: Article

References (33)

1. BERTOLETT, A., FERRARI, C., FIACCADORI, F., PENNA. A., MARGOLSKEE, R., SCHLICHT, H. & FOWLER, P. (1991). HLA class-I restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleotide antigen. Proceedings of the National Academy of Sciences, USA 88, 10445-10449.
2. BERTOLETTI, A., CHISARI, F. V., PENNA, A., GUILHOT. S., GALATI, L., MISSALE, G. & FOWLER, P. (1993). Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein. Journal of Virology 67, 2376-2380
3. CARMAN, W. F., ALESSANDRO, R. Z., KARAYIANNIS, J., WATERS, G , MAZILLO, E., TANZI, A., ZUCKERMEN, J. & THOMAS, H. G. (1994). Vaccine induced escape mutants of hepatitis B virus. Lancet 336, 325-329.
4. CHISARI, F. V., FERRARI, C. & MONDELLI, M. (1989). Hepatitis B virus structure and biology. Microbiology and Pathology 6, 311 318.
5. DE CAMPOS-LIMA, P. O., VEVITSKY, V., BROOKS, J., LEE, S. P., HU, L. F. & MASUCCI, M. G. (1994). T cell responses and virus evolution : loss of HLA-A11 restricted CTL epitopes in Epstein-Barr virus isolates from highly AI l-positive populations by selective mutation at anchor residues. Journal of Experimental Medicine 179, 1297-1302
6. EHATA, T., OMATA, M., YOKOSUKA, O., HOSODA, K. & OHIO. M. (1992). Variations in codons 84-101 in core nucleotide sequence correlate with hepatocellular injury in chronic hepatitis B infection. Journal of Clinical Investigation 89, 332-338.
7. EISENLOHR, L. C., YEWDELL, J. W. & BENNICK, J. R. (1992). Flanking sequences influence the presentation of an endogenous synthesized peptide to cytotoxic T lymphocytes. Journal of Experimental Medicine 175, 481-189.
8. HADZIYANNIS, S J., LIEBERMAN, H. M., KARVOUNTZIS, G. G. & SHAFRITZ, D. A. (1983). Analysis of liver, nuclear HBcAg, viral replication and hepatitis B virus DNA in liver and serum of HBeAg versus anti-HBe positive carriers of hepatitis B virus. Hepalologv 3, 656-662.
9. HATTON, T., ZHOU, S. & STANDRING, D. N. (1992). RNA- and DNAbinding activities in hepatitis B virus capsid protein: a model for their roles in viral replication. Journal of Virology 66, 5232-5241.
10. HOOFNAGLE, J. H., DUSHEIKO, G. M., SEEFF, L. B., JONES, E. A., WAGGONER, J. G. & BALES, Z.B. (1981). Seroconversion from hepatitis B e antigen to antibody in chronic type B hepatitis. Annals of Internal Medicine 94, 744-748.
11. HOOFNAGLE, J. H., SHAFRITZ, D. A. & POPPER, H. (1987). Chronic type B hepatitis and the 'heaithy' hepatitis B surface antigen carrier state. Hepatology 7, 758-763.
12. HUR, G. M., LEE, Y. I., SHU, D. J., LEE, J. H. & LEE, Y. I. (1996) Gradual accumulation of mutations in precore region of HBV in patients with chronic active hepatitis: implications of clustering changes in a small region of the HBV core region. Journal of Medical Virology 48, 38-46.
13. KANEKO, S. & MILLER, R. H. (1989). Heterogeneity of the core gene sequence in a patient chronically infected with hepatitis B virus. Journal of Infectious Diseases 160, 903-904.
14. KOUP, A., R. (1994). Virus escape from CTL recognition. Journal of Experimental Medicine 180, 779-782.
15. MILICH, D R., HUGHES, J. R., HOUGHREN, R., MCLACHLAN, A. & JONES, J. E. (1989). Functional identification of agretopic and epitopic residues within an HBcAg T cell determinant. Journal of Immunology 143, 3141-3147.
16. MISSALE, G., REDEKER, A., PERSON, J., FOWLER, P., GUILHOT. S., SCHLICHT, H.J & FERRARI, C. (1993). HLA-A31 and HLA-Aw68 restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis. Journal of Experimental Medicine 177, 751-762.
17. NASSAL, M. & RIEGER, A. (1993). An intramolecular disulfide bridge between cys-7 and cys-61 determines the structure of the secretory core gene product (e antigen) of HBV. Journal of Virologv 67, 4307-4315.
18. NASSAL, M., RIEGER, A. & STEINAK, O. (1992) Topological analysis of hepatitis B virus core particle by cysteme-cysteine cross-linking. Journal of Molecular Biology 225, 1013-1025.
19. NAYERSINA, R., FOWKER, P., GUILHOT, S., MISSALE, G., CERNY, A., SCHLICHT, H J., VITIELLO, A., CHESNUT, R., PERSON. J. L., REDEKER, A. & CHISARI, F. V. (1993). HLA-A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes dunne hepatitis B virus infection. Journal of Immunology 150, 4659-1671.
20. OKAMOTO, H., YOTSUMOTO. Y., AKAHANE, T., YAMAXAKA, Y., MlYAZAKI, Y , SUGAl, F., TSUDA, T., TANAKA, Y. & MAYUMI, M. (1990). Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. Journal of Virology 64, 1298-1303.
21. OMATA, M., EHATA, T., YOKOSUKA, O., HOSODA, K. & OHTO, M. (1990). Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis. New England Journal of Medicine 324, 1699-1704.
22. Ou, J.-H., LAUB, O. L. & RTJTTER, W. J. (1986). Hepatitis B virus precore region targets the core antigen to cellular membranes and causes the secretion of the antigen. Proceedings of the National Academy of Sciences, USA 83, 1578-1582.
23. PENNA, A., GIUBERCI, T., TONG, M. J., RIBERA, E., FIACCADORI, F. & CHRISARI, F. V. (1987). Intrahepatic nucleocapsid antigen-specific T cell in chronic active hepatitis B. Journal of Immunology 139, 2050-2058.
24. PENNA, A., CHRISARI, F. V., BERTOLETTI, A., MISSALE, G., FOWLER, P., GIUBERTI, T. & FIACCADORI, F. (1991). Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen. Journal of Experimental Medicine 174, 1565-1570.
25. RAIMONDO, G., STEMLER, M., SCHNEIDER, R., WILDNER, G., SQUADRITO, G. & WILL, H. (1990). Latency and reactivation of a precore mutant hepatitis B virus in a chronically infected patient. Journal of Hepatology 11, 374-380.
26. REALDI, G., ALBERTI, A., RUGGE, M., BORTOLOTTI, F., RIGOLI, A. M., TREMOLADA, F. & RUOL, A. (1980). Seroconversion from hepatitis B e antigen to anti-HBe in chronic hepatitis B virus infection. Gasrroemerology 79, 195-199
27. ROTZSCHKE-, O. & FALK, K. (1991). Naturally-occurring peptide antigens derived from the MHC class-1-resiricted processing pathway. Immunology Today 12, 447-451.
28. SANGER, F., NICKLEN, S. & COULSON, A. R. (1977). DNA sequencing with chain-terminating inhibitors. Proceedings of the National Academy of Sciences, USA 74, 5463-5467.
29. SANTANTONIO, T., JUNG, M. C., SCHNEIDER, R., PASTORE, G., PAPE, G. R. & WILL, H. (1991). Selection for a pre-C stop codon mutation in a hepatitis B variant with a pre-C initiation codon mutation during interferon treatment. Journal of Hepatology 13, 368-371.
30. TAKEDA, K., AKAHANE, Y., SUZUKI, H., OKAMOTO, H., TSUDA, F., MIYAKAWA, Y. & MAYUMI, M. (1990). Defects in the precore region of the HBV genome in patients with chronic hepatitis B after sustained seroconversion from HBeAg to anti-HBe induced spontaneously or with interferon therapy. Hepatology 12, 1284-1289.
31. TONG, S., LI, J., VITVITSKI, L. & TREPO, C. (1990). Active hepatitis B virus replication in the presence of anti-HBe is associated with viral variants containing an inactive pre-C region. Virology 176, 596-603.
32. TURKASPA, R., KLIN, A. & AHARONSON, S. (1992). Hepatitis B virus precore mutants are identical in carriers from various ethnic origins and are associated with a range of liver disease. Hepatology 16, 1338-1342.
33. VENTO, S., HEGARTY, J. E., ALBERTI, A., O'BRIEN, C. J., ALEXANDER, G. J. M., EDDLESTON, A, L. & WILLIAMS, R. (1985). T lympocytes sensitization to HBeAg and T cell-mediated unresponsiveness to HBsAg in hepatitis B virus-related chronic liver disease. Hepatology 5, 192-197.